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新型雙環(huán)衍生物的制作方法_5

文檔序號(hào):8366916閱讀:來(lái)源:國(guó)知局
6 (7H)-基)-2- (6-異丙基-3, 3-二甲基-2, 3-二氫-IH-茚-5-基氧基)乙酮; (3aS,8aR)-2-(lH-苯并三唑-5-羰基)-八氫-吡咯并[3,4-d]氮雜罩-6-甲酸 2- 氟-4_二氟甲氧基-節(jié)酯; 1-((3&1?,8&5)-2-(1!1-苯并[(1][1,2,3]三唑-5-羰基)八氫吡咯并[3,4-(1]氮雜罩. -6(7H)_基)-2-(5-氯-2-(三氟甲基)苯氧基)乙酮; 1-[ (3aS,8aR) -2- (1H-苯并三唑-5-羰基)-1,3, 3a,4, 5, 7,8,8a-八氫吡咯并[3,4-d] 氮雜罩-6-基]-2- (2-叔丁基-4-甲氧基苯氧基)乙酮; 4-[2-[ (3aS,8aR) -2- (1H-苯并三唑-5-羰基)-1,3, 3a,4, 5, 7,8,8a-八氫吡咯并[3, 4-d]氮雜卓_ _6_基]_2_氧代乙氧基]_3_丙_2_基苯甲臆; 1-[ (3aS,8aR) -2- (1H-苯并三唑-5-羰基)-1,3, 3a,4, 5, 7,8,8a-八氫吡咯并[3,4-d] 氮雜卓_ _6_基]-3_[3-氟-4-(2, 2, 2-二氟乙氧基)苯基]丙-1-酮; 1-[ (3aS,8aR) -2- (1H-苯并三唑-5-羰基)-1,3, 3a,4, 5, 7,8,8a-八氫吡咯并[3,4-d] 氮雜卓_ _6_基]-3_[2-氟-4-(2, 2, 2-二氟乙氧基)苯基]丙-1-酮; (3aS,8aR)-2-(lH-苯并三唑-5-羰基)-八氫-吡咯并[3,4-d]氮雜草-6-甲酸 3- 氟-4- (2, 2, 2-二氟-乙氧基)-節(jié)酯; (3aS,8aR)-2-(lH-苯并三唑-5-羰基)-八氫-吡咯并[3,4-d]氮雜草-6-甲酸 2-氟-4- (2, 2, 2-二氟-乙氧基)-節(jié)酯; (3aS,8aR) -2- (1H-苯并三唑-5-羰基)-八氫-吡咯并[3,4-d]氮雜罩-6-甲酸4- (2, 2, 2-二氟-乙氧基)-節(jié)酯; (3aS,6aS)-5-(3H-[l,2,3]三唑并[4,5-b]批啶-6-羰基)-六氫-吡咯并[3,4-c]批 咯-2-甲酸4-三氟甲氧基-芐酯; 1-[ (3aR,6aR) -5- (1H-三唑并[4, 5-b]吡啶-5-羰基)-1,3, 3a,4,6,6a-六氫吡咯并 [3,4-c]吡咯-2-基]-3-[4-(三氟甲氧基)苯基]丙-1-酮; (3aS,6aS)-5-(3H-[l,2,3]三唑并[4,5-c]吡啶-6-羰基)-六氫-吡咯并[3,4-c]批 咯-2-甲酸4-三氟甲氧基-芐酯; (3aS,6aS)-5-(4-氟-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 4- 二氟甲氧基-節(jié)酯; (3aS,6aS)-5-(7-氟-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 4-二氟甲氧基-節(jié)酯; (3aS,6aS)-5-(6-氟-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 4-二氟甲氧基-節(jié)酯; (3aS,6aS)-5-(4-氯-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 4-二氟甲氧基-節(jié)酯; (3aS,6aS)-5-(6-三氟甲基-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-甲酸4-三氟甲氧基-芐酯; (3aS,6aS)-5-(4-甲基-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲 酸4-三氟甲氧基-芐酯; (3aS,6aS)-5-(6-甲基-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲 酸4-三氟甲氧基-芐酯; l-[(3aR,6aR)-5-(4-氟-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-3-(4-三氟甲氧基-苯基)-丙-1-酮; (4-乙氧基喹啉-2-基)((3aS,6aS)-5-((R)-4,5,6,7-四氫-IH-苯并[d] [1,2,3]三 唑-5-羰基)六氫吡咯并[3,4-c]吡咯-2(1H)-基)甲酮; (4-乙氧基喹啉-2-基)((3aS,6aS)-5-(4-氟-IH-苯并[d] [1,2,3]三唑-5-羰基) 六氫吡咯并[3,4-c]吡咯-2 (IH)-基)甲酮; 6-[(3&1?,631?)-2-[3-[4-(二氣甲氧基)苯基]丙醜基]-1,3,33,4,6,63-六氫1批略并 [3,4-c]吡咯-5-羰基]-3H-1,3-苯并噁唑-2-酮; (363.663) -5-(2-氧代-2,3-二氫1-苯并卩惡唑-6-撰基)-六氫1-批略并[3,4-(3]批 咯-2-甲酸4-三氟甲氧基-芐酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基-芐酯; (3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸4-(1, 1,2, 2-四氟-乙氧基)-節(jié)酯; (3aS,6aS)-5-(1H-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸4-二氟 甲氧基-3-氟-節(jié)酯; (3aS,6aS)-5-(lH-[l,2,3]三唑并[4,5-b]批啶-5-羰基)-六氫-吡咯并[3,4-c]批 咯-2-甲酸3-氟-4-三氟甲氧基-芐酯; (3aS,6aS)-5-(1H-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸4-二氟 甲氧基-芐酯; (3aS,6aS)-5-(lH-[l,2,3]三唑并[4,5-b]批啶-5-羰基)-六氫-吡咯并[3,4-c]批 咯-2-甲酸4-三氟甲氧基-芐酯; (3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 3-氟-4_二氟甲氧基-節(jié)酯; (3&5,6&5)-5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-(2, 2, 2-二氟-乙氧基)-節(jié)酯; (3aS,6aS)-5-(1H-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸5-三氟 甲氧基-吡啶-2-基甲酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸4-氰基-2-異丙基-芐酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸4-氰基-2-異丙基-5-甲基-芐酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸2-氟-4-三氟甲氧基-芐酯; (3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 2-氟-4_二氟甲氧基-節(jié)酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基_2_乙氧基-節(jié)酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸3-氟-4-三氟甲氧基-芐酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基_2_異丙基-節(jié)酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基-2-異丙基-5-甲基-芐酯; (3aS,6aS)-5-(l,4,6,7-四氫-[1,2,3]三唑并[4,5-c]吡啶-5-羰基)-六氫-吡咯 并[3,4-c]吡咯-2-甲酸4-三氟甲氧基-芐酯; (3aR,6aR)-5-(1H-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸4-三氟 甲氧基-芐酯; (3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 2-氟-4_二氟甲基-節(jié)酯; (3aS,6aS)-5-(1H-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸4-三氟 甲基-芐酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸4-三氟甲氧基-芐酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸4-三氟甲基-芐酯; (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c] 吡咯-2-甲酸3-氯-5-甲磺?;?芐酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基-2-甲磺?;?芐酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基_2_乙氧基_5_氟-節(jié)酯; (3aS,6aS) -5- (4-甲氧基-IH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲 酸4-三氟甲氧基-芐酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基-2-環(huán)丁氧基-節(jié)酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基_2_異丙氧基-節(jié)酯; (365.663) -5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-甲酸4-氰 基_2_ (2, 2, 2-二氟-乙氧基)-節(jié)酯; (3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡咯-2-甲酸 4-氯-2-乙氧基_5_氟-節(jié)酯; (E)-I-[反式-2-(1Η-苯并三唑-5-基甲基)-八氫-吡咯并[3,4-c]吡 啶-5-基]-3- (4-三氟甲氧基-苯基)-丙烯酮; (3&5,6&5)-5-(4-氨磺?;?哌啶-1-羰基)-六氫-吡咯并[3,4-(:]吡咯-2-甲酸 4_三氟甲氧基-芐酯; l-[(3aR,6aR)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-3- (6-苯基-吡啶-3-基)-丙-1-酮; l-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2- (2-異丙基-苯氧基)-乙酮; l-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2-(2-三氟甲基-苯氧基)-乙酮; I- [ (3aS,6aS) -5- (1H-苯并三唑-5-羰基)-六氫-批咯并[3,4-c]批咯-2-基]-2-(聯(lián) 苯-2-基氧基)-乙酮; (E) -1-[ (3aS,6aS) -5- ((R) -4, 5,6, 7-四氫-IH-苯并三唑-5-羰基)-六氫-吡咯并 [3,4-c]吡咯-2-基]-3-(4-三氟甲氧基-苯基)-丙烯酮; 1-((3&1?,6&1〇-5-(〇〇-4,5,6,7-四氫-1!1-苯并[(1][1,2,3]三唑-5-羰基)六氫吡咯 并[3,4-c]吡咯-2 (IH)-基)-3-(4-(三氟甲氧基)苯基)丙-1-酮; l-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2- (2-氯-4-三氟甲氧基-苯氧基)-乙酮; l-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2- (2-吡咯-1-基-苯氧基)-乙酮; 4-{2-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2-氧代-乙氧基} -3-甲氧基-苯甲腈; 4-{2-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2-氧代-乙氧基}-苯甲腈; 1- [(3&3,6&3)-5-(1!1-苯并三唑-5-羰基)-六氫-吡咯并[3,4-(3]吡咯-2-基]-2-苯 氧基-乙酮; 2- {2-[(3aS,6aS)-5-(lH-苯并三唑-5-羰基)-六氫-吡咯并[3,4-c]吡 咯-2-基]-2-氧代-乙氧基} -5-三氟甲氧基-苯甲腈; 1-((3&1?,8&5)-2-(1!1-苯并[(1][1,2,3]三唑-5-羰基)八氫吡咯并[3,4-(1]氮雜萆. -6 (7H)-基)-2- (2-異丙基-5-甲基苯氧基)乙酮; (1H-苯并三唑-5-基)-[(3aS,6aS) -5- (6-三氟甲氧基-IH-吲哚-2-羰基)-六氫-批 咯并[3,4-c]吡咯-2-基]-甲酮; (1H-苯并三唑-5-基)-[(3aS,6aS) -5- (5-三氟甲氧基-IH-吲哚-2-羰基)-六氫-批 咯并[3,4-c]吡咯-2-基]-甲酮; 1-[反式-2_(111-苯并三唑-5-羰基)-八氫-吡咯并[3,4-(3]吡啶-5-基]-3-(4-三 氟甲氧基-苯基)-丙-1-酮; 1-[反式-2_(1H-苯并三唑-5-基甲基)-八氫-吡咯并[3,4-c]批啶-5-基]-3-(4-三 氟甲氧基-苯基)-丙-1-酮; 1-((3&1?,8&5)-2-(1!1-苯并[(1][1,2,3]三唑-5-羰基)八氫吡咯并[3,4-(1]氮雜罩. -6 (7H)-基)-3-(3-氯-5-(三氟甲基)苯基)丙-1-酮; 1-((3&1?,8&5)-2-(1!1-苯并[(1][1,2,3]三唑-5-羰基)八氫吡咯并[3,4-(1]氮雜罩. -6(7H)_基)-3-(4-甲氧基-2-(三氟甲基)苯基)丙-1-酮; 1-((3&1?,8&5)-2-(1!1-苯并[(1][1,2,3]三唑-5-羰基)八氫吡咯并[3,4-(1]氮雜罩. -6 (7H)-基)-3- (2-環(huán)丙基苯基)丙-1-酮; 1-[ (3aR,6aR) -5- (1H-苯并三唑-5-羰基)-1,3, 3a,4,6,6a-六氫吡咯并[3,4-c]吡 咯-2-基]-3-[3-甲氧基-5-(三氟甲氧基)苯基]丙-1-酮; l-[(3aS,6aS)-5-(lH-苯
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