專利名稱：用于控制寄生蟲的苯并咪唑－或吲哚－氨基乙腈衍生物的制作方法
技術(shù)領(lǐng)域：
本發(fā)明涉及新的式I的氨基乙腈化合物 其中R1表示氫、鹵素、氰基、硝基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷硫基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷基羰基、鹵代-C1-C6-烷基羰基、C1-C6-烷基亞硫?；?、C1-C6-烷基磺酰基、C1-C6-烷基氨基、二(C1-C6-烷基)氨基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；Ⅺu代-C1-C6-烷基亞硫?；?、C1-C6-烷基磺酰基和鹵代-C1-C6-烷基磺?；?；R2表示氫、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷硫基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷基亞硫?；?、C1-C6-烷基磺?；?、NR8R9、未取代或被一次或多次取代的雜芳基、未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基和鹵代-C1-C6-烷氧基；R3、R4和R5也互相獨(dú)立，表示氫、鹵素、C1-C6-烷基、鹵代-C1-C6-烷基、未取代或被一次或多次取代的C3-C6-環(huán)烷基，所述取代基互相獨(dú)立并并選自下列基團(tuán)鹵素和C1-C6-烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；Ⅺu代-C1-C6-烷基亞硫?；?、C1-C6-烷基磺?；?、鹵代-C1-C6-烷基磺酰基、C1-C6-烷基氨基或二-(C1-C6-烷基)氨基；或R4和R5一起表示C2-C6-亞烷基；R6表示氫、C1-C6-烷基、C1-C6-烷基羰基、C1-C6-烷氧基-C1-C6-烷基、氨基羰基、C1-C6-烷氧基羰基、鹵代-C1-C6-烷基羰基、硫代-C1-C6-烷基羰基或芐基；R7表示氫、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基、二(C1-C6-烷基)氨基、未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基、鹵代-C2-C6-鏈烯基、C2-C6-炔基、C3-C6-環(huán)烷基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基磺?；趸Ⅺu代-C1-C6-烷基磺?；趸?、C1-C6-烷基亞硫?；?、鹵代-C1-C6-烷基亞硫?；?、C1-C6-烷基磺?；?、鹵代-C1-C6-烷基磺酰基、C2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫酰基、鹵代-C2-C6-鏈烯基亞硫?；2-C6-鏈烯基磺?；?、鹵代-C2-C6-鏈烯基磺?；?、C1-C6-烷基氨基、二(C1-C6-烷基)氨基、C1-C6-烷基磺酰基氨基、鹵代-C1-C6-烷基磺?；被?、C1-C6-烷基羰基、鹵代-C1-C6-烷基羰基、C1-C6-烷氧基羰基、C1-C6-烷基氨基羰基、二(C1-C6-烷基)氨基羰基；未取代或被一次或多次取代的芳基-C1-C6-烷基、未取代或被一次或多次取代的芳基氨基、未取代或被一次或多次取代的芳基羰基、未取代或被一次或多次取代的芳基羰基氧基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C6-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C6-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺?；?、未取代或被一次或多次取代的芳基磺?；被?、未取代或被一次或多次取代的吡啶基氧基以及未取代或被一次或多次取代的苯基乙炔基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；Ⅺu代-C1-C6-烷基亞硫?；?、C1-C6-烷基磺?；望u代-C1-C6-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈碾s芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；?、鹵代-C1-C6-烷基亞硫?；2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫?；Ⅺu代-C2-C6-鏈烯基亞硫?；1-C6-烷基磺?；望u代-C1-C6-烷基磺?；2-C6-鏈烯基磺酰基、鹵代-C2-C6-鏈烯基磺?；1-C6-烷基氨基和二-(C1-C6-烷基)氨基；未取代或被一次或多次取代的萘基或喹啉基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；?、鹵代-C1-C6-烷基亞硫?；?、C2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫?；?、鹵代-C2-C6-鏈烯基亞硫?；?、C1-C6-烷基磺?；望u代-C1-C6-烷基磺?；?、C2-C6-鏈烯基磺?；?、鹵代-C2-C6-鏈烯基磺?；?、C1-C6-烷基氨基和二-(C1-C6-烷基)氨基；R8和R9互相獨(dú)立，表示氫、C1-C6-烷基、C1-C6-烷氧基羰基、C1-C6-烷基羰基、C1-C6-烷硫基羰基、硫代-C1-C6-烷基羰基、芳基或雜芳基；X表示C(R10)或N；R10表示氫、氰基、硝基、C1-C6-烷基、鹵代-C1-C6-烷基或C1-C6-烷氧基；Y表示鍵、C(O)、C(S)或S(O)n；a表示1、2或3；且n為0、1或2。
本發(fā)明還涉及這些化合物的制備方法、它們在控制體內(nèi)和體外外寄生蟲中的用途，特別是在溫血型生產(chǎn)家畜和家養(yǎng)動物和植物中的用途，并且還涉及含有這些化合物的殺蟲劑。
具有殺蟲活性的取代的氨基乙腈化合物在例如EP-0.953.565 A2中有所描述。然而，該文獻(xiàn)中特別公開的活性成分不能充分滿足效力和活性作用譜的需求。因此還需要具有更高的殺蟲性質(zhì)的活性成分。申請人發(fā)現(xiàn)式I的氨基乙腈化合物具有很好的殺蟲性質(zhì)，特別是在控制生產(chǎn)家畜和家養(yǎng)動物以及植物體內(nèi)和上的體內(nèi)和體外寄生蟲上具有更加突出的效果。
芳基為苯基或萘基。
雜芳基為吡啶基、嘧啶基、s-三嗪基、1，2，4-三嗪基、噻吩基、呋喃基、吡咯基、吡唑基、咪唑基、噻唑基、三唑基、噁唑基、噻二唑基、噁二唑基、苯并噻吩基、苯并呋喃基、苯并噻唑基、吲哚基或吲唑基，優(yōu)選吡啶基、嘧啶基、s-三嗪基或1，2，4-三嗪基，特別是吡啶基或嘧啶基。
烷基-作為基團(tuán)本身或其它基團(tuán)和化合物的構(gòu)成要素，例如鹵代-烷基、烷氧基和烷硫基-為(在每一情況下適當(dāng)考慮所述基團(tuán)或化合物的特定碳原子數(shù))直鏈(如甲基、乙基、丙基、丁基、戊基或己基)或支鏈(如異丙基、異丁基、仲-丁基、叔-丁基、異戊基、新戊基或異己基)。
鏈烯基-作為基團(tuán)本身或其它基團(tuán)和化合物的構(gòu)成要素-為(在每一情況下適當(dāng)考慮所述基團(tuán)或化合物的特定碳原子數(shù)以及共軛或單獨(dú)的雙鍵)-直鏈(如烯丙基、2-丁烯基、3-戊烯基、1-己烯基或1，3-己二烯基)或支鏈(如異丙烯基、異丁烯基、異戊二烯基、叔-戊烯基或異己烯基)。
炔基-作為基團(tuán)本身或其它基團(tuán)和化合物的構(gòu)成要素-為(在每一情況下適當(dāng)考慮所述基團(tuán)或化合物的特定碳原子數(shù)以及共軛或單獨(dú)的雙鍵)-直鏈(如炔丙基、2-丁炔基、3-戊炔基、1-己炔基、1-庚炔基或3-己烯-1-炔基)或支鏈(如3-甲基丁-1-炔基、4-乙基戊-1-炔基或4-甲基己-2-炔基)。
環(huán)烷基-作為基團(tuán)本身或其它基團(tuán)和化合物的構(gòu)成要素如鹵代環(huán)烷基-為(在每一情況下適當(dāng)考慮所述基團(tuán)或化合物的特定碳原子數(shù))環(huán)丙基、環(huán)丁基、環(huán)戊基或環(huán)己基。
鹵素-作為基團(tuán)本身或其它基團(tuán)和化合物的構(gòu)成要素如鹵代烷基、鹵代烷氧基和鹵代烷硫基-為氟、氯、溴或碘，特別是氟、氯或溴，特別是氟或氯。
含有鹵素取代的碳的基團(tuán)和化合物，如鹵代烷基、鹵代烷氧基或鹵代烷硫基，可以被部分鹵化或全部鹵化，在多重鹵化的情況下，該鹵素取代基可以相同或不同。鹵代-烷基的實(shí)例-作為基團(tuán)本身或作為其他基團(tuán)和化合物的構(gòu)成要素(如鹵代-烷氧基或鹵代-烷硫基)-為被氟、氯和/或溴一至三取代的甲基(如CHF2或CF3)；被氟、氯和/或溴一至五取代的乙基(如CH2CF3、CF2CF3、CF2CCl3、CF2CHCl2、CF2CHF2、CF2CFCl2、CF2CHBr2、CF2CHClF、CF2CHBrF或CClFCHClF)；被氟、氯和/或溴一至七取代的丙基或異丙基(如CH2CHBrCH2Br、CF2CHFCF3、CH2CF2CF3或CH(CF3)2)；被氟、氯和/或溴一至九取代的丁基或它的一個異構(gòu)體(如CF(CF3)CHFCF3或CH2(CF2)2CF3)；被氟、氯和/或溴一至十一取代的戊基或它的一個異構(gòu)體(如CF(CF3)(CHF)2CF3或CH2(CF2)3CF3)；和被氟、氯和/或溴一至十三取代的己基或它的一個異構(gòu)體(如(CH2)4CHBrCH2Br、CF2(CHF)4CF3、CH2(CF2)4CF3或C(CF3)2(CHF)2CF3)。
烷氧基基團(tuán)優(yōu)選具有長度為1至6個碳原子的鏈。烷氧基為例如甲氧基、乙氧基、丙氧基、異丙氧基、n-丁氧基、異丁氧基、仲-丁氧基和叔-丁氧基，以及戊氧基和己氧基的異構(gòu)體；優(yōu)選甲氧基和乙氧基。鹵代烷氧基基團(tuán)優(yōu)選具有長度為1至6個碳原子的鏈。鹵代烷氧基為例如氟代甲氧基、二氟甲氧基、三氟甲氧基、2，2，2-三氟乙氧基、1，1，2，2-四氟乙氧基、2-氟乙氧基、2-氯乙氧基、2，2-二氟乙氧基和2，2，2-三氯乙氧基；優(yōu)選二氟甲氧基、2-氯乙氧基和三氟甲氧基。
烷硫基基團(tuán)優(yōu)選具有長度為1至6個碳原子的鏈。烷硫基為例如甲硫基、乙硫基、丙硫基、異丙硫基、n-丁硫基、異丁硫基、仲-丁硫基或叔-丁硫基，優(yōu)選甲硫基和乙硫基。
本發(fā)明范圍內(nèi)的優(yōu)選實(shí)施方案為(1)式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C4-烷基磺酰基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；特別是氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；最特別是氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；(2)式I化合物，其中R2表示氫、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷硫基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基或C1-C4-烷基磺?；惶貏e是氫、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷硫基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；最特別是氫、甲基、鹵代甲基、甲硫基、甲氧基或鹵代甲氧基；(3)式I化合物，其中R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C3-C6-環(huán)烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基；C1-C4-烷硫基和鹵代-C1-C4-烷硫基；或R4和R5一起為C2-C6-亞烷基；特別是，R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C2-烷基、鹵代-C1-C2-烷基或C3-C6-環(huán)烷基；最特別是，R3、R4和R5互相獨(dú)立，為氫、甲基或鹵代甲基；(4)式I化合物，其中R6為氫、C1-C4-烷基、C1-C4-烷基羰基、C1-C6-烷氧基-C1-C6-烷基或芐基；特別是氫、C1-C2-烷基、C1-C2-烷基羰基或芐基；最特別是氫或C1-C2-烷基；(5)式I化合物，其中R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基、鹵代-C2-C4-鏈烯基、C2-C4-炔基、C3-C6-環(huán)烷基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；趸?、鹵代-C1-C4-烷基磺?；趸?、C1-C4-烷基磺酰基、鹵代-C1-C4-烷基磺?；2-C4-鏈烯基磺?；Ⅺu代-C2-C4-鏈烯基磺?；?、C1-C4-烷基氨基、二(C1-C4-烷基)氨基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C6-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺?；臀慈〈虮灰淮位蚨啻稳〈倪拎せ趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?br> 未取代或被一次或多次取代的雜芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；未取代或被一次或多次取代的萘基或喹啉基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C2-C4-鏈烯硫基、鹵代-C2-C4-鏈烯硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；特別是未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；?、鹵代-C1-C2-烷基磺酰基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C2-烷基和未取代或被一次或多次取代的吡啶基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；望u代-C1-C2-烷基磺酰基；未取代或被一次或多次取代的雜芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；望u代-C1-C2-烷基磺?；蛔钐貏e是未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基和未取代或被一次或多次取代的芳基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基和鹵代-C1-C2-烷氧基；(6)式I化合物，其中R10表示氫、氰基、硝基或C1-C4-烷基；特別是氫或氰基；最特別是氫；(7)式I化合物，其中Y為C(O)或S(O)n；特別是C(O)；(8)式I化合物，其中a為1或2；特別是1；(9)式I化合物，其中n為2；(10)式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C4-烷基磺?；蛭慈〈蛉〈谋窖趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；R2為氫、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷硫基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基或C1-C4-烷基磺酰基；R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C3-C6-環(huán)烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基；C1-C4-烷硫基和鹵代-C1-C4-烷硫基；或R4和R5一起為C2-C6-亞烷基；R6為氫、C1-C4-烷基、C1-C4-烷基羰基、C1-C6-烷氧基-C1-C6-烷基或芐基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基、鹵代-C2-C4-鏈烯基、C2-C4-炔基、C3-C6-環(huán)烷基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；趸Ⅺu代-C1-C4-烷基磺?；趸?、C1-C4-烷基磺?；Ⅺu代-C1-C4-烷基磺?；?、C2-C4-鏈烯基磺?；?、鹵代-C2-C4-鏈烯基磺?；1-C4-烷基氨基、二(C1-C4-烷基)氨基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C6-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺?；臀慈〈虮灰淮位蚨啻稳〈倪拎せ趸鋈〈ハ嗒?dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈碾s芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；未取代或被一次或多次取代的萘基或喹啉基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C2-C4-鏈烯硫基、鹵代-C2-C4-鏈烯硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；Y為C(O)或S(O)n；a表示1或2；且n表示2；(11)式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；R2表示氫、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷硫基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；R3、R4和R5互相獨(dú)立，表示氫、鹵素、C1-C2-烷基、鹵代-C1-C2-烷基或C3-C6-環(huán)烷基；R6表示氫、C1-C2-烷基、C1-C2-烷基羰基或芐基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺酰基、鹵代-C1-C2-烷基磺酰基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C2-烷基和未取代或被一次或多次取代的吡啶基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺酰基和鹵代-C1-C2-烷基磺?；?；未取代或被一次或多次取代的雜芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺酰基和鹵代-C1-C2-烷基磺?；籖10表示氫或氰基；Y表示C(O)；且a表示1；(12)式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；R2表示氫、甲基、鹵代甲基、甲硫基、甲氧基或鹵代甲氧基；R3、R4和R5互相獨(dú)立，表示氫、甲基或鹵代甲基；R6表示氫或C1-C2-烷基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基和未取代或被一次或多次取代的芳基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基和鹵代-C1-C2-烷氧基；R10表示氫；Y表示C(O)；且a為1。
在本發(fā)明的上下文中，特別優(yōu)選的式I化合物在表1中列出，并且最特別的在合成實(shí)施例中列出。
本發(fā)明的另一個目的是制備分別為游離形式或鹽形式的式I化合物的方法，例如其特征在于將式II化合物
式II化合物是已知的或可以根據(jù)已知相應(yīng)化合物制備的類似方法制備，且其中R1、R2、R3、R4、R5、R6、X和a如式I定義中給出，與式III化合物反應(yīng)Q-Y-R7III，式III化合物是已知的或可以根據(jù)已知相應(yīng)化合物制備的類似方法制備，其中Y和R7如式I定義給出，且Q為離去基團(tuán)，任選在堿催化劑存在下反應(yīng)，并且如果需要，將根據(jù)該方法或其他方法得到的游離形式或鹽形式的式I化合物轉(zhuǎn)化為另一式I化合物，將根據(jù)該方法得到的異構(gòu)體的混合物分離并將根據(jù)該方法分離的所需的異構(gòu)體和/或得到的游離的式I化合物轉(zhuǎn)化為鹽，或?qū)⒏鶕?jù)該方法得到的式I化合物的鹽轉(zhuǎn)化為游離的式I化合物或另一種鹽。
上文有關(guān)式I化合物的鹽的描述也適用于上下文中列出的起始原料的鹽。
所述反應(yīng)物可以采用它們原有的形式相互反應(yīng)，即不需加入溶劑或稀釋劑(如在熔融狀態(tài)下)。然而，在大部分情況下，優(yōu)選加入惰性溶劑或稀釋劑或它們的混合物。這些溶劑或稀釋劑的實(shí)例有芳族、脂族和脂環(huán)族烴和鹵化烴，例如苯、甲苯、二甲苯、1，3，5-三甲基苯、萘滿、氯苯、二氯苯、溴苯、石油醚、己烷、環(huán)己烷、二氯甲烷、三氯甲烷、四氯甲烷、二氯乙烷、三氯乙烯或四氯乙烯；醚，如乙醚、二丙醚、二異丙醚、二丁醚、叔-丁基甲醚、乙二醇單甲醚、乙二醇單乙醚、乙二醇二甲基醚、二甲氧基二乙醚、四氫呋喃或二噁烷；酮如丙酮、甲基乙酮或甲基異丁酮；酰胺，如N，N-二甲酰胺、N，N-二乙酰胺、N，N-二甲基乙酰胺、N-甲基吡咯烷酮或六甲基磷酸三酰胺；腈，如乙腈或丙腈；以及亞砜，如二甲基亞砜。
優(yōu)選的離去基團(tuán)為鹵素，特別是氯。
有利于反應(yīng)的適當(dāng)?shù)膲A為如堿金屬或堿土金屬氫氧化物、氫化物、氨化物、烷醇化物、乙酸鹽、碳酸鹽、二烷基氨化物或烷基甲硅烷基氨化物；烷基胺、亞烷基二胺、任選N-烷基化的、任選未飽和的環(huán)烷基胺、堿性雜環(huán)、銨氫氧化物以及碳環(huán)胺?？商岬降膶?shí)例有氫氧化鈉、氫化鈉、氨化鈉、甲醇化鈉、乙酸鈉、碳酸鈉、叔-丁醇化鉀、氫氧化鉀、碳酸鉀、氫化鉀、二異丙基氨化鋰、雙(三甲基甲硅烷基)-氨化鉀、氫化鈣、三乙胺、二異丙基乙胺、三亞乙基二胺、環(huán)己胺、N-環(huán)己基-N，N-二甲基胺、N，N-二乙基苯胺、吡啶、4-(N，N-二甲基氨基)吡啶、奎寧環(huán)、N-甲基嗎啉、芐基三甲基銨氫氧化物以及1，5-二氮雜雙環(huán)[5.4.0]十一碳-5-烯(DBU)。優(yōu)選二異丙基乙基胺和4-(N，N-二甲基氨基)吡啶。
該反應(yīng)優(yōu)選在溫度約0℃至約100℃范圍內(nèi)進(jìn)行，優(yōu)選約10℃至約40℃。
在優(yōu)選的方法中，于室溫下、在鹵化烴(優(yōu)選二氯甲烷)中、在堿(優(yōu)選二異丙基乙基胺和4-(N，N-二甲基氨基)吡啶的混合物)存在下，使式II化合物與式III化合物反應(yīng)。
本發(fā)明的進(jìn)一步目標(biāo)是制備分別為游離形式或鹽形式的式II化合物的方法，例如其特征在于將式IV化合物 式IV化合物是已知的或可以根據(jù)已知相應(yīng)化合物類似的方法生成，其中R1、R2、R3、R4、R5、X和a如式I定義，與無機(jī)或有機(jī)氰化物和式R6-NH2化合物反應(yīng)，式R6-NH2化合物是已知的或可以根據(jù)已知相應(yīng)化合物類似的方法生成，且其中R6如式I定義，并且如果需要，將根據(jù)該方法或其他方法得到的游離形式或鹽形式的式II化合物轉(zhuǎn)化為另一式II化合物，將根據(jù)該方法得到的異構(gòu)體的混合物分離并將根據(jù)該方法分離的所需的異構(gòu)體和/或得到的游離的式H化合物轉(zhuǎn)化為鹽，或?qū)⒏鶕?jù)該方法得到的式II化合物的鹽轉(zhuǎn)化為游離的式II化合物或其他鹽。
適當(dāng)?shù)那杌餅榍杌c、氰化鉀、三甲基甲硅烷基氰化物和丙酮合氰化氫。
羰基化合物(如式IV)與氰化物和胺(如式R6-NH2的胺)的反應(yīng)的常規(guī)方法即為斯特勒克反應(yīng)，如在Organic Synthesis Coll.Vol.3，88(1973)中所述。
化合物I的鹽可以采用已知的方法生成。例如，用適當(dāng)?shù)乃峄蜻m當(dāng)?shù)碾x子交換劑處理化合物I得到酸加成鹽，而用適當(dāng)?shù)膲A或適當(dāng)?shù)碾x子交換劑處理則可得到堿加成鹽。
化合物I的鹽可以采用常用方法轉(zhuǎn)化為游離化合物I，例如，用適當(dāng)?shù)膲A性組合物或適當(dāng)?shù)碾x子交換劑處理酸加成鹽，用適當(dāng)?shù)乃峄蜻m當(dāng)?shù)碾x子交換劑處理堿加成鹽。
化合物I的鹽可以采用已知的方法轉(zhuǎn)化為化合物I的其他鹽；例如，酸加成鹽可以轉(zhuǎn)化為其他酸加成鹽，如采用酸的適當(dāng)?shù)慕饘冫}(如鈉、鋇或銀鹽，如乙酸銀)處理無機(jī)酸鹽，如鹽酸鹽，該處理在適當(dāng)?shù)娜軇┲羞M(jìn)行，得到不溶性無機(jī)鹽(如氯化銀)，由此可從反應(yīng)混合物中沉淀出來。
基于所述方法和/或反應(yīng)條件，具有鹽形成性質(zhì)的化合物I可以以游離形式或鹽形式獲得。
化合物I也可以以它們的水合物的形式獲得和/或也可以包括其他溶劑，例如用于需要時(shí)使化合物結(jié)晶時(shí)固體形式中存在的溶劑。
化合物I和II可以任選以光學(xué)和/或幾何學(xué)異構(gòu)體或它們的混合物的形式存在。本發(fā)明不僅涉及純異構(gòu)體，也涉及所有可能的異構(gòu)混合物，并且盡管沒有在每一立體化學(xué)描述中特別指出，但在上下文中均為此含義。
可以通過該方法或其他方法得到化合物I和II的非對映異構(gòu)體混合物，并且可以采用已知的方法分離，基于它們的組分的物理-化學(xué)差異，可轉(zhuǎn)化為純的非對映異構(gòu)體，例如通過分級結(jié)晶、蒸餾和/或?qū)游觥?br> 因此，根據(jù)已知的方法可以將獲得的對映體混合物分離為純的異構(gòu)體，例如通過自光學(xué)活性溶劑中重結(jié)晶，在手性吸附劑上層析，例如在適當(dāng)?shù)奈⑸飵椭?，于乙酰纖維素上高壓液相層析(HPLC)，用特定的固定化酶裂解，通過包合物形成(例如采用手性冠醚)，在此只有一個對映體絡(luò)合。
根據(jù)本發(fā)明，除分離相應(yīng)的異構(gòu)體混合物外，也可以采用通常已知的非對映選擇或?qū)τ尺x擇合成方法得到純的非對映異構(gòu)體或?qū)τ丑w，如采用本發(fā)明方法使用具有相應(yīng)的適當(dāng)?shù)牧Ⅲw化學(xué)的離析物。
優(yōu)選分離或合成生物學(xué)上更具活性的異構(gòu)體，如對映體，前提是單一成分具有不同的生物效能。
在本發(fā)明的方法中，使用的起始原料和中間體優(yōu)選為可以生成說明書開始所述的特別有用的化合物I的那些起始原料和中間體。
本發(fā)明特別涉及實(shí)施例所描述的制備方法。
本發(fā)明的目的還包括新的可以根據(jù)本發(fā)明的方法用于制備化合物I的起始原料和中間體，以及它們的使用和制備它們的方法。
由于它們具有廣譜活性并可在害蟲防治(特別是包括動物內(nèi)和外寄生蟲的防治)中用作活性成分，本發(fā)明的化合物I具有重要的價(jià)值，同時(shí)化合物I在溫血動物、魚類和植物中均具有十分良好的耐受性。
在本發(fā)明文中，外寄生蟲可以被理解為特別是昆蟲、螨和蜱。這些包括的昆蟲如下鱗翹目、鞘翅目、同翅亞目、異翅亞目、雙翅目、纓翅目、直翅目、虱目、蚤目、食毛目、纓尾目、等翅目、嚙蟲目和膜翅目。然而，特別可提及的外寄生蟲是指那些困擾人類或動物并攜帶病原體的外寄生蟲，例如雙翅昆蟲(如家蠅、Musca vetustissima、秋家蠅、小毛廁蠅、肉蠅、銅綠蠅、牛皮蠅、紋皮下蠅(Hypodermalineatum)、金蠅(chrysomyia chloropyga)、人皮蠅(dermatobiahominis)、美洲錐蠅、普通馬蠅(gasterophilus intestinalis)、羊狂蠅、廄螫蠅)、擾血蠅(Haematobia irritans)和蠓(midges)(長角亞目)(如蚊科、蚋科、毛蛉科)，另外還指吸血寄生蟲，例如蚤(如貓?jiān)楹凸吩?貓和狗蚤)、印鼠客蚤、致癢蚤、穿皮潛蚤(dermatophilus penetrans)、虱子(如羊嚙虱(Damalina ovis)、Pediculus humanis、biting flies和馬蠅(虻科)、Haematopota spp.(如Haematopota pluvialis)、Tabanidea spp.(如Tabanus nigrovittatus)、Chrysopsinae spp.(如Chrysops caecutiens)、采采蠅(如采采蠅屬)、biting昆蟲，特別是蟑螂(如德國蜚蠊(Blatellagermanica)、東方蜚蠊、美洲蜚蠊)、螨(如雞皮刺螨、疥螨、羊癢螨和Psorergates spp.)，另外還包括蜱。后者屬于螨類。已知的典型的蜱有，例如牛蜱屬、花蜱屬、暗眼蜱屬、革蜱屬、血蜱屬、眼蜱屬、硬蜱屬、扇革蜱屬(rhipicentor)、巨肢蜱屬(margaropus)、扇頭蜱屬(phipicephalus)、銳緣蜱屬(argas)、耳蜱屬(otobius)和鈍緣蜱屬(ornithodors)及其他，優(yōu)選寄生于溫血動物的蜱，所述溫血動物包括飼養(yǎng)動物(如牛、豬、綿羊和山羊)、家禽(如雞、火雞和鵝)、帶毛動物(如貂、狐貍、栗鼠、兔及其他)，以及家畜(如貓和狗)，還有人。
化合物I也可以用于防治衛(wèi)生害蟲，特別是雙翅目的麻蠅科、Anophilidae和蚊科家族；直翅目、網(wǎng)翅目(如蜚蠊科家族)和膜翅目(如蟻科家族)。
化合物I也對防治寄生螨和植物昆蟲具有較好的功效。它們對防治螨類的蜘蛛螨的卵、蛹和葉螨科(葉螨屬和全爪螨屬)的成蟲也是有效的。
它們對防治同翅目sucking昆蟲(特別是防治蚜科、飛虱科、葉蟬蚪、木虱科、Loccidae、盾蚧科和Eriophydidae(如柑橘類的水果的銹螨)家族的害蟲)；半翅目、異翅亞目和纓翅目，以及鱗翅目、鞘翅目、雙翅目和直翅目的食植物昆蟲具有很高的活性。
它們也類似地適于用作土壤殺蟲劑以防治土壤中的害蟲。
因此，式I化合物對防治所有農(nóng)作物(如谷物、棉花、大米、玉米、大豆、馬鈴薯、蔬菜、水果、煙草、蛇麻草、柑橘、鱷梨和其它農(nóng)作物)上所有發(fā)展階段的的吸作物(sucking)昆蟲和食作物(eating)昆蟲均有效。
式I化合物也對防治根結(jié)線蟲屬、胞囊線蟲屬、短體線蟲屬、莖線蟲屬、穿孔線蟲屬、Rizoglyphus等類的植物線蟲有效。
具體而言，這些化合物對防治蠕蟲有效，其中內(nèi)寄生線蟲和吸蟲可以引發(fā)哺乳動物和家禽的嚴(yán)重疾病，所述哺乳動物和家禽為例如綿羊、豬、山羊、牛、馬、驢、狗、貓、豚鼠和奇異鳥(exotic bird)。此處所指的典型的線蟲為血矛線蟲屬、毛樣線蟲屬、奧斯他胃蟲屬、細(xì)頸線蟲屬、庫柏絲、蛔蟲、仰口線蟲屬(bunostonum)、細(xì)節(jié)線蟲屬(oesophagostonum)、Charbertia、鞭蟲屬、如圓屬(strongylus)、Trichonema、網(wǎng)尾屬、毛細(xì)線蟲屬、異刺屬、弓首蟲、禽蛔屬、尖尾線蟲屬(oxyuris)、鉤蟲屬(ancylostoma)、鉤蟲屬(uncinaria)、弓蛔線蟲屬(toxascaris)和副蛔蟲屬(parascaris)。吸蟲包括，特別是，F(xiàn)asciolideae家族，特別是肝片形吸蟲。式I化合物特別的優(yōu)點(diǎn)是它們能夠防治那些對基于苯并咪唑的活性成分具有抗性的寄生蟲。
細(xì)頸線蟲屬、庫柏絲和細(xì)節(jié)線蟲屬的某些害蟲在宿主動物的腸道內(nèi)大量滋生，然而，其他血矛屬和奧斯他胃蟲屬的害蟲在胃中寄生，網(wǎng)尾屬的害蟲則在肺中寄生。絲蟲科和Setariidae家族的寄生蟲可在內(nèi)細(xì)胞組織和器官(如心臟、血管、淋巴管和皮下組織)中發(fā)現(xiàn)。特別值得注意的寄生蟲是寄生于狗體內(nèi)的犬心蟲，犬惡絲蟲。式I化合物對這些寄生蟲具有很好的控制效果。
另外，式I化合物適于控制人類致病的寄生蟲。包括在消化道內(nèi)出現(xiàn)的典型寄生蟲鉤蟲屬、板口線蟲屬、蛔蟲、糞桿線蟲屬、旋毛形線蟲屬、毛細(xì)線蟲屬、鞭蟲屬和蟯蟲屬等。本發(fā)明的化合物也對控制絲蟲科的吳策線蟲屬(Wuchereria)、布氏絲蟲屬(Brugia)、盤尾絲蟲屬(Onchocerca)和羅阿絲蟲屬(Loa)的寄生蟲有效，這些寄生蟲在血液、組織和各種器官中均可發(fā)現(xiàn)，本發(fā)明的化合物也對控制Dracunculus和糞桿線蟲屬和旋毛線蟲屬寄生蟲有效，這些寄生蟲則特別是在胃腸道內(nèi)感染。
本發(fā)明式I化合物的優(yōu)良的殺蟲活性相應(yīng)于殺滅所述害蟲的死亡率為至少50-60％。特別地，式I化合物的長效性是顯著的。
式I化合物優(yōu)選以其原有形式或優(yōu)選與用于制劑領(lǐng)域的傳統(tǒng)輔助劑一起使用，并且可以采用已知的方法進(jìn)行加工從而得到，例如，可乳化的濃縮物、可直接稀釋的溶液、稀乳劑、可溶粉劑、顆?；蚓酆衔镔|(zhì)中的微囊。就組合物而言，其使用方法則可依照所要達(dá)到的目的和具體情況來選擇。
制劑(即包含式I活性成分或這些活性成分與其他活性成分的組合，并且任選還含有固體或液體輔助劑的藥物、制劑或組合物)可以以已知的常規(guī)方法生產(chǎn)，例如充分混合和/或與將活性成分與其他組分一起研磨(例如與溶劑、固體載體和任選表面活性化合物(表面活性劑))。
所述的溶劑可以為醇(如乙醇、丙醇或丁醇)、二醇以及它們的醚和酯(如丙二醇、雙丙甘醇醚、乙二醇、乙二醇單甲基或-乙基醚)、酮(如環(huán)己酮、異佛樂酮或diacetanol alcohol)、強(qiáng)極性溶劑(如N-甲基-2-吡咯烷酮、二甲基亞砜或二甲酰胺)、或水、植物油(如油菜、蓖麻、椰子或大豆油等，如果合適，也可以用硅油)。
優(yōu)選的用于溫血動物控制寄生蟲的藥物應(yīng)用形式包括溶液、乳液、懸浮液(液體藥劑)、食品添加劑、粉劑、片劑(包括泡騰片劑)、大丸劑(boli)、膠囊、微囊和灌注劑(pour-on formulation)，在此必須考慮到制劑賦形劑的生理相容性。
片劑和大丸劑的粘合劑可以為化學(xué)改性的聚合天然物質(zhì)，該物質(zhì)可溶于水或醇，例如淀粉、纖維素或蛋白質(zhì)衍生物(如甲基纖維素、羧甲基纖維素、乙基羥乙基纖維素、蛋白質(zhì)(如玉米蛋白、明膠等)以及合成聚合物(如聚乙烯醇、聚乙烯吡咯烷酮等)。該片劑也可包含填充劑(如淀粉、微晶纖維素、糖、乳糖等)、助流劑和崩解劑。
如果該驅(qū)蟲劑以飼料濃縮物的形式提供，則使用的載體為如性能飼料(performance feeds)、飼料雜糧(feed grain)或蛋白質(zhì)濃縮物。除了活性成分外，這些飼料的濃縮物或組合物還可以包括添加劑、維生素、抗生素、化療劑或其他殺蟲劑、主要抑菌劑、抑真菌劑、抑制球蟲劑，甚至還可以包括激素制劑、具有合成代謝作用的物質(zhì)或促進(jìn)生長的物質(zhì)，這些會影響屠宰的動物肉的質(zhì)量，但另一方面卻對生物體有益。如果將該組合物或?qū)⑹絀的活性成分直接加入飼料或飲水槽中，則該配制的包含活性成分的飼料或飲料的濃度優(yōu)選為約0.0005至0.02％重量(5-200ppm)。
本發(fā)明的式I化合物可以單獨(dú)或與其它生物殺滅劑聯(lián)合使用。它們可以與具有類似活性的殺蟲劑聯(lián)合使用，如用來增加活性，或與具有其它活性的物質(zhì)聯(lián)合使用，如用來增加活性的范圍。也可以加入所稱的驅(qū)蟲劑。如果需要增加對內(nèi)寄生蟲(例如蠕蟲)的活性范圍，式I化合物適于與具有殺滅內(nèi)寄生蟲性質(zhì)的物質(zhì)聯(lián)合。當(dāng)然，它們也可以與抗菌組合物聯(lián)合使用。因?yàn)槭絀化合物為殺成蟲藥，即因?yàn)樗鼈儗τ诔墒炱诘哪繕?biāo)寄生蟲特別有效，所以加入殺滅幼寄生蟲的殺蟲劑十分有效。以這種方法，可以對抗造成巨大經(jīng)濟(jì)損失的大部分寄生蟲。另外，該方法也可以充分避免抗性的形成。多種物質(zhì)的組合也可以產(chǎn)生協(xié)同作用，即可以減少活性成分總量，這符合生態(tài)學(xué)的要求。優(yōu)選的和特別優(yōu)選的成對的化合物的組合如下文所述，其中除式I化合物外，所述組合還可以包括一個或多個這樣的化合物對。
適當(dāng)?shù)脑谠摶旌衔镏写嬖诘幕衔飳梢詾闅⑸飫缇哂懈鞣N活性機(jī)制的殺蟲劑和殺螨劑，其名稱如下文所述，并且早已為本領(lǐng)域技術(shù)人員所知，如幾丁質(zhì)合成抑制劑、生成調(diào)節(jié)劑；作為保幼激素的活性成分；作為殺成蟲藥的活性成分；廣譜殺蟲劑、廣譜殺螨劑和殺線蟲劑；還有人們熟知的驅(qū)蟲和昆蟲-和/或螨-抑制物質(zhì)、所述驅(qū)蟲劑或剝離劑。
非限定性的適當(dāng)?shù)臍⑾x劑和殺螨劑的實(shí)例為
非-限制性的適當(dāng)?shù)尿?qū)蟲劑名稱的實(shí)例如下文所述，少數(shù)驅(qū)蟲劑除具有驅(qū)蟲活性外，還具有殺蟲和殺螨活性，部分已在上文中列出。
(A1)吡喹酮＝2-環(huán)己基羰基-4-氧代-1，2，3，6，7，11b-六氫-4H-吡嗪并[2，1-α]異喹啉(A2)氯氰碘柳胺＝3，5-二碘代-N-[5-氯-2-甲基-4-(a-氰基-4-氯芐基)苯基]水楊基酰胺(A3)三氯苯噠唑＝5-氯-6-(2，3-二氯苯氧基)-2-甲硫基-1H-苯并咪唑(A4)左旋咪唑＝L-(-)-2，3，5，6-四氫-6-苯基咪唑并[2，1b]噻唑(A5)甲苯噠唑＝(5-苯甲?；?1H-苯并咪唑-2-基)氨基甲酸甲酯(A6)Omphalotin＝在WO 97/20857中描述的真菌發(fā)光臍菇的大環(huán)發(fā)酵產(chǎn)物(A7)阿維菌素＝阿維菌素B1(A8)伊維菌素＝22，23-二氫阿維菌素B1(A9)莫西菌素＝5-O-脫甲基-28-脫氧基-25-(1，3-二甲基-1-丁烯基)-6，28-環(huán)氧基-23-(甲氧基亞氨基)-犬心安B(A10)多拉菌素＝25-環(huán)己基-5-O-脫甲基-25-脫(1-甲基丙基)-阿維菌素A1a(A11)密滅?。饺陌睞3和犬心安A4的混合物(A12)Milbemycinoxim＝密滅汀5-肟非-限制性的適當(dāng)?shù)尿?qū)蟲劑和剝離劑的實(shí)例有(R1)DEET(N，N-二乙基-m-甲苯酰胺)(R2)KBR 3023N-丁基-2-氧基羰基-(2-羥基)-哌啶(R3)Cymiazole＝N-2，3-二氫-3-甲基-1，3-噻唑-2-叉基-2，4-二甲苯胺所述混合物的組合對本領(lǐng)域的技術(shù)人員來講非常熟悉。大部分在各種版本的Pesticide Manual，The British Crop Protection Council，倫敦，其他的各種版本的Merck Index，Merck & Co.，Inc.，Rahway，新澤西州，USA中有描述或?qū)＠墨I(xiàn)中有描述。因此，下文所列的文獻(xiàn)僅作為示例，而不用于限制。
(I)2-甲基-2-(甲硫基)丙醛-O-甲基氨基甲酰肟(涕滅威)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第26頁；(II)S-(3，4-二氫-4-氧代苯并[d]-[1，2，3]-三嗪3-基甲基)O，O-二甲基-二硫逐磷酸酯(甲基谷硫磷)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第67頁；(III)乙基-N-[2，3-二氫-2，2-二甲基苯并呋喃-7-基氧基羰基-(甲基)氨基硫代]-N-異丙基-β-丙氨酸酯(丙硫克百威)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第96頁；(IV)2-甲基聯(lián)苯-3-基甲基-(Z)-(1RS)-順式-3-(2-氯-3，3，3-三氟丙-1-烯基)-2，2-二甲基環(huán)丙烷甲酸酯(聯(lián)苯菊酯)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第118頁；(V)2-叔-丁基亞氨基3-異丙基-5-苯基-1，3，5-噻二嗪-4-酮(噻嗪酮)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第157頁；(VI)2，3-二氫-2，2-二甲基苯并呋喃-7-基-甲基氨基甲酸酯(克百威)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第186頁；(VII)2，3-二氫-2，2-二甲基苯并呋喃-7-基-(二丁基氨基硫代)甲基氨基甲酸酯(好安威)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第188頁；(VIII)S，S′-(2-二甲基氨基三亞甲基)-雙(硫代氨基甲酸酯)(殺螟丹)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第193頁；(IX)1-[3，5-二氯-4-(3-氯-5-三氟甲基-2-吡啶基氧基)苯基]-3-(2，6-二氟苯甲?；?-脲(定蟲隆)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，213頁；(X)O，O-二乙基-O-3，5，6-三氯-2-吡啶基-硫逐磷酸酯(毒死蜱)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第235頁；(XI)(RS)-α-氰基-4-氟-3-苯氧基芐基-(1RS，3RS；1RS，3RS)-3-(2，2-二氯-乙烯基)-2，2-二-甲基環(huán)丙烷甲酸酯(氟氯氰菊酯)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第293頁；(XII)(S)-α-氰基3-苯氧基芐基-(Z)-(1R，3R)-3-(2-氯-3，3，3-三氟丙烯基)-2，2-二甲基環(huán)丙烷甲酸酯和(R)-α-氰基-3-苯氧基芐基-(Z)-(1R，3R)-3-(2-氯-3，3，3-三氟丙烯基)-2，2-二甲基環(huán)丙烷甲酸酯(氯氟氰菊酪)的混合物，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第300頁；(XIII)包含(S)-α-氰基-3-苯氧基芐基-(Z)-(1R，3R)-3-(2，2-二氯乙烯基)-2，2-二甲基環(huán)丙烷甲酸酯和(R)-α-氰基-3-苯氧基芐基-(1S，3S)-3-(2，2-二氯乙烯基)-2，2-二甲基環(huán)丙烷甲酸酯的外消旋物(α-氯氰菊酯)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第308頁；(XIV)(S)-α-氰基-3-苯氧基芐基(1RS，3RS，1RS，3RS)-3-(2，2-二氯乙烯基)-2，2-二甲基環(huán)丙烷甲酸酯的立體異構(gòu)體的混合物(ζ-氯氰菊酯)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第314頁；(XV)(S)-α-氰基-3-苯氧基芐基-(1R，3R)-3-(2，2-二溴乙烯基)-2，2-二甲基環(huán)丙烷甲酸酯(溴氰菊酯)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第344頁；(XVI)(4-氯苯基)-3-(2，6-二氟苯甲?；?脲(除蟲脲)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第395頁；(XVII)(1，4，5，6，7，7-六氯-8，9，10-三降冰-5-烯-2，3-亞基雙亞甲基)-亞硫酸酯(硫丹)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第459頁；(XVIII)α-乙硫基-o-甲苯基-甲基氨基甲酸酯(乙硫甲威)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第479頁；(XIX)O，O-二甲基-O-4-硝基-m-甲苯基-硫逐磷酸酯(殺螟硫磷)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第514頁；(XX)2-仲-丁基苯基-甲基氨基甲酸酯(仲丁威)，The Pesticide Manuai，11thEd.(1997)，The British Crop Protection Council，倫敦，第516頁；(XXI)(RS)-α-氰基-3-苯氧基芐基-(RS)-2-(4-氯苯基)-3-甲基丁酸酯(氰戊菊酯)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectiouCouncil，倫敦，第539頁；(XXII)S-[甲酸基(甲基)氨基甲酰甲基]-O，O-二甲基-二硫逐磷酸酯(安果)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第625頁；(XXIII)4-甲硫基-3，5-二甲苯基-甲基氨基甲酸酯(滅蟲威)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第813頁；(XXIV)7-氯雙環(huán)[3.2.0]庚-2，6-二烯-6-基-二甲基磷酸酯(庚蟲磷)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第670頁；(XXV)1-(6-氯-3-吡啶基甲基)-N-硝基亞咪唑烷-2-叉基胺(吡蟲啉)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第706頁；(XXVI)2-異丙基苯基-甲基氨基甲酸酯(異丙威)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第729頁；(XXVII)O，S-二甲基-硫代磷酰胺(甲胺磷)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第808頁；(XXVIII)S-甲基-N-(甲基氨基甲酰氧基)硫代亞氨逐乙酸酯(滅多威)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第815頁；(XXIX)甲基-3-(二甲氧基磷酰基氧基)丁-2-烯酸酯(速滅磷)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第844頁；
(XXX)O，O-二乙基-O-4-硝基苯基-硫逐磷酸酯(對硫磷)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第926頁；(XXXI)O，O-二甲基-O-4-硝基苯基-硫逐磷酸酯(甲基對硫磷)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第928頁；(XXXII)S-6-氯-2，3-二氫-2-氧代-1，3-苯并噁唑-3-基甲基-O，O-二乙基-二硫逐磷酸酯(伏殺硫磷)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第963頁；(XXXIII)2-二甲基氨基-5，6-二甲基嘧啶-4-基-二甲基氨基甲酸酯(抗蚜威)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第985頁；(XXXIV)2-異丙氧基苯基-甲基氨基甲酸酯(殘殺威)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1036頁；(XXXV)1-(3，5-二氯-2，4-二氟苯基)-3-(2，6-二氟苯甲?；?脲(伏蟲隆)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1158頁；(XXXVI)S-叔-丁硫基甲基-O，O-二甲基-二硫逐磷酸酯(特丁硫磷)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1165頁；(XXXVII)(3-叔-丁基-1-二甲基氨基甲酰-1H-1，2，4-三唑-5-基-硫代)-乙酸乙酯，(唑蚜威)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第1224頁；(XXXVIII)阿維菌素，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第3頁；(XXXIX)2-仲-丁基苯基-甲基氨基甲酸酯(仲丁威)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第516頁；
(XL)N-叔-丁基-N′-(4-乙基苯甲?；?-3，5-二甲基苯甲酰肼(蟲酰肼)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1147頁；(XLI)(±)-5-氨基-1-(2，6-二氯-α，α，α-三氟-p-甲苯基)-4-三氟甲基-亞磺?；?吡唑-3-甲腈(銳勁特)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第545頁；(XLII)(RS)-α-氰基-4-氟-3-苯氧基芐基(1RS，3RS；1RS，3RS)-3-(2，2-二氯-乙烯基)-2，2-二甲基環(huán)丙烷甲酸酯(β-氟氯氰菊酯)，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第295頁；(XLIII)(4-乙氧基苯基)-[3-(4-氟-3-苯氧基苯基)丙基](二甲基)硅烷(硅醚菊酯)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第1105頁；(XLIV)(E)-α-(1，3-二甲基-5-苯氧基吡唑-4-基-亞甲基氨基-氧基)-p-甲苯甲酸叔-丁酯(唑螨酯)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第530頁；(XLV)2-叔-丁基-5-(4-叔-丁基芐硫)-4-氯噠嗪-3(2H)-酮(速螨酮)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1161頁；(XLVI)4-[[4-(1，1-二甲基苯基)苯基]乙氧基]-喹唑啉(芬殺螨)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第507頁；(XLVII)4-苯氧基苯基-(RS)-2-(吡啶基氧基)丙基-醚(比普塞芬)，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1073頁；(XLVIII)5-氯-N-{2-[4-(2-乙氧基乙基)-2，3-二甲基苯氧基]乙基}-6-乙基嘧啶-4-胺(畢汰芬)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第1070頁；(XLIX)(E)-N-(6-氯-3-吡啶基甲基)-N-乙基-N′-甲基-2-硝基亞乙烯基二胺(吡蟲胺)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第880頁；(L)(E)-N1-[(6-氯-3-吡啶基)甲基]-N2-氰基-N1-甲基乙脒(NI-25，啶蟲脒)，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第9頁；(LI)阿維菌素B1，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第3頁；(LII)植物的昆蟲-活性提取物，特別是(2R，6aS，12aS)-1，2，6，6a，12，12a-六氫-2-異丙烯基-8，9-二甲氧基-苯并吡喃并[3，4-b]呋喃并[2，3-h]苯并吡喃-6-酮(魚藤酮)，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第1097頁；以及印度苦楝的提取物，特別是印楝素，The Pesticide Manual，11thEd.(1997)，The British CropProtection Council，倫敦，第59頁；和(LIII)包含昆蟲-活性的線蟲類的制劑，優(yōu)選Heterorhabditis bacteriophora和Heterorhabditis megidis，The Pesticide Manual，11thEd.(1997)，TheBritish Crop Protection Council，倫敦，第671頁；Steinernema feltiae，The Pesticide Manual，11thEd.(1997)，The British Crop ProtectionCouncil，倫敦，第1115頁以及Steinernema scapterisci，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1116頁；(LIV)得自枯草桿菌的制劑，The Pesticide Manual，11thEd.(1997)，TheBritish Crop Protection Council，倫敦，第72頁；或得自蘇云金桿菌株(除了分離自GC91或NCTC11821的化合物)的制劑；The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第73頁；(LV)包含昆蟲-活性真菌的制劑，優(yōu)選蠟階輪枝菌，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1266頁；Beauveria brogniartii，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第85頁以及白僵菌，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第83頁；(LVI)包含昆蟲-活性病毒的制劑，優(yōu)選Neodipridon Sertifer NPV，ThePesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第1342頁；Mamestra brassicae NPV，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第759頁以及Cydia pomonella granulosis病毒，The Pesticide Manual，11thEd.(1997)，The British Crop Protection Council，倫敦，第291頁；(CLXXXI)7-氯-2，3，4a，5-四氫-2-[甲氧基羰基(4-三氟甲氧基苯基)氨基甲酰]吲哚并[1，2e]噁唑啉-4a-甲酸酯(DPX-MP062，噁二唑蟲)，The PesticideManual，11thEd.(1997)，The British Crop Protection Council，倫敦，第453頁；(CLXXXII)N’-叔-丁基-N’-(3，5-二甲基苯甲酰基)-3-甲氧基-2-甲基苯甲酰肼(RH-2485，甲氧蟲酰肼)，The Pesticide Manual，11thEd.(1997)，The BritishCrop Protection Council，倫敦，第1094頁；以及(CLXXXIII)(N’-[4-甲氧基-聯(lián)苯-3-基]-肼甲酸異丙酯(D 2341)，BrightonCrop Protection Conference，1996，487-493；(R2)Book of Abstracts，212th ACS National Meeting Orlando，F(xiàn)L，August25-29(1996)，AGRO-020.出版商American Chemical Society，華盛頓，D.C.CONEN63BFAF.
作為上文詳述的結(jié)論，本發(fā)明的實(shí)質(zhì)進(jìn)一步涉及控制溫血動物寄生蟲的聯(lián)合制劑，其特征為除了式I化合物外，它們還包含至少另外一種具有相同或不同活性范圍的活性成分及至少一種生理學(xué)上可接受的載體。本發(fā)明不僅限于兩種化合物的組合。
通常，本發(fā)明的該驅(qū)蟲組合物含有0.1-99％重量的式I、Ia或它們的混合物作為活性成分，特別是0.1-95％重量，含有99.9-1％重量的固體或液體混合物，特別是99.8-5％，包括0-25％重量的表面活性劑，特別是0.1-25％。
本發(fā)明組合物在所治療動物上的應(yīng)用可以通過局部、經(jīng)口、胃腸外或皮下的方式，該組合物可以采用溶液、乳劑、懸浮劑、drenches(獸用頓服藥)、粉劑、片劑、大丸劑(boli)、膠囊劑和噴淋劑(pour-on)溶液的形式給藥。
該噴淋或噴灑(spot-on)方法包含在皮膚或表皮的特定位置給予式I化合物，優(yōu)選在動物的頸部或脊椎。如通過藥棉或噴淋或噴灑制劑至表皮的相對小的范圍來給予化合物，由此，借助于制劑中活性成分的擴(kuò)散特性和動物的運(yùn)動，所述活性物質(zhì)幾乎可以自動分散至大范圍的毛皮。
噴淋或噴灑制劑最好包含載體，該載體可迅速促進(jìn)藥物在宿主動物的皮膚表面或表皮分散，并通常為可分散的油。適當(dāng)?shù)妮d體為如油溶液；醇和異丙醇的溶液，例如2-辛基十二醇或油醇溶液；單甲酸酯溶液，例如十四酸異丙酯、棕櫚酸異丙酯、草酸月桂酸酯、油酸油基酯、油酸癸酯、月桂酸己酯、油酸油酯、油酸癸酯、C12-C18長鏈飽和脂肪醇的癸酸酯；二羧酸酯溶液，例如鄰苯二甲酸二丁酯、異鄰苯二甲酸二異丙酯、脂肪酸二異丙酯、己二酸二-正-丁酯或也可以為脂肪酸酯溶液，例如與二醇形成的酯。最好加入分散劑，例如藥學(xué)或化妝品工業(yè)已知的那些。實(shí)例如2-吡咯烷酮、2-(N-烷基)吡咯烷酮、丙酮、聚乙二醇和它們的醚和酯、丙二醇或合成甘油三酯。
該油溶液可以包括例如植物油，例如橄欖油、花生油、芝麻油、松香油、亞麻籽油或蓖麻油。植物油也可以以環(huán)氧化的形式存在。也可以采用石蠟和硅油。
通常噴淋或噴灑制劑含有1-20％重量的式I化合物，0.1-50％重量的分散劑以及45-98.9％重量的溶劑。
噴淋或噴灑方法也特別優(yōu)選用于畜禽例如牛、馬、綿羊或豬，其中采用口服或注射治療所有動物是困難并且耗時(shí)的。由于噴淋或噴灑方法操作簡單，所以這些方法必然也可以用于所有其它動物，包括個體家畜或?qū)櫸铮⑶矣捎谶@些可以不在獸醫(yī)專家在場的情況下使用，所以它們備受動物飼養(yǎng)者所推寵。
盡管優(yōu)選以濃縮物的方式制備該商品，但是最終的消費(fèi)者通常使用其稀制劑。
為了獲得特別的效果，這樣的組合物還可以包含其他添加劑，例如穩(wěn)定劑、消泡劑、粘性調(diào)節(jié)劑、粘合劑或增粘劑以及其它活性成分。
本發(fā)明還包括消費(fèi)者最終使用的類型的驅(qū)蟲組合物。
在本發(fā)明的每一用于控制害蟲的方法或本發(fā)明的每一害蟲控制組合物中，式I的活性成分可以所有的空間異構(gòu)體或它們的混合物形式使用。
本發(fā)明也包括預(yù)防保護(hù)溫血動物(特別是生產(chǎn)家畜、家畜和寵物)對抗寄生蟲的方法，其特征是將式I活性成分或由該活性成分制備的制劑作為飼料添加劑、飲料、或也可以以固體或液體采用口服、注射或胃腸外形式給予所述動物。本發(fā)明也包括本發(fā)明的式I化合物用于所述方法的用途。
下述實(shí)施例僅是用于說明本發(fā)明、而不是用于限制本發(fā)明的范圍，術(shù)語活性成分代表表格中所列出的物質(zhì)。
具體而言，優(yōu)選的制劑以下列方式配制(％＝重量百分比)制劑實(shí)施例1.顆粒a)b)活性成分5％ 10％高嶺土 94％ -高分散性硅酸1％ -硅鎂土 - 90％將該活性成分溶于二氯甲烷，噴灑至載體上并隨后將溶劑真空蒸發(fā)濃縮。這樣的顆?？梢耘c動物飼料混合在一起。
2.顆?；钚猿煞? 3％聚乙二醇(mw 200) 3％高嶺土94％(mw＝分子量)將精細(xì)研磨活性成分均勻地在混和器中與用聚乙二醇潤濕的高嶺土混合。通過該方法，可得到無塵包衣顆粒。
3.片劑或大丸劑I 活性成分 33.00％
甲基纖維素0.80％高分散性硅酸 0.80％玉米淀粉 8.40％II 乳糖晶體 22.50％玉米淀粉 17.00％微晶纖維素16.50％硬脂酸鎂 1.00％I 將甲基纖維素在水中攪拌。當(dāng)該物質(zhì)膨脹后，與硅酸一同攪拌，并使混合物均勻懸浮。將活性成分和玉米淀粉混合。將水懸浮液加入該混合物并揉成團(tuán)。通過12M篩?；玫降奈镔|(zhì)并干燥。
II 將所有4種賦形劑充分混合。
III 混合由I和II得到的預(yù)混合物并壓制成片劑或大丸劑。
4.注射劑A.油性載體(緩釋)1.活性成分0.1-1.0g花生油加至100ml2.活性成分0.1-1.0g芝麻油加至100ml制備將活性成分溶于部分油，同時(shí)攪拌，并且如果需要，輕微加熱，隨后冷卻，補(bǔ)加油至所需體積后，通過適當(dāng)?shù)?.22mm孔的濾膜無菌過濾。
B水可混溶的溶劑(平均釋放率)活性成分 0.1-1.0g4-羥基甲基-1，3-二氧戊環(huán)(甲醛縮甘油) 40g1，2-丙二醇 加至100ml活性成分 0.1-1.0g甘油二甲縮酮 40g1，2-丙二醇 加至100ml制備將活性成分溶于部分溶劑，同時(shí)攪拌，加入溶劑至所需的體積并通過適當(dāng)?shù)?.22mm孔的濾膜無菌過濾。
C.水溶劑(迅速釋放)1.活性成分0.1-1.0g聚乙氧基蓖麻油(40個氧化乙烯單位) 10g1，2-丙二醇 20g芐基醇1g注射用水 加至100ml2.活性成分0.1-1.0g聚乙氧基脫水山梨糖醇單油酸酯(20個氧化乙烯單位)8g4-羥基甲基-1，3-二氧戊環(huán)(甲醛縮甘油)20g芐基醇 1g注射用水加至100ml制備將活性成分溶于溶劑和表面活性劑，并用水制成所需體積。通過適當(dāng)?shù)?.22mm孔的濾膜無菌過濾。
5.噴淋劑A.
活性成分 5g十四酸異丙酯 10g異丙醇加至100mlB活性成分 2g月桂酸己酯5g中鏈甘油三酯 15g乙醇 加至100mlC.
活性成分 2g油酸油酯 5gN-甲基-吡咯烷酮 40g異丙醇加至100ml含水體系也可以優(yōu)選以口服和/或胃內(nèi)(intraruminal)形式給藥。
組合物也可以包含另外的添加劑，例如穩(wěn)定劑(如適當(dāng)?shù)沫h(huán)氧化植物油(環(huán)氧化椰子油、油菜籽油或大豆油))、消泡劑(如硅油)、防腐劑、粘性調(diào)節(jié)劑、粘合劑、增粘劑以及肥料或其它活性成分以達(dá)到特定的效果。
所述組合物也可以加入另外的生物活性物質(zhì)或添加劑(這些物質(zhì)對式I化合物沒有不良影響，并且對所治療的宿主動物無副作用)，以及無機(jī)鹽或維生素。
下述實(shí)施例是用于說明本發(fā)明，而不是用于限制本發(fā)明。字母“h”代表小時(shí)。
制備實(shí)施例實(shí)施例1N-[1-氰基-1-甲基-2-(2-三氟甲基苯并咪唑-1-基)-乙基]-4-三氟甲氧基苯甲酰胺 a)將4g的2-三氟甲基苯并咪唑、2.8g氯丙酮、3.4g碳酸鉀和0.32g碘化鉀溶于50ml丙酮并于回流下沸騰4小時(shí)。冷卻后，濾出沉淀，用丙酮洗滌并真空干燥。由此得到1-(2-三氟甲基苯并咪唑-1-基)-丙酮。
b)將5.2g的1-(2-三氟甲基苯并咪唑-1-基)-丙酮、1.3g氰化鈉和3.4g氯化銨溶于27ml的25％氨水溶液并于室溫下攪拌20小時(shí)。隨后用乙酸乙酯自反應(yīng)混合物中提取粗品產(chǎn)物，有機(jī)相用水和飽和的氯化鈉溶液洗滌，經(jīng)硫酸鎂干燥并蒸發(fā)濃縮。然后，殘留物經(jīng)快速層析純化。得到2-氨基-2-甲基-3-(2-三氟甲基苯并咪唑-1-基)-丙腈。
c)于室溫下，將300mg的2-氨基-2-甲基-3-(2-三氟甲基苯并咪唑-1-基)-丙腈、292mg的4-(2-三氟甲氧基)-苯甲酰氯、143mg乙基二異丙基胺和13.4mg的4-二甲基氨基吡啶的10ml無水二氯甲烷混合物攪拌30小時(shí)。隨后，用乙酸乙酯稀釋，隨后順次用飽和的碳酸氫鈉溶液、2N鹽酸水溶液，最后用飽和的氯化鈉溶液洗滌。經(jīng)硫酸鎂干燥有機(jī)相并蒸發(fā)濃縮，殘留物用二乙醚再結(jié)晶。通過該方法，得到目標(biāo)化合物，熔點(diǎn)194℃。
下表中列出名稱的物質(zhì)也可以采用類似于上文所述的方法制備。熔點(diǎn)的值以℃表示。Bd.表示鍵。
表1 No. X Y1R1R2R71物理數(shù)據(jù)1.1 C(H)Bd.HHH1.2 C(H)Bd.HH2-Cl1.3 C(H)Bd.HH3-Cl1.4 C(H)Bd.HH4-Cl1.5 C(H)Bd.HH2-F1.6 C(H)Bd.HH3-F1.7 C(H)Bd.HH4-F1.8 C(H)Bd.HH2-CH31.9 C(H)Bd.HH3-CH31.10C(H)Bd.HH4-CH31.11C(H)Bd.HH2-OCH31.12C(H)Bd.HH3-OCH31.13C(H)Bd.HH4-OCH31.14C(H)Bd.HH2-CF31.15C(H)Bd.HH3-CF31.16C(H)Bd.HH4-CF31.17C(H)Bd.HH2-OCF31.18C(H)Bd.HH3-OCF31.19C(H)Bd.HH4-OCF31.20C(H)Bd.HH2-OCF2CF21.21C(H)Bd.HH3-OCF2CF21.22C(H)Bd.HH4-OCF2CF21.23C(H)Bd.HH2-OC2F51.24C(H)Bd.HH3-OC2F51.25C(H)Bd.HH4-OC2F51.26C(H)Bd.HH2-OC6H51.27C(H)Bd.HH3-OC6H51.28C(H)Bd.HH4-OC6H51.29C(H)Bd.HH2-C(O)C6H51.30C(H)Bd.HH3-C(O)C6H51.31C(H)Bd.HH4-C(O)C6H51.32C(H)Bd.HCH3H1.33C(H)Bd.HCH32-Cl1.34C(H)Bd.HCH33-Cl1.35C(H)Bd.HCH34-Cl1.36C(H)Bd.HCH32-F1.37C(H)Bd.HCH33-F1.38C(H)Bd.HCH34-F1.39C(H)Bd.HCH32-CH31.40C(H)Bd.HCH33-CH31.41C(H)Bd.HCH34-CH31.42C(H)Bd.HCH32-OCH31.43C(H)Bd.HCH33-OCH31.44C(H)Bd.HCH34-OCH31.45C(H)Bd.HCH32-CF3
1.46 C(H)Bd.HCH33-CF31.47 C(H)Bd.HCH34-CF31.48 C(H)Bd.HCH32-OCF31.49 C(H)Bd.HCH33-OCF31.50 C(H)Bd.HCH34-OCF31.51 C(H)Bd.HCH32-OCF2CF21.52 C(H)Bd.HCH33-OCF2CF21.53 C(H)Bd.HCH34-OCF2CF21.54 C(H)Bd.HCH32-OC2F51.55 C(H)Bd.HCH33-OC2F51.56 C(H)Bd.HCH34-OC2F51.57 C(H)Bd.HCH32-OC6H51.58 C(H)Bd.HCH33-OC6H51.59 C(H)Bd.HCH34-OC6H51.60 C(H)Bd.HCH32-C(O)C6H51.61 C(H)Bd.HCH33-C(O)C6H51.62 C(H)Bd.HCH34-C(O)C6H51.63 C(H)Bd.HCF3H1.64 C(H)Bd.HCF32-Cl1.65 C(H)Bd.HCF33-Cl1.66 C(H)Bd.HCF34-Cl1.67 C(H)Bd.HCF32-F1.68 C(H)Bd.HCF33-F1.69 C(H)Bd.HCF34-F1.70 C(H)Bd.HCF32-CH31.71 C(H)Bd.HCF33-CH31.72 C(H)Bd.HCF34-CH31.73 C(H)Bd.HCF32-OCH31.74 C(H)Bd.HCF33-OCH31.75 C(H)Bd.HCF34-OCH31.76 C(H)Bd.HCF32-CF31.77 C(H)Bd.HCF33-CF31.78 C(H)Bd.HCF34-CF31.79 C(H)Bd.HCF32-OCF31.80 C(H)Bd.HCF33-OCF31.81 C(H)Bd.HCF34-OCF31.82 C(H)Bd.HCF32-OCF2CF21.83 C(H)Bd.HCF33-OCF2CF21.84 C(H)Bd.HCF34-OCF2CF21.85 C(H)Bd.HCF32-OC2F51.86 C(H)Bd.HCF33-OC2F51.87 C(H)Bd.HCF34-OC2F51.88 C(H)Bd.HCF32-OC6H51.89 C(H)Bd.HCF33-OC6H51.90 C(H)Bd.HCF34-OC6H51.91 C(H)Bd.HCF32-C(O)C6H51.92 C(H)Bd.HCF33-C(O)C6H51.93 C(H)Bd.HCF34-C(O)C6H51.94 C(H)Bd.HSCH3H1.95 C(H)Bd.HSCH32-Cl1.96 C(H)Bd.HSCH33-Cl1.97 C(H)Bd.HSCH34-Cl1.98 C(H)Bd.HSCH32-F1.99 C(H)Bd.HSCH33-F1.100 C(H)Bd.HSCH34-F
1.101 C(H)Bd.H SCH32-CH31.102 C(H)Bd.H SCH33-CH31.103 C(H)Bd.H SCH34-CH31.104 C(H)Bd.H SCH32-OCH31.105 C(H)Bd.H SCH33-OCH31.106 C(H)Bd.H SCH34-OCH31.107 C(H)Bd.H SCH32-CF31.108 C(H)Bd.H SCH33-CF31.109 C(H)Bd.H SCH34-CF31.110 C(H)Bd.H SCH32-OCF31.111 C(H)Bd.H SCH33-OCF31.112 C(H)Bd.H SCH34-OCF31.113 C(H)Bd.H SCH32-OCF2CF21.114 C(H)Bd.H SCH33-OCF2CF21.115 C(H)Bd.H SCH34-OCF2CF21.116 C(H)Bd.H SCH32-OC2F51.117 C(H)Bd.H SCH33-OC2F51.118 C(H)Bd.H SCH34-OC2F51.119 C(H)Bd.H SCH32-OC6H51.120 C(H)Bd.H SCH33-OC6H51.121 C(H)Bd.H SCH34-OC6H51.122 C(H)Bd.H SCH32-C(O)C6H51.123 C(H)Bd.H SCH33-C(O)C6H51.124 C(H)Bd.H SCH34-C(O)C6H51.125 C(H)Bd.H 噻唑-4-基 H1.126 C(H)Bd.H 噻唑-4-基 2-Cl1.127 C(H)Bd.H 噻唑-4-基 3-Cl1.128 C(H)Bd.H 噻唑-4-基 4-Cl1.129 C(H)Bd.H 噻唑-4-基 2-F1.130 C(H)Bd.H 噻唑-4-基 3-F1.131 C(H)Bd.H 噻唑-4-基 4-F1.132 C(H)Bd.H 噻唑-4-基 2-CH31.133 C(H)Bd.H 噻唑-4-基 3-CH31.134 C(H)Bd.H 噻唑-4-基 4-CH31.135 C(H)Bd.H 噻唑-4-基 2-OCH31.136 C(H)Bd.H 噻唑-4-基 3-OCH31.137 C(H)Bd.H 噻唑-4-基 4-OCH31.138 C(H)Bd.H 噻唑-4-基 2-CF31.139 C(H)Bd.H 噻唑-4-基 3-CF31.140 C(H)Bd.H 噻唑-4-基 4-CF31.141 C(H)Bd.H 噻唑-4-基 2-OCF31.142 C(H)Bd.H 噻唑-4-基 3-OCF31.143 C(H)Bd.H 噻唑-4-基 4-OCF31.144 C(H)Bd.H 噻唑-4-基 2-OCF2CF21.145 C(H)Bd.H 噻唑-4-基 3-OCF2CF21.146 C(H)Bd.H 噻唑-4-基 4-OCF2CF21.147 C(H)Bd.H 噻唑-4-基 2-OC2F51.148 C(H)Bd.H 噻唑-4-基 3-OC2F51.149 C(H)Bd.H 噻唑-4-基 4-OC2F51.150 C(H)Bd.H 噻唑-4-基 2-OC6H51.151 C(H)Bd.H 噻唑-4-基 3-OC6H51.152 C(H)Bd.H 噻唑-4-基 4-OC6H5
1.153 C(H)Bd.H噻唑-4-基2-C(O)C6H51.154 C(H)Bd.H噻唑-4-基3-C(O)C6H51.155 C(H)Bd.H噻唑-4-基4-C(O)C6H51.156 C(H)Bd.5-Cl HH1.157 C(H)Bd.5-Cl H2-Cl1.158 C(H)Bd.5-Cl H3-Cl1.159 C(H)Bd.5-Cl H4-Cl1.160 C(H)Bd.5-Cl H2-F1.161 C(H)Bd.5-Cl H3-F1.162 C(H)Bd.5-Cl H4-F1.163 C(H)Bd.5-Cl H2-CH31.164 C(H)Bd.5-Cl H3-CH31.165 C(H)Bd.5-Cl H4-CH31.166 C(H)Bd.5-Cl H2-OCH31.167 C(H)Bd.5-Cl H3-OCH31.168 C(H)Bd.5-Cl H4-OCH31.169 C(H)Bd.5-Cl H2-CF31.170 C(H)Bd.5-Cl H3-CF31.171 C(H)Bd.5-Cl H4-CF3m.p.137°1.172 C(H)Bd.5-Cl H2-OCF31.173 C(H)Bd.5-Cl H3-OCF31.174 C(H)Bd.5-Cl H4-OCF3m.p.80°1.175 C(H)Bd.5-Cl H2-OCF2CF21.176 C(H)Bd.5-Cl H3-OCF2CF21.177 C(H)Bd.5-Cl H4-OCF2CF21.178 C(H)Bd.5-Cl H2-OC2F51.179 C(H)Bd.5-Cl H3-OC2F51.180 C(H)Bd.5-Cl H4-OC2F51.181 C(H)Bd.5-Cl H2-OC6H51.182 C(H)Bd.5-Cl H3-OC6H51.183 C(H)Bd.5-Cl H4-OC6H51.184 C(H)Bd.5-Cl H2-C(O)C6H51.185 C(H)Bd.5-Cl H3-C(O)C6H51.186 C(H)Bd.5-Cl H4-C(C)C6H51.187 C(H)Bd.5-Cl CH3H1.188 C(H)Bd.5-Cl CH32-Cl1.189 C(H)Bd.5-Cl CH33-Cl1.190 C(H)Bd.5-Cl CH34-Cl1.191 C(H)Bd.5-Cl CH32-F1.192 C(H)Bd.5-Cl CH33-F1.193 C(H)Bd.5-Cl CH34-F1.194 C(H)Bd.5-Cl CH32-CH31.195 C(H)Bd.5-Cl CH33-CH31.196 C(H)Bd.5-Cl CH34-CH31.197 C(H)Bd.5-Cl CH32-OCH31.198 C(H)Bd.5-Cl CH33-OCH31.199 C(H)Bd.5-Cl CH34-OCH31.200 C(H)Bd.5-Cl CH32-CF31.201 C(H)Bd.5-Cl CH33-CF31.202 C(H)Bd.5-Cl CH34-CF31.203 C(H)Bd.5-Cl CH32-OCF31.204 C(H)Bd.5-Cl CH33-OCF31.205 C(H)Bd.5-Cl CH34-OCF3m.p.168°1.206 C(H)Bd.5-Cl CH32-OCF2CF21.207 C(H)Bd.5-Cl CH33-OCF2CF2
1.208 C(H)Bd.5-ClCH34-OCF2CF21.209 C(H)Bd.5-ClCH32-OC2F51.210 C(H)Bd.5-ClCH33-OC2F51.211 C(H)Bd.5-ClCH34-OC2F51.212 C(H)Bd.5-ClCH32-OC6H51.213 C(H)Bd.5-ClCH33-OC6H51.214 C(H)Bd.5-ClCH34-OC6H51.215 C(H)Bd.5-ClCH32-C(O)C6H51.216 C(H)Bd.5-ClCH33-C(O)C6H51.217 C(H)Bd.5-ClCH34-C(O)C6H51.218 C(H)Bd.5-ClCF3H1.219 C(H)Bd.5-ClCF32-Cl1.220 C(H)Bd.5-ClCF33-Cl1.221 C(H)Bd.5-ClCF34-Cl1.222 C(H)Bd.5-ClCF32-F1.223 C(H)Bd.5-ClCF33-F1.224 C(H)Bd.5-ClCF34-F1.225 C(H)Bd.5-ClCF32-CH31.226 C(H)Bd.5-ClCF33-CH31.227 C(H)Bd.5-ClCF34-CH31.228 C(H)Bd.5-ClCF32-OCH31.229 C(H)Bd.5-ClCF33-OCH31.230 C(H)Bd.5-ClCF34-OCH31.231 C(H)Bd.5-ClCF32-CF31.232 C(H)Bd.5-ClCF33-CF31.233 C(H)Bd.5-ClCF34-CF31.234 C(H)Bd.5-ClCF32-OCF31.235 C(H)Bd.5-ClCF33-OCF31.236 C(H)Bd.5-ClCF34-OCF31.237 C(H)Bd.5-ClCF32-OCF2CF21.238 C(H)Bd.5-ClCF33-OCF2CF21.239 C(H)Bd.5-ClCF34-OCF2CF21.240 C(H)Bd.5-ClCF32-OC2F51.241 C(H)Bd.5-ClCF33-OC2F51.242 C(H)Bd.5-ClCF34-OC2F51.243 C(H)Bd.5-ClCF32-OC6H51.244 C(H)Bd.5-ClCF33-OC6H51.245 C(H)Bd.5-ClCF34-OC6H51.246 C(H)Bd.5-ClCF32-C(O)C6H51.247 C(H)Bd.5-ClCF33-C(O)C6H51.248 C(H)Bd.5-ClCF34-C(O)C6H51.249 C(H)Bd.5-ClSCH3H1.250 C(H)Bd.5-ClSCH32-Cl1.251 C(H)Bd.5-ClSCH33-Cl1.252 C(H)Bd.5-ClSCH34-Cl1.253 C(H)Bd.5-ClSCH32-F1.254 C(H)Bd.5-ClSCH33-F1.255 C(H)Bd.5-ClSCH34-F1.256 C(H)Bd.5-ClSCH32-CH31.257 C(H)Bd.5-ClSCH33-CH31.258 C(H)Bd.5-ClSCH34-CH31.259 C(H)Bd.5-ClSCH32-OCH31.260 C(H)Bd.5-ClSCH33-OCH31.261 C(H)Bd.5-ClSCH34-OCH31.262 C(H)Bd.5-ClSCH32-CF3
1.263 C(H)Bd.5-ClSCH33-CF31.264 C(H)Bd.5-ClSCH34-CF31.265 C(H)Bd.5-ClSCH32-OCF31.266 C(H)Bd.5-ClSCH33-OCF31.267 C(H)Bd.5-ClSCH34-OCF31.268 C(H)Bd.5-ClSCH32-OCF2CF21.269 C(H)Bd.5-ClSCH33-OCF2CF21.270 C(H)Bd.5-ClSCH34-OCF2CF21.271 C(H)Bd.5-ClSCH32-OC2F51.272 C(H)Bd.5-ClSCH33-OC2F51.273 C(H)Bd.5-ClSCH34-OC2F51.274 C(H)Bd.5-ClSCH32-OC6H51.275 C(H)Bd.5-ClSCH33-OC6H51.276 C(H)Bd.5-ClSCH34-OC6H51.277 C(H)Bd.5-ClSCH32-C(O)C6H51.278 C(H)Bd.5-ClSCH33-C(O)C6H51.279 C(H)Bd.5-ClSCH34-C(O)C6H51.280 C(H)Bd.5-Cl噻唑-4-基 H1.281 C(H)Bd.5-Cl噻唑-4-基 2-Cl1.282 C(H)Bd.5-Cl噻唑-4-基 3-Cl1.283 C(H)Bd.5-Cl噻唑-4-基 4-Cl1.284 C(H)Bd.5-Cl噻唑-4-基 2-F1.285 C(H)Bd.5-Cl噻唑-4-基 3-F1.286 C(H)Bd.5-Cl噻唑-4-基 4-F1.287 C(H)Bd.5-Cl噻唑-4-基 2-CH31.288 C(H)Bd.5-Cl噻唑-4-基 3-CH31.289 C(H)Bd.5-Cl噻唑-4-基 4-CH31.290 C(H)Bd.5-Cl噻唑-4-基 2-OCH31.291 C(H)Bd.5-Cl噻唑-4-基 3-OCH31.292 C(H)Bd.5-Cl噻唑-4-基 4-OCH31.293 C(H)Bd.5-Cl噻唑-4-基 2-CF31.294 C(H)Bd.5-Cl噻唑-4-基 3-CF31.295 C(H)Bd.5-Cl噻唑-4-基 4-CF31.296 C(H)Bd.5-Cl噻唑-4-基 2-OCF31.297 C(H)Bd.5-Cl噻唑-4-基 3-OCF31.298 C(H)Bd.5-Cl噻唑-4-基 4-OCF31.299 C(H)Bd.5-Cl噻唑-4-基 2-OCF2CF21.300 C(H)Bd.5-Cl噻唑-4-基 3-OCF2CF21.301 C(H)Bd.5-Cl噻唑-4-基 4-OCF2CF21.302 C(H)Bd.5-Cl噻唑-4-基 2-OC2F51.303 C(H)Bd.5-Cl噻唑-4-基 3-OC2F51.304 C(H)Bd.5-Cl噻唑-4-基 4-OC2F51.305 C(H)Bd.5-Cl噻唑-4-基 2-OC6H51.306 C(H)Bd.5-Cl噻唑-4-基 3-OC6H51.307 C(H)Bd.5-Cl噻唑-4-基 4-OC6H51.308 C(H)Bd.5-Cl噻唑-4-基 2-C(O)C6H51.309 C(H)Bd.5-Cl噻唑-4-基 3-C(O)C6H51.310 C(H)Bd.5-Cl噻唑-4-基 4-C(O)C6H51.311 C(H)Bd.6-ClH H1.312 C(H)Bd.6-ClH 2-Cl1.313 C(H)Bd.6-ClH 3-Cl
1.314 C(H)Bd.6-ClH 4-Cl1.315 C(H)Bd.6-ClH 2-F1.316 C(H)Bd.6-ClH 3-F1.317 C(H)Bd.6-ClH 4-F1.318 C(H)Bd.6-ClH 2-CH31.319 C(H)Bd.6-ClH 3-CH31.320 C(H)Bd.6-ClH 4-CH31.321 C(H)Bd.6-ClH 2-OCH31.322 C(H)Bd.6-ClH 3-OCH31.323 C(H)Bd.6-ClH 4-OCH31.324 C(H)Bd.6-ClH 2-CF31.325 C(H)Bd.6-ClH 3-CF31.326 C(H)Bd.6-ClH 4-CF31.327 C(H)Bd.6-ClH 2-OCF31.328 C(H)Bd.6-ClH 3-OCF31.329 C(H)Bd.6-ClH 4-OCF3油1.330 C(H)Bd.6-ClH 2-OCF2CF21.331 C(H)Bd.6-ClH 3-OCF2CF21.332 C(H)Bd.6-ClH 4-OCF2CF21.333 C(H)Bd.6-ClH 2-OC2F51.334 C(H)Bd.6-ClH 3-OC2F51.335 C(H)Bd.6-ClH 4-OC2F51.336 C(H)Bd.6-ClH 2-OC6H51.337 C(H)Bd.6-ClH 3-OC6H51.338 C(H)Bd.6-ClH 4-OC6H51.339 C(H)Bd.6-ClH 2-C(O)C6H51.340 C(H)Bd.6-ClH 3-C(O)C6H51.341 C(H)Bd.6-ClH 4-C(O)C6H51.342 C(H)Bd.6-ClCH3H1.343 C(H)Bd.6-ClCH32-Cl1.344 C(H)Bd.6-ClCH33-Cl1.345 C(H)Bd.6-ClCH34-Cl1.346 C(H)Bd.6-ClCH32-F1.347 C(H)Bd.6-ClCH33-F1.348 C(H)Bd.6-ClCH34-F1.349 C(H)Bd.6-ClCH32-CH31.350 C(H)Bd.6-ClCH33-CH31.351 C(H)Bd.6-ClCH34-CH31.352 C(H)Bd.6-ClCH32-OCH31.353 C(H)Bd.6-ClCH33-OCH31.354 C(H)Bd.6-ClCH34-OCH31.355 C(H)Bd.6-ClCH32-CF31.356 C(H)Bd.6-ClCH33-CF31.357 C(H)Bd.6-ClCH34-CF31.358 C(H)Bd.6-ClCH32-OCF31.359 C(H)Bd.6-ClCH33-OCF31.360 C(H)Bd.6-ClCH34-OCF31.361 C(H)Bd.6-ClCH32-OCF2CF21.362 C(H)Bd.6-ClCH33-OCF2CF21.363 C(H)Bd.6-ClCH34-OCF2CF21.364 C(H)Bd.6-ClCH32-OC2F51.365 C(H)Bd.6-ClCH33-OC2F51.366 C(H)Bd.6-ClCH34-OC2F51.367 C(H)Bd.6-ClCH32-OC6H51.368 C(H)Bd.6-ClCH33-OC6H5
1.369 C(H)Bd.6-ClCH34-OC6H51.370 C(H)Bd.6-ClCH32-C(O)C6H51.371 C(H)Bd.6-ClCH33-C(O)C6H51.372 C(H)Bd.6-ClCH34-C(O)C6H51.373 C(H)Bd.6-ClCF3H1.374 C(H)Bd.6-ClCF32-Cl1.375 C(H)Bd.6-ClCF33-Cl1.376 C(H)Bd.6-ClCF34-Cl1.377 C(H)Bd.6-ClCF32-F1.378 C(H)Bd.6-ClCF33-F1.379 C(H)Bd.6-ClCF34-F1.380 C(H)Bd.6-ClCF32-CH31.381 C(H)Bd.6-ClCF33-CH31.382 C(H)Bd.6-ClCF34-CH31.383 C(H)Bd.6-ClCF32-OCH31.384 C(H)Bd.6-ClCF33-OCH31.385 C(H)Bd.6-ClCF34-OCH31.386 C(H)Bd.6-ClCF32-CF31.387 C(H)Bd.6-ClCF33-CF31.388 C(H)Bd.6-ClCF34-CF31.389 C(H)Bd.6-ClCF32-OCF31.390 C(H)Bd.6-ClCF33-OCF31.391 C(H)Bd.6-ClCF34-OCF31.392 C(H)Bd.6-ClCF32-OCF2CF21.393 C(H)Bd.6-ClCF33-OCF2CF21.394 C(H)Bd.6-ClCF34-OCF2CF21.395 C(H)Bd.6-ClCF32-OC2F51.396 C(H)Bd.6-ClCF33-OC2F51.397 C(H)Bd.6-ClCF34-OC2F51.398 C(H)Bd.6-ClCF32-OC6H51.399 C(H)Bd.6-ClCF33-OC6H51.400 C(H)Bd.6-ClCF34-OC6H51.401 C(H)Bd.6-ClCF32-C(O)C6H51.402 C(H)Bd.6-ClCF33-C(O)C6H51.403 C(H)Bd.6-ClCF34-C(O)C6H51.404 C(H)Bd.6-ClSCH3H1.405 C(H)Bd.6-ClSCH32-Cl1.406 C(H)Bd.6-ClSCH33-Cl1.407 C(H)Bd.6-ClSCH34-Cl1.408 C(H)Bd.6-ClSCH32-F1.409 C(H)Bd.6-ClSCH33-F1.410 C(H)Bd.6-ClSCH34-F1.411 C(H)Bd.6-ClSCH32-CH31.412 C(H)Bd.6-ClSCH33-CH31.413 C(H)Bd.6-ClSCH34-CH31.414 C(H)Bd.6-ClSCH32-OCH31.415 C(H)Bd.6-ClSCH33-OCH31.417 C(H)Bd.6-ClSCH32-CF31.418 C(H)Bd.6-ClSCH33-CF31.419 C(H)Bd.6-ClSCH34-CF31.420 C(H)Bd.6-ClSCH32-OCF31.421 C(H)Bd.6-ClSCH33-OCF31.422 C(H)Bd.6-ClSCH34-OCF31.423 C(H)Bd.6-ClSCH32-OCF2CF2
1.424 C(H)Bd.6-Cl SCH33-OCF2CF21.425 C(H)Bd.6-Cl SCH34-OCF2CF21.426 C(H)Bd.6-Cl SCH32-OC2F51.427 C(H)Bd.6-Cl SCH33-OC2F51.428 C(H)Bd.6-Cl SCH34-OC2F51.429 C(H)Bd.6-Cl SCH32-OC6H51.430 C(H)Bd.6-Cl SCH33-OC6H51.431 C(H)Bd.6-Cl SCH34-OC6H51.432 C(H)Bd.6-Cl SCH32-C(O)C6H51.433 C(H)Bd.6-Cl SCH33-C(O)C6H51.434 C(H)Bd.6-Cl SCH34-C(O)C6H51.435 C(H)Bd.6-Cl 噻唑-4-基H1.436 C(H)Bd.6-Cl 噻唑-4-基2-Cl1.437 C(H)Bd.6-Cl 噻唑-4-基3-Cl1.438 C(H)Bd.6-Cl 噻唑-4-基4-Cl1.439 C(H)Bd.6-Cl 噻唑-4-基2-F1.440 C(H)Bd.6-Cl 噻唑-4-基3-F1.441 C(H)Bd.6-Cl 噻唑-4-基4-F1.442 C(H)Bd.6-Cl 噻唑-4-基2-CH31.443 C(H)Bd.6-Cl 噻唑-4-基3-CH31.444 C(H)Bd.6-Cl 噻唑-4-基4-CH31.445 C(H)Bd.6-Cl 噻唑-4-基2-OCH31.446 C(H)Bd.6-Cl 噻唑-4-基3-OCH31.447 C(H)Bd.6-Cl 噻唑-4-基4-OCH31.448 C(H)Bd.6-Cl 噻唑-4-基2-CF31.449 C(H)Bd.6-Cl 噻唑-4-基3-CF31.450 C(H)Bd.6-Cl 噻唑-4-基4-CF31.451 C(H)Bd.6-Cl 噻唑-4-基2-OCF31.452 C(H)Bd.6-Cl 噻唑-4-基3-OCF31.453 C(H)Bd.6-Cl 噻唑-4-基4-OCF31.454 C(H)Bd.6-Cl 噻唑-4-基2-OCF2CF21.455 C(H)Bd.6-Cl 噻唑-4-基3-OCF2CF21.456 C(H)Bd.6-Cl 噻唑-4-基4-OCF2CF21.457 C(H)Bd.6-Cl 噻唑-4-基2-OC2F51.458 C(H)Bd.6-Cl 噻唑-4-基3-OC2F51.459 C(H)Bd.6-Cl 噻唑-4-基4-OC2F51.460 C(H)Bd.6-Cl 噻唑-4-基2-OC6H51.461 C(H)Bd.6-Cl 噻唑-4-基3-OC6H51.462 C(H)Bd.6-Cl 噻唑-4-基4-OC6H51.463 C(H)Bd.6-Cl 噻唑-4-基2-C(O)C6H51.464 C(H)Bd.6-Cl 噻唑-4-基3-C(O)C6H51.465 C(H)Bd.6-Cl 噻唑-4-基4-C(O)C6H51.466 C(H)Bd.5-F HH1.467 C(H)Bd.5-F H2-Cl1.468 C(H)Bd.5-F H3-Cl1.469 C(H)Bd.5-F H4-Cl1.470 C(H)Bd.5-F H2-F1.471 C(H)Bd.5-F H3-F1.472 C(H)Bd.5-F H4-F1.473 C(H)Bd.5-F H2-CH31.474 C(H)Bd.5-F H3-CH3
1.475 C(H)Bd.5-F H 4-CH31.476 C(H)Bd.5-F H 2-OCH31.477 C(H)Bd.5-F H 3-OCH31.478 C(H)Bd.5-F H 4-OCH31.479 C(H)Bd.5-F H 2-CF31.480 C(H)Bd.5-F H 3-CF31.481 C(H)Bd.5-F H 4-CF31.482 C(H)Bd.5-F H 2-OCF31.483 C(H)Bd.5-F H 3-OCF31.484 C(H)Bd.5-F H 4-OCF3晶體1.485 C(H)Bd.5-F H 2-OCF2CF21.486 C(H)Bd.5-F H 3-OCF2CF21.487 C(H)Bd.5-F H 4-OCF2CF21.488 C(H)Bd.5-F H 2-OC2F51.489 C(H)Bd.5-F H 3-OC2F51.490 C(H)Bd.5-F H 4-OC2F51.491 C(H)Bd.5-F H 2-OC6H51.492 C(H)Bd.5-F H 3-OC6H51.493 C(H)Bd.5-F H 4-OC6H51.494 C(H)Bd.5-F H 2-C(O)C6H51.495 C(H)Bd.5-F H 3-C(O)C6H51.496 C(H)Bd.5-F H 4-C(O)C6H51.497 C(H)Bd.5-F CH3H1.498 C(H)Bd.5-F CH32-Cl1.499 C(H)Bd.5-F CH33-Cl1.500 C(H)Bd.5-F CH34-Cl1.501 C(H)Bd.5-F CH32-F1.502 C(H)Bd.5-F CH33-F1.503 C(H)Bd.5-F CH34-F1.504 C(H)Bd.5-F CH32-CH31.505 C(H)Bd.5-F CH33-CH31.506 C(H)Bd.5-F CH34-CH31.507 C(H)Bd.5-F CH32-OCH31.508 C(H)Bd.5-F CH33-OCH31.509 C(H)Bd.5-F CH34-OCH31.510 C(H)Bd.5-F CH32-CF31.511 C(H)Bd.5-F CH33-CF31.512 C(H)Bd.5-F CH34-CF31.513 C(H)Bd.5-F CH32-OCF31.514 C(H)Bd.5-F CH33-OCF31.515 C(H)Bd.5-F CH34-OCF31.516 C(H)Bd.5-F CH32-OCF2CF21.517 C(H)Bd.5-F CH33-OCF2CF21.518 C(H)Bd.5-F CH34-OCF2CF21.519 C(H)Bd.5-F CH32-OC2F51.520 C(H)Bd.5-F CH33-OC2F51.521 C(H)Bd.5-F CH34-OC2F51.522 C(H)Bd.5-F CH32-OC6H51.523 C(H)Bd.5-F CH33-OC6H51.524 C(H)Bd.5-F CH34-OC6H51.525 C(H)Bd.5-F CH32-C(O)C6H51.526 C(H)Bd.5-F CH33-C(O)C6H51.527 C(H)Bd.5-F CH34-C(O)C6H51.528 C(H)Bd.5-F CF3H1.529 C(H)Bd.5-F CF32-Cl
1.530 C(H)Bd.5-F CF33-Cl1.531 C(H)Bd.5-F CF34-Cl1.532 C(H)Bd.5-F CF32-F1.533 C(H)Bd.5-F CF33-F1.534 C(H)Bd.5-F CF34-F1.535 C(H)Bd.5-F CF32-CH31.536 C(H)Bd.5-F CF33-CH31.537 C(H)Bd.5-F CF34-CH31.538 C(H)Bd.5-F CF32-OCH31.539 C(H)Bd.5-F CF33-OCH31.540 C(H)Bd.5-F CF34-OCH31.541 C(H)Bd.5-F CF32-CF31.542 C(H)Bd.5-F CF33-CF31.543 C(H)Bd.5-F CF34-CF31.544 C(H)Bd.5-F CF32-OCF31.545 C(H)Bd.5-F CF33-OCF31.546 C(H)Bd.5-F CF34-OCF31.547 C(H)Bd.5-F CF32-OCF2CF21.548 C(H)Bd.5-F CF33-OCF2CF21.549 C(H)Bd.5-F CF34-OCF2CF21.550 C(H)Bd.5-F CF32-OC2F51.551 C(H)Bd.5-F CF33-OC2F51.552 C(H)Bd.5-F CF34-OC2F51.553 C(H)Bd.5-F CF32-OC6H51.554 C(H)Bd.5-F CF33-OC6H51.555 C(H)Bd.5-F CF34-OC6H51.556 C(H)Bd.5-F CF32-C(O)C6H51.557 C(H)Bd.5-F CF33-C(O)C6H51.558 C(H)Bd.5-F CF34-C(O)C6H51.559 C(H)Bd.5-F SCH3H1.560 C(H)Bd.5-F SCH32-Cl1.561 C(H)Bd.5-F SCH33-Cl1.562 C(H)Bd.5-F SCH34-Cl1.563 C(H)Bd.5-F SCH32-F1.564 C(H)Bd.5-F SCH33-F1.565 C(H)Bd.5-F SCH34-F1.566 C(H)Bd.5-F SCH32-CH31.567 C(H)Bd.5-F SCH33-CH31.568 C(H)Bd.5-F SCH34-CH31.569 C(H)Bd.5-F SCH32-OCH31.570 C(H)Bd.5-F SCH33-OCH31.571 C(H)Bd.5-F SCH34-OCH31.572 C(H)Bd.5-F SCH32-CF31.573 C(H)Bd.5-F SCH33-CF31.574 C(H)Bd.5-F SCH34-CF31.575 C(H)Bd.5-F SCH32-OCF31.576 C(H)Bd.5-F SCH33-OCF31.577 C(H)Bd.5-F SCH34-OCF31.578 C(H)Bd.5-F SCH32-OCF2CF21.579 C(H)Bd.5-F SCH33-OCF2CF21.580 C(H)Bd.5-F SCH34-OCF2CF21.581 C(H)Bd.5-F SCH32-OC2F51.582 C(H)Bd.5-F SCH33-OC2F51.583 C(H)Bd.5-F SCH34-OC2F51.584 C(H)Bd.5-F SCH32-OC6H5
1.585 C(H)Bd.5-F SCH33-OC6H51.586 C(H)Bd.5-F SCH34-OC6H51.587 C(H)Bd.5-F SCH32-C(O)C6H51.588 C(H)Bd.5-F SCH33-C(O)C6H51.589 C(H)Bd.5-F SCH34-C(O)C6H51.590 C(H)Bd.5-F 噻唑-4-基H1.591 C(H)Bd.5-F 噻唑-4-基2-Cl1.592 C(H)Bd.5-F 噻唑-4-基3-Cl1.593 C(H)Bd.5-F 噻唑-4-基4-Cl1.594 C(H)Bd.5-F 噻唑-4-基2-F1.595 C(H)Bd.5-F 噻唑-4-基3-F1.596 C(H)Bd.5-F 噻唑-4-基4-F1.597 C(H)Bd.5-F 噻唑-4-基2-CH31.598 C(H)Bd.5-F 噻唑-4-基3-CH31.599 C(H)Bd.5-F 噻唑-4-基4-CH31.600 C(H)Bd.5-F 噻唑-4-基2-OCH31.601 C(H)Bd.5-F 噻唑-4-基3-OCH31.602 C(H)Bd.5-F 噻唑-4-基4-OCH31.603 C(H)Bd.5-F 噻唑-4-基2-CF31.604 C(H)Bd.5-F 噻唑-4-基3-CF31.605 C(H)Bd.5-F 噻唑-4-基4-CF31.606 C(H)Bd.5-F 噻唑-4-基2-OCF31.607 C(H)Bd.5-F 噻唑-4-基3-OCF31.608 C(H)Bd.5-F 噻唑-4-基4-OCF31.609 C(H)Bd.5-F 噻唑-4-基2-OCF2CF21.610 C(H)Bd.5-F 噻唑-4-基3-OCF2CF21.611 C(H)Bd.5-F 噻唑-4-基4-OCF2CF21.612 C(H)Bd.5-F 噻唑-4-基2-OC2F51.613 C(H)Bd.5-F 噻唑-4-基3-OC2F51.614 C(H)Bd.5-F 噻唑-4-基4-OC2F51.615 C(H)Bd.5-F 噻唑-4-基2-OC6H51.616 C(H)Bd.5-F 噻唑-4-基3-OC6H51.617 C(H)Bd.5-F 噻唑-4-基4-OC6H51.618 C(H)Bd.5-F 噻唑-4-基2-C(O)C6H51.619 C(H)Bd.5-F 噻唑-4-基3-C(O)C6H51.620 C(H)Bd.5-F 噻唑-4-基4-C(O)C6H51.621 C(H)Bd.5-CNHH1.622 C(H)Bd.5-CNH2-Cl1.623 C(H)Bd.5-CNH3-Cl1.624 C(H)Bd.5-CNH4-Cl1.625 C(H)Bd.5-CNH2-F1.626 C(H)Bd.5-CNH3-F1.627 C(H)Bd.5-CNH4-F1.628 C(H)Bd.5-CNH2-CH31.629 C(H)Bd.5-CNH3-CH31.630 C(H)Bd.5-CNH4-CH31.631 C(H)Bd.5-CNH2-OCH31.632 C(H)Bd.5-CNH3-OCH31.633 C(H)Bd.5-CNH4-OCH31.634 C(H)Bd.5-CNH2-CF31.635 C(H)Bd.5-CNH3-CF3
1.636 C(H)Bd.5-CN H4-CF31.637 C(H)Bd.5-CN H2-OCF31.638 C(H)Bd.5-CN H3-OCF31.639 C(H)Bd.5-CN H4-OCF3m.p.166°1.640 C(H)Bd.5-CN H2-OCF2CF21.641 C(H)Bd.5-CN H3-OCF2CF21.642 C(H)Bd.5-CN H4-OCF2CF21.643 C(H)Bd.5-CN H2-OC2F51.644 C(H)Bd.5-CN H3-OC2F51.645 C(H)Bd.5-CN H4-OC2F51.646 C(H)Bd.5-CN H2-OC6H51.647 C(H)Bd.5-CN H3-OC6H51.648 C(H)Bd.5-CN H4-OC6H51.649 C(H)Bd.5-CN H2-C(O)C6H51.650 C(H)Bd.5-CN H3-C(O)C6H51.651 C(H)Bd.5-CN H4-C(O)C6H51.652 C(H)Bd.5-CN CH3H1.653 C(H)Bd.5-CN CH32-Cl1.654 C(H)Bd.5-CN CH33-Cl1.655 C(H)Bd.5-CN CH34-Cl1.656 C(H)Bd.5-CN CH32-F1.657 C(H)Bd.5-CN CH33-F1.658 C(H)Bd.5-CN CH34-F1.659 C(H)Bd.5-CN CH32-CH31.660 C(H)Bd.5-CN CH33-CH31.661 C(H)Bd.5-CN CH34-CH31.662 C(H)Bd.5-CN CH32-OCH31.663 C(H)Bd.5-CN CH33-OCH31.664 C(H)Bd.5-CN CH34-OCH31.665 C(H)Bd.5-CN CH32-CF31.666 C(H)Bd.5-CN CH33-CF31.667 C(H)Bd.5-CN CH34-CF31.668 C(H)Bd.5-CN CH32-OCF31.669 C(H)Bd.5-CN CH33-OCF31.670 C(H)Bd.5-CN CH34-OCF31.671 C(H)Bd.5-CN CH32-OCF2CF21.672 C(H)Bd.5-CN CH33-OCF2CF21.673 C(H)Bd.5-CN CH34-OCF2CF21.674 C(H)Bd.5-CN CH32-OC2F51.675 C(H)Bd.5-CN CH33-OC2F51.676 C(H)Bd.5-CN CH34-OC2F51.677 C(H)Bd.5-CN CH32-OC6H51.678 C(H)Bd.5-CN CH33-OC6H51.679 C(H)Bd.5-CN CH34-OC6H51.680 C(H)Bd.5-CN CH32-C(O)C6H51.681 C(H)Bd.5-CN CH33-C(O)C6H51.682 C(H)Bd.5-CN CH34-C(O)C6H51.683 C(H)Bd.5-CN CF3H1.684 C(H)Bd.5-CN CF32-Cl1.685 C(H)Bd.5-CN CF33-Cl1.686 C(H)Bd.5-CN CF34-Cl1.687 C(H)Bd.5-CN CF32-F1.688 C(H)Bd.5-CN CF33-F1.689 C(H)Bd.5-CN CF34-F1.690 C(H)Bd.5-CN CF32-CH3
1.691 C(H)Bd.5-CN CF33-CH31.692 C(H)Bd.5-CN CF34-CH31.693 C(H)Bd.5-CN CF32-OCH31.694 C(H)Bd.5-CN CF33-OCH31.695 C(H)Bd.5-CN CF34-OCH31.696 C(H)Bd.5-CN CF32-CF31.697 C(H)Bd.5-CN CF33-CF31.698 C(H)Bd.5-CN CF34-CF31.699 C(H)Bd.5-CN CF32-OCF31.700 C(H)Bd.5-CN CF33-OCF31.701 C(H)Bd.5-CN CF34-OCF31.702 C(H)Bd.5-CN CF32-OCF2CF21.703 C(H)Bd.5-CN CF33-OCF2CF21.704 C(H)Bd.5-CN CF34-OCF2CF21.705 C(H)Bd.5-CN CF32-OC2F51.706 C(H)Bd.5-CN CF33-OC2F51.707 C(H)Bd.5-CN CF34-OC2F51.708 C(H)Bd.5-CN CF32-OC6H51.709 C(H)Bd.5-CN CF33-OC6H51.710 C(H)Bd.5-CN CF34-OC6H51.711 C(H)Bd.5-CN CF32-C(O)C6H51.712 C(H)Bd.5-CN CF33-C(O)C6H51.713 C(H)Bd.5-CN CF34-C(O)C6H51.714 C(H)Bd.5-CN SCH3H1.715 C(H)Bd.5-CN SCH32-Cl1.716 C(H)Bd.5-CN SCH33-Cl1.717 C(H)Bd.5-CN SCH34-Cl1.718 C(H)Bd.5-CN SCH32-F1.719 C(H)Bd.5-CN SCH33-F1.720 C(H)Bd.5-CN SCH34-F1.721 C(H)Bd.5-CN SCH32-CH31.722 C(H)Bd.5-CN SCH33-CH31.723 C(H)Bd.5-CN SCH34-CH31.724 C(H)Bd.5-CN SCH32-OCH31.725 C(H)Bd.5-CN SCH33-OCH31.726 C(H)Bd.5-CN SCH34-OCH31.727 C(H)Bd.5-CN SCH32-CF31.728 C(H)Bd.5-CN SCH33-CF31.729 C(H)Bd.5-CN SCH34-CF31.730 C(H)Bd.5-CN SCH32-OCF31.731 C(H)Bd.5-CN SCH33-OCF31.732 C(H)Bd.5-CN SCH34-OCF31.733 C(H)Bd.5-CN SCH32-OCF2CF21.734 C(H)Bd.5-CN SCH33-OCF2CF21.735 C(H)Bd.5-CN SCH34-OCF2CF21.736 C(H)Bd.5-CN SCH32-OC2F51.737 C(H)Bd.5-CN SCH33-OC2F51.738 C(H)Bd.5-CN SCH34-OC2F51.739 C(H)Bd.5-CN SCH32-OC6H51.740 C(H)Bd.5-CN SCH33-OC6H51.741 C(H)Bd.5-CN SCH34-OC6H51.742 C(H)Bd.5-CN SCH32-C(O)C6H51.743 C(H)Bd.5-CN SCH33-C(O)C6H51.744 C(H)Bd.5-CN SCH34-C(O)C6H51.745 C(H)Bd.5-CN 噻唑-4-基 H
1.746 C(H)Bd.5-CN 噻唑-4-基2-Cl1.747 C(H)Bd.5-CN 噻唑-4-基3-Cl1.748 C(H)Bd.5-CN 噻唑-4-基4-Cl1.749 C(H)Bd.5-CN 噻唑-4-基2-F1.750 C(H)Bd.5-CN 噻唑-4-基3-F1.751 C(H)Bd.5-CN 噻唑-4-基4-F1.752 C(H)Bd.5-CN 噻唑-4-基2-CH31.753 C(H)Bd.5-CN 噻唑-4-基3-CH31.754 C(H)Bd.5-CN 噻唑-4-基4-CH31.755 C(H)Bd.5-CN 噻唑-4-基2-OCH31.756 C(H)Bd.5-CN 噻唑-4-基3-OCH31.757 C(H)Bd.5-CN 噻唑-4-基4-OCH31.758 C(H)Bd.5-CN 噻唑-4-基2-CF31.759 C(H)Bd.5-CN 噻唑-4-基3-CF31.760 C(H)Bd.5-CN 噻唑-4-基4-CF31.761 C(H)Bd.5-CN 噻唑-4-基2-OCF31.762 C(H)Bd.5-CN 噻唑-4-基3-OCF31.763 C(H)Bd.5-CN 噻唑-4-基4-OCF31.764 C(H)Bd.5-CN 噻唑-4-基2-OCF2CF21.765 C(H)Bd.5-CN 噻唑-4-基3-OCF2CF21.766 C(H)Bd.5-CN 噻唑-4-基4-OCF2CF21.767 C(H)Bd.5-CN 噻唑-4-基2-OC2F51.768 C(H)Bd.5-CN 噻唑-4-基3-OC2F51.769 C(H)Bd.5-CN 噻唑-4-基4-OC2F51.770 C(H)Bd.5-CN 噻唑-4-基2-OC6H51.771 C(H)Bd.5-CN 噻唑-4-基3-OC6H51.772 C(H)Bd.5-CN 噻唑-4-基4-OC6H51.773 C(H)Bd.5-CN 噻唑-4-基2-C(O)C6H51.774 C(H)Bd.5-CN 噻唑-4-基3-C(O)C6H51.775 C(H)Bd.5-CN 噻唑-4-基4-C(O)C6H51.776 C(H)Bd.5-OCH3HH1.777 C(H)Bd.5-OCH3H2-Cl1.778 C(H)Bd.5-OCH3H3-Cl1.779 C(H)Bd.5-OCH3H4-Cl1.780 C(H)Bd.5-OCH3H2-F1.781 C(H)Bd.5-OCH3H3-F1.782 C(H)Bd.5-OCH3H4-F1.783 C(H)Bd.5-OCH3H2-CH31.784 C(H)Bd.5-OCH3H3-CH31.785 C(H)Bd.5-OCH3H4-CH31.786 C(H)Bd.5-OCH3H2-OCH31.787 C(H)Bd.5-OCH3H3-OCH31.788 C(H)Bd.5-OCH3H4-OCH31.789 C(H)Bd.5-OCH3H2-CF31.790 C(H)Bd.5-OCH3H3-CF31.791 C(H)Bd.5-OCH3H4-CF31.792 C(H)Bd.5-OCH3H2-OCF31.793 C(H)Bd.5-OCH3H3-OCF31.794 C(H)Bd.5-OCH3H4-OCF31.795 C(H)Bd.5-OCH3H2-OCF2CF21.796 C(H)Bd.5-OCH3H3-OCF2CF2
1.797 C(H)Bd.5-OCH3H 4-OCF2CF21.798 C(H)Bd.5-OCH3H 2-OC2F51.799 C(H)Bd.5-OCH3H 3-OC2F51.800 C(H)Bd.5-OCH3H 4-OC2F51.801 C(H)Bd.5-OCH3H 2-OC6H51.802 C(H)Bd.5-OCH3H 3-OC6H51.803 C(H)Bd.5-OCH3H 4-OC6H51.804 C(H)Bd.5-OCH3H 2-C(O)C6H51.805 C(H)Bd.5-OCH3H 3-C(O)C6H51.806 C(H)Bd.5-OCH3H 4-C(O)C6H51.807 C(H)Bd.5-OCH3CH3H1.808 C(H)Bd.5-OCH3CH32-Cl1.809 C(H)Bd.5-OCH3CH33-Cl1.810 C(H)Bd.5-OCH3CH34-Cl1.811 C(H)Bd.5-OCH3CH32-F1.812 C(H)Bd.5-OCH3CH33-F1.813 C(H)Bd.5-OCH3CH34-F1.814 C(H)Bd.5-OCH3CH32-CH31.815 C(H)Bd.5-OCH3CH33-CH31.816 C(H)Bd.5-OCH3CH34-CH31.817 C(H)Bd.5-OCH3CH32-OCH31.818 C(H)Bd.5-OCH3CH33-OCH31.819 C(H)Bd.5-OCH3CH34-OCH31.820 C(H)Bd.5-OCH3CH32-CF31.821 C(H)Bd.5-OCH3CH33-CF31.822 C(H)Bd.5-OCH3CH34-CF31.823 C(H)Bd.5-OCH3CH32-OCF31.824 C(H)Bd.5-OCH3CH33-OCF31.825 C(H)Bd.5-OCH3CH34-OCF31.826 C(H)Bd.5-OCH3CH32-OCF2CF21.827 C(H)Bd.5-OCH3CH33-OCF2CF21.828 C(H)Bd.5-OCH3CH34-OCF2CF21.829 C(H)Bd.5-OCH3CH32-OC2F51.830 C(H)Bd.5-OCH3CH33-OC2F51.831 C(H)Bd.5-OCH3CH34-OC2F51.832 C(H)Bd.5-OCH3CH32-OC6H51.833 C(H)Bd.5-OCH3CH33-OC6H51.834 C(H)Bd.5-OCH3CH34-OC6H51.835 C(H)Bd.5-OCH3CH32-C(O)C6H51.836 C(H)Bd.5-OCH3CH33-C(O)C6H51.837 C(H)Bd.5-OCH3CH34-C(O)C6H51.838 C(H)Bd.5-OCH3CF3H1.839 C(H)Bd.5-OCH3CF32-Cl1.840 C(H)Bd.5-OCH3CF33-Cl1.841 C(H)Bd.5-OCH3CF34-Cl1.842 C(H)Bd.5-OCH3CF32-F1.843 C(H)Bd.5-OCH3CF33-F1.844 C(H)Bd.5-OCH3CF34-F1.845 C(H)Bd.5-OCH3CF32-CH31.846 C(H)Bd.5-OCH3CF33-CH31.847 C(H)Bd.5-OCH3CF34-CH31.848 C(H)Bd.5-OCH3CF32-OCH31.849 C(H)Bd.5-OCH3CF33-OCH31.850 C(H)Bd.5-OCH3CF34-OCH31.851 C(H)Bd.5-OCH3CF32-CF3
1.852 C(H)Bd.5-OCH3CF33-CF31.853 C(H)Bd.5-OCH3CF34-CF31.854 C(H)Bd.5-OCH3CF32-OCF31.855 C(H)Bd.5-OCH3CF33-OCF31.856 C(H)Bd.5-OCH3CF34-OCF31.857 C(H)Bd.5-OCH3CF32-OCF2CF21.858 C(H)Bd.5-OCH3CF33-OCF2CF21.859 C(H)Bd.5-OCH3CF34-OCF2CF21.860 C(H)Bd.5-OCH3CF32-OC2F51.861 C(H)Bd.5-OCH3CF33-OC2F51.862 C(H)Bd.5-OCH3CF34-OC2F51.863 C(H)Bd.5-OCH3CF32-OC6H51.864 C(H)Bd.5-OCH3CF33-OC6H51.865 C(H)Bd.5-OCH3CF34-OC6H51.866 C(H)Bd.5-OCH3CF32-C(O)C6H51.867 C(H)Bd.5-OCH3CF33-C(O)C6H51.868 C(H)Bd.5-OCH3CF34-C(O)C6H51.869 C(H)Bd.5-OCH3SCH3H1.870 C(H)Bd.5-OCH3SCH32-Cl1.871 C(H)Bd.5-OCH3SCH33-Cl1.872 C(H)Bd.5-OCH3SCH34-Cl1.873 C(H)Bd.5-OCH3SCH32-F1.874 C(H)Bd.5-OCH3SCH33-F1.875 C(H)Bd.5-OCH3SCH34-F1.876 C(H)Bd.5-OCH3SCH32-CH31.877 C(H)Bd.5-OCH3SCH33-CH31.878 C(H)Bd.5-OCH3SCH34-CH31.879 C(H)Bd.5-OCH3SCH32-OCH31.880 C(H)Bd.5-OCH3SCH33-OCH31.881 C(H)Bd.5-OCH3SCH34-OCH31.882 C(H)Bd.5-OCH3SCH32-CF31.883 C(H)Bd.5-OCH3SCH33-CF31.884 C(H)Bd.5-OCH3SCH34-CF31.885 C(H)Bd.5-OCH3SCH32-OCF31.886 C(H)Bd.5-OCH3SCH33-OCF31.887 C(H)Bd.5-OCH3SCH34-OCF31.888 C(H)Bd.5-OCH3SCH32-OCF2CF21.889 C(H)Bd.5-OCH3SCH33-OCF2CF21.890 C(H)Bd.5-OCH3SCH34-OCF2CF21.891 C(H)Bd.5-OCH3SCH32-OC2F51.892 C(H)Bd.5-OCH3SCH33-OC2F51.893 C(H)Bd.5-OCH3SCH34-OC2F51.894 C(H)Bd.5-OCH3SCH32-OC6H51.895 C(H)Bd.5-OCH3SCH33-OC6H51.896 C(H)Bd.5-OCH3SCH34-OC6H51.897 C(H)Bd.5-OCH3SCH32-C(O)C6H51.898 C(H)Bd.5-OCH3SCH33-C(O)C6H51.899 C(H)Bd.5-OCH3SCH34-C(O)C6H51.900 C(H)Bd.5-OCH3噻唑-4-基H1.901 C(H)Bd.5-OCH3噻唑-4-基2-Cl1.902 C(H)Bd.5-OCH3噻唑-4-基3-Cl1.903 C(H)Bd.5-OCH3噻唑-4-基4-Cl1.904 C(H)Bd.5-OCH3噻唑-4-基2-F1.905 C(H)Bd.5-OCH3噻唑-4-基3-F
1.906 C(H)Bd.5-OCH3噻唑-4-基4-F1.907 C(H)Bd.5-OCH3噻唑-4-基2-CH31.908 C(H)Bd.5-OCH3噻唑-4-基3-CH31.909 C(H)Bd.5-OCH3噻唑-4-基4-CH31.910 C(H)Bd.5-OCH3噻唑-4-基2-OCH31.911 C(H)Bd.5-OCH3噻唑-4-基3-OCH31.912 C(H)Bd.5-OCH3噻唑-4-基4-OCH31.913 C(H)Bd.5-OCH3噻唑-4-基2-CF31.914 C(H)Bd.5-OCH3噻唑-4-基3-CF31.915 C(H)Bd.5-OCH3噻唑-4-基4-CF31.916 C(H)Bd.5-OCH3噻唑-4-基2-OCF31.917 C(H)Bd.5-OCH3噻唑-4-基3-OCF31.918 C(H)Bd.5-OCH3噻唑-4-基4-OCF31.919 C(H)Bd.5-OCH3噻唑-4-基2-OCF2CF21.920 C(H)Bd.5-OCH3噻唑-4-基3-OCF2CF21.921 C(H)Bd.5-OCH3噻唑-4-基4-OCF2CF21.922 C(H)Bd.5-OCH3噻唑-4-基2-OC2F51.923 C(H)Bd.5-OCH3噻唑-4-基3-OC2F51.924 C(H)Bd.5-OCH3噻唑-4-基4-OC2F51.925 C(H)Bd.5-OCH3噻唑-4-基2-OC6H51.926 C(H)Bd.5-OCH3噻唑-4-基3-OC6H51.927 C(H)Bd.5-OCH3噻唑-4-基4-OC6H51.928 C(H)Bd.5-OCH3噻唑-4-基2-C(O)C6H51.929 C(H)Bd.5-OCH3噻唑-4-基3-C(O)C6H51.930 C(H)Bd.5-OCH3噻唑-4-基4-C(O)C6H51.931 C(H)Bd.4-OCH3H4-CFm.p.171°1.932 C(H)Bd.4-OCH3H4-OCFm.p.174°1.933 C(H)Bd.4-OCH2C6H5H4-OCF3m.p.73°1.934 C(H)Bd. -NO2H4-OCF3m.p.190°1.935 C(H)CH2H HH1.936 C(H)CH2H H2-Cl1.937 C(H)CH2H H3-Cl1.938 C(H)CH2H H4-Cl1.939 C(H)CH2H H2-F1.940 C(H)CH2H H3-F1.941 C(H)CH2H H4-F1.942 C(H)CH2H H2-CH31.943 C(H)CH2H H3-CH31.944 C(H)CH2H H4-CH31.945 C(H)CH2H H2-OCH31.946 C(H)CH2H H3-OCH31.947 C(H)CH2H H4-OCH31.948 C(H)CH2H H2-CF31.949 C(H)CH2H H3-CF31.950 C(H)CH2H H4-CF31.951 C(H)CH2H H2-OCF31.952 C(H)CH2H H3-OCF31.953 C(H)CH2H H4-OCF31.954 C(H)CH2H H2-OCF2CF21.955 C(H)CH2H H3-OCF2CF21.956 C(H)CH2H H4-OCF2CF21.957 C(H)CH2H H2-OC2F5
1.958 C(H)CH2H H 3-OC2F51.959 C(H)CH2H H 4-OC2F51.960 C(H)CH2H H 2-OC6H51.961 C(H)CH2H H 3-OC6H51.962 C(H)CH2H H 4-OC6H51.963 C(H)CH2H H 2-C(O)C6H51.964 C(H)CH2H H 3-C(O)C6H51.965 C(H)CH2H H 4-C(O)C6H51.966 C(H)CH2H CH3H1.967 C(H)CH2H CH32-Cl1.968 C(H)CH2H CH33-Cl1.969 C(H)CH2H CH34-Cl1.970 C(H)CH2H CH32-F1.971 C(H)CH2H CH33-F1.972 C(H)CH2H CH34-F1.973 C(H)CH2H CH32-CH31.974 C(H)CH2H CH33-CH31.975 C(H)CH2H CH34-CH31.976 C(H)CH2H CH32-OCH31.977 C(H)CH2H CH33-OCH31.978 C(H)CH2H CH34-OCH31.979 C(H)CH2H CH32-CF31.980 C(H)CH2H CH33-CF31.981 C(H)CH2H CH34-CF31.982 C(H)CH2H CH32-OCF31.983 C(H)CH2H CH33-OCF31.984 C(H)CH2H CH34-OCF31.985 C(H)CH2H CH32-OCF2CF21.986 C(H)CH2H CH33-OCF2CF21.987 C(H)CH2H CH34-OCF2CF21.988 C(H)CH2H CH32-OC2F51.989 C(H)CH2H CH33-OC2F51.990 C(H)CH2H CH34-OC2F51.991 C(H)CH2H CH32-OC6H51.992 C(H)CH2H CH33-OC6H51.993 C(H)CH2H CH34-OC6H51.994 C(H)CH2H CH32-C(O)C6H51.995 C(H)CH2H CH33-C(O)C6H51.996 C(H)CH2H CH34-C(O)C6H51.997 C(H)CH2H CF3H1.998 C(H)CH2H CF32-Cl1.999 C(H)CH2H CF33-Cl1.1000 C(H)CH2H CF34-Cl1.1001 C(H)CH2H CF32-F1.1002 C(H)CH2H CF33-F1.1003 C(H)CH2H CF34-F1.1004 C(H)CH2H CF32-CH31.1005 C(H)CH2H CF33-CH31.1006 C(H)CH2H CF34-CH31.1007 C(H)CH2H CF32-OCH31.1008 C(H)CH2H CF33-OCH31.1009 C(H)CH2H CF34-OCH31.1010 C(H)CH2H CF32-CF31.1011 C(H)CH2H CF33-CF31.1012 C(H)CH2H CF34-CF3
1.1013 C(H)CH2H CF32-OCF31.1014 C(H)CH2H CF33-OCF31.1015 C(H)CH2H CF34-OCF31.1016 C(H)CH2H CF32-OCF2CF21.1017 C(H)CH2H CF33-OCF2CF21.1018 C(H)CH2H CF34-OCF2CF21.1019 C(H)CH2H CF32-OC2F51.1020 C(H)CH2H CF33-OC2F51.1021 C(H)CH2H CF34-OC2F51.1022 C(H)CH2H CF32-OC6H51.1023 C(H)CH2H CF33-OC6H51.1024 C(H)CH2H CF34-OC6H51.1025 C(H)CH2H CF32-C(O)C6H51.1026 C(H)CH2H CF33-C(O)C6H51.1027 C(H)CH2H CF34-C(O)C6H51.1028 C(H)CH2H SCH3H1.1029 C(H)CH2H SCH32-Cl1.1030 C(H)CH2H SCH33-Cl1.1031 C(H)CH2H SCH34-Cl1.1032 C(H)CH2H SCH32-F1.1033 C(H)CH2H SCH33-F1.1034 C(H)CH2H SCH34-F1.1035 C(H)CH2H SCH32-CH31.1036 C(H)CH2H SCH33-CH31.1037 C(H)CH2H SCH34-CH31.1038 C(H)CH2H SCH32-OCH31.1039 C(H)CH2H SCH33-OCH31.1040 C(H)CH2H SCH34-OCH31.1041 C(H)CH2H SCH32-CF31.1042 C(H)CH2H SCH33-CF31.1043 C(H)CH2H SCH34-CF31.1044 C(H)CH2H SCH32-OCF31.1045 C(H)CH2H SCH33-OCF31.1046 C(H)CH2H SCH34-OCF31.1047 C(H)CH2H SCH32-OCF2CF21.1048 C(H)CH2H SCH33-OCF2CF21.1049 C(H)CH2H SCH34-OCF2CF21.1050 C(H)CH2H SCH32-OC2F51.1051 C(H)CH2H SCH33-OC2F51.1052 C(H)CH2H SCH34-OC2F51.1053 C(H)CH2H SCH32-OC6H51.1054 C(H)CH2H SCH33-OC6H51.1055 C(H)CH2H SCH34-OC6H51.1056 C(H)CH2H SCH32-C(O)C6H51.1057 C(H)CH2H SCH33-C(O)C6H51.1058 C(H)CH2H SCH34-C(O)C6H51.1059 C(H)CH2H 噻唑-4-基H1.1060 C(H)CH2H 噻唑-4-基2-Cl1.1061 C(H)CH2H 噻唑-4-基3-Cl1.1062 C(H)CH2H 噻唑-4-基4-Cl1.1063 C(H)CH2H 噻唑-4-基2-F1.1064 C(H)CH2H 噻唑-4-基3-F1.1065 C(H)CH2H 噻唑-4-基4-F1.1066 C(H)CH2H 噻唑-4-基2-CH3
1.1067 C(H)CH2H 噻唑-4-基3-CH31.1068 C(H)CH2H 噻唑-4-基4-CH31.1069 C(H)CH2H 噻唑-4-基2-OCH31.1070 C(H)CH2H 噻唑-4-基3-OCH31.1071 C(H)CH2H 噻唑-4-基4-OCH31.1072 C(H)CH2H 噻唑-4-基2-CF31.1073 C(H)CH2H 噻唑-4-基3-CF31.1074 C(H)CH2H 噻唑-4-基4-CF31.1075 C(H)CH2H 噻唑-4-基2-OCF31.1076 C(H)CH2H 噻唑-4-基3-OCF31.1077 C(H)CH2H 噻唑-4-基4-OCF31.1078 C(H)CH2H 噻唑-4-基2-OCF2CF21.1079 C(H)CH2H 噻唑-4-基3-OCF2CF21.1080 C(H)CH2H 噻唑-4-基4-OCF2CF21.1081 C(H)CH2H 噻唑-4-基2-OC2F51.1082 C(H)CH2H 噻唑-4-基3-OC2F51.1083 C(H)CH2H 噻唑-4-基4-OC2F51.1084 C(H)CH2H 噻唑-4-基2-OC6H51.1085 C(H)CH2H 噻唑-4-基3-OC6H51.1086 C(H)CH2H 噻唑-4-基4-OC6H51.1087 C(H)CH2H 噻唑-4-基2-C(O)C6H51.1088 C(H)CH2H 噻唑-4-基3-C(O)C6H51.1089 C(H)CH2H 噻唑-4-基4-C(O)C6H51.1090 C(H)CH25-Cl HH1.1091 C(H)CH25-Cl H2-Cl1.1092 C(H)CH25-Cl H3-Cl1.1093 C(H)CH25-Cl H4-Cl1.1094 C(H)CH25-Cl H2-F1.1095 C(H)CH25-Cl H3-F1.1096 C(H)CH25-Cl H4-F1.1097 C(H)CH25-Cl H2-CH31.1098 C(H)CH25-Cl H3-CH31.1099 C(H)CH25-Cl H4-CH31.1100 C(H)CH25-Cl H2-OCH31.1101 C(H)CH25-Cl H3-OCH31.1102 C(H)CH25-Cl H4-OCH31.1103 C(H)CH25-Cl H2-CF31.1104 C(H)CH25-Cl H3-CF31.1105 C(H)CH25-Cl H4-CF31.1106 C(H)CH25-Cl H2-OCF31.1107 C(H)CH25-Cl H3-OCF31.1108 C(H)CH25-Cl H4-OCF31.1109 C(H)CH25-Cl H2-OCF2CF21.1110 C(H)CH25-Cl H3-OCF2CF21.1111 C(H)CH25-Cl H4-OCF2CF21.1112 C(H)CH25-Cl H2-OC2F51.1113 C(H)CH25-Cl H3-OC2F51.1114 C(H)CH25-Cl H4-OC2F51.1115 C(H)CH25-Cl H2-OC6H51.1116 C(H)CH25-Cl H3-OC6H51.1117 C(H)CH25-Cl H4-OC6H51.1118 C(H)CH25-Cl H2-C(O)C6H5
1.1119 C(H)CH25-Cl H 3-C(O)C6H51.1120 C(H)CH25-Cl H 4-C(O)C6H51.1121 C(H)CH25-Cl CH3H1.1122 C(H)CH25-Cl CH32-Cl1.1123 C(H)CH25-Cl CH33-Cl1.1124 C(H)CH25-Cl CH34-Cl1.1125 C(H)CH25-Cl CH32-F1.1126 C(H)CH25-Cl CH33-F1.1127 C(H)CH25-Cl CH34-F1.1128 C(H)CH25-Cl CH32-CH31.1129 C(H)CH25-Cl CH33-CH31.1130 C(H)CH25-Cl CH34-CH31.1131 C(H)CH25-Cl CH32-OCH31.1132 C(H)CH25-Cl CH33-OCH31.1133 C(H)CH25-Cl CH34-OCH31.1134 C(H)CH25-Cl CH32-CF31.1135 C(H)CH25-Cl CH33-CF31.1136 C(H)CH25-Cl CH34-CF31.1137 C(H)CH25-Cl CH32-OCF31.1138 C(H)CH25-Cl CH33-OCF31.1139 C(H)CH25-Cl CH34-OCF31.1140 C(H)CH25-Cl CH32-OCF2CF21.1141 C(H)CH25-Cl CH33-OCF2CF21.1142 C(H)CH25-Cl CH34-OCF2CF21.1143 C(H)CH25-Cl CH32-OC2F51.1144 C(H)CH25-Cl CH33-OC2F51.1145 C(H)CH25-Cl CH34-OC2F51.1146 C(H)CH25-Cl CH32-OC6H51.1147 C(H)CH25-Cl CH33-OC6H51.1148 C(H)CH25-Cl CH34-OC6H51.1149 C(H)CH25-Cl CH32-C(O)C6H51.1150 C(H)CH25-Cl CH33-C(O)C6H51.1151 C(H)CH25-Cl CH34-C(O)C6H51.1152 C(H)CH25-Cl CF3H1.1153 C(H)CH25-Cl CF32-Cl1.1154 C(H)CH25-Cl CF33-Cl1.1155 C(H)CH25-Cl CF34-Cl1.1156 C(H)CH25-Cl CF32-F1.1157 C(H)CH25-Cl CF33-F1.1158 C(H)CH25-Cl CF34-F1.1159 C(H)CH25-Cl CF32-CH31.1160 C(H)CH25-Cl CF33-CH31.1161 C(H)CH25-Cl CF34-CH31.1162 C(H)CH25-Cl CF32-OCH31.1163 C(H)CH25-Cl CF33-OCH31.1164 C(H)CH25-Cl CF34-OCH31.1165 C(H)CH25-Cl CF32-CF31.1166 C(H)CH25-Cl CF33-CF31.1167 C(H)CH25-Cl CF34-CF31.1168 C(H)CH25-Cl CF32-OCF31.1169 C(H)CH25-Cl CF33-OCF31.1170 C(H)CH25-Cl CF34-OCF31.1171 C(H)CH25-Cl CF32-OCF2CF21.1172 C(H)CH25-Cl CF33-OCF2CF21.1173 C(H)CH25-Cl CF34-OCF2CF2
1.1174 C(H)CH25-Cl CF32-OC2F51.1175 C(H)CH25-Cl CF33-OC2F51.1176 C(H)CH25-Cl CF34-OC2F51.1177 C(H)CH25-Cl CF32-OC6H51.1178 C(H)CH25-Cl CF33-OC6H51.1179 C(H)CH25-Cl CF34-OC6H51.1180 C(H)CH25-Cl CF32-C(O)C6H51.1181 C(H)CH25-Cl CF33-C(O)C6H51.1182 C(H)CH25-Cl CF34-C(O)C6H51.1183 C(H)CH25-Cl SCH3H1.1184 C(H)CH25-Cl SCH32-Cl1.1185 C(H)CH25-Cl SCH33-Cl1.1186 C(H)CH25-Cl SCH34-Cl1.1187 C(H)CH25-Cl SCH32-F1.1188 C(H)CH25-Cl SCH33-F1.1189 C(H)CH25-Cl SCH34-F1.1190 C(H)CH25-Cl SCH32-CH31.1191 C(H)CH25-Cl SCH33-CH31.1192 C(H)CH25-Cl SCH34-CH31.1193 C(H)CH25-Cl SCH32-OCH31.1194 C(H)CH25-Cl SCH33-OCH31.1195 C(H)CH25-Cl SCH34-OCH31.1196 C(H)CH25-Cl SCH32-CF31.1197 C(H)CH25-Cl SCH33-CF31.1198 C(H)CH25-Cl SCH34-CF31.1199 C(H)CH25-Cl SCH32-OCF31.1200 C(H)CH25-Cl SCH33-OCF31.1201 C(H)CH25-Cl SCH34-OCF31.1202 C(H)CH25-Cl SCH32-OCF3CF21.1203 C(H)CH25-Cl SCH33-OCF2CF21.1204 C(H)CH25-Cl SCH34-OCF2CF21.1205 C(H)CH25-Cl SCH32-OC2F51.1206 C(H)CH25-Cl SCH33-OC2F51.1207 C(H)CH25-Cl SCH34-OC2F51.1208 C(H)CH25-Cl SCH32-OC6H51.1209 C(H)CH25-Cl SCH33-OC6H51.1210 C(H)CH25-Cl SCH34-OC6H51.1211 C(H)CH25-Cl SCH32-C(O)C6H51.1212 C(H)CH25-Cl SCH33-C(O)C6H51.1213 C(H)CH25-Cl SCH34-C(O)C6H51.1214 C(H)CH25-Cl 噻唑-4-基 H1.1215 C(H)CH25-Cl 噻唑-4-基 2-Cl1.1216 C(H)CH25-Cl 噻唑-4-基 3-Cl1.1217 C(H)CH25-Cl 噻唑-4-基 4-Cl1.1218 C(H)CH25-Cl 噻唑-4-基 2-F1.1219 C(H)CH25-Cl 噻唑-4-基 3-F1.1220 C(H)CH25-Cl 噻唑-4-基 4-F1.1221 C(H)CH25-Cl 噻唑-4-基 2-CH31.1222 C(H)CH25-Cl 噻唑-4-基 3-CH31.1223 C(H)CH25-Cl 噻唑-4-基 4-CH31.1224 C(H)CH25-Cl 噻唑-4-基 2-OCH31.1225 C(H)CH25-Cl 噻唑-4-基 3-OCH31.1226 C(H)CH25-Cl 噻唑-4-基 4-OCH3
1.1227 C(H)CH25-Cl 噻唑-4-基2-CF31.1228 C(H)CH25-Cl 噻唑-4-基3-CF31.1229 C(H)CH25-Cl 噻唑-4-基4-CF31.1230 C(H)CH25-Cl 噻唑-4-基2-OCF31.1231 C(H)CH25-Cl 噻唑-4-基3-OCF31.1232 C(H)CH25-Cl 噻唑-4-基4-OCF31.1233 C(H)CH25-Cl 噻唑-4-基2-OCF2CF21.1234 C(H)CH25-Cl 噻唑-4-基3-OCF2CF21.1235 C(H)CH25-Cl 噻唑-4-基4-OCF2CF21.1236 C(H)CH25-Cl 噻唑-4-基2-OC2F51.1237 C(H)CH25-Cl 噻唑-4-基3-OC2F51.1238 C(H)CH25-Cl 噻唑-4-基4-OC2F51.1239 C(H)CH25-Cl 噻唑-4-基2-OC6H51.1240 C(H)CH25-Cl 噻唑-4-基3-OC6H51.1241 C(H)CH25-Cl 噻唑-4-基4-OC6H51.1242 C(H)CH25-Cl 噻唑-4-基2-C(O)C6H51.1243 C(H)CH25-Cl 噻唑-4-基3-C(O)C6H51.1244 C(H)CH25-Cl 噻唑-4-基4-C(O)C6H51.1245 C(H)CH26-Cl HH1.1246 C(H)CH26-Cl H2-Cl1.1247 C(H)CH26-Cl H3-Cl1.1248 C(H)CH26-Cl H4-Cl1.1249 C(H)CH26-Cl H2-F1.1250 C(H)CH26-Cl H3-F1.1251 C(H)CH26-Cl H4-F1.1252 C(H)CH26-Cl H2-CH31.1253 C(H)CH26-Cl H3-CH31.1254 C(H)CH26-Cl H4-CH31.1255 C(H)CH26-Cl H2-OCH31.1256 C(H)CH26-Cl H3-OCH31.1257 C(H)CH26-Cl H4-OCH31.1258 C(H)CH26-Cl H2-CF31.1259 C(H)CH26-Cl H3-CF31.1260 C(H)CH26-Cl H4-CF31.1261 C(H)CH26-Cl H2-OCF31.1262 C(H)CH26-Cl H3-OCF31.1263 C(H)CH26-Cl H4-OCF31.1264 C(H)CH26-Cl H2-OCF2CF21.1265 C(H)CH26-Cl H3-OCF2CF21.1266 C(H)CH26-Cl H4-OCF2CF21.1267 C(H)CH26-Cl H2-OC2F51.1268 C(H)CH26-Cl H3-OC2F51.1269 C(H)CH26-Cl H4-OC2F51.1270 C(H)CH26-Cl H2-OC6H51.1271 C(H)CH26-Cl H3-OC6H51.1272 C(H)CH26-Cl H4-OC6H51.1273 C(H)CH26-Cl H2-C(O)C6H51.1274 C(H)CH26-Cl H3-C(O)C6H51.1275 C(H)CH26-Cl H4-C(O)C6H51.1276 C(H)CH26-Cl CH3H1.1277 C(H)CH26-Cl CH32-Cl1.1278 C(H)CH26-Cl CH33-Cl1.1279 C(H)CH26-Cl CH34-Cl
1.1280 C(H)CH26-Cl CH32-F1.1281 C(H)CH26-Cl CH33-F1.1282 C(H)CH26-Cl CH34-F1.1283 C(H)CH26-Cl CH32-CH31.1284 C(H)CH26-Cl CH33-CH31.1285 C(H)CH26-Cl CH34-CH31.1286 C(H)CH26-Cl CH32-OCH31.1287 C(H)CH26-Cl CH33-OCH31.1288 C(H)CH26-Cl CH34-OCH31.1289 C(H)CH26-Cl CH32-CF31.1290 C(H)CH26-Cl CH33-CF31.1291 C(H)CH26-Cl CH34-CF31.1292 C(H)CH26-Cl CH32-OCF31.1293 C(H)CH26-Cl CH33-OCF31.1294 C(H)CH26-Cl CH34-OCF31.1295 C(H)CH26-Cl CH32-OCF2CF21.1296 C(H)CH26-Cl CH33-OCF2CF21.1297 C(H)CH26-Cl CH34-OCF2CF21.1298 C(H)CH26-Cl CH32-OC2F51.1299 C(H)CH26-Cl CH33-OC2F51.1300 C(H)CH26-Cl CH34-OC2F51.1301 C(H)CH26-Cl CH32-OC6H51.1302 C(H)CH26-Cl CH33-OC6H51.1303 C(H)CH26-Cl CH34-OC6H51.1304 C(H)CH26-Cl CH32-C(O)C6H51.1305 C(H)CH26-Cl CH33-C(O)C6H51.1306 C(H)CH26-Cl CH34-C(O)C6H51.1307 C(H)CH26-Cl CF3H1.1308 C(H)CH26-Cl CF32-Cl1.1309 C(H)CH26-Cl CF33-Cl1.1310 C(H)CH26-Cl CF34-Cl1.1311 C(H)CH26-Cl CF32-F1.1312 C(H)CH26-Cl CF33-F1.1313 C(H)CH26-Cl CF34-F1.1314 C(H)CH26-Cl CF32-CH31.1315 C(H)CH26-Cl CF33-CH31.1316 C(H)CH26-Cl CF34-CH31.1317 C(H)CH26-Cl CF32-OCH31.1318 C(H)CH26-Cl CF33-OCH31.1319 C(H)CH26-Cl CF34-OCH31.1320 C(H)CH26-Cl CF32-CF31.1321 C(H)CH26-Cl CF33-CF31.1322 C(H)CH26-Cl CF34-CF31.1323 C(H)CH26-Cl CF32-OCF31.1324 C(H)CH26-Cl CF33-OCF31.1325 C(H)CH26-Cl CF34-OCF31.1326 C(H)CH26-Cl CF32-OCF2CF21.1327 C(H)CH26-Cl CF33-OCF2CF21.1328 C(H)CH26-Cl CF34-OCF2CF21.1329 C(H)CH26-Cl CF32-OC2F51.1330 C(H)CH26-Cl CF33-OC2F51.1331 C(H)CH26-Cl CF34-OC2F51.1332 C(H)CH26-Cl CF32-OC6H51.1333 C(H)CH26-Cl CF33-OC6H51.1334 C(H)CH26-Cl CF34-OC6H5
1.1335 C(H)CH26-Cl CF32-C(O)C6H51.1336 C(H)CH26-Cl CF33-C(O)C6H51.1337 C(H)CH26-Cl CF34-C(O)C6H51.1338 C(H)CH26-Cl SCH3H1.1339 C(H)CH26-Cl SCH32-Cl1.1340 C(H)CH26-Cl SCH33-Cl1.1341 C(H)CH26-Cl SCH34-Cl1.1342 C(H)CH26-Cl SCH32-F1.1343 C(H)CH26-Cl SCH33-F1.1344 C(H)CH26-Cl SCH34-F1.1345 C(H)CH26-Cl SCH32-CH31.1346 C(H)CH26-Cl SCH33-CH31.1347 C(H)CH26-Cl SCH34-CH31.1348 C(H)CH26-Cl SCH32-OCH31.1349 C(H)CH26-Cl SCH33-OCH31.1350 C(H)CH26-Cl SCH34-OCH31.1351 C(H)CH26-Cl SCH32-CF31.1352 C(H)CH26-Cl SCH33-CF31.1353 C(H)CH26-Cl SCH34-CF31.1354 C(H)CH26-Cl SCH32-OCF31.1355 C(H)CH26-Cl SCH33-OCF31.1356 C(H)CH26-Cl SCH34-OCF31.1357 C(H)CH26-Cl SCH32-OCF2CF21.1358 C(H)CH26-Cl SCH33-OCF2CF21.1359 C(H)CH26-Cl SCH34-OCF2CF21.1360 C(H)CH26-Cl SCH32-OC2F51.1361 C(H)CH26-Cl SCH33-OC2F51.1362 C(H)CH26-Cl SCH34-OC2F51.1363 C(H)CH26-Cl SCH32-OC6H51.1364 C(H)CH26-Cl SCH33-OC6H51.1365 C(H)CH26-Cl SCH34-OC6H51.1366 C(H)CH26-Cl SCH32-C(O)C6H51.1367 C(H)CH26-Cl SCH33-C(O)C6H51.1368 C(H)CH26-Cl SCH34-C(O)C6H51.1369 C(H)CH26-Cl 噻唑-4-基 H1.1370 C(H)CH26-Cl 噻唑-4-基 2-Cl1.1371 C(H)CH26-Cl 噻唑-4-基 3-Cl1.1372 C(H)CH26-Cl 噻唑-4-基 4-Cl1.1373 C(H)CH26-Cl 噻唑-4-基 2-F1.1374 C(H)CH26-Cl 噻唑-4-基 3-F1.1375 C(H)CH26-Cl 噻唑-4-基 4-F1.1376 C(H)CH26-Cl 噻唑-4-基 2-CH31.1377 C(H)CH26-Cl 噻唑-4-基 3-CH31.1378 C(H)CH26-Cl 噻唑-4-基 4-CH31.1379 C(H)CH26-Cl 噻唑-4-基 2-OCH31.1380 C(H)CH26-Cl 噻唑-4-基 3-OCH31.1381 C(H)CH26-Cl 噻唑-4-基 4-OCH31.1382 C(H)CH26-Cl 噻唑-4-基 2-CF31.1383 C(H)CH26-Cl 噻唑-4-基 3-CF31.1384 C(H)CH26-Cl 噻唑-4-基 4-CF31.1385 C(H)CH26-Cl 噻唑-4-基 2-OCF31.1386 C(H)CH26-Cl 噻唑-4-基 3-OCF31.1387 C(H)CH26-Cl 噻唑-4-基 4-OCF3
1.1388 C(H)CH26-Cl 噻唑-4-基2-OCF2CF21.1389 C(H)CH26-Cl 噻唑-4-基3-OCF2CF21.1390 C(H)CH26-Cl 噻唑-4-基4-OCF2CF21.1391 C(H)CH26-Cl 噻唑-4-基2-OC2F51.1392 C(H)CH26-Cl 噻唑-4-基3-OC2F51.1393 C(H)CH26-Cl 噻唑-4-基4-OC2F51.1394 C(H)CH26-Cl 噻唑-4-基2-OC6H51.1395 C(H)CH26-Cl 噻唑-4-基3-OC6H51.1396 C(H)CH26-Cl 噻唑-4-基4-OC6H51.1397 C(H)CH26-Cl 噻唑-4-基2-C(O)C6H51.1398 C(H)CH26-Cl 噻唑-4-基3-C(O)C6H51.1399 C(H)CH26-Cl 噻唑-4-基4-C(O)C6H51.1400 C(H)CH25-FHH1.1401 C(H)CH25-FH2-Cl1.1402 C(H)CH25-FH3-Cl1.1403 C(H)CH25-FH4-Cl1.1404 C(H)CH25-FH2-F1.1405 C(H)CH25-FH3-F1.1406 C(H)CH25-FH4-F1.1407 C(H)CH25-FH2-CH31.1408 C(H)CH25-FH3-CH31.1409 C(H)CH25-FH4-CH31.1410 C(H)CH25-FH2-OCH31.1411 C(H)CH25-FH3-OCH31.1412 C(H)CH25-FH4-OCH31.1413 C(H)CH25-FH2-CF31.1414 C(H)CH25-FH3-CF31.1415 C(H)CH25-FH4-CF31.1416 C(H)CH25-FH2-OCF31.1417 C(H)CH25-FH3-OCF31.1418 C(H)CH25-FH4-OCF31.1419 C(H)CH25-FH2-OCF2CF21.1420 C(H)CH25-FH3-OCF2CF21.1421 C(H)CH25-FH4-OCF2CF21.1422 C(H)CH25-FH2-OC2F51.1423 C(H)CH25-FH3-OC2F51.1424 C(H)CH25-FH4-OC2F51.1425 C(H)CH25-FH2-OC6H51.1426 C(H)CH25-FH3-OC6H51.1427 C(H)CH25-FH4-OC6H51.1428 C(H)CH25-FH2-C(O)C6H51.1429 C(H)CH25-FH3-C(O)C6H51.1430 C(H)CH25-FH4-C(O)C6H51.1431 C(H)CH25-FCH3H1.1432 C(H)CH25-FCH32-Cl1.1433 C(H)CH25-FCH33-Cl1.1434 C(H)CH25-FCH34-Cl1.1435 C(H)CH25-FCH32-F1.1436 C(H)CH25-FCH33-F1.1437 C(H)CH25-FCH34-F1.1438 C(H)CH25-FCH32-CH31.1439 C(H)CH25-FCH33-CH31.1440 C(H)CH25-FCH34-CH31.1441 C(H)CH25-FCH32-OCH3
1.1442 C(H)CH25-F CH33-OCH31.1443 C(H)CH25-F CH34-OCH31.1444 C(H)CH25-F CH32-CF31.1445 C(H)CH25-F CH33-CF31.1446 C(H)CH25-F CH34-CF31.1447 C(H)CH25-F CH32-OCF31.1448 C(H)CH25-F CH33-OCF31.1449 C(H)CH25-F CH34-OCF31.1450 C(H)CH25-F CH32-OCF2CF21.1451 C(H)CH25-F CH33-OCF2CF21.1452 C(H)CH25-F CH34-OCF2CF21.1453 C(H)CH25-F CH32-OC2F51.1454 C(H)CH25-F CH33-OC2F51.1455 C(H)CH25-F CH34-OC2F51.1456 C(H)CH25-F CH32-OC6H51.1457 C(H)CH25-F CH33-OC6H51.1458 C(H)CH25-F CH34-OC6H51.1459 C(H)CH25-F CH32-C(O)C6H51.1460 C(H)CH25-F CH33-C(O)C6H51.1461 C(H)CH25-F CH34-C(O)C6H51.1462 C(H)CH25-F CF3H1.1463 C(H)CH25-F CF32-Cl1.1464 C(H)CH25-F CF33-Cl1.1465 C(H)CH25-F CF34-Cl1.1466 C(H)CH25-F CF32-F1.1467 C(H)CH25-F CF33-F1.1468 C(H)CH25-F CF34-F1.1469 C(H)CH25-F CF32-CH31.1470 C(H)CH25-F CF33-CH31.1471 C(H)CH25-F CF34-CH31.1472 C(H)CH25-F CF32-OCH31.1473 C(H)CH25-F CF33-OCH31.1474 C(H)CH25-F CF34-OCH31.1475 C(H)CH25-F CF32-CF31.1476 C(H)CH25-F CF33-CF31.1477 C(H)CH25-F CF34-CF31.1478 C(H)CH25-F CF32-OCF31.1479 C(H)CH25-F CF33-OCF31.1480 C(H)CH25-F CF34-OCF31.1481 C(H)CH25-F CF32-OCF2CF21.1482 C(H)CH25-F CF33-OCF2CF21.1483 C(H)CH25-F CF34-OCF2CF21.1484 C(H)CH25-F CF32-OC2F51.1485 C(H)CH25-F CF33-OC2F51.1486 C(H)CH25-F CF34-OC2F51.1487 C(H)CH25-F CF32-OC6H51.1488 C(H)CH25-F CF33-OC6H51.1489 C(H)CH25-F CF34-OC6H51.1490 C(H)CH25-F CF32-C(O)C6H51.1491 C(H)CH25-F CF33-C(O)C6H51.1492 C(H)CH25-F CF34-C(O)C6H51.1493 C(H)CH25-F SCH3H1.1494 C(H)CH25-F SCH32-Cl1.1495 C(H)CH25-F SCH33-Cl1.1496 C(H)CH25-F SCH34-Cl
1.1497 C(H)CH25-F SCH32-F1.1498 C(H)CH25-F SCH33-F1.1499 C(H)CH25-F SCH34-F1.1500 C(H)CH25-F SCH32-CH31.1501 C(H)CH25-F SCH33-CH31.1502 C(H)CH25-F SCH34-CH31.1503 C(H)CH25-F SCH32-OCH31.1504 C(H)CH25-F SCH33-OCH31.1505 C(H)CH25-F SCH34-OCH31.1506 C(H)CH25-F SCH32-CF31.1507 C(H)CH25-F SCH33-CF31.1508 C(H)CH25-F SCH34-CF31.1509 C(H)CH25-F SCH32-OCF31.1510 C(H)CH25-F SCH33-OCF31.1511 C(H)CH25-F SCH34-OCF31.1512 C(H)CH25-F SCH32-OCF2CF21.1513 C(H)CH25-F SCH33-OCF2CF21.1514 C(H)CH25-F SCH34-OCF2CF21.1515 C(H)CH25-F SCH32-OC2F51.1516 C(H)CH25-F SCH33-OC2F51.1517 C(H)CH25-F SCH34-OC2F51.1518 C(H)CH25-F SCH32-OC6H51.1519 C(H)CH25-F SCH33-OC6H51.1520 C(H)CH25-F SCH34-OC6H51.1521 C(H)CH25-F SCH32-C(O)C6H51.1522 C(H)CH25-F SCH33-C(O)C6H51.1523 C(H)CH25-F SCH34-C(O)C6H51.1524 C(H)CH25-F 噻唑-4-基 H1.1525 C(H)CH25-F 噻唑-4-基 2-Cl1.1526 C(H)CH25-F 噻唑-4-基 3-Cl1.1527 C(H)CH25-F 噻唑-4-基 4-Cl1.1528 C(H)CH25-F 噻唑-4-基 2-F1.1529 C(H)CH25-F 噻唑-4-基 3-F1.1530 C(H)CH25-F 噻唑-4-基 4-F1.1531 C(H)CH25-F 噻唑-4-基 2-CH31.1532 C(H)CH25-F 噻唑-4-基 3-CH31.1533 C(H)CH25-F 噻唑-4-基 4-CH31.1534 C(H)CH25-F 噻唑-4-基 2-OCH31.1535 C(H)CH25-F 噻唑-4-基 3-OCH31.1536 C(H)CH25-F 噻唑-4-基 4-OCH31.1537 C(H)CH25-F 噻唑-4-基 2-CF31.1538 C(H)CH25-F 噻唑-4-基 3-CF31.1539 C(H)CH25-F 噻唑-4-基 4-CF31.1540 C(H)CH25-F 噻唑-4-基 2-OCF31.1541 C(H)CH25-F 噻唑-4-基 3-OCF31.1542 C(H)CH25-F 噻唑-4-基 4-OCF31.1543 C(H)CH25-F 噻唑-4-基 2-OCF2CF21.1544 C(H)CH25-F 噻唑-4-基 3-OCF2CF21.1545 C(H)CH25-F 噻唑-4-基 4-OCF2CF21.1546 C(H)CH25-F 噻唑-4-基 2-OC2F51.1547 C(H)CH25-F 噻唑-4-基 3-OC2F51.1548 C(H)CH25-F 噻唑-4-基 4-OC3F5
1.1549 C(H)CH25-F噻唑-4-基2-OC6H51.1550 C(H)CH25-F噻唑-4-基3-OC6H51.1551 C(H)CH25-F噻唑-4-基4-OC6H51.1552 C(H)CH25-F噻唑-4-基2-C(O)C6H51.1553 C(H)CH25-F噻唑-4-基3-C(O)C6H51.1554 C(H)CH25-F噻唑-4-基4-C(O)C6H51.1555 C(H)CH25-CN HH1.1556 C(H)CH25-CN H2-Cl1.1557 C(H)CH25-CN H3-Cl1.1558 C(H)CH25-CN H4-Cl1.1559 C(H)CH25-CN H2-F1.1560 C(H)CH25-CN H3-F1.1561 C(H)CH25-CN H4-F1.1562 C(H)CH25-CN H2-CH31.1563 C(H)CH25-CN H3-CH31.1564 C(H)CH25-CN H4-CH31.1565 C(H)CH25-CN H2-OCH31.1566 C(H)CH25-CN H3-OCH31.1567 C(H)CH25-CN H4-OCH31.1568 C(H)CH25-CN H2-CF31.1569 C(H)CH25-CN H3-CF31.1570 C(H)CH25-CN H4-CF31.1571 C(H)CH25-CN H2-OCF31.1572 C(H)CH25-CN H3-OCF31.1573 C(H)CH25-CN H4-OCF31.1574 C(H)CH25-CN H2-OCF2CF21.1575 C(H)CH25-CN H3-OCF2CF21.1576 C(H)CH25-CN H4-OCF2CF21.1577 C(H)CH25-CN H2-OC2F51.1578 C(H)CH25-CN H3-OC2F51.1579 C(H)CH25-CN H4-OC2F51.1580 C(H)CH25-CN H2-OC6H51.1581 C(H)CH25-CN H3-OC6H51.1582 C(H)CH25-CN H4-OC6H51.1583 C(H)CH25-CN H2-C(O)C6H51.1584 C(H)CH25-CN H3-C(O)C6H51.1585 C(H)CH25-CN H4-C(O)C6H51.1586 C(H)CH25-CN CH3H1.1587 C(H)CH25-CN CH32-Cl1.1588 C(H)CH25-CN CH33-Cl1.1589 C(H)CH25-CN CH34-Cl1.1590 C(H)CH25-CN CH32-F1.1591 C(H)CH25-CN CH33-F1.1592 C(H)CH25-CN CH34-F1.1593 C(H)CH25-CN CH32-CH31.1594 C(H)CH25-CN CH33-CH31.1595 C(H)CH25-CN CH34-CH31.1596 C(H)CH25-CN CH32-OCH31.1597 C(H)CH25-CN CH33-OCH31.1598 C(H)CH25-CN CH34-OCH31.1599 C(H)CH25-CN CH32-CF31.1600 C(H)CH25-CN CH33-CF31.1601 C(H)CH25-CN CH34-CF31.1602 C(H)CH25-CN CH32-OCF3
1.1603 C(H)CH25-CN CH33-OCF31.1604 C(H)CH25-CN CH34-OCF31.1605 C(H)CH25-CN CH32-OCF2CF21.1606 C(H)CH25-CN CH33-OCF2CF21.1607 C(H)CH25-CN CH34-OCF2CF21.1608 C(H)CH25-CN CH32-OC2F51.1609 C(H)CH25-CN CH33-OC2F51.1610 C(H)CH25-CN CH34-OC2F51.1611 C(H)CH25-CN CH32-OC6H51.1612 C(H)CH25-CN CH33-OC6H51.1613 C(H)CH25-CN CH34-OC6H51.1614 C(H)CH25-CN CH32-C(O)C6H51.1615 C(H)CH25-CN CH33-C(O)C6H51.1616 C(H)CH25-CN CH34-C(O)C6H51.1617 C(H)CH25-CN CF3H1.1618 C(H)CH25-CN CF32-Cl1.1619 C(H)CH25-CN CF33-Cl1.1620 C(H)CH25-CN CF34-Cl1.1621 C(H)CH25-CN CF32-F1.1622 C(H)CH25-CN CF33-F1.1623 C(H)CH25-CN CF34-F1.1624 C(H)CH25-CN CF32-CH31.1625 C(H)CH25-CN CF33-CH31.1626 C(H)CH25-CN CF34-CH31.1627 C(H)CH25-CN CF32-OCH31.1628 C(H)CH25-CN CF33-OCH31.1629 C(H)CH25-CN CF34-OCH31.1630 C(H)CH25-CN CF32-CF31.1631 C(H)CH25-CN CF33-CF31.1632 C(H)CH25-CN CF34-CF31.1633 C(H)CH25-CN CF32-OCF31.1634 C(H)CH25-CN CF33-OCF31.1635 C(H)CH25-CN CF34-OCF31.1636 C(H)CH25-CN CF32-OCF2CF21.1637 C(H)CH25-CN CF33-OCF2CF21.1638 C(H)CH25-CN CF34-OCF2CF21.1639 C(H)CH25-CN CF32-OC2F51.1640 C(H)CH25-CN CF33-OC2F51.1641 C(H)CH25-CN CF34-OC2F51.1642 C(H)CH25-CN CF32-OC6H51.1643 C(H)CH25-CN CF33-OC6H51.1644 C(H)CH25-CN CF34-OC6H51.1645 C(H)CH25-CN CF32-C(O)C6H51.1646 C(H)CH25-CN CF33-C(O)C6H51.1647 C(H)CH25-CN CF34-C(O)C6H51.1648 C(H)CH25-CN SCH3H1.1649 C(H)CH25-CN SCH32-Cl1.1650 C(H)CH25-CN SCH33-Cl1.1651 C(H)CH25-CN SCH34-Cl1.1652 C(H)CH25-CN SCH32-F1.1653 C(H)CH25-CN SCH33-F1.1654 C(H)CH25-CN SCH34-F1.1655 C(H)CH25-CN SCH32-CH31.1656 C(H)CH25-CN SCH33-CH31.1657 C(H)CH25-CN SCH34-CH3
1.1658 C(H)CH25-CN SCH32-OCH31.1659 C(H)CH25-CN SCH33-OCH31.1660 C(H)CH25-CN SCH34-OCH31.1661 C(H)CH25-CN SCH32-CF31.1662 C(H)CH25-CN SCH33-CF31.1663 C(H)CH25-CN SCH34-CF31.1664 C(H)CH25-CN SCH32-OCF31.1665 C(H)CH25-CN SCH33-OCF31.1666 C(H)CH25-CN SCH34-OCF31.1667 C(H)CH25-CN SCH32-OCF2CF21.1668 C(H)CH25-CN SCH33-OCF2CF21.1669 C(H)CH25-CN SCH34-OCF2CF21.1670 C(H)CH25-CN SCH32-OC2F51.1671 C(H)CH25-CN SCH33-OC2F51.1672 C(H)CH25-CN SCH34-OC2F51.1673 C(H)CH25-CN SCH32-OC6H51.1674 C(H)CH25-CN SCH33-OC6H51.1675 C(H)CH25-CN SCH34-OC6H51.1676 C(H)CH25-CN SCH32-C(O)C6H51.1677 C(H)CH25-CN SCH33-C(O)C6H51.1678 C(H)CH25-CN SCH34-C(O)C6H51.1679 C(H)CH25-CN 噻唑-4-基H1.1680 C(H)CH25-CN 噻唑-4-基2-Cl1.1681 C(H)CH25-CN 噻唑-4-基3-Cl1.1682 C(H)CH25-CN 噻唑-4-基4-Cl1.1683 C(H)CH25-CN 噻唑-4-基2-F1.1684 C(H)CH25-CN 噻唑-4-基3-F1.1685 C(H)CH25-CN 噻唑-4-基4-F1.1686 C(H)CH25-CN 噻唑-4-基2-CH31.1687 C(H)CH25-CN 噻唑-4-基3-CH31.1688 C(H)CH25-CN 噻唑-4-基4-CH31.1689 C(H)CH25-CN 噻唑-4-基2-OCH31.1690 C(H)CH25-CN 噻唑-4-基3-OCH31.1691 C(H)CH25-CN 噻唑-4-基4-OCH31.1692 C(H)CH25-CN 噻唑-4-基2-CF31.1693 C(H)CH25-CN 噻唑-4-基3-CF31.1694 C(H)CH25-CN 噻唑-4-基4-CF31.1695 C(H)CH25-CN 噻唑-4-基2-OCF31.1696 C(H)CH25-CN 噻唑-4-基3-OCF31.1697 C(H)CH25-CN 噻唑-4-基4-OCF31.1698 C(H)CH25-CN 噻唑-4-基2-OCF2CF21.1699 C(H)CH25-CN 噻唑-4-基3-OCF2CF21.1700 C(H)CH25-CN 噻唑-4-基4-OCF2CF21.1701 C(H)CH25-CN 噻唑-4-基2-OC2F51.1702 C(H)CH25-CN 噻唑-4-基3-OC2F51.1703 C(H)CH25-CN 噻唑-4-基4-OC2F51.1704 C(H)CH25-CN 噻唑-4-基2-OC6H51.1705 C(H)CH25-CN 噻唑-4-基3-OC6H51.1706 C(H)CH25-CN 噻唑-4-基4-OC6H51.1707 C(H)CH25-CN 噻唑-4-基2-C(O)C6H51.1708 C(H)CH25-CN 噻唑-4-基3-C(O)C6H5
1.1709 C(H)CH25-CN 噻唑-4-基4-C(O)C6H51.1710 C(H)CH25-OCH3HH1.1711 C(H)CH25-OCH3H2-Cl1.1712 C(H)CH25-OCH3H3-Cl1.1713 C(H)CH25-OCH3H4-Cl1.1714 C(H)CH25-OCH3H2-F1.1715 C(H)CH25-OCH3H3-F1.1716 C(H)CH25-OCH3H4-F1.1717 C(H)CH25-OCH3H2-CH31.1718 C(H)CH25-OCH3H3-CH31.1719 C(H)CH25-OCH3H4-CH31.1720 C(H)CH25-OCH3H2-OCH31.1721 C(H)CH25-OCH3H3-OCH31.1722 C(H)CH25-OCH3H4-OCH31.1723 C(H)CH25-OCH3H2-CF31.1724 C(H)CH25-OCH3H3-CF31.1725 C(H)CH25-OCH3H4-CF31.1726 C(H)CH25-OCH3H2-OCF31.1727 C(H)CH25-OCH3H3-OCF31.1728 C(H)CH25-OCH3H4-OCF31.1729 C(H)CH25-OCH3H2-OCF2CF21.1730 C(H)CH25-OCH3H3-OCF2CF21.1731 C(H)CH25-OCH3H4-OCF2CF21.1732 C(H)CH25-OCH3H2-OC2F51.1733 C(H)CH25-OCH3H3-OC2F51.1734 C(H)CH25-OCH3H4-OC2F51.1735 C(H)CH25-OCH3H2-OC6H51.1736 C(H)CH25-OCH3H3-OC6H51.1737 C(H)CH25-OCH3H4-OC6H51.1738 C(H)CH25-OCH3H2-C(O)C6H51.1739 C(H)CH25-OCH3H3-C(O)C6H51.1740 C(H)CH25-OCH3H4-C(O)C6H51.1741 C(H)CH25-OCH3CH3H1.1742 C(H)CH25-OCH3CH32-Cl1.1743 C(H)CH25-OCH3CH33-Cl1.1744 C(H)CH25-OCH3CH34-Cl1.1745 C(H)CH25-OCH3CH32-F1.1746 C(H)CH25-OCH3CH33-F1.1747 C(H)CH25-OCH3CH34-F1.1748 C(H)CH25-OCH3CH32-CH31.1749 C(H)CH25-OCH3CH33-CH31.1750 C(H)CH25-OCH3CH34-CH31.1751 C(H)CH25-OCH3CH32-OCH31.1752 C(H)CH25-OCH3CH33-OCH31.1753 C(H)CH25-OCH3CH34-OCH31.1754 C(H)CH25-OCH3CH32-CF31.1755 C(H)CH25-OCH3CH33-CF31.1756 C(H)CH25-OCH3CH34-CF31.1757 C(H)CH25-OCH3CH32-OCF31.1758 C(H)CH25-OCH3CH33-OCF31.1759 C(H)CH25-OCH3CH34-OCF31.1760 C(H)CH25-OCH3CH32-OCF2CF21.1761 C(H)CH25-OCH3CH33-OCF2CF21.1762 C(H)CH25-OCH3CH34-OCF2CF21.1763 C(H)CH25-OCH3CH32-OC2F5
1.1764 C(H)CH25-OCH3CH33-OC2F51.1765 C(H)CH25-OCH3CH34-OC2F51.1766 C(H)CH25-OCH3CH32-OC6H51.1767 C(H)CH25-OCH3CH33-OC6H51.1768 C(H)CH25-OCH3CH34-OC6H51.1769 C(H)CH25-OCH3CH32-C(O)C6H51.1770 C(H)CH25-OCH3CH33-C(O)C6H51.1771 C(H)CH25-OCH3CH34-C(O)C6H51.1772 C(H)CH25-OCH3CF3H1.1773 C(H)CH25-OCH3CF32-Cl1.1774 C(H)CH25-OCH3CF33-Cl1.1775 C(H)CH25-OCH3CF34-Cl1.1776 C(H)CH25-OCH3CF32-F1.1777 C(H)CH25-OCH3CF33-F1.1778 C(H)CH25-OCH3CF34-F1.1779 C(H)CH25-OCH3CF32-CH31.1780 C(H)CH25-OCH3CF33-CH31.1781 C(H)CH25-OCH3CF34-CH31.1782 C(H)CH25-OCH3CF32-OCH31.1783 C(H)CH25-OCH3CF33-OCH31.1784 C(H)CH25-OCH3CF34-OCH31.1785 C(H)CH25-OCH3CF32-CF31.1786 C(H)CH25-OCH3CF33-CF31.1787 C(H)CH25-OCH3CF34-CF31.1788 C(H)CH25-OCH3CF32-OCF31.1789 C(H)CH25-OCH3CF33-OCF31.1790 C(H)CH25-OCH3CF34-OCF31.1791 C(H)CH25-OCH3CF32-OCF2CF21.1792 C(H)CH25-OCH3CF33-OCF2CF21.1793 C(H)CH25-OCH3CF34-OCF2CF21.1794 C(H)CH25-OCH3CF32-OC2F51.1795 C(H)CH25-OCH3CF33-OC2F51.1796 C(H)CH25-OCH3CF34-OC2F51.1797 C(H)CH25-OCH3CF32-OC6H51.1798 C(H)CH25-OCH3CF33-OC6H51.1799 C(H)CH25-OCH3CF34-OC6H51.1800 C(H)CH25-OCH3CF32-C(O)C6H51.1801 C(H)CH25-OCH3CF33-C(O)C6H51.1802 C(H)CH25-OCH3CF34-C(O)C6H51.1803 C(H)CH25-OCH3SCH3H1.1804 C(H)CH25-OCH3SCH32-Cl1.1805 C(H)CH25-OCH3SCH33-Cl1.1806 C(H)CH25-OCH3SCH34-Cl1.1807 C(H)CH25-OCH3SCH32-F1.1808 C(H)CH25-OCH3SCH33-F1.1809 C(H)CH25-OCH3SCH34-F1.1810 C(H)CH25-OCH3SCH32-CH31.1811 C(H)CH25-OCH3SCH33-CH31.1812 C(H)CH25-OCH3SCH34-CH31.1813 C(H)CH25-OCH3SCH32-OCH31.1814 C(H)CH25-OCH3SCH33-OCH31.1815 C(H)CH25-OCH3SCH34-OCH31.1816 C(H)CH25-OCH3SCH32-CF31.1817 C(H)CH25-OCH3SCH33-CF31.1818 C(H)CH25-OCH3SCH34-CF3
1.1819 C(H)CH25-OCH3SCH32-OCF31.1820 C(H)CH25-OCH3SCH33-OCF31.1821 C(H)CH25-OCH3SCH34-OCF31.1822 C(H)CH25-OCH3SCH32-OCF2CF21.1823 C(H)CH25-OCH3SCH33-OCF2CF21.1824 C(H)CH25-OCH3SCH34-OCF2CF21.1825 C(H)CH25-OCH3SCH32-OC2F51.1826 C(H)CH25-OCH3SCH33-OC2F51.1827 C(H)CH25-OCH3SCH34-OC2F51.1828 C(H)CH25-OCH3SCH32-OC6H51.1829 C(H)CH25-OCH3SCH33-OC6H51.1830 C(H)CH25-OCH3SCH34-OC6H51.1831 C(H)CH25-OCH3SCH32-C(O)C6H51.1832 C(H)CH25-OCH3SCH33-C(O)C6H51.1833 C(H)CH25-OCH3SCH34-C(O)C6H51.1834 C(H)CH25-OCH3噻唑-4-基H1.1835 C(H)CH25-OCH3噻唑-4-基2-Cl1.1836 C(H)CH25-OCH3噻唑-4-基3-Cl1.1837 C(H)CH25-OCH3噻唑-4-基4-Cl1.1838 C(H)CH25-OCH3噻唑-4-基2-F1.1839 C(H)CH25-OCH3噻唑-4-基3-F1.1840 C(H)CH25-OCH3噻唑-4-基4-F1.1841 C(H)CH25-OCH3噻唑-4-基2-CH31.1842 C(H)CH25-OCH3噻唑-4-基3-CH31.1843 C(H)CH25-OCH3噻唑-4-基4-CH31.1844 C(H)CH25-OCH3噻唑-4-基2-OCH31.1845 C(H)CH25-OCH3噻唑-4-基3-OCH31.1846 C(H)CH25-OCH3噻唑-4-基4-OCH31.1847 C(H)CH25-OCH3噻唑-4-基2-CF31.1848 C(H)CH25-OCH3噻唑-4-基3-CF31.1849 C(H)CH25-OCH3噻唑-4-基4-CF31.1850 C(H)CH25-OCH3噻唑-4-基2-OCF31.1851 C(H)CH25-OCH3噻唑-4-基3-OCF31.1852 C(H)CH25-OCH3噻唑-4-基4-OCF31.1853 C(H)CH25-OCH3噻唑-4-基2-OCF2CF21.1854 C(H)CH25-OCH3噻唑-4-基3-OCF2CF21.1855 C(H)CH25-OCH3噻唑-4-基4-OCF2CF21.1856 C(H)CH25-OCH3噻唑-4-基2-OC2F51.1857 C(H)CH25-OCH3噻唑-4-基3-OC2F51.1858 C(H)CH25-OCH3噻唑-4-基4-OC2F51.1859 C(H)CH25-OCH3噻唑-4-基2-OC6H51.1860 C(H)CH25-OCH3噻唑-4-基3-OC6H51.1861 C(H)CH25-OCH3噻唑-4-基4-OC6H51.1862 C(H)CH25-OCH3噻唑-4-基2-C(O)C6H51.1863 C(H)CH25-OCH3噻唑-4-基3-C(O)C6H51.1864 C(H)CH25-OCH3噻唑-4-基4-C(O)C6H51.1865 C(CN) Bd. H HH1.1866 C(CN) Bd. H H2-Cl1.1867 C(CN) Bd. H H3-Cl1.1868 C(CN) Bd. H H4-Cl1.1869 C(CN) Bd. H H2-F
1.1870 C(CN) Bd.H H 3-F1.1871 C(CN) Bd.H H 4-F1.1872 C(CN) Bd.H H 2-CH31.1873 C(CN) Bd.H H 3-CH31.1874 C(CN) Bd.H H 4-CH31.1875 C(CN) Bd.H H 2-OCH31.1876 C(CN) Bd.H H 3-OCH31.1877 C(CN) Bd.H H 4-OCH31.1878 C(CN) Bd.H H 2-CF31.1879 C(CN) Bd.H H 3-CF31.1880 C(CN) Bd.H H 4-CF31.1881 C(CN) Bd.H H 2-OCF31.1882 C(CN) Bd.H H 3-OCF31.1883 C(CN) Bd.H H 4-OCF31.1884 C(CN) Bd.H H 2-OCF2CF21.1885 C(CN) Bd.H H 3-OCF2CF21.1886 C(CN) Bd.H H 4-OCF2CF21.1887 C(CN) Bd.H H 2-OC2F51.1888 C(CN) Bd.H H 3-OC2F51.1889 C(CN) Bd.H H 4-OC2F51.1890 C(CN) Bd.H H 2-OC6H51.1891 C(CN) Bd.H H 3-OC6H51.1892 C(CN) Bd.H H 4-OC6H51.1893 C(CN) Bd.H H 2-C(O)C6H51.1894 C(CN) Bd.H H 3-C(O)C6H51.1895 C(CN) Bd.H H 4-C(O)C6H51.1896 C(CN) Bd.H CH3H1.1897 C(CN) Bd.H CH32-Cl1.1898 C(CN) Bd.H CH33-Cl1.1899 C(CN) Bd.H CH34-Cl1.1900 C(CN) Bd.H CH32-F1.1901 C(CN) Bd.H CH33-F1.1902 C(CN) Bd.H CH34-F1.1903 C(CN) Bd.H CH32-CH31.1904 C(CN) Bd.H CH33-CH31.1905 C(CN) Bd.H CH34-CH31.1906 C(CN) Bd.H CH32-OCH31.1907 C(CN) Bd.H CH33-OCH31.1908 C(CN) Bd.H CH34-OCH31.1909 C(CN) Bd.H CH32-CF31.1910 C(CN) Bd.H CH33-CF31.1911 C(CN) Bd.H CH34-CF31.1912 C(CN) Bd.H CH32-OCF31.1913 C(CN) Bd.H CH33-OCF31.1914 C(CN) Bd.H CH34-OCF31.1915 C(CN) Bd.H CH32-OCF2CF21.1916 C(CN) Bd.H CH33-OCF2CF21.1917 C(CN) Bd.H CH34-OCF2CF21.1918 C(CN) Bd.H CH32-OC2F51.1919 C(CN) Bd.H CH33-OC2F51.1920 C(CN) Bd.H CH34-OC2F51.1921 C(CN) Bd.H CH32-OC6H51.1922 C(CN) Bd.H CH33-OC6H51.1923 C(CN) Bd.H CH34-OC6H51.1924 C(CN) Bd.H CH32-C(O)C6H5
1.1925 C(CN) Bd.HCH33-C(O)C6H51.1926 C(CN) Bd.HCH34-C(O)C6H51.1927 C(CN) Bd.HCF3H1.1928 C(CN) Bd.HCF32-Cl1.1929 C(CN) Bd.HCF33-Cl1.1930 C(CN) Bd.HCF34-Cl1.1931 C(CN) Bd.HCF32-F1.1932 C(CN) Bd.HCF33-F1.1933 C(CN) Bd.HCF34-F1.1934 C(CN) Bd.HCF32-CH31.1935 C(CN) Bd.HCF33-CH31.1936 C(CN) Bd.HCF34-CH31.1937 C(CN) Bd.HCF32-OCH31.1938 C(CN) Bd.HCF33-OCH31.1939 C(CN) Bd.HCF34-OCH31.1940 C(CN) Bd.HCF32-CF31.1941 C(CN) Bd.HCF33-CF31.1942 C(CN) Bd.HCF34-CF31.1943 C(CN) Bd.HCF32-OCF31.1944 C(CN) Bd.HCF33-OCF31.1945 C(CN) Bd.HCF34-OCF31.1946 C(CN) Bd.HCF32-OCF2CF21.1947 C(CN) Bd.HCF33-OCF2CF21.1948 C(CN) Bd.HCF34-OCF2CF21.1949 C(CN) Bd.HCF32-OC2F51.1950 C(CN) Bd.HCF33-OC2F51.1951 C(CN) Bd.HCF34-OC2F51.1952 C(CN) Bd.HCF32-OC6H51.1953 C(CN) Bd.HCF33-OC6H51.1954 C(CN) Bd.HCF34-OC6H51.1955 C(CN) Bd.HCF32-C(O)C6H51.1956 C(CN) Bd.HCF33-C(O)C6H51.1957 C(CN) Bd.HCF34-C(O)C6H51.1958 C(CN) Bd.HSCH3H1.1959 C(CN) Bd.HSCH32-Cl1.1960 C(CN) Bd.HSCH33-Cl1.1961 C(CN) Bd.HSCH34-Cl1.1962 C(CN) Bd.HSCH32-F1.1963 C(CN) Bd.HSCH33-F1.1964 C(CN) Bd.HSCH34-F1.1965 C(CN) Bd.HSCH32-CH31.1966 C(CN) Bd.HSCH33-CH31.1967 C(CN) Bd.HSCH34-CH31.1968 C(CN) Bd.HSCH32-OCH31.1969 C(CN) Bd.HSCH33-OCH31.1970 C(CN) Bd.HSCH34-OCH31.1971 C(CN) Bd.HSCH32-CF31.1972 C(CN) Bd.HSCH33-CF31.1973 C(CN) Bd.HSCH34-CF31.1974 C(CN) Bd.HSCH32-OCF31.1975 C(CN) Bd.HSCH33-OCF31.1976 C(CN) Bd.HSCH34-OCF31.1977 C(CN) Bd.HSCH32-OCF2CF21.1978 C(CN) Bd.HSCH33-OCF2CF21.1979 C(CN) Bd.HSCH34-OCF2CF2
1.1980 C(CN) Bd.HSCH32-OC2F51.1981 C(CN) Bd.HSCH33-OC2F51.1982 C(CN) Bd.HSCH34-OC2F51.1983 C(CN) Bd.HSCH32-OC6H51.1984 C(CN) Bd.HSCH33-OC6H51.1985 C(CN) Bd.HSCH34-OC6H51.1986 C(CN) Bd.HSCH32-C(O)C6H51.1987 C(CN) Bd.HSCH33-C(O)C6H51.1988 C(CN) Bd.HSCH34-C(O)C6H51.1989 C(CN) Bd.H噻唑-4-基H1.1990 C(CN) Bd.H噻唑-4-基2-Cl1.1991 C(CN) Bd.H噻唑-4-基3-Cl1.1992 C(CN) Bd.H噻唑-4-基4-Cl1.1993 C(CN) Bd.H噻唑-4-基2-F1.1994 C(CN) Bd.H噻唑-4-基3-F1.1995 C(CN) Bd.H噻唑-4-基4-F1.1996 C(CN) Bd.H噻唑-4-基2-CH31.1997 C(CN) Bd.H噻唑-4-基3-CH31.1998 C(CN) Bd.H噻唑-4-基4-CH31.1999 C(CN) Bd.H噻唑-4-基2-OCH31.2000 C(CN) Bd.H噻唑-4-基3-OCH31.2001 C(CN) Bd.H噻唑-4-基4-OCH31.2002 C(CN) Bd.H噻唑-4-基2-CF31.2003 C(CN) Bd.H噻唑-4-基3-CF31.2004 C(CN) Bd.H噻唑-4-基4-CF31.2005 C(CN) Bd.H噻唑-4-基2-OCF31.2006 C(CN) Bd.H噻唑-4-基3-OCF31.2007 C(CN) Bd.H噻唑-4-基4-OCF31.2008 C(CN) Bd.H噻唑-4-基2-OCF2CF21.2009 C(CN) Bd.H噻唑-4-基3-OCF2CF21.2010 C(CN) Bd.H噻唑-4-基4-OCF2CF21.2011 C(CN) Bd.H噻唑-4-基2-OC2F51.2012 C(CN) Bd.H噻唑-4-基3-OC2F51.2013 C(CN) Bd.H噻唑-4-基4-OC2F51.2014 C(CN) Bd.H噻唑-4-基2-OC6H51.2015 C(CN) Bd.H噻唑-4-基3-OC6H51.2016 C(CN) Bd.H噻唑-4-基4-OC6H51.2017 C(CN) Bd.H噻唑-4-基2-C(O)C6H51.2018 C(CN) Bd.H噻唑-4-基3-C(O)C6H51.2019 C(CN) Bd.H噻唑-4-基4-C(O)C6H51.2020 C(CN) Bd.5-Cl HH1.2021 C(CN) Bd.5-Cl H2-Cl1.2022 C(CN) Bd.5-Cl H3-Cl1.2023 C(CN) Bd.5-Cl H4-Cl1.2024 C(CN) Bd.5-Cl H2-F1.2025 C(CN) Bd.5-Cl H3-F1.2026 C(CN) Bd.5-Cl H4-F1.2027 C(CN) Bd.5-Cl H2-CH31.2028 C(CN) Bd.5-Cl H3-CH31.2029 C(CN) Bd.5-Cl H4-CH31.2030 C(CN) Bd.5-Cl H2-OCH3
1.2031 C(CN) Bd.5-Cl H3-OCH31.2032 C(CN) Bd.5-Cl H4-OCH31.2033 C(CN) Bd.5-Cl H2-CF31.2034 C(CN) Bd.5-Cl H3-CF31.2035 C(CN) Bd.5-Cl H4-CF31.2036 C(CN) Bd.5-Cl H2-OCF31.2037 C(CN) Bd.5-Cl H3-OCF31.2038 C(CN) Bd.5-Cl H4-OCF31.2039 C(CN) Bd.5-Cl H2-OCF2CF21.2040 C(CN) Bd.5-Cl H3-OCF2CF21.2041 C(CN) Bd.5-Cl H4-OCF2CF21.2042 C(CN) Bd.5-Cl H2-OC2F51.2043 C(CN) Bd.5-Cl H3-OC2F51.2044 C(CN) Bd.5-Cl H4-OC2F51.2045 C(CN) Bd.5-Cl H2-OC6H51.2046 C(CN) Bd.5-Cl H3-OC6H51.2047 C(CN) Bd.5-Cl H4-OC6H51.2048 C(CN) Bd.5-Cl H2-C(O)C6H51.2049 C(CN) Bd.5-Cl H3-C(O)C6H51.2050 C(CN) Bd.5-Cl H4-C(O)C6H51.2051 C(CN) Bd.5-Cl CH3H1.2052 C(CN) Bd.5-Cl CH32-Cl1.2053 C(CN) Bd.5-Cl CH33-Cl1.2054 C(CN) Bd.5-Cl CH34-Cl1.2055 C(CN) Bd.5-Cl CH32-F1.2056 C(CN) Bd.5-Cl CH33-F1.2057 C(CN) Bd.5-Cl CH34-F1.2058 C(CN) Bd.5-Cl CH32-CH31.2059 C(CN) Bd.5-Cl CH33-CH31.2060 C(CN) Bd.5-Cl CH34-CH31.2061 C(CN) Bd.5-Cl CH32-OCH31.2062 C(CN) Bd.5-Cl CH33-OCH31.2063 C(CN) Bd.5-Cl CH34-OCH31.2064 C(CN) Bd.5-Cl CH32-CF31.2065 C(CN) Bd.5-Cl CH33-CF31.2066 C(CN) Bd.5-Cl CH34-CF31.2067 C(CN) Bd.5-Cl CH32-OCF31.2068 C(CN) Bd.5-Cl CH33-OCF31.2069 C(CN) Bd.5-Cl CH34-OCF31.2070 C(CN) Bd.5-Cl CH32-OCF2CF21.2071 C(CN) Bd.5-Cl CH33-OCF2CF21.2072 C(CN) Bd.5-Cl CH34-OCF2CF21.2073 C(CN) Bd.5-Cl CH32-OC2F51.2074 C(CN) Bd.5-Cl CH33-OC2F51.2075 C(CN) Bd.5-Cl CH34-OC2F51.2076 C(CN) Bd.5-Cl CH32-OC6H51.2077 C(CN) Bd.5-Cl CH33-OC6H51.2078 C(CN) Bd.5-Cl CH34-OC6H51.2079 C(CN) Bd.5-Cl CH32-C(O)C6H51.2080 C(CN) Bd.5-Cl CH33-C(O)C6H51.2081 C(CN) Bd.5-Cl CH34-C(O)C6H51.2082 C(CN) Bd.5-Cl CF3H1.2083 C(CN) Bd.5-Cl CF32-Cl1.2084 C(CN) Bd.5-Cl CF33-Cl1.2085 C(CN) Bd.5-Cl CF34-Cl
1.2086 C(CN)Bd.5-Cl CF32-F1.2087 C(CN)Bd.5-Cl CF33-F1.2088 C(CN)Bd.5-Cl CF34-F1.2089 C(CN)Bd.5-Cl CF32-CH31.2090 C(CN)Bd.5-Cl CF33-CH31.2091 C(CN)Bd.5-Cl CF34-CH31.2092 C(CN)Bd.5-Cl CF32-OCH31.2093 C(CN)Bd.5-Cl CF33-OCH31.2094 C(CN)Bd.5-Cl CF34-OCH31.2095 C(CN)Bd.5-Cl CF32-CF31.2096 C(CN)Bd.5-Cl CF33-CF31.2097 C(CN)Bd.5-Cl CF34-CF31.2098 C(CN)Bd.5-Cl CF32-OCF31.2099 C(CN)Bd.5-Cl CF33-OCF31.2100 C(CN)Bd.5-Cl CF34-OCF31.2101 C(CN)Bd.5-Cl CF32-OCF2CF21.2102 C(CN)Bd.5-Cl CF33-OCF2CF21.2103 C(CN)Bd.5-Cl CF34-OCF2CF21.2104 C(CN)Bd.5-Cl CF32-OC2F51.2105 C(CN)Bd.5-Cl CF33-OC2F51.2106 C(CN)Bd.5-Cl CF34-OC2F51.2107 C(CN)Bd.5-Cl CF32-OC6H51.2108 C(CN)Bd.5-Cl CF33-OC6H51.2109 C(CN)Bd.5-Cl CF34-OC6H51.2110 C(CN)Bd.5-Cl CF32-C(O)C6H51.2111 C(CN)Bd.5-Cl CF33-C(O)C6H51.2112 C(CN)Bd.5-Cl CF34-C(O)C6H51.2113 C(CN)Bd.5-Cl SCH3H1.2114 C(CN)Bd.5-Cl SCH32-Cl1.2115 C(CN)Bd.5-Cl SCH33-Cl1.2116 C(CN)Bd.5-Cl SCH34-Cl1.2117 C(CN)Bd.5-Cl SCH32-F1.2118 C(CN)Bd.5-Cl SCH33-F1.2119 C(CN)Bd.5-Cl SCH34-F1.2120 C(CN)Bd.5-Cl SCH32-CH31.2121 C(CN)Bd.5-Cl SCH33-CH31.2122 C(CN)Bd.5-Cl SCH34-CH31.2123 C(CN)Bd.5-Cl SCH32-OCH31.2124 C(CN)Bd.5-Cl SCH33-OCH31.2125 C(CN)Bd.5-Cl SCH34-OCH31.2126 C(CN)Bd.5-Cl SCH32-CF31.2127 C(CN)Bd.5-Cl SCH33-CF31.2128 C(CN)Bd.5-Cl SCH34-CF31.2129 C(CN)Bd.5-Cl SCH32-OCF31.2130 C(CN)Bd.5-Cl SCH33-OCF31.2131 C(CN)Bd.5-Cl SCH34-OCF31.2132 C(CN)Bd.5-Cl SCH32-OCF2CF21.2133 C(CN)Bd.5-Cl SCH33-OCF2CF21.2134 C(CN)Bd.5-Cl SCH34-OCF2CF21.2135 C(CN)Bd.5-Cl SCH32-OC2F51.2136 C(CN)Bd.5-Cl SCH33-OC2F51.2137 C(CN)Bd.5-Cl SCH34-OC2F51.2138 C(CN)Bd.5-Cl SCH32-OC6H51.2139 C(CN)Bd.5-Cl SCH33-OC6H51.2140 C(CN)Bd.5-Cl SCH34-OC6H5
1.2141 C(CN) Bd.5-Cl SCH32-C(O)C6H51.2142 C(CN) Bd.5-Cl SCH33-C(O)C6H51.2143 C(CN) Bd.5-Cl SCH34-C(O)C6H51.2144 C(CN) Bd.5-Cl 噻唑-4-基H1.2145 C(CN) Bd.5-Cl 噻唑-4-基2-Cl1.2146 C(CN) Bd.5-Cl 噻唑-4-基3-Cl1.2147 C(CN) Bd.5-Cl 噻唑-4-基4-Cl1.2148 C(CN) Bd.5-Cl 噻唑-4-基2-F1.2149 C(CN) Bd.5-Cl 噻唑-4-基3-F1.2150 C(CN) Bd.5-Cl 噻唑-4-基4-F1.2151 C(CN) Bd.5-Cl 噻唑-4-基2-CH31.2152 C(CN) Bd.5-Cl 噻唑-4-基3-CH31.2153 C(CN) Bd.5-Cl 噻唑-4-基4-CH31.2154 C(CN) Bd.5-Cl 噻唑-4-基2-OCH31.2155 C(CN) Bd.5-Cl 噻唑-4-基3-OCH31.2156 C(CN) Bd.5-Cl 噻唑-4-基4-OCH31.2157 C(CN) Bd.5-Cl 噻唑-4-基2-CF31.2158 C(CN) Bd.5-Cl 噻唑-4-基3-CF31.2159 C(CN) Bd.5-Cl 噻唑-4-基4-CF31.2160 C(CN) Bd.5-Cl 噻唑-4-基2-OCF31.2161 C(CN) Bd.5-Cl 噻唑-4-基3-OCF31.2162 C(CN) Bd.5-Cl 噻唑-4-基4-OCF31.2163 C(CN) Bd.5-Cl 噻唑-4-基2-OCF2CF21.2164 C(CN) Bd.5-Cl 噻唑-4-基3-OCF2CF21.2165 C(CN) Bd.5-Cl 噻唑-4-基4-OCF2CF21.2166 C(CN) Bd.5-Cl 噻唑-4-基2-OC2F51.2167 C(CN) Bd.5-Cl 噻唑-4-基3-OC2F51.2168 C(CN) Bd.5-Cl 噻唑-4-基4-OC2F51.2169 C(CN) Bd.5-Cl 噻唑-4-基2-OC6H51.2170 C(CN) Bd.5-Cl 噻唑-4-基3-OC6H51.2171 C(CN) Bd.5-Cl 噻唑-4-基4-OC6H51.2172 C(CN) Bd.5-Cl 噻唑-4-基2-C(O)C6H51.2173 C(CN) Bd.5-Cl 噻唑-4-基3-C(O)C6H51.2174 C(CN) Bd.5-Cl 噻唑-4-基4-C(O)C6H51.2175 C(CN) Bd.6-Cl HH1.2176 C(CN) Bd.6-Cl H2-Cl1.2177 C(CN) Bd.6-Cl H3-Cl1.2178 C(CN) Bd.6-Cl H4-Cl1.2179 C(CN) Bd.6-Cl H2-F1.2180 C(CN) Bd.6-Cl H3-F1.2181 C(CN) Bd.6-Cl H4-F1.2182 C(CN) Bd.6-Cl H2-CH31.2183 C(CN) Bd.6-Cl H3-CH31.2184 C(CN) Bd.6-Cl H4-CH31.2185 C(CN) Bd.6-Cl H2-OCH31.2186 C(CN) Bd.6-Cl H3-OCH31.2187 C(CN) Bd.6-Cl H4-OCH31.2188 C(CN) Bd.6-Cl H2-CF31.2189 C(CN) Bd.6-Cl H3-CF31.2190 C(CN) Bd.6-Cl H4-CF31.2191 C(CN) Bd.6-Cl H2-OCF3
1.2192 C(CN) Bd.6-Cl H3-OCF31.2193 C(CN) Bd.6-Cl H4-OCF31.2194 C(CN) Bd.6-Cl H2-OCF2CF21.2195 C(CN) Bd.6-Cl H3-OCF2CF21.2196 C(CN) Bd.6-Cl H4-OCF2CF21.2197 C(CN) Bd.6-Cl H2-OC2F51.2198 C(CN) Bd.6-Cl H3-OC2F51.2199 C(CN) Bd.6-Cl H4-OC2F51.2200 C(CN) Bd.6-Cl H2-OC6H51.2201 C(CN) Bd.6-Cl H3-OC6H51.2202 C(CN) Bd.6-Cl H4-OC6H51.2203 C(CN) Bd.6-Cl H2-C(O)C6H51.2204 C(CN) Bd.6-Cl H3-C(O)C6H51.2205 C(CN) Bd.6-Cl H4-C(O)C6H51.2206 C(CN) Bd.6-Cl CH3H1.2207 C(CN) Bd.6-Cl CH32-Cl1.2208 C(CN) Bd.6-Cl CH33-Cl1.2209 C(CN) Bd.6-Cl CH34-Cl1.2210 C(CN) Bd.6-Cl CH32-F1.2211 C(CN) Bd.6-Cl CH33-F1.2212 C(CN) Bd.6-Cl CH34-F1.2213 C(CN) Bd.6-Cl CH32-CH31.2214 C(CN) Bd.6-Cl CH33-CH31.2215 C(CN) Bd.6-Cl CH34-CH31.2216 C(CN) Bd.6-Cl CH32-OCH31.2217 C(CN) Bd.6-Cl CH33-OCH31.2218 C(CN) Bd.6-Cl CH34-OCH31.2219 C(CN) Bd.6-Cl CH32-CF31.2220 C(CN) Bd.6-Cl CH33-CF31.2221 C(CN) Bd.6-Cl CH34-CFX1.2222 C(CN) Bd.6-Cl CH32-OCF31.2223 C(CN) Bd.6-Cl CH33-OCF31.2224 C(CN) Bd.6-Cl CH34-OCF31.2225 C(CN) Bd.6-Cl CH32-OCF2CF21.2226 C(CN) Bd.6-Cl CH33-OCF2CF21.2227 C(CN) Bd.6-Cl CH34-OCF2CF21.2228 C(CN) Bd.6-Cl CH32-OC2F51.2229 C(CN) Bd.6-Cl CH33-OC2F51.2230 C(CN) Bd.6-Cl CH34-OC2F51.2231 C(CN) Bd.6-Cl CH32-OC6H51.2232 C(CN) Bd.6-Cl CH33-OC6H51.2233 C(CN) Bd.6-Cl CH34-OC6H51.2234 C(CN) Bd.6-Cl CH32-C(O)C6H51.2235 C(CN) Bd.6-Cl CH33-C(O)C6H51.2236 C(CN) Bd.6-Cl CH34-C(O)C6H51.2237 C(CN) Bd.6-Cl CF3H1.2238 C(CN) Bd.6-Cl CF32-Cl1.2239 C(CN) Bd.6-Cl CF33-Cl1.2240 C(CN) Bd.6-Cl CF34-Cl1.2241 C(CN) Bd.6-Cl CF32-F1.2242 C(CN) Bd.6-Cl CF33-F1.2243 C(CN) Bd.6-Cl CF34-F1.2244 C(CN) Bd.6-Cl CF32-CH31.2245 C(CN) Bd.6-Cl CF33-CH31.2246 C(CN) Bd.6-Cl CF34-CH3
1.2247 C(CN)Bd.6-Cl CF32-OCH31.2248 C(CN)Bd.6-Cl CF33-OCH31.2249 C(CN)Bd.6-Cl CF34-OCH31.2250 C(CN)Bd.6-Cl CF32-CF31.2251 C(CN)Bd.6-Cl CF33-CF31.2252 C(CN)Bd.6-Cl CF34-CF31.2253 C(CN)Bd.6-Cl CF32-OCF31.2254 C(CN)Bd.6-Cl CF33-OCF31.2255 C(CN)Bd.6-Cl CF34-OCF31.2256 C(CN)Bd.6-Cl CF32-OCF2CF21.2257 C(CN)Bd.6-Cl CF33-OCF2CF21.2258 C(CN)Bd.6-Cl CF34-OCF2CF21.2259 C(CN)Bd.6-Cl CF32-OC2F51.2260 C(CN)Bd.6-Cl CF33-OC2F51.2261 C(CN)Bd.6-Cl CF34-OC2F51.2262 C(CN)Bd.6-Cl CF32-OC6H51.2263 C(CN)Bd.6-Cl CF33-OC6H51.2264 C(CN)Bd.6-Cl CF34-OC6H51.2265 C(CN)Bd.6-Cl CF32-C(O)C6H51.2266 C(CN)Bd.6-Cl CF33-C(O)C6H51.2267 C(CN)Bd.6-Cl CF34-C(O)C6H51.2268 C(CN)Bd.6-Cl SCH3H1.2269 C(CN)Bd.6-Cl SCH32-Cl1.2270 C(CN)Bd.6-Cl SCH33-Cl1.2271 C(CN)Bd.6-Cl SCH34-Cl1.2272 C(CN)Bd.6-Cl SCH32-F1.2273 C(CN)Bd.6-Cl SCH33-F1.2274 C(CN)Bd.6-Cl SCH34-F1.2275 C(CN)Bd.6-Cl SCH32-CH31.2276 C(CN)Bd.6-Cl SCH33-CH31.2277 C(CN)Bd.6-Cl SCH34-CH31.2278 C(CN)Bd.6-Cl SCH32-OCH31.2279 C(CN)Bd.6-Cl SCH33-OCH31.2280 C(CN)Bd.6-Cl SCH34-OCH31.2281 C(CN)Bd.6-Cl SCH32-CF31.2282 C(CN)Bd.6-Cl SCH33-CF31.2283 C(CN)Bd.6-Cl SCH34-CF31.2284 C(CN)Bd.6-Cl SCH32-OCF31.2285 C(CN)Bd.6-Cl SCH33-OCF31.2286 C(CN)Bd.6-Cl SCH34-OCF31.2287 C(CN)Bd.6-Cl SCH32-OCF2CF21.2288 C(CN)Bd.6-Cl SCH33-OCF2CF21.2289 C(CN)Bd.6-Cl SCH34-OCF2CF21.2290 C(CN)Bd.6-Cl SCH32-OC2F51.2291 C(CN)Bd.6-Cl SCH33-OC2F51.2292 C(CN)Bd.6-Cl SCH34-OC2F51.2293 C(CN)Bd.6-Cl SCH32-OC6H51.2294 C(CN)Bd.6-Cl SCH33-OC6H51.2295 C(CN)Bd.6-Cl SCH34-OC6H51.2296 C(CN)Bd.6-Cl SCH32-C(O)C6H51.2297 C(CN)Bd.6-Cl SCH33-C(O)C6H51.2298 C(CN)Bd.6-Cl SCH34-C(O)C6H51.2299 C(CN)Bd.6-Cl 噻唑-4-基 H1.2300 C(CN)Bd.6-Cl 噻唑-4-基 2-Cl1.2301 C(CN)Bd.6-Cl 噻唑-4-基 3-Cl
1.2302 C(CN) Bd.6-Cl 噻唑-4-基4-Cl1.2303 C(CN) Bd.6-Cl 噻唑-4-基2-F1.2304 C(CN) Bd.6-Cl 噻唑-4-基3-F1.2305 C(CN) Bd.6-Cl 噻唑-4-基4-F1.2306 C(CN) Bd.6-Cl 噻唑-4-基2-CH31.2307 C(CN) Bd.6-Cl 噻唑-4-基3-CH31.2308 C(CN) Bd.6-Cl 噻唑-4-基4-CH31.2309 C(CN) Bd.6-Cl 噻唑-4-基2-OCH31.2310 C(CN) Bd.6-Cl 噻唑-4-基3-OCH31.2311 C(CN) Bd.6-Cl 噻唑-4-基4-OCH31.2312 C(CN) Bd.6-Cl 噻唑-4-基2-CF31.2313 C(CN) Bd.6-Cl 噻唑-4-基3-CF31.2314 C(CN) Bd.6-Cl 噻唑-4-基4-CF31.2315 C(CN) Bd.6-Cl 噻唑-4-基2-OCF31.2316 C(CN) Bd.6-Cl 噻唑-4-基3-OCF31.2317 C(CN) Bd.6-Cl 噻唑-4-基4-OCF31.2318 C(CN) Bd.6-Cl 噻唑-4-基2-OCF2CF21.2319 C(CN) Bd.6-Cl 噻唑-4-基3-OCF2CF21.2320 C(CN) Bd.6-Cl 噻唑-4-基4-OCF2CF21.2321 C(CN) Bd.6-Cl 噻唑-4-基2-OC2F51.2322 C(CN) Bd.6-Cl 噻唑-4-基3-OC2F51.2323 C(CN) Bd.6-Cl 噻唑-4-基4-OC2F51.2324 C(CN) Bd.6-Cl 噻唑-4-基2-OC6H51.2325 C(CN) Bd.6-Cl 噻唑-4-基3-OC6H51.2326 C(CN) Bd.6-Cl 噻唑-4-基4-OC6H51.2327 C(CN) Bd.6-Cl 噻唑-4-基2-C(O)C6H51.2328 C(CN) Bd.6-Cl 噻唑-4-基3-C(O)C6H51.2329 C(CN) Bd.6-Cl 噻唑-4-基4-C(O)C6H51.2330 C(CN) Bd.5-F HH1.2331 C(CN) Bd.5-F H2-Cl1.2332 C(CN) Bd.5-F H3-Cl1.2333 C(CN) Bd.5-F H4-Cl1.2334 C(CN) Bd.5-F H2-F1.2335 C(CN) Bd.5-F H3-F1.2336 C(CN) Bd.5-F H4-F1.2337 C(CN) Bd.5-F H2-CH31.2338 C(CN) Bd.5-F H3-CH31.2339 C(CN) Bd.5-F H4-CH31.2340 C(CN) Bd.5-F H2-OCH31.2341 C(CN) Bd.5-F H3-OCH31.2342 C(CN) Bd.5-F H4-OCH31.2343 C(CN) Bd.5-F H2-CF31.2344 C(CN) Bd.5-F H3-CF31.2345 C(CN) Bd.5-F H4-CF31.2346 C(CN) Bd.5-F H2-OCF31.2347 C(CN) Bd.5-F H3-OCF31.2348 C(CN) Bd.5-F H4-OCF31.2349 C(CN) Bd.5-F H2-OCF2CF21.2350 C(CN) Bd.5-F H3-OCF2CF21.2351 C(CN) Bd.5-F H4-OCF2CF21.2352 C(CN) Bd.5-F H2-OC2F51.2353 C(CN) Bd.5-F H3-OC2F5
1.2354 C(CN)Bd.5-F H 4-OC2F51.2355 C(CN)Bd.5-F H 2-OC6H51.2356 C(CN)Bd.5-F H 3-OC6H51.2357 C(CN)Bd.5-F H 4-OC6H51.2358 C(CN)Bd.5-F H 2-C(O)C6H51.2359 C(CN)Bd.5-F H 3-C(O)C6H51.2360 C(CN)Bd.5-F H 4-C(O)C6H51.2361 C(CN)Bd.5-F CH3H1.2362 C(CN)Bd.5-F CH32-Cl1.2363 C(CN)Bd.5-F CH33-Cl1.2364 C(CN)Bd.5-F CH34-Cl1.2365 C(CN)Bd.5-F CH32-F1.2366 C(CN)Bd.5-F CH33-F1.2367 C(CN)Bd.5-F CH34-F1.2368 C(CN)Bd.5-F CH32-CH31.2369 C(CN)Bd.5-F CH33-CH31.2370 C(CN)Bd.5-F CH34-CH31.2371 C(CN)Bd.5-F CH32-OCH31.2372 C(CN)Bd.5-F CH33-OCH31.2373 C(CN)Bd.5-F CH34-OCH31.2374 C(CN)Bd.5-F CH32-CF31.2375 C(CN)Bd.5-F CH33-CF31.2376 C(CN)Bd.5-F CH34-CF31.2377 C(CN)Bd.5-F CH32-OCF31.2378 C(CN)Bd.5-F CH33-OCF31.2379 C(CN)Bd.5-F CH34-OCF31.2380 C(CN)Bd.5-F CH32-OCF2CF21.2381 C(CN)Bd.5-F CH33-OCF2CF21.2382 C(CN)Bd.5-F CH34-OCF2CF21.2383 C(CN)Bd.5-F CH32-OC2F51.2384 C(CN)Bd.5-F CH33-OC2F51.2385 C(CN)Bd.5-F CH34-OC2F51.2386 C(CN)Bd.5-F CH32-OC6H51.2387 C(CN)Bd.5-F CH33-OC6H51.2388 C(CN)Bd.5-F CH34-OC6H51.2389 C(CN)Bd.5-F CH32-C(O)C6H51.2390 C(CN)Bd.5-F CH33-C(O)C6H51.2391 C(CN)Bd.5-F CH34-C(O)C6H51.2392 C(CN)Bd.5-F CF3H1.2393 C(CN)Bd.5-F CF32-Cl1.2394 C(CN)Bd.5-F CF33-Cl1.2395 C(CN)Bd.5-F CF34-Cl1.2396 C(CN)Bd.5-F CF32-F1.2397 C(CN)Bd.5-F CF33-F1.2398 C(CN)Bd.5-F CF34-F1.2399 C(CN)Bd.5-F CF32-CH31.2400 C(CN)Bd.5-F CF33-CH31.2401 C(CN)Bd.5-F CF34-CH31.2402 C(CN)Bd.5-F CF32-OCH31.2403 C(CN)Bd.5-F CF33-OCH31.2404 C(CN)Bd.5-F CF34-OCH31.2405 C(CN)Bd.5-F CF32-CF31.2406 C(CN)Bd.5-F CF33-CF31.2407 C(CN)Bd.5-F CF34-CF31.2408 C(CN)Bd.5-F CF32-OCF3
1.2409 C(CN)Bd.5-F CF33-OCF31.2410 C(CN)Bd.5-F CF34-OCF31.2411 C(CN)Bd.5-F CF32-OCF2CF21.2412 C(CN)Bd.5-F CF33-OCF2CF21.2413 C(CN)Bd.5-F CF34-OCF2CF21.2414 C(CN)Bd.5-F CF32-OC2F51.2415 C(CN)Bd.5-F CF33-OC2F51.2416 C(CN)Bd.5-F CF34-OC2F51.2417 C(CN)Bd.5-F CF32-OC6H51.2418 C(CN)Bd.5-F CF33-OC6H51.2419 C(CN)Bd.5-F CF34-OC6H51.2420 C(CN)Bd.5-F CF32-C(O)C6H51.2421 C(CN)Bd.5-F CF33-C(O)C6H51.2422 C(CN)Bd.5-F CF34-C(O)C6H51.2423 C(CN)Bd.5-F SCH3H1.2424 C(CN)Bd.5-F SCH32-Cl1.2425 C(CN)Bd.5-F SCH33-Cl1.2426 C(CN)Bd.5-F SCH34-Cl1.2427 C(CN)Bd.5-F SCH32-F1.2428 C(CN)Bd.5-F SCH33-F1.2429 C(CN)Bd.5-F SCH34-F1.2430 C(CN)Bd.5-F SCH32-CH31.2431 C(CN)Bd.5-F SCH33-CH31.2432 C(CN)Bd.5-F SCH34-CH31.2433 C(CN)Bd.5-F SCH32-OCH31.2434 C(CN)Bd.5-F SCH33-OCH31.2435 C(CN)Bd.5-F SCH34-OCH31.2436 C(CN)Bd.5-F SCH32-CF31.2437 C(CN)Bd.5-F SCH33-CF31.2438 C(CN)Bd.5-F SCH34-CF31.2439 C(CN)Bd.5-F SCH32-OCF31.2440 C(CN)Bd.5-F SCH33-OCF31.2441 C(CN)Bd.5-F SCH34-OCF31.2442 C(CN)Bd.5-F SCH32-OCF2CF21.2443 C(CN)Bd.5-F SCH33-OCF2CF21.2444 C(CN)Bd.5-F SCH34-OCF2CF21.2445 C(CN)Bd.5-F SCH32-OC2F51.2446 C(CN)Bd.5-F SCH33-OC2F51.2447 C(CN)Bd.5-F SCH34-OC2F51.2448 C(CN)Bd.5-F SCH32-OC6H51.2449 C(CN)Bd.5-F SCH33-OC6H51.2450 C(CN)Bd.5-F SCH34-OC6H51.2451 C(CN)Bd.5-F SCH32-C(O)C6H51.2452 C(CN)Bd.5-F SCH33-C(O)C6H51.2453 C(CN)Bd.5-F SCH34-C(O)C6H51.2454 C(CN)Bd.5-F 噻唑-4-基 H1.2455 C(CN)Bd.5-F 噻唑-4-基 2-Cl1.2456 C(CN)Bd.5-F 噻唑-4-基 3-Cl1.2457 C(CN)Bd.5-F 噻唑-4-基 4-Cl1.2458 C(CN)Bd.5-F 噻唑-4-基 2-F1.2459 C(CN)Bd.5-F 噻唑-4-基 3-F1.2460 C(CN)Bd.5-F 噻唑-4-基 4-F1.2461 C(CN)Bd.5-F 噻唑-4-基 2-CH31.2462 C(CN)Bd.5-F 噻唑-4-基 3-CH3
1.2463 C(CN)Bd.5-F 噻唑-4-基4-CH31.2464 C(CN)Bd.5-F 噻唑-4-基2-OCH31.2465 C(CN)Bd.5-F 噻唑-4-基3-OCH31.2466 C(CN)Bd.5-F 噻唑-4-基4-OCH31.2467 C(CN)Bd.5-F 噻唑-4-基2-CF31.2468 C(CN)Bd.5-F 噻唑-4-基3-CF31.2469 C(CN)Bd.5-F 噻唑-4-基4-CF31.2470 C(CN)Bd.5-F 噻唑-4-基2-OCF31.2471 C(CN)Bd.5-F 噻唑-4-基3-OCF31.2472 C(CN)Bd.5-F 噻唑-4-基4-OCF31.2473 C(CN)Bd.5-F 噻唑-4-基2-OCF2CF21.2474 C(CN)Bd.5-F 噻唑-4-基3-OCF2CF21.2475 C(CN)Bd.5-F 噻唑-4-基4-OCF2CF21.2476 C(CN)Bd.5-F 噻唑-4-基2-OC2F51.2477 C(CN)Bd.5-F 噻唑-4-基3-OC2F51.2478 C(CN)Bd.5-F 噻唑-4-基4-OC2F51.2479 C(CN)Bd.5-F 噻唑-4-基2-OC6H51.2480 C(CN)Bd.5-F 噻唑-4-基3-OC6H51.2481 C(CN)Bd.5-F 噻唑-4-基4-OC6H51.2482 C(CN)Bd.5-F 噻唑-4-基2-C(O)C6H51.2483 C(CN)Bd.5-F 噻唑-4-基3-C(O)C6H51.2484 C(CN)Bd.5-F 噻唑-4-基4-C(O)C6H51.2485 C(CN)Bd.5-CN HH1.2486 C(CN)Bd.5-CN H2-Cl1.2487 C(CN)Bd.5-CN H3-Cl1.2488 C(CN)Bd.5-CN H4-Cl1.2489 C(CN)Bd.5-CN H2-F1.2490 C(CN)Bd.5-CN H3-F1.2491 C(CN)Bd.5-CN H4-F1.2492 C(CN)Bd.5-CN H2-CH31.2493 C(CN)Bd.5-CN H3-CH31.2494 C(CN)Bd.5-CN H4-CH31.2495 C(CN)Bd.5-CN H2-OCH31.2496 C(CN)Bd.5-CN H3-OCH31.2497 C(CN)Bd.5-CN H4-OCH31.2498 C(CN)Bd.5-CN H2-CF31.2499 C(CN)Bd.5-CN H3-CF31.2500 C(CN)Bd.5-CN H4-CF31.2501 C(CN)Bd.5-CN H2-OCF31.2502 C(CN)Bd.5-CN H3-OCF31.2503 C(CN)Bd.5-CN H4-OCF31.2504 C(CN)Bd.5-CN H2-OCF2CF21.2505 C(CN)Bd.5-CN H3-OCF2CF21.2506 C(CN)Bd.5-CN H4-OCF2CF21.2507 C(CN)Bd.5-CN H2-OC2F51.2508 C(CN)Bd.5-CN H3-OC2F51.2509 C(CN)Bd.5-CN H4-OC2F51.2510 C(CN)Bd.5-CN H2-OC6H51.2511 C(CN)Bd.5-CN H3-OC6H51.2512 C(CN)Bd.5-CN H4-OC6H51.2513 C(CN)Bd.5-CN H2-C(O)C6H51.2514 C(CN)Bd.5-CN H3-C(O)C6H5
1.2515 C(CN)Bd.5-CN H 4-C(O)C6H51.2516 C(CN)Bd.5-CN CH3H1.2517 C(CN)Bd.5-CN CH32-Cl1.2518 C(CN)Bd.5-CN CH33-Cl1.2519 C(CN)Bd.5-CN CH34-Cl1.2520 C(CN)Bd.5-CN CH32-F1.2521 C(CN)Bd.5-CN CH33-F1.2522 C(CN)Bd.5-CN CH34-F1.2523 C(CN)Bd.5-CN CH32-CH31.2524 C(CN)Bd.5-CN CH33-CH31.2525 C(CN)Bd.5-CN CH34-CH31.2526 C(CN)Bd.5-CN CH32-OCH31.2527 C(CN)Bd.5-CN CH33-OCH31.2528 C(CN)Bd.5-CN CH34-OCH31.2529 C(CN)Bd.5-CN CH32-CF31.2530 C(CN)Bd.5-CN CH33-CF31.2531 C(CN)Bd.5-CN CH34-CF31.2532 C(CN)Bd.5-CN CH32-OCF31.2533 C(CN)Bd.5-CN CH33-OCF31.2534 C(CN)Bd.5-CN CH34-OCF31.2535 C(CN)Bd.5-CN CH32-OCF2CF21.2536 C(CN)Bd.5-CN CH33-OCF2CF21.2537 C(CN)Bd.5-CN CH34-OCF2CF21.2538 C(CN)Bd.5-CN CH32-OC2F51.2539 C(CN)Bd.5-CN CH33-OC2F51.2540 C(CN)Bd.5-CN CH34-OC2F51.2541 C(CN)Bd.5-CN CH32-OC6H51.2542 C(CN)Bd.5-CN CH33-OC6H51.2543 C(CN)Bd.5-CN CH34-OC6H51.2544 C(CN)Bd.5-CN CH32-C(O)C6H51.2545 C(CN)Bd.5-CN CH33-C(O)C6H51.2546 C(CN)Bd.5-CN CH34-C(O)C6H51.2547 C(CN)Bd.5-CN CF3H1.2548 C(CN)Bd.5-CN CF32-Cl1.2549 C(CN)Bd.5-CN CF33-Cl1.2550 C(CN)Bd.5-CN CF34-Cl1.2551 C(CN)Bd.5-CN CF32-F1.2552 C(CN)Bd.5-CN CF33-F1.2553 C(CN)Bd.5-CN CF34-F1.2554 C(CN)Bd.5-CN CF32-CH31.2555 C(CN)Bd.5-CN CF33-CH31.2556 C(CN)Bd.5-CN CF34-CH31.2557 C(CN)Bd.5-CN CF32-OCH31.2558 C(CN)Bd.5-CN CF33-OCH31.2559 C(CN)Bd.5-CN CF34-OCH31.2560 C(CN)Bd.5-CN CF32-CF31.2561 C(CN)Bd.5-CN CF33-CF31.2562 C(CN)Bd.5-CN CF34-CF31.2563 C(CN)Bd.5-CN CF32-OCF31.2564 C(CN)Bd.5-CN CF33-OCF31.2565 C(CN)Bd.5-CN CF34-OCF31.2566 C(CN)Bd.5-CN CF32-OCF2CF21.2567 C(CN)Bd.5-CN CF33-OCF2CF21.2568 C(CN)Bd.5-CN CF34-OCF2CF21.2569 C(CN)Bd.5-CN CF32-OC2F5
1.2570 C(CN)Bd.5-CN CF33-OC2F51.2571 C(CN)Bd.5-CN CF34-OC2F51.2572 C(CN)Bd.5-CN CF32-OC6H51.2573 C(CN)Bd.5-CN CF33-OC6H51.2574 C(CN)Bd.5-CN CF34-OC56H51.2575 C(CN)Bd.5-CN CF32-C(O)C6H51.2576 C(CN)Bd.5-CN CF33-C(O)C6H51.2577 C(CN)Bd.5-CN CF34-C(O)C6H51.2578 C(CN)Bd.5-CN SCH3H1.2579 C(CN)Bd.5-CN SCH32-Cl1.2580 C(CN)Bd.5-CN SCH33-Cl1.2581 C(CN)Bd.5-CN SCH34-Cl1.2582 C(CN)Bd.5-CN SCH32-F1.2583 C(CN)Bd.5-CN SCH33-F1.2584 C(CN)Bd.5-CN SCH34-F1.2585 C(CN)Bd.5-CN SCH32-CH31.2586 C(CN)Bd.5-CN SCH33-CH31.2587 C(CN)Bd.5-CN SCH34-CH31.2588 C(CN)Bd.5-CN SCH32-OCH31.2589 C(CN)Bd.5-CN SCH33-OCH31.2590 C(CN)Bd.5-CN SCH34-OCH31.2591 C(CN)Bd.5-CN SCH32-CF31.2592 C(CN)Bd.5-CN SCH33-CF31.2593 C(CN)Bd.5-CN SCH34-CF31.2594 C(CN)Bd.5-CN SCH32-OCF31.2595 C(CN)Bd.5-CN SCH33-OCF31.2596 C(CN)Bd.5-CN SCH34-OCF31.2597 C(CN)Bd.5-CN SCH32-OCF2CF21.2598 C(CN)Bd.5-CN SCH33-OCF2CF21.2599 C(CN)Bd.5-CN SCH34-OCF2CF21.2600 C(CN)Bd.5-CN SCH32-OC2F51.2601 C(CN)Bd.5-CN SCH33-OC2F51.2602 C(CN)Bd.5-CN SCH34-OC2F51.2603 C(CN)Bd.5-CN SCH32-OC6H51.2604 C(CN)Bd.5-CN SCH33-OC6H51.2605 C(CN)Bd.5-CN SCH34-OC6H51.2606 C(CN)Bd.5-CN SCH32-C(O)C6H51.2607 C(CN)Bd.5-CN SCH33-C(O)C6H51.2608 C(CN)Bd.5-CN SCH34-C(O)C6H51.2609 C(CN)Bd.5-CN 噻唑-4-基 H1.2610 C(CN)Bd.5-CN 噻唑-4-基 2-Cl1.2611 C(CN)Bd.5-CN 噻唑-4-基 3-Cl1.2612 C(CN)Bd.5-CN 噻唑-4-基 4-Cl1.2613 C(CN)Bd.5-CN 噻唑-4-基 2-F1.2614 C(CN)Bd.5-CN 噻唑-4-基 3-F1.2615 C(CN)Bd.5-CN 噻唑-4-基 4-F1.2616 C(CN)Bd.5-CN 噻唑-4-基 2-CH31.2617 C(CN)Bd.5-CN 噻唑-4-基 3-CH31.2618 C(CN)Bd.5-CN 噻唑-4-基 4-CH31.2619 C(CN)Bd.5-CN 噻唑-4-基 2-OCH31.2620 C(CN)Bd.5-CN 噻唑-4-基 3-OCH31.2621 C(CN)Bd.5-CN 噻唑-4-基 4-OCH31.2622 C(CN)Bd.5-CN 噻唑-4-基 2-CF3
1.2623 C(CN) Bd.5-CN 噻唑-4-基3-CF31.2624 C(CN) Bd.5-CN 噻唑-4-基4-CF31.2625 C(CN) Bd.5-CN 噻唑-4-基2-OCF31.2626 C(CN) Bd.5-CN 噻唑-4-基3-OCF31.2627 C(CN) Bd.5-CN 噻唑-4-基4-OCF31.2628 C(CN) Bd.5-CN 噻唑-4-基2-OCF2CF21.2629 C(CN) Bd.5-CN 噻唑-4-基3-OCF2CF21.2630 C(CN) Bd.5-CN 噻唑-4-基4-OCF2CF21.2631 C(CN) Bd.5-CN 噻唑-4-基2-OC2F51.2632 C(CN) Bd.5-CN 噻唑-4-基3-OC2F51.2633 C(CN) Bd.5-CN 噻唑-4-基4-OC2F51.2634 C(CN) Bd.5-CN 噻唑-4-基2-OC6H51.2635 C(CN) Bd.5-CN 噻唑-4-基3-OC6H51.2636 C(CN) Bd.5-CN 噻唑-4-基4-OC6H51.2637 C(CN) Bd.5-CN 噻唑-4-基2-C(O)C6H51.2638 C(CN) Bd.5-CN 噻唑-4-基3-C(O)C6H51.2639 C(CN) Bd.5-CN 噻唑-4-基4-C(O)C6H51.2640 C(CN) Bd.5-OCH3HH1.2641 C(CN) Bd.5-OCH3H2-Cl1.2642 C(CN) Bd.5-OCH3H3-Cl1.2643 C(CN) Bd.5-OCH3H4-Cl1.2644 C(CN) Bd.5-OCH3H2-F1.2645 C(CN) Bd.5-OCH3H3-F1.2646 C(CN) Bd.5-OCH3H4-F1.2647 C(CN) Bd.5-OCH3H2-CH31.2648 C(CN) Bd.5-OCH3H3-CH31.2649 C(CN) Bd.5-OCH3H4-CH31.2650 C(CN) Bd.5-OCH3H2-OCH31.2651 C(CN) Bd.5-OCH3H3-OCH31.2652 C(CN) Bd.5-OCH3H4-OCH31.2653 C(CN) Bd.5-OCH3H2-CF31.2654 C(CN) Bd.5-OCH3H3-CF31.2655 C(CN) Bd.5-OCH3H4-CF31.2656 C(CN) Bd.5-OCH3H2-OCF31.2657 C(CN) Bd.5-OCH3H3-OCF31.2658 C(CN) Bd.5-OCH3H4-OCF31.2659 C(CN) Bd.5-OCH3H2-OCF2CF21.2660 C(CN) Bd.5-OCH3H3-OCF2CF21.2661 C(CN) Bd.5-OCH3H4-OCF2CF21.2662 C(CN) Bd.5-OCH3H2-OC2F51.2663 C(CN) Bd.5-OCH3H3-OC2F51.2664 C(CN) Bd.5-OCH3H4-OC2F51.2665 C(CN) Bd.5-OCH3H2-OC6H51.2666 C(CN) Bd.5-OCH3H3-OC6H51.2667 C(CN) Bd.5-OCH3H4-OC6H51.2668 C(CN) Bd.5-OCH3H2-C(O)C6H51.2669 C(CN) Bd.5-OCH3H3-C(O)C6H51.2670 C(CN) Bd.5-OCH3H4-C(O)C6H51.2671 C(CN) Bd.5-OCH3CH3H1.2672 C(CN) Bd.5-OCH3CH32-Cl1.2673 C(CN) Bd.5-OCH3CH33-Cl1.2674 C(CN) Bd.5-OCH3CH34-Cl1.2675 C(CN) Bd.5-OCH3CH32-F
1.2676 C(CN)Bd.5-OCH3CH33-F1.2677 C(CN)Bd.5-OCH3CH34-F1.2678 C(CN)Bd.5-OCH3CH32-CH31.2679 C(CN)Bd.5-OCH3CH33-CH31.2680 C(CN)Bd.5-OCH3CH34-CH31.2681 C(CN)Bd.5-OCH3CH32-OCH31.2682 C(CN)Bd.5-OCH3CH33-OCH31.2683 C(CN)Bd.5-OCH3CH34-OCH31.2684 C(CN)Bd.5-OCH3CH32-CF31.2685 C(CN)Bd.5-OCH3CH33-CF31.2686 C(CN)Bd.5-OCH3CH34-CF31.2687 C(CN)Bd.5-OCH3CH32-OCF31.2688 C(CN)Bd.5-OCH3CH33-OCF31.2689 C(CN)Bd.5-OCH3CH34-OCF31.2690 C(CN)Bd.5-OCH3CH32-OCF2CF21.2691 C(CN)Bd.5-OCH3CH33-OCF2CF21.2692 C(CN)Bd.5-OCH3CH34-OCF2CF21.2693 C(CN)Bd.5-OCH3CH32-OC2F51.2694 C(CN)Bd.5-OCH3CH33-OC2F51.2695 C(CN)Bd.5-OCH3CH34-OC2F51.2696 C(CN)Bd.5-OCH3CH32-OC6H51.2697 C(CN)Bd.5-OCH3CH33-OC6H51.2698 C(CN)Bd.5-OCH3CH34-OC6H51.2699 C(CN)Bd.5-OCH3CH32-C(O)C6H51.2700 C(CN)Bd.5-OCH3CH33-C(O)C6H51.2701 C(CN)Bd.5-OCH3CH34-C(O)C6H51.2702 C(CN)Bd.5-OCH3CF3H1.2703 C(CN)Bd.5-OCH3CF32-Cl1.2704 C(CN)Bd.5-OCH3CF33-Cl1.2705 C(CN)Bd.5-OCH3CF34-Cl1.2706 C(CN)Bd.5-OCH3CF32-F1.2707 C(CN)Bd.5-OCH3CF33-F1.2708 C(CN)Bd.5-OCH3CF34-F1.2709 C(CN)Bd.5-OCH3CF32-CH31.2710 C(CN)Bd.5-OCH3CF33-CH31.2711 C(CN)Bd.5-OCH3CF34-CH31.2712 C(CN)Bd.5-OCH3CF32-OCH31.2713 C(CN)Bd.5-OCH3CF33-OCH31.2714 C(CN)Bd.5-OCH3CF34-OCH31.2715 C(CN)Bd.5-OCH3CF32-CF31.2716 C(CN)Bd.5-OCH3CF33-CF31.2717 C(CN)Bd.5-OCH3CF34-CF31.2718 C(CN)Bd.5-OCH3CF32-OCF31.2719 C(CN)Bd.5-OCH3CF33-OCF31.2720 C(CN)Bd.5-OCH3CF34-OCF31.2721 C(CN)Bd.5-OCH3CF32-OCF2CF21.2722 C(CN)Bd.5-OCH3CF33-OCF2CF21.2723 C(CN)Bd.5-OCH3CF34-OCF2CF21.2724 C(CN)Bd.5-OCH3CF32-OC2F51.2725 C(CN)Bd.5-OCH3CF33-OC2F51.2726 C(CN)Bd.5-OCH3CF34-OC2F51.2727 C(CN)Bd.5-OCH3CF32-OC6H51.2728 C(CN)Bd.5-OCH3CF33-OC6H51.2729 C(CN)Bd.5-OCH3CF34-OC6H51.2730 C(CN)Bd.5-OCH3CF32-C(O)C6H5
1.2731 C(CN)Bd.5-OCH3CF33-C(O)C6H51.2732 C(CN)Bd.5-OCH3CF34-C(O)C6H51.2733 C(CN)Bd.5-OCH3SCH3H1.2734 C(CN)Bd.5-OCH3SCH32-Cl1.2735 C(CN)Bd.5-OCH3SCH33-Cl1.2736 C(CN)Bd.5-OCH3SCH34-Cl1.2737 C(CN)Bd.5-OCH3SCH32-F1.2738 C(CN)Bd.5-OCH3SCH33-F1.2739 C(CN)Bd.5-OCH3SCH34-F1.2740 C(CN)Bd.5-OCH3SCH32-CH31.2741 C(CN)Bd.5-OCH3SCH33-CH31.2742 C(CN)Bd.5-OCH3SCH34-CH31.2743 C(CN)Bd.5-OCH3SCH32-OCH31.2744 C(CN)Bd.5-OCH3SCH33-OCH31.2745 C(CN)Bd.5-OCH3SCH34-OCH31.2746 C(CN)Bd.5-OCH3SCH32-CF31.2747 C(CN)Bd.5-OCH3SCH33-CF31.2748 C(CN)Bd.5-OCH3SCH34-CF31.2749 C(CN)Bd.5-OCH3SCH32-OCF31.2750 C(CN)Bd.5-OCH3SCH33-OCF31.2751 C(CN)Bd.5-OCH3SCH34-OCF31.2752 C(CN)Bd.5-OCH3SCH32-OCF2CF21.2753 C(CN)Bd.5-OCH3SCH33-OCF2CF21.2754 C(CN)Bd.5-OCH3SCH34-OCF2CF21.2755 C(CN)Bd.5-OCH3SCH32-OC2F51.2756 C(CN)Bd.5-OCH3SCH33-OC2F51.2757 C(CN)Bd.5-OCH3SCH34-OC2F51.2758 C(CN)Bd.5-OCH3SCH32-OC6H51.2759 C(CN)Bd.5-OCH3SCH33-OC6H51.2760 C(CN)Bd.5-OCH3SCH34-OC6H51.2761 C(CN)Bd.5-OCH3SCH32-C(O)C6H51.2762 C(CN)Bd.5-OCH3SCH33-C(O)C6H51.2763 C(CN)Bd.5-OCH3SCH34-C(O)C6H51.2764 C(CN)Bd.5-OCH3噻唑-4-基 H1.2765 C(CN)Bd.5-OCH3噻唑-4-基 2-Cl1.2766 C(CN)Bd.5-OCH3噻唑-4-基 3-Cl1.2767 C(CN)Bd.5-OCH3噻唑-4-基 4-Cl1.2768 C(CN)Bd.5-OCH3噻唑-4-基 2-F1.2769 C(CN)Bd.5-OCH3噻唑-4-基 3-F1.2770 C(CN)Bd.5-OCH3噻唑-4-基 4-F1.2771 C(CN)Bd.5-OCH3噻唑-4-基 2-CH31.2772 C(CN)Bd.5-OCH3噻唑-4-基 3-CH31.2773 C(CN)Bd.5-OCH3噻唑-4-基 4-CH31.2774 C(CN)Bd.5-OCH3噻唑-4-基 2-OCH31.2775 C(CN)Bd.5-OCH3噻唑-4-基 3-OCH31.2776 C(CN)Bd.5-OCH3噻唑-4-基 4-OCH31.2777 C(CN)Bd.5-OCH3噻唑-4-基 2-CF31.2778 C(CN)Bd.5-OCH3噻唑-4-基 3-CF31.2779 C(CN)Bd.5-OCH3噻唑-4-基 4-CF31.2780 C(CN)Bd.5-OCH3噻唑-4-基 2-OCF31.2781 C(CN)Bd.5-OCH3噻唑-4-基 3-OCF31.2782 C(CN)Bd.5-OCH3噻唑-4-基 4-OCF31.2783 C(CN)Bd.5-OCH3噻唑-4-基 2-OCF2CF2
1.2784 C(CN) Bd. 5-OCH3噻唑-4-基3-OCF2CF21.2785 C(CN) Bd. 5-OCH3噻唑-4-基4-OCF2CF21.2786 C(CN) Bd. 5-OCH3噻唑-4-基2-OC2F51.2787 C(CN) Bd. 5-OCH3噻唑-4-基3-OC2F51.2788 C(CN) Bd. 5-OCH3噻唑-4-基4-OC2F51.2789 C(CN) Bd. 5-OCH3噻唑-4-基2-OC6H51.2790 C(CN) Bd. 5-OCH3噻唑-4-基3-OC6H51.2791 C(CN) Bd. 5-OCH3噻唑-4-基4-OC6H51.2792 C(CN) Bd. 5-OCH3噻唑-4-基2-C(O)C6H51.2793 C(CN) Bd. 5-OCH3噻唑-4-基3-C(O)C6H51.2794 C(CN) Bd. 5-OCH3噻唑-4-基4-C(O)C6H51.2795 C(CN) CH2H HH1.2796 C(CN) CH2H H2-Cl1.2797 C(CN) CH2H H3-Cl1.2798 C(CN) CH2H H4-Cl1.2799 C(CN) CH2H H2-F1.2800 C(CN) CH2H H3-F1.2801 C(CN) CH2H H4-F1.2802 C(CN) CH2H H2-CH31.2803 C(CN) CH2H H3-CH31.2804 C(CN) CH2H H4-CH31.2805 C(CN) CH2H H2-OCH31.2806 C(CN) CH2H H3-OCH31.2807 C(CN) CH2H H4-OCH31.2808 C(CN) CH2H H2-CF31.2809 C(CN) CH2H H3-CF31.2810 C(CN) CH2H H4-CF31.2811 C(CN) CH2H H2-OCF31.2812 C(CN) CH2H H3-OCF31.2813 C(CN) CH2H H4-OCF31.2814 C(CN) CH2H H2-OCF2CF21.2815 C(CN) CH2H H3-OCF2CF21.2816 C(CN) CH2H H4-OCF2CF21.2817 C(CN) CH2H H2-OC2F51.2818 C(CN) CH2H H3-OC2F51.2819 C(CN) CH2H H4-OC2F51.2820 C(CN) CH2H H2-OC6H51.2821 C(CN) CH2H H3-OC6H51.2822 C(CN) CH2H H4-OC6H51.2823 C(CN) CH2H H2-C(O)C6H51.2824 C(CN) CH2H H3-C(O)C6H51.2825 C(CN) CH2H H4-C(O)C6H51.2826 C(CN) CH2H CH3H1.2827 C(CN) CH2H CH32-Cl1.2828 C(CN) CH2H CH33-Cl1.2829 C(CN) CH2H CH34-Cl1.2830 C(CN) CH2H CH32-F1.2831 C(CN) CH2H CH33-F1.2832 C(CN) CH2H CH34-F1.2833 C(CN) CH2H CH32-CH31.2834 C(CN) CH2H CH33-CH31.2835 C(CN) CH2H CH34-CH31.2836 C(CN) CH2H CH32-OCH31.2837 C(CN) CH2H CH33-OCH3
1.2838 C(CN)CH2HCH34-OCH31.2839 C(CN)CH2HCH32-CF31.2840 C(CN)CH2HCH33-CF31.2841 C(CN)CH2HCH34-CF31.2842 C(CN)CH2HCH32-OCF31.2843 C(CN)CH2HCH33-OCF31.2844 C(CN)CH2HCH34-OCF31.2845 C(CN)CH2HCH32-OCF2CF21.2846 C(CN)CH2HCH33-OCF2CF21.2847 C(CN)CH2HCH34-OCF2CF21.2848 C(CN)CH2HCH32-OC2F51.2849 C(CN)CH2HCH33-OC2F51.2850 C(CN)CH2HCH34-OC2F51.2851 C(CN)CH2HCH32-OC6H51.2852 C(CN)CH2HCH33-OC6H51.2853 C(CN)CH2HCH34-OC6H51.2854 C(CN)CH2HCH32-C(O)C6H51.2855 C(CN)CH2HCH33-C(O)C6H51.2856 C(CN)CH2HCH34-C(O)C6H51.2857 C(CN)CH2HCF3H1.2858 C(CN)CH2HCF32-Cl1.2859 C(CN)CH2HCF33-Cl1.2860 C(CN)CH2HCF34-Cl1.2861 C(CN)CH2HCF32-F1.2862 C(CN)CH2HCF33-F1.2863 C(CN)CH2HCF34-F1.2864 C(CN)CH2HCF32-CH31.2865 C(CN)CH2HCF33-CH31.2866 C(CN)CH2HCF34-CH31.2867 C(CN)CH2HCF32-OCH31.2868 C(CN)CH2HCF33-OCH31.2869 C(CN)CH2HCF34-OCH31.2870 C(CN)CH2HCF32-CF31.2871 C(CN)CH2HCF33-CF31.2872 C(CN)CH2HCF34-CF31.2873 C(CN)CH2HCF32-OCF31.2874 C(CN)CH2HCF33-OCF31.2875 C(CN)CH2HCF34-OCF31.2876 C(CN)CH2HCF32-OCF2CF21.2877 C(CN)CH2HCF33-OCF2CF21.2878 C(CN)CH2HCF34-OCF2CF21.2879 C(CN)CH2HCF32-OC2F51.2880 C(CN)CH2HCF33-OC2F51.2881 C(CN)CH2HCF34-OC2F51.2882 C(CN)CH2HCF32-OC6H51.2883 C(CN)CH2HCF33-OC6H51.2884 C(CN)CH2HCF34-OC6H51.2885 C(CN)CH2HCF32-C(O)C6H51.2886 C(CN)CH2HCF33-C(O)C6H51.2887 C(CN)CH2HCF34-C(O)C6H51.2888 C(CN)CH2HSCH3H1.2889 C(CN)CH2HSCH32-Cl1.2890 C(CN)CH2HSCH33-Cl1.2891 C(CN)CH2HSCH34-Cl1.2892 C(CN)CH2HSCH32-F
1.2893 C(CN)CH2HSCH33-F1.2894 C(CN)CH2HSCH34-F1.2895 C(CN)CH2HSCH32-CH31.2896 C(CN)CH2HSCH33-CH31.2897 C(CN)CH2HSCH34-CH31.2898 C(CN)CH2HSCH32-OCH31.2899 C(CN)CH2HSCH33-OCH31.2900 C(CN)CH2HSCH34-OCH31.2901 C(CN)CH2HSCH32-CF31.2902 C(CN)CH2HSCH33-CF31.2903 C(CN)CH2HSCH34-CF31.2904 C(CN)CH2HSCH32-OCF31.2905 C(CN)CH2HSCH33-OCF31.2906 C(CN)CH2HSCH34-OCF31.2907 C(CN)CH2HSCH32-OCF2CF21.2908 C(CN)CH2HSCH33-OCF2CF21.2909 C(CN)CH2HSCH34-OCF2CF21.2910 C(CN)CH2HSCH32-OC2F51.2911 C(CN)CH2HSCH33-OC2F51.2912 C(CN)CH2HSCH34-OC2F51.2913 C(CN)CH2HSCH32-OC6H51.2914 C(CN)CH2HSCH33-OC6H51.2915 C(CN)CH2HSCH34-OC6H51.2916 C(CN)CH2HSCH32-C(O)C6H51.2917 C(CN)CH2HSCH33-C(O)C6H51.2918 C(CN)CH2HSCH34-C(O)C6H51.2919 C(CN)CH2H噻唑-4-基H1.2920 C(CN)CH2H噻唑-4-基2-Cl1.2921 C(CN)CH2H噻唑-4-基3-Cl1.2922 C(CN)CH2H噻唑-4-基4-Cl1.2923 C(CN)CH2H噻唑-4-基2-F1.2924 C(CN)CH2H噻唑-4-基3-F1.2925 C(CN)CH2H噻唑-4-基4-F1.2926 C(CN)CH2H噻唑-4-基2-CH31.2927 C(CN)CH2H噻唑-4-基3-CH31.2928 C(CN)CH2H噻唑-4-基4-CH31.2929 C(CN)CH2H噻唑-4-基2-OCH31.2930 C(CN)CH2H噻唑-4-基3-OCH31.2931 C(CN)CH2H噻唑-4-基4-OCH31.2932 C(CN)CH2H噻唑-4-基2-CF31.2933 C(CN)CH2H噻唑-4-基3-CF31.2934 C(CN)CH2H噻唑-4-基4-CF31.2935 C(CN)CH2H噻唑-4-基2-OCF31.2936 C(CN)CH2H噻唑-4-基3-OCF31.2937 C(CN)CH2H噻唑-4-基4-OCF31.2938 C(CN)CH2H噻唑-4-基2-OCF2CF21.2939 C(CN)CH2H噻唑-4-基3-OCF2CF21.2940 C(CN)CH2H噻唑-4-基4-OCF2CF21.2941 C(CN)CH2H噻唑-4-基2-OC2F51.2942 C(CN)CH2H噻唑-4-基3-OC2F51.2943 C(CN)CH2H噻唑-4-基4-OC2F51.2944 C(CN)CH2H噻唑-4-基2-OC6H5
1.2945 C(CN) CH2H 噻唑-4-基3-OC6H51.2946 C(CN) CH2H 噻唑-4-基4-OC6H51.2947 C(CN) CH2H 噻唑-4-基2-C(O)C6H51.2948 C(CN) CH2H 噻唑-4-基3-C(O)C6H51.2949 C(CN) CH2H 噻唑-4-基4-C(O)C6H51.2950 C(CN) CH25-Cl HH1.2951 C(CN) CH25-Cl H2-Cl1.2952 C(CN) CH25-Cl H3-Cl1.2953 C(CN) CH25-Cl H4-Cl1.2954 C(CN) CH25-Cl H2-F1.2955 C(CN) CH25-Cl H3-F1.2956 C(CN) CH25-Cl H4-F1.2957 C(CN) CH25-Cl H2-CH31.2958 C(CN) CH25-Cl H3-CH31.2959 C(CN) CH25-Cl H4-CH31.2960 C(CN) CH25-Cl H2-OCH31.2961 C(CN) CH25-Cl H3-OCH31.2962 C(CN) CH25-Cl H4-OCH31.2963 C(CN) CH25-Cl H2-CF31.2964 C(CN) CH25-Cl H3-CF31.2965 C(CN) CH25-Cl H4-CF31.2966 C(CN) CH25-Cl H2-OCF31.2967 C(CN) CH25-Cl H3-OCF31.2968 C(CN) CH25-Cl H4-OCF31.2969 C(CN) CH25-Cl H2-OCF2CF21.2970 C(CN) CH25-Cl H3-OCF2CF21.2971 C(CN) CH25-Cl H4-OCF2CF21.2972 C(CN) CH25-Cl H2-OC2F51.2973 C(CN) CH25-Cl H3-OC2F51.2974 C(CN) CH25-Cl H4-OC2F51.2975 C(CN) CH25-Cl H2-OC6H51.2976 C(CN) CH25-Cl H3-OC6H51.2977 C(CN) CH25-Cl H4-OC6H51.2978 C(CN) CH25-Cl H2-C(O)C6H51.2979 C(CN) CH25-Cl H3-C(O)C6H51.2980 C(CN) CH25-Cl H4-C(O)C6H51.2981 C(CN) CH25-Cl CH3H1.2982 C(CN) CH25-Cl CH32-Cl1.2983 C(CN) CH25-Cl CH33-Cl1.2984 C(CN) CH25-Cl CH34-Cl1.2985 C(CN) CH25-Cl CH32-F1.2986 C(CN) CH25-Cl CH33-F1.2987 C(CN) CH25-Cl CH34-F1.2988 C(CN) CH25-Cl CH32-CH31.2989 C(CN) CH25-Cl CH33-CH31.2990 C(CN) CH25-Cl CH34-CH31.2991 C(CN) CH25-Cl CH32-OCH31.2992 C(CN) CH25-Cl CH33-OCH31.2993 C(CN) CH25-Cl CH34-OCH31.2994 C(CN) CH25-Cl CH32-CF31.2995 C(CN) CH25-Cl CH33-CF31.2996 C(CN) CH25-Cl CH34-CF31.2997 C(CN) CH25-Cl CH32-OCF31.2998 C(CN) CH25-Cl CH33-OCF31.2999 C(CN) CH25-Cl CH34-OCF3
1.3000 C(CN)CH25-Cl CH32-OCF2CF21.3001 C(CN)CH25-Cl CH33-OCF2CF21.3002 C(CN)CH25-Cl CH34-OCF2CF21.3003 C(CN)CH25-Cl CH32-OC2F51.3004 C(CN)CH25-Cl CH33-OC2F51.3005 C(CN)CH25-Cl CH34-OC2F51.3006 C(CN)CH25-Cl CH32-OC6H51.3007 C(CN)CH25-Cl CH33-OC6H51.3008 C(CN)CH25-Cl CH34-OC6H51.3009 C(CN)CH25-Cl CH32-C(O)C6H51.3010 C(CN)CH25-Cl CH33-C(O)C6H51.3011 C(CN)CH25-Cl CH34-C(O)C6H51.3012 C(CN)CH25-Cl CF3H1.3013 C(CN)CH25-Cl CF32-Cl1.3014 C(CN)CH25-Cl CF33-Cl1.3015 C(CN)CH25-Cl CF34-Cl1.3016 C(CN)CH25-Cl CF32-F1.3017 C(CN)CH25-Cl CF33-F1.3018 C(CN)CH25-Cl CF34-F1.3019 C(CN)CH25-Cl CF32-CH31.3020 C(CN)CH25-Cl CF33-CH31.3021 C(CN)CH25-Cl CF34-CH31.3022 C(CN)CH25-Cl CF32-OCH31.3023 C(CN)CH25-Cl CF33-OCH31.3024 C(CN)CH25-Cl CF34-OCH31.3025 C(CN)CH25-Cl CF32-CF31.3026 C(CN)CH25-Cl CF33-CF31.3027 C(CN)CH25-Cl CF34-CF31.3028 C(CN)CH25-Cl CF32-OCF31.3029 C(CN)CH25-Cl CF33-OCF31.3030 C(CN)CH25-Cl CF34-OCF31.3031 C(CN)CH25-Cl CF32-OCF2CF21.3032 C(CN)CH25-Cl CF33-OCF2CF21.3033 C(CN)CH25-Cl CF34-OCF2CF21.3034 C(CN)CH25-Cl CF32-OC2F51.3035 C(CN)CH25-Cl CF33-OC2F51.3036 C(CN)CH25-Cl CF34-OC2F51.3037 C(CN)CH25-Cl CF32-OC6H51.3038 C(CN)CH25-Cl CF33-OC6H51.3039 C(CN)CH25-Cl CF34-OC6H51.3040 C(CN)CH25-Cl CF32-C(O)C6H51.3041 C(CN)CH25-Cl CF33-C(O)C6H51.3042 C(CN)CH25-Cl CF34-C(O)C6H51.3043 C(CN)CH25-Cl SCH3H1.3044 C(CN)CH25-Cl SCH32-Cl1.3045 C(CN)CH25-Cl SCH33-Cl1.3046 C(CN)CH25-Cl SCH34-Cl1.3047 C(CN)CH25-Cl SCH32-F1.3048 C(CN)CH25-Cl SCH33-F1.3049 C(CN)CH25-Cl SCH34-F1.3050 C(CN)CH25-Cl SCH32-CH31.3051 C(CN)CH25-Cl SCH33-CH31.3052 C(CN)CH25-Cl SCH34-CH31.3053 C(CN)CH25-Cl SCH32-OCH31.3054 C(CN)CH25-Cl SCH33-OCH3
1.3055 C(CN)CH25-Cl SCH34-OCH31.3056 C(CN)CH25-Cl SCH32-CF31.3057 C(CN)CH25-Cl SCH33-CF31.3058 C(CN)CH25-Cl SCH34-CF31.3059 C(CN)CH25-Cl SCH32-OCF31.3060 C(CN)CH25-Cl SCH33-OCF31.3061 C(CN)CH25-Cl SCH34-OCF31.3062 C(CN)CH25-Cl SCH32-OCF2CF21.3063 C(CN)CH25-Cl SCH33-OCF2CF21.3064 C(CN)CH25-Cl SCH34-OCF2CF21.3065 C(CN)CH25-Cl SCH32-OC2F51.3066 C(CN)CH25-Cl SCH33-OC2F51.3067 C(CN)CH25-Cl SCH34-OC2F51.3068 C(CN)CH25-Cl SCH32-OC6H51.3069 C(CN)CH25-Cl SCH33-OC6H51.3070 C(CN)CH25-Cl SCH34-OC6H51.3071 C(CN)CH25-Cl SCH32-C(O)C6H51.3072 C(CN)CH25-Cl SCH33-C(O)C6H51.3073 C(CN)CH25-Cl SCH34-C(O)C6H51.3074 C(CN)CH25-Cl 噻唑-4-基H1.3075 C(CN)CH25-Cl 噻唑-4-基2-Cl1.3076 C(CN)CH25-Cl 噻唑-4-基3-Cl1.3077 C(CN)CH25-Cl 噻唑-4-基4-Cl1.3078 C(CN)CH25-Cl 噻唑-4-基2-F1.3079 C(CN)CH25-Cl 噻唑-4-基3-F1.3080 C(CN)CH25-Cl 噻唑-4-基4-F1.3081 C(CN)CH25-Cl 噻唑-4-基2-CH31.3082 C(CN)CH25-Cl 噻唑-4-基3-CH31.3083 C(CN)CH25-Cl 噻唑-4-基4-CH31.3084 C(CN)CH25-Cl 噻唑-4-基2-OCH31.3085 C(CN)CH25-Cl 噻唑-4-基3-OCH31.3086 C(CN)CH25-Cl 噻唑-4-基4-OCH31.3087 C(CN)CH25-Cl 噻唑-4-基2-CF31.3088 C(CN)CH25-Cl 噻唑-4-基3-CF31.3089 C(CN)CH25-Cl 噻唑-4-基4-CF31.3090 C(CN)CH25-Cl 噻唑-4-基2-OCF31.3091 C(CN)CH25-Cl 噻唑-4-基3-OCF31.3092 C(CN)CH25-Cl 噻唑-4-基4-OCF31.3093 C(CN)CH25-Cl 噻唑-4-基2-OCF2CF21.3094 C(CN)CH25-Cl 噻唑-4-基3-OCF2CF21.3095 C(CN)CH25-Cl 噻唑-4-基4-OCF2CF21.3096 C(CN)CH25-Cl 噻唑-4-基2-OC2F51.3097 C(CN)CH25-Cl 噻唑-4-基3-OC2F51.3098 C(CN)CH25-Cl 噻唑-4-基4-OC2F51.3099 C(CN)CH25-Cl 噻唑-4-基2-OC6H51.3100 C(CN)CH25-Cl 噻唑-4-基3-OC6H51.3101 C(CN)CH25-Cl 噻唑-4-基4-OC6H51.3102 C(CN)CH25-Cl 噻唑-4-基2-C(O)C6H51.3103 C(CN)CH25-Cl 噻唑-4-基3-C(O)C6H51.3104 C(CN)CH25-Cl 噻唑-4-基4-C(O)C6H51.3105 C(CN)CH26-Cl HH
1.3106 C(CN) CH26-Cl H2-Cl1.3107 C(CN) CH26-Cl H3-Cl1.3108 C(CN) CH26-Cl H4-Cl1.3109 C(CN) CH26-Cl H2-F1.3110 C(CN) CH26-Cl H3-F1.3111 C(CN) CH26-Cl H4-F1.3112 C(CN) CH26-Cl H2-CH31.3113 C(CN) CH26-Cl H3-CH31.3114 C(CN) CH26-Cl H4-CH31.3115 C(CN) CH26-Cl H2-OCH31.3116 C(CN) CH26-Cl H3-OCH31.3117 C(CN) CH26-Cl H4-OCH31.3118 C(CN) CH26-Cl H2-CF31.3119 C(CN) CH26-Cl H3-CF31.3120 C(CN) CH26-Cl H4-CF31.3121 C(CN) CH26-Cl H2-OCF31.3122 C(CN) CH26-Cl H3-OCF31.3123 C(CN) CH26-Cl H4-OCF31.3124 C(CN) CH26-Cl H2-OCF2CF21.3125 C(CN) CH26-Cl H3-OCF2CF21.3126 C(CN) CH26-Cl H4-OCF2CF21.3127 C(CN) CH26-Cl H2-OC2F51.3128 C(CN) CH26-Cl H3-OC2F51.3129 C(CN) CH26-Cl H4-OC2F51.3130 C(CN) CH26-Cl H2-OC6H51.3131 C(CN) CH26-Cl H3-OC6H51.3132 C(CN) CH26-Cl H4-OC6H51.3133 C(CN) CH26-Cl H2-C(O)C6H51.3134 C(CN) CH26-Cl H3-C(O)C6H51.3135 C(CN) CH26-Cl H4-C(O)C6H51.3136 C(CN) CH26-Cl CH3H1.3137 C(CN) CH26-Cl CH32-Cl1.3138 C(CN) CH26-Cl CH33-Cl1.3139 C(CN) CH26-Cl CH34-Cl1.3140 C(CN) CH26-Cl CH32-F1.3141 C(CN) CH26-Cl CH33-F1.3142 C(CN) CH26-Cl CH34-F1.3143 C(CN) CH26-Cl CH32-CH31.3144 C(CN) CH26-Cl CH33-CH31.3145 C(CN) CH26-Cl CH34-CH31.3146 C(CN) CH26-Cl CH32-OCH31.3147 C(CN) CH26-Cl CH33-OCH31.3148 C(CN) CH26-Cl CH34-OCH31.3149 C(CN) CH26-Cl CH32-CF31.3150 C(CN) CH26-Cl CH33-CF31.3151 C(CN) CH26-Cl CH34-CF31.3152 C(CN) CH26-Cl CH32-OCF31.3153 C(CN) CH26-Cl CH33-OCF31.3154 C(CN) CH26-Cl CH34-OCF31.3155 C(CN) CH26-Cl CH32-OCF2CF21.3156 C(CN) CH26-Cl CH33-OCF2CF21.3157 C(CN) CH26-Cl CH34-OCF2CF21.3158 C(CN) CH26-Cl CH32-OC2F51.3159 C(CN) CH26-Cl CH33-OC2F51.3160 C(CN) CH26-Cl CH34-OC2F5
1.3161 C(CN) CH26-Cl CH32-OC6H51.3162 C(CN) CH26-Cl CH33-OC6H5l.3163 C(CN) CH26-Cl CH34-OC6H51.3164 C(CN) CH26-Cl CH32-C(O)C6H51.3165 C(CN) CH26-Cl CH33-C(O)C6H51.3166 C(CN) CH26-Cl CH34-C(O)C6H51.3167 C(CN) CH26-Cl CF3H1.3168 C(CN) CH26-Cl CF32-Cl1.3169 C(CN) CH26-Cl CF33-Cl1.3170 C(CN) CH26-Cl CF34-Cl1.3171 C(CN) CH26-Cl CF32-F1.3172 C(CN) CH26-Cl CF33-F1.3173 C(CN) CH26-Cl CF34-F1.3174 C(CN) CH26-Cl CF32-CH31.3175 C(CN) CH26-Cl CF33-CH31.3176 C(CN) CH26-Cl CF34-CH31.3177 C(CN) CH26-Cl CF32-OCH31.3178 C(CN) CH26-Cl CF33-OCH31.3179 C(CN) CH26-Cl CF34-OCH31.3180 C(CN) CH26-Cl CF32-CF31.3181 C(CN) CH26-Cl CF33-CF31.3182 C(CN) CH26-Cl CF34-CF31.3183 C(CN) CH26-Cl CF32-OCF31.3184 C(CN) CH26-Cl CF33-OCF31.3185 C(CN) CH26-Cl CF34-OCF31.3186 C(CN) CH26-Cl CF32-OCF2CF21.3187 C(CN) CH26-Cl CF33-OCF2CF21.3188 C(CN) CH26-Cl CF34-OCF2CF21.3189 C(CN) CH26-Cl CF32-OC2F51.3190 C(CN) CH26-Cl CF33-OC2F51.3191 C(CN) CH26-Cl CF34-OC2F51.3192 C(CN) CH26-Cl CF32-OC6H51.3193 C(CN) CH26-Cl CF33-OC6H51.3194 C(CN) CH26-Cl CF34-OC6H51.3195 C(CN) CH26-Cl CF32-C(O)C6H51.3196 C(CN) CH26-Cl CF33-C(O)C6H51.3197 C(CN) CH26-Cl CF34-C(O)C6H51.3198 C(CN) CH26-Cl SCH3H1.3199 C(CN) CH26-Cl SCH32-Cl1.3200 C(CN) CH26-Cl SCH33-Cl1.3201 C(CN) CH26-Cl SCH34-Cl1.3202 C(CN) CH26-Cl SCH32-F1.3203 C(CN) CH26-Cl SCH33-F1.3204 C(CN) CH26-Cl SCH34-F1.3205 C(CN) CH26-Cl SCH32-CH31.3206 C(CN) CH26-Cl SCH33-CH31.3207 C(CN) CH26-Cl SCH34-CH31.3208 C(CN) CH26-Cl SCH32-OCH31.3209 C(CN) CH26-Cl SCH33-OCH31.3210 C(CN) CH26-Cl SCH34-OCH31.3211 C(CN) CH26-Cl SCH32-CF31.3212 C(CN) CH26-Cl SCH33-CF31.3213 C(CN) CH26-Cl SCH34-CF31.3214 C(CN) CH26-Cl SCH32-OCF31.3215 C(CN) CH26-Cl SCH33-OCF3
1.3216 C(CN) CH26-Cl SCH34-OCF31.3217 C(CN) CH26-Cl SCH32-OCF2CF21.3218 C(CN) CH26-Cl SCH33-OCF2CF21.3219 C(CN) CH26-Cl SCH34-OCF2CF21.3220 C(CN) CH26-Cl SCH32-OC2F51.3221 C(CN) CH26-Cl SCH33-OC2F51.3222 C(CN) CH26-Cl SCH34-OC2F51.3223 C(CN) CH26-Cl SCH32-OC6H51.3224 C(CN) CH26-Cl SCH33-OC6H51.3225 C(CN) CH26-Cl SCH34-OC6H51.3226 C(CN) CH26-Cl SCH32-C(O)C6H51 3227 C(CN) CH26-Cl SCH33-C(O)C6H51.3228 C(CN) CH26-Cl SCH34-C(O)C6H51.3229 C(CN) CH26-Cl 噻唑-4-基H1.3230 C(CN) CH26-Cl 噻唑-4-基2-Cl1.3231 C(CN) CH26-Cl 噻唑-4-基3-Cl1.3232 C(CN) CH26-Cl 噻唑-4-基4-Cl1.3233 C(CN) CH26-Cl 噻唑-4-基2-F1.3234 C(CN) CH26-Cl 噻唑-4-基3-F1.3235 C(CN) CH26-Cl 噻唑-4-基4-F1.3236 C(CN) CH26-Cl 噻唑-4-基2-CH31.3237 C(CN) CH26-Cl 噻唑-4-基3-CH31.3238 C(CN) CH26-Cl 噻唑-4-基4-CH31.3239 C(CN) CH26-Cl 噻唑-4-基2-OCH31.3240 C(CN) CH26-Cl 噻唑-4-基3-OCH31.3241 C(CN) CH26-Cl 噻唑-4-基4-OCH31.3242 C(CN) CH26-Cl 噻唑-4-基2-CF31.3243 C(CN) CH26-Cl 噻唑-4-基3-CF31.3244 C(CN) CH26-Cl 噻唑-4-基4-CF31.3245 C(CN) CH26-Cl 噻唑-4-基2-OCF31.3246 C(CN) CH26-Cl 噻唑-4-基3-OCF31.3247 C(CN) CH26-Cl 噻唑-4-基4-OCF31.3248 C(CN) CH26-Cl 噻唑-4-基2-OCF2CF21.3249 C(CN) CH26-Cl 噻唑-4-基3-OCF2CF21.3250 C(CN) CH26-Cl 噻唑-4-基4-OCF2CF21.3251 C(CN) CH26-Cl 噻唑-4-基2-OC2F51.3252 C(CN) CH26-Cl 噻唑-4-基3-OC2F51.3253 C(CN) CH26-Cl 噻唑-4-基4-OC2F51.3254 C(CN) CH26-Cl 噻唑-4-基2-OC6H51.3255 C(CN) CH26-Cl 噻唑-4-基3-OC6H51.3256 C(CN) CH26-Cl 噻唑-4-基4-OC6H51.3257 C(CN) CH26-Cl 噻唑-4-基2-C(O)C6H51.3258 C(CN) CH26-Cl 噻唑-4-基3-C(O)C6H51.3259 C(CN) CH26-Cl 噻唑-4-基4-C(O)C6H51.3260 C(CN) CH25-F HH1.3261 C(CN) CH25-F H2-Cl1.3262 C(CN) CH25-F H3-Cl1.3263 C(CN) CH25-F H4-Cl1.3264 C(CN) CH25-F H2-F1.3265 C(CN) CH25-F H3-F1.3266 C(CN) CH25-F H4-F
1.3267 C(CN) CH25-F H 2-CH31.3268 C(CN) CH25-F H 3-CH31.3269 C(CN) CH25-F H 4-CH31.3270 C(CN) CH25-F H 2-OCH31.3271 C(CN) CH25-F H 3-OCH31.3272 C(CN) CH25-F H 4-OCH31.3273 C(CN) CH25-F H 2-CF31.3274 C(CN) CH25-F H 3-CF31.3275 C(CN) CH25-F H 4-CF31.3276 C(CN) CH25-F H 2-OCF31.3277 C(CN) CH25-F H 3-OCF31.3278 C(CN) CH25-F H 4-OCF31.3279 C(CN) CH25-F H 2-OCF2CF21.3280 C(CN) CH25-F H 3-OCF2CF21.3281 C(CN) CH25-F H 4-OCF2CF21.3282 C(CN) CH25-F H 2-OC2F51.3283 C(CN) CH25-F H 3-OC2F51.3284 C(CN) CH25-F H 4-OC2F51.3285 C(CN) CH25-F H 2-OC6H51.3286 C(CN) CH25-F H 3-OC6H51.3287 C(CN) CH25-F H 4-OC6H51.3288 C(CN) CH25-F H 2-C(O)C6H51.3289 C(CN) CH25-F H 3-C(O)C6H51.3290 C(CN) CH25-F H 4-C(O)C6H51.3291 C(CN) CH25-F CH3H1.3292 C(CN) CH25-F CH32-Cl1.3293 C(CN) CH25-F CH33-Cl1.3294 C(CN) CH25-F CH34-Cl1.3295 C(CN) CH25-F CH32-F1.3296 C(CN) CH25-F CH33-F1.3297 C(CN) CH25-F CH34-F1.3298 C(CN) CH25-F CH32-CH31.3299 C(CN) CH25-F CH33-CH31.3300 C(CN) CH25-F CH34-CH31.3301 C(CN) CH25-F CH32-OCH31.3302 C(CN) CH25-F CH33-OCH31.3303 C(CN) CH25-F CH34-OCH31.3304 C(CN) CH25-F CH32-CF31.3305 C(CN) CH25-F CH33-CF31.3306 C(CN) CH25-F CH34-CF31.3307 C(CN) CH25-F CH32-OCF31.3308 C(CN) CH25-F CH33-OCF31.3309 C(CN) CH25-F CH34-OCF31.3310 C(CN) CH25-F CH32-OCF2CF21.3311 C(CN) CH25-F CH33-OCF2CF21.3312 C(CN) CH25-F CH34-OCF2CF21.3313 C(CN) CH25-F CH32-OC2F51.3314 C(CN) CH25-F CH33-OC2F51.3315 C(CN) CH25-F CH34-OC2F51.3316 C(CN) CH25-F CH32-OC6H51.3317 C(CN) CH25-F CH33-OC6H51.3318 C(CN) CH25-F CH34-OC6H51.3319 C(CN) CH25-F CH32-C(O)C6H51.3320 C(CN) CH25-F CH33-C(O)C6H51.3321 C(CN) CH25-F CH34-C(O)C6H5
1.3322 C(CN)CH25-F CF3H1.3323 C(CN)CH25-F CF32-Cl1.3324 C(CN)CH25-F CF33-Cl1.3325 C(CN)CH25-F CF34-Cl1.3326 C(CN)CH25-F CF32-F1.3327 C(CN)CH25-F CF33-F1.3328 C(CN)CH25-F CF34-F1.3329 C(CN)CH25-F CF32-CH31.3330 C(CN)CH25-F CF33-CH31.3331 C(CN)CH25-F CF34-CH31.3332 C(CN)CH25-F CF32-OCH31.3333 C(CN)CH25-F CF33-OCH31.3334 C(CN)CH25-F CF34-OCH31.3335 C(CN)CH25-F CF32-CF31.3336 C(CN)CH25-F CF33-CF31.3337 C(CN)CH25-F CF34-CF31.3338 C(CN)CH25-F CF32-OCF31.3339 C(CN)CH25-F CF33-OCF31.3340 C(CN)CH25-F CF34-OCF31.3341 C(CN)CH25-F CF32-OCF2CF21.3342 C(CN)CH25-F CF33-OCF2CF21.3343 C(CN)CH25-F CF34-OCF2CF21.3344 C(CN)CH25-F CF32-OC2F51.3345 C(CN)CH25-F CF33-OC2F51.3346 C(CN)CH25-F CF34-OC2F51.3347 C(CN)CH25-F CF32-OC6H51.3348 C(CN)CH25-F CF33-OC6H51.3349 C(CN)CH25-F CF34-OC6H51.3350 C(CN)CH25-F CF32-C(O)C6H51.3351 C(CN)CH25-F CF33-C(O)C6H51.3352 C(CN)CH25-F CF34-C(O)C6H51.3353 C(CN)CH25-F SCH3H1.3354 C(CN)CH25-F SCH32-Cl1.3355 C(CN)CH25-F SCH33-Cl1.3356 C(CN)CH25-F SCH34-Cl1.3357 C(CN)CH25-F SCH32-F1.3358 C(CN)CH25-F SCH33-F1.3359 C(CN)CH25-F SCH34-F1.3360 C(CN)CH25-F SCH32-CH31.3361 C(CN)CH25-F SCH33-CH31.3362 C(CN)CH25-F SCH34-CH31.3363 C(CN)CH25-F SCH32-OCH31.3364 C(CN)CH25-F SCH33-OCH31.3365 C(CN)CH25-F SCH34-OCH31.3366 C(CN)CH25-F SCH32-CF31.3367 C(CN)CH25-F SCH33-CF31.3368 C(CN)CH25-F SCH34-CF31.3369 C(CN)CH25-F SCH32-OCF31.3370 C(CN)CH25-F SCH33-OCF31.3371 C(CN)CH25-F SCH34-OCF31.3372 C(CN)CH25-F SCH32-OCF2CF21.3373 C(CN)CH25-F SCH33-OCF2CF21.3374 C(CN)CH25-F SCH34-OCF2CF21.3375 C(CN)CH25-F SCH32-OC2F51.3376 C(CN)CH25-F SCH33-OC2F5
1.3377 C(CN) CH25-F SCH34-OC2F51.3378 C(CN) CH25-F SCH32-OC6H51.3379 C(CN) CH25-F SCH33-OC6H51.3380 C(CN) CH25-F SCH34-OC6H51.3381 C(CN) CH25-F SCH32-C(O)C6H51.3382 C(CN) CH25-F SCH33-C(O)C6H51.3383 C(CN) CH25-F SCH34-C(O)C6H51.3384 C(CN) CH25-F 噻唑-4-基H1.3385 C(CN) CH25-F 噻唑-4-基2-Cl1.3386 C(CN) CH25-F 噻唑-4-基3-Cl1.3387 C(CN) CH25-F 噻唑-4-基4-Cl1.3388 C(CN) CH25-F 噻唑-4-基2-F1.3389 C(CN) CH25-F 噻唑-4-基3-F1.3390 C(CN) CH25-F 噻唑-4-基4-F1.3391 C(CN) CH25-F 噻唑-4-基2-CH31.3392 C(CN) CH25-F 噻唑-4-基3-CH31.3393 C(CN) CH25-F 噻唑-4-基4-CH31.3394 C(CN) CH25-F 噻唑-4-基2-OCH31.3395 C(CN) CH25-F 噻唑-4-基3-OCH31.3396 C(CN) CH25-F 噻唑-4-基4-OCH31.3397 C(CN) CH25-F 噻唑-4-基2-CF31.3398 C(CN) CH25-F 噻唑-4-基3-CF31.3399 C(CN) CH25-F 噻唑-4-基4-CF31.3400 C(CN) CH25-F 噻唑-4-基2-OCF31.3401 C(CN) CH25-F 噻唑-4-基3-OCF31.3402 C(CN) CH25-F 噻唑-4-基4-OCF31.3403 C(CN) CH25-F 噻唑-4-基2-OCF2CF21.3404 C(CN) CH25-F 噻唑-4-基3-OCF2CF21.3405 C(CN) CH25-F 噻唑-4-基4-OCF2CF21.3406 C(CN) CH25-F 噻唑-4-基2-OC2F51.3407 C(CN) CH25-F 噻唑-4-基3-OC2F51.3408 C(CN) CH25-F 噻唑-4-基4-OC2F51.3409 C(CN) CH25-F 噻唑-4-基2-OC6H51.3410 C(CN) CH25-F 噻唑-4-基3-OC6H51.3411 C(CN) CH25-F 噻唑-4-基4-OC6H51.3412 C(CN) CH25-F 噻唑-4-基2-C(O)C6H51.3413 C(CN) CH25-F 噻唑-4-基3-C(O)C6H51.3414 C(CN) CH25-F 噻唑-4-基4-C(O)C6H51.3415 C(CN) CH25-CN HH1.3416 C(CN) CH25-CN H2-Cl1.3417 C(CN) CH25-CN H3-Cl1.3418 C(CN) CH25-CN H4-Cl1.3419 C(CN) CH25-CN H2-F1.3420 C(CN) CH25-CN H3-F1.3421 C(CN) CH25-CN H4-F1.3422 C(CN) CH25-CN H2-CH31.3423 C(CN) CH25-CN H3-CH31.3424 C(CN) CH25-CN H4-CH31.3425 C(CN) CH25-CN H2-OCH31.3426 C(CN) CH25-CN H3-OCH31.3427 C(CN) CH25-CN H4-OCH3
1.3428 C(CN) CH25-CN H2-CF31.3429 C(CN) CH25-CN H3-CF31.3430 C(CN) CH25-CN H4-CF31.3431 C(CN) CH25-CN H2-OCF31.3432 C(CN) CH25-CN H3-OCF31.3433 C(CN) CH25-CN H4-OCF31.3434 C(CN) CH25-CN H2-OCF2CF21.3435 C(CN) CH25-CN H3-OCF2CF21.3436 C(CN) CH25-CN H4-OCF2CF21.3437 C(CN) CH25-CN H2-OC2F51.3438 C(CN) CH25-CN H3-OC2F51.3439 C(CN) CH25-CN H4-OC2F51.3440 C(CN) CH25-CN H2-OC6H51.3441 C(CN) CH25-CN H3-OC6H51.3442 C(CN) CH25-CN H4-OC6H51.3443 C(CN) CH25-CN H2-C(O)C6H51.3444 C(CN) CH25-CN H3-C(O)C6H51.3445 C(CN) CH25-CN H4-C(O)C6H51.3446 C(CN) CH25-CN CH3H1.3447 C(CN) CH25-CN CH32-Cl1.3448 C(CN) CH25-CN CH33-Cl1.3449 C(CN) CH25-CN CH34-Cl1.3450 C(CN) CH25-CN CH32-F1.3451 C(CN) CH25-CN CH33-F1.3452 C(CN) CH25-CN CH34-F1.3453 C(CN) CH25-CN CH32-CH31.3454 C(CN) CH25-CN CH33-CH31.3455 C(CN) CH25-CN CH34-CH31.3456 C(CN) CH25-CN CH32-OCH31.3457 C(CN) CH25-CN CH33-OCH31.3458 C(CN) CH25-CN CH34-OCH31.3459 C(CN) CH25-CN CH32-CF31.3460 C(CN) CH25-CN CH33-CF31.3461 C(CN) CH25-CN CH34-CF31.3462 C(CN) CH25-CN CH32-OCF31.3463 C(CN) CH25-CN CH33-OCF31.3464 C(CN) CH25-CN CH34-OCF31.3465 C(CN) CH25-CN CH32-OCF2CF21.3466 C(CN) CH25-CN CH33-OCF2CF21.3467 C(CN) CH25-CN CH34-OCF2CF21.3468 C(CN) CH25-CN CH32-OC2F51.3469 C(CN) CH25-CN CH33-OC2F51.3470 C(CN) CH25-CN CH34-OC2F51.3471 C(CN) CH25-CN CH32-OC6H51.3472 C(CN) CH25-CN CH33-OC6H51.3473 C(CN) CH25-CN CH34-OC6H51.3474 C(CN) CH25-CN CH32-C(O)C6H51.3475 C(CN) CH25-CN CH33-C(O)C6H51.3476 C(CN) CH25-CN CH34-C(O)C6H51.3477 C(CN) CH25-CN CF3H1.3478 C(CN) CH25-CN CF32-Cl1.3479 C(CN) CH25-CN CF33-Cl1.3480 C(CN) CH25-CN CF34-Cl1.3481 C(CN) CH25-CN CF32-F1.3482 C(CN) CH25-CN CF33-F
1.3483 C(CN) CH25-CN CF34-F1.3484 C(CN) CH25-CN CF32-CH31.3485 C(CN) CH25-CN CF33-CH31.3486 C(CN) CH25-CN CF34-CH31.3487 C(CN) CH25-CN CF32-OCH31.3488 C(CN) CH25-CN CF33-OCH31.3489 C(CN) CH25-CN CF34-OCH31.3490 C(CN) CH25-CN CF32-CF31.3491 C(CN) CH25-CN CF33-CF31.3492 C(CN) CH25-CN CF34-CF31.3493 C(CN) CH25-CN CF32-OCF31.3494 C(CN) CH25-CN CF33-OCF31.3495 C(CN) CH25-CN CF34-OCF31.3496 C(CN) CH25-CN CF32-OCF2CF21.3497 C(CN) CH25-CN CF33-OCF2CF21.3498 C(CN) CH25-CN CF34-OCF2CF21.3499 C(CN) CH25-CN CF32-OC2F51.3500 C(CN) CH25-CN CF33-OC2F51.3501 C(CN) CH25-CN CF34-OC2F51.3502 C(CN) CH25-CN CF32-OC6H51.3503 C(CN) CH25-CN CF33-OC6H51.3504 C(CN) CH25-CN CF34-OC6H51.3505 C(CN) CH25-CN CF32-C(O)C6H51.3506 C(CN) CH25-CN CF33-C(O)C6H51.3507 C(CN) CH25-CN CF34-C(O)C6H51.3508 C(CN) CH25-CN SCH3H1.3509 C(CN) CH25-CN SCH32-Cl1.3510 C(CN) CH25-CN SCH33-Cl1.3511 C(CN) CH25-CN SCH34-Cl1.3512 C(CN) CH25-CN SCH32-F1.3513 C(CN) CH25-CN SCH33-F1.3514 C(CN) CH25-CN SCH34-F1.3515 C(CN) CH25-CN SCH32-CH31.3516 C(CN) CH25-CN SCH33-CH31.3517 C(CN) CH25-CN SCH34-CH31.3518 C(CN) CH25-CN SCH32-OCH31.3519 C(CN) CH25-CN SCH33-OCH31.3520 C(CN) CH25-CN SCH34-OCH31.3521 C(CN) CH25-CN SCH32-CF31.3522 C(CN) CH25-CN SCH33-CF31.3523 C(CN) CH25-CN SCH34-CF31.3524 C(CN) CH25-CN SCH32-OCF31.3525 C(CN) CH25-CN SCH33-OCF31.3526 C(CN) CH25-CN SCH34-OCF31.3527 C(CN) CH25-CN SCH32-OCF2CF21.3528 C(CN) CH25-CN SCH33-OCF2CF21.3529 C(CN) CH25-CN SCH34-OCF2CF21.3530 C(CN) CH25-CN SCH32-OC2F51.3531 C(CN) CH25-CN SCH33-OC2F51.3532 C(CN) CH25-CN SCH34-OC2F51.3533 C(CN) CH25-CN SCH32-OC6H51.3534 C(CN) CH25-CN SCH33-OC6H51.3535 C(CN) CH25-CN SCH34-OC6H51.3536 C(CN) CH25-CN SCH32-C(O)C6H51.3537 C(CN) CH25-CN SCH33-C(O)C6H5
1.3538 C(CN) CH25-CNSCH34-C(O)C6H51.3539 C(CN) CH25-CN噻唑-4-基H1.3540 C(CN) CH25-CN噻唑-4-基2-Cl1.3541 C(CN) CH25-CN噻唑-4-基3-Cl1.3542 C(CN) CH25-CN噻唑-4-基4-Cl1.3543 C(CN) CH25-CN噻唑-4-基2-F1.3544 C(CN) CH25-CN噻唑-4-基3-F1.3545 C(CN) CH25-CN噻唑-4-基4-F1.3546 C(CN) CH25-CN噻唑-4-基2-CH31.3547 C(CN) CH25-CN噻唑-4-基3-CH31.3548 C(CN) CH25-CN噻唑-4-基4-CH31.3549 C(CN) CH25-CN噻唑-4-基2-OCH31.3550 C(CN) CH25-CN噻唑-4-基3-OCH31.3551 C(CN) CH25-CN噻唑-4-基4-OCH31.3552 C(CN) CH25-CN噻唑-4-基2-CF31.3553 C(CN) CH25-CN噻唑-4-基3-CF31.3554 C(CN) CH25-CN噻唑-4-基4-CF31.3555 C(CN) CH25-CN噻唑-4-基2-OCF31.3556 C(CN) CH25-CN噻唑-4-基3-OCF31.3557 C(CN) CH25-CN噻唑-4-基4-OCF31.3558 C(CN) CH25-CN噻唑-4-基2-OCF2CF21.3559 C(CN) CH25-CN噻唑-4-基3-OCF2CF21.3560 C(CN) CH25-CN噻唑-4-基4-OCF2CF21.3561 C(CN) CH25-CN噻唑-4-基2-OC2F51.3562 C(CN) CH25-CN噻唑-4-基3-OC2F51.3563 C(CN) CH25-CN噻唑-4-基4-OC2F51.3564 C(CN) CH25-CN噻唑-4-基2-OC6H51.3565 C(CN) CH25-CN噻唑-4-基3-OC6H51.3566 C(CN) CH25-CN噻唑-4-基4-OC6H51.3567 C(CN) CH25-CN噻唑-4-基2-C(O)C6H51.3568 C(CN) CH25-CN噻唑-4-基3-C(O)C6H51.3569 C(CN) CH25-CN噻唑-4-基4-C(O)C6H51.3570 C(CN) CH25-OCH3HH1.3571 C(CN) CH25-OCH3H2-Cl1.3572 C(CN) CH25-OCH3H3-Cl1.3573 C(CN) CH25-OCH3H4-Cl1.3574 C(CN) CH25-OCH3H2-F1.3575 C(CN) CH25-OCH3H3-F1.3576 C(CN) CH25-OCH3H4-F1.3577 C(CN) CH25-OCH3H2-CH31.3578 C(CN) CH25-OCH3H3-CH31.3579 C(CN) CH25-OCH3H4-CH31.3580 C(CN) CH25-OCH3H2-OCH31.3581 C(CN) CH25-OCH3H3-OCH31.3582 C(CN) CH25-OCH3H4-OCH31.3583 C(CN) CH25-OCH3H2-CF31.3584 C(CN) CH25-OCH3H3-CF31.3585 C(CN) CH25-OCH3H4-CF31.3586 C(CN) CH25-OCH3H2-OCF31.3587 C(CN) CH25-OCH3H3-OCF31.3588 C(CN) CH25-OCH3H4-OCF3
1.3589 C(CN) CH25-OCH3H 2-OCF2CF21.3590 C(CN) CH25-OCH3H 3-OCF2CF21.3591 C(CN) CH25-OCH3H 4-OCF2CF21.3592 C(CN) CH25-OCH3H 2-OC2F51.3593 C(CN) CH25-OCH3H 3-OC2F51.3594 C(CN) CH25-OCH3H 4-OC2F51.3595 C(CN) CH25-OCH3H 2-OC6H51.3596 C(CN) CH25-OCH3H 3-OC6H51.3597 C(CN) CH25-OCH3H 4-OC6H51.3598 C(CN) CH25-OCH3H 2-C(O)C6H51.3599 C(CN) CH25-OCH3H 3-C(O)C6H51.3600 C(CN) CH25-OCH3H 4-C(O)C6H51.3601 C(CN) CH25-OCH3CH3H1.3602 C(CN) CH25-OCH3CH32-Cl1.3603 C(CN) CH25-OCH3CH33-Cl1.3604 C(CN) CH25-OCH3CH34-Cl1.3605 C(CN) CH25-OCH3CH32-F1.3606 C(CN) CH25-OCH3CH33-F1.3607 C(CN) CH25-OCH3CH34-F1.3608 C(CN) CH25-OCH3CH32-CH31.3609 C(CN) CH25-OCH3CH33-CH31.3610 C(CN) CH25-OCH3CH34-CH31.3611 C(CN) CH25-OCH3CH32-OCH31.3612 C(CN) CH25-OCH3CH33-OCH31.3613 C(CN) CH25-OCH3CH34-OCH31.3614 C(CN) CH25-OCH3CH32-CF31.3615 C(CN) CH25-OCH3CH33-CF31.3616 C(CN) CH25-OCH3CH34-CF31.3617 C(CN) CH25-OCH3CH32-OCF31.3618 C(CN) CH25-OCH3CH33-OCF31.3619 C(CN) CH25-OCH3CH34-OCF31.3620 C(CN) CH25-OCH3CH32-OCF2CF21.3621 C(CN) CH25-OCH3CH33-OCF2CF21.3622 C(CN) CH25-OCH3CH34-OCF2CF21.3623 C(CN) CH25-OCH3CH32-OC2F51.3624 C(CN) CH25-OCH3CH33-OC2F51.3625 C(CN) CH25-OCH3CH34-OC2F51.3626 C(CN) CH25-OCH3CH32-OC6H51.3627 C(CN) CH25-OCH3CH33-OC6H51.3628 C(CN) CH25-OCH3CH34-OC6H51.3629 C(CN) CH25-OCH3CH32-C(O)C6H51.3630 C(CN) CH25-OCH3CH33-C(O)C6H51.3631 C(CN) CH25-OCH3CH34-C(O)C6H51.3632 C(CN) CH25-OCH3CF3H1.3633 C(CN) CH25-OCH3CF32-Cl1.3634 C(CN) CH25-OCH3CF33-Cl1.3635 C(CN) CH25-OCH3CF34-Cl1.3636 C(CN) CH25-OCH3CF32-F1.3637 C(CN) CH25-OCH3CF33-F1.3638 C(CN) CH25-OCH3CF34-F1.3639 C(CN) CH25-OCH3CF32-CH31.3640 C(CN) CH25-OCH3CF33-CH31.3641 C(CN) CH25-OCH3CF34-CH31.3642 C(CN) CH25-OCH3CF32-OCH31.3643 C(CN) CH25-OCH3CF33-OCH3
1.3644 C(CN) CH25-OCH3CF34-OCH31.3645 C(CN) CH25-OCH3CF32-CF31.3646 C(CN) CH25-OCH3CF33-CF31.3647 C(CN) CH25-OCH3CF34-CF31.3648 C(CN) CH25-OCH3CF32-OCF31.3649 C(CN) CH25-OCH3CF33-OCF31.3650 C(CN) CH25-OCH3CF34-OCF31.3651 C(CN) CH25-OCH3CF32-OCF2CF21.3652 C(CN) CH25-OCH3CF33-OCF2CF21.3653 C(CN) CH25-OCH3CF34-OCF2CF21.3654 C(CN) CH25-OCH3CF32-OC2F51.3655 C(CN) CH25-OCH3CF33-OC2F51.3656 C(CN) CH25-OCH3CF34-OC2F51.3657 C(CN) CH25-OCH3CF32-OC6H51.3658 C(CN) CH25-OCH3CF33-OC6H51.3659 C(CN) CH25-OCH3CF34-OC6H51.3660 C(CN) CH25-OCH3CF32-C(O)C6H51.3661 C(CN) CH25-OCH3CF33-C(O)C6H51.3662 C(CN) CH25-OCH3CF34-C(O)C6H51.3663 C(CN) CH25-OCH3SCH3H1.3664 C(CN) CH25-OCH3SCH32-Cl1.3665 C(CN) CH25-OCH3SCH33-Cl1.3666 C(CN) CH25-OCH3SCH34-Cl1.3667 C(CN) CH25-OCH3SCH32-F1.3668 C(CN) CH25-OCH3SCH33-F1.3669 C(CN) CH25-OCH3SCH34-F1.3670 C(CN) CH25-OCH3SCH32-CH31.3671 C(CN) CH25-OCH3SCH33-CH31.3672 C(CN) CH25-OCH3SCH34-CH31.3673 C(CN) CH25-OCH3SCH32-OCH31.3674 C(CN) CH25-OCH3SCH33-OCH31.3675 C(CN) CH25-OCH3SCH34-OCH31.3676 C(CN) CH25-OCH3SCH32-CF31.3677 C(CN) CH25-OCH3SCH33-CF31.3678 C(CN) CH25-OCH3SCH34-CF31.3679 C(CN) CH25-OCH3SCH32-OCF31.3680 C(CN) CH25-OCH3SCH33-OCF31.3681 C(CN) CH25-OCH3SCH34-OCF31.3682 C(CN) CH25-OCH3SCH32-OCF2CF21.3683 C(CN) CH25-OCH3SCH33-OCF2CF21.3684 C(CN) CH25-OCH3SCH34-OCF2CF21.3685 C(CN) CH25-OCH3SCH32-OC2F51.3686 C(CN) CH25-OCH3SCH33-OC2F51.3687 C(CN) CH25-OCH3SCH34-OC2F51.3688 C(CN) CH25-OCH3SCH32-OC6H51.3689 C(CN) CH25-OCH3SCH33-OC6H51.3690 C(CN) CH25-OCH3SCH34-OC6H51.3691 C(CN) CH25-OCH3SCH32-C(O)C6H51.3692 C(CN) CH25-OCH3SCH33-C(O)C6H51.3693 C(CN) CH25-OCH3SCH34-C(O)C6H51.3694 C(CN) CH25-OCH3噻唑-4-基 H1.3695 C(CN) CH25-OCH3噻唑-4-基 2-Cl1.3696 C(CN) CH25-OCH3噻唑-4-基 3-Cl1.3697 C(CN) CH25-OCH3噻唑-4-基 4-Cl1.3698 C(CN) CH25-OCH3噻唑-4-基 2-F
1.3699 C(CN) CH25-OCH3噻唑-4-基3-F1.3700 C(CN) CH25-OCH3噻唑-4-基4-F1.3701 C(CN) CH25-OCH3噻唑-4-基2-CH31.3702 C(CN) CH25-OCH3噻唑-4-基3-CH31.3703 C(CN) CH25-OCH3噻唑-4-基4-CH31.3704 C(CN) CH25-OCH3噻唑-4-基2-OCH31.3705 C(CN) CH25-OCH3噻唑-4-基3-OCH31.3706 C(CN) CH25-OCH3噻唑-4-基4-OCH31.3707 C(CN) CH25-OCH3噻唑-4-基2-CF31.3708 C(CN) CH25-OCH3噻唑-4-基3-CF31.3709 C(CN) CH25-OCH3噻唑-4-基4-CF31.3710 C(CN) CH25-OCH3噻唑-4-基2-OCF31.3711 C(CN) CH25-OCH3噻唑-4-基3-OCF31.3712 C(CN) CH25-OCH3噻唑-4-基4-OCF31.3713 C(CN) CH25-OCH3噻唑-4-基2-OCF2CF21.3714 C(CN) CH25-OCH3噻唑-4-基3-OCF2CF21.3715 C(CN) CH25-OCH3噻唑-4-基4-OCF2CF21.3716 C(CN) CH25-OCH3噻唑-4-基2-OC2F51.3717 C(CN) CH25-OCH3噻唑-4-基3-OC2F51.3718 C(CN) CH25-OCH3噻唑-4-基4-OC2F51.3719 C(CN) CH25-OCH3噻唑-4-基2-OC6H51.3720 C(CN) CH25-OCH3噻唑-4-基3-OC6H51.3721 C(CN) CH25-OCH3噻唑-4-基4-OC6H51.3722 C(CN) CH25-OCH3噻唑-4-基2-C(O)C6H51.3723 C(CN) CH25-OCH3噻唑-4-基3-C(O)C6H51.3724 C(CN) CH25-OCH3噻唑-4-基4-C(O)C6H51.3725 N Bd. H HH1.3726 N Bd. H H2-Cl1.3727 N Bd. H H3-Cl1.3728 N Bd. H H4-Cl1.3729 N Bd. H H2-F1.3730 N Bd. H H3-F1.3731 N Bd. H H4-F1.3732 N Bd. H H2-CH31.3733 N Bd. H H3-CH31.3734 N Bd. H H4-CH31.3735 N Bd. H H2-OCH31.3736 N Bd. H H3-OCH31.3737 N Bd. H H4-OCH31.3738 N Bd. H H2-CF31.3739 N Bd. H H3-CF31.3740 N Bd. H H4-CF31.3741 N Bd. H H2-OCF31.3742 N Bd. H H3-OCF31.3743 N Bd. H H4-OCF3m.p.199°1.3744 N Bd. H H2-OCF2CF21.3745 N Bd. H H3-OCF2CF21.3746 N Bd. H H4-OCF2CF21.3747 N Bd. H H2-OC2F51.3748 N Bd. H H3-OC2F51.3749 N Bd. H H4-OC2F51.3750 N Bd. H H2-OC6H5
1.3751 NBd.H H 3-OC6H51.3752 NBd.H H 4-OC6H51.3753 NBd.H H 2-C(O)C6H51.3754 NBd.H H 3-C(O)C6H51.3755 NBd.H H 4-C(O)C6H51.3756 NBd.H CH3H1.3757 NBd.H CH32-Cl1.3758 NBd.H CH33-Cl1.3759 NBd.H CH34-Cl1.3760 NBd.H CH32-F1.3761 NBd.H CH33-F1.3762 NBd.H CH34-F1.3763 NBd.H CH32-CH31.3764 NBd.H CH33-CH31.3765 NBd.H CH34-CH31.3766 NBd.H CH32-OCH31.3767 NBd.H CH33-OCH31.3768 NBd.H CH34-OCH31.3769 NBd.H CH32-CF31.3770 NBd.H CH33-CF31.3771 NBd.H CH34-CF31.3772 NBd.H CH32-OCF31.3773 NBd.H CH33-OCF31.3774 NBd.H CH34-OCF31.3775 NBd.H CH32-OCF2CF21.3776 NBd.H CH33-OCF2CF21.3777 NBd.H CH34-OCF2CF21.3778 NBd.H CH32-OC2F51.3779 NBd.H CH33-OC2F51.3780 NBd.H CH34-OC2F51.3781 NBd.H CH32-OC6H51.3782 NBd.H CH33-OC6H51.3783 NBd.H CH34-OC6H51.3784 NBd.H CH32-C(O)C6H51.3785 NBd.H CH33-C(O)C6H51.3786 NBd.H CH34-C(O)C6H51.3787 NBd.H CF3H1.3788 NBd.H CF32-Cl1.3789 NBd.H CF33-Cl1.3790 NBd.H CF34-Cl1.3791 NBd.H CF32-F1.3792 NBd.H CF33-F1.3793 NBd.H CF34-F1.3794 NBd.H CF32-CH31.3795 NBd.H CF33-CH31.3796 NBd.H CF34-CH31.3797 NBd.H CF32-OCH31.3798 NBd.H CF33-OCH31.3799 NBd.H CF34-OCH31.3800 NBd.H CF32-CF31.3801 NBd.H CF33-CF31.3802 NBd.H CF34-CF3m.p.203°1.3803 NBd.H CF32-OCF31.3804 NBd.H CF33-OCF31.3805 NBd.H CF34-OCF3m.p.194°
1.3806 NBd.H CF32-OCF2CF21.3807 NBd.H CF33-OCF2CF21.3808 NBd.H CF34-OCF2CF2m.p.195°1.3809 NBd.H CF32-OC2F51.3810 NBd.H CF33-OC2F51.3811 NBd.H CF34-OC2F51.3812 NBd.H CF32-OC6H51.3813 NBd.H CF33-OC6H51.3814 NBd.H CF34-OC6H5m.p.169°1.3815 NBd.H CF32-C(O)C6H51.3816 NBd.H CF33-C(O)C6H51.3817 NBd.H CF34-C(O)C6HX1.3818 NBd.H SCH3H1.3819 NBd.H SCH32-Cl1.3820 NBd.H SCH33-Cl1.3821 NBd.H SCH34-Cl1.3822 NBd.H SCH32-F1.3823 NBd.H SCH33-F1.3824 NBd.H SCH34-F1.3825 NBd.H SCH32-CH31.3826 NBd.H SCH33-CH31.3827 NBd.H SCH34-CH31.3828 NBd.H SCH32-OCH31.3829 NBd.H SCH33-OCH31.3830 NBd.H SCH34-OCH31.3831 NBd.H SCH32-CF31.3832 NBd.H SCH33-CF31.3833 NBd.H SCH34-CF31.3834 NBd.H SCH32-OCF31.3835 NBd.H SCH33-OCF31.3836 NBd.H SCH34-OCF3m.p.62°1.3837 NBd.H SCH32-OCF2CF21.3838 NBd.H SCH33-OCF2CF21.3839 NBd.H SCH34-OCF2CF21.3840 NBd.H SCH32-OC2F51.3841 NBd.H SCH33-OC2F51.3842 NBd.H SCH34-OC2F51.3843 NBd.H SCH32-OC6H51.3844 NBd.H SCH33-OC6H51.3845 NBd.H SCH34-OC6H5m.p.199°1.3846 NBd.H SCH32-C(O)C6H51.3847 NBd.H SCH33-C(O)C6H51.3848 NBd.H SCH34-C(O)C6H51.3849 NBd.H 噻唑-4-基 H1.3850 NBd.H 噻唑-4-基 2-Cl1.3851 NBd.H 噻唑-4-基 3-Cl1.3852 NBd.H 噻唑-4-基 4-Cl1.3853 NBd.H 噻唑-4-基 2-F1.3854 NBd.H 噻唑-4-基 3-F1.3855 NBd.H 噻唑-4-基 4-F1.3856 NBd.H 噻唑-4-基 2-CH31.3857 NBd.H 噻唑-4-基 3-CH31.3858 NBd.H 噻唑-4-基 4-CH31.3859 NBd.H 噻唑-4-基 2-OCH3
1.3860 NBd.H 噻唑-4-基3-OCH31.3861 NBd.H 噻唑-4-基4-OCH31.3862 NBd.H 噻唑-4-基2-CF31.3863 NBd.H 噻唑-4-基3-CF31.3864 NBd.H 噻唑-4-基4-CF31.3865 NBd.H 噻唑-4-基2-OCF31.3866 NBd.H 噻唑-4-基3-OCF31.3867 NBd.H 噻唑-4-基4-OCF3m.p.171°1.3868 NBd.H 噻唑-4-基2-OCF2CF21.3869 NBd.H 噻唑-4-基3-OCF2CF21.3870 NBd.H 噻唑-4-基4-OCF2CF21.3871 NBd.H 噻唑-4-基2-OC2F51.3872 NBd.H 噻唑-4-基3-OC2F51.3873 NBd.H 噻唑-4-基4-OC2F51.3874 NBd.H 噻唑-4-基2-OC6H51.3875 NBd.H 噻唑-4-基3-OC6H51.3876 NBd.H 噻唑-4-基4-OC6H51.3877 NBd.H 噻唑-4-基2-C(O)C6H51.3878 NBd.H 噻唑-4-基3-C(O)C6H51.3879 NBd.H 噻唑-4-基4-C(O)C6H51.3880 NBd.5-Cl HH1.3881 NBd.5-Cl H2-Cl1.3882 NBd.5-Cl H3-Cl1.3883 NBd.5-Cl H4-Cl1.3884 NBd.5-Cl H2-F1.3885 NBd.5-Cl H3-F1.3886 NBd.5-Cl H4-F1.3887 NBd.5-Cl H2-CH31.3888 NBd.5-Cl H3-CH31.3889 NBd.5-Cl H4-CH31.3890 NBd.5-Cl H2-OCH31.3891 NBd.5-Cl H3-OCH31.3892 NBd.5-Cl H4-OCH31.3893 NBd.5-Cl H2-CF31.3894 NBd.5-Cl H3-CF31.3895 NBd.5-Cl H4-CF31.3896 NBd.5-Cl H2-OCF31.3897 NBd.5-Cl H3-OCF31.3898 NBd.5-Cl H4-OCF31.3899 NBd.5-Cl H2-OCF2CF21.3900 NBd.5-Cl H3-OCF2CF21.3901 NBd.5-Cl H4-OCF2CF21.3902 NBd.5-Cl H2-OC2F51.3903 NBd.5-Cl H3-OC2F51.3904 NBd.5-Cl H4-OC2F51.3905 NBd.5-Cl H2-OC6H51.3906 NBd.5-Cl H3-OC6H51.3907 NBd.5-Cl H4-OC6H51.3908 NBd.5-Cl H2-C(O)C6H51.3909 NBd.5-Cl H3-C(O)C6H51.3910 NBd.5-Cl H4-C(O)C6H51.3911 NBd.5-Cl CH3H1.3912 NBd.5-Cl CH32-Cl
1.3913 NBd.5-ClCH33-Cl1.3914 NBd.5-ClCH34-Cl1.3915 NBd.5-ClCH32-F1.3916 NBd.5-ClCH33-F1.3917 NBd.5-ClCH34-F1.3918 NBd.5-ClCH32-CH31.3919 NBd.5-ClCH33-CH31.3920 NBd.5-ClCH34-CH31.3921 NBd.5-ClCH32-OCH31.3922 NBd.5-ClCH33-OCH31.3923 NBd.5-ClCH34-OCH31.3924 NBd.5-ClCH32-CF31.3925 NBd.5-ClCH33-CF31.3926 NBd.5-ClCH34-CF31.3927 NBd.5-ClCH32-OCF31.3928 NBd.5-ClCH33-OCF31.3929 NBd.5-ClCH34-OCF31.3930 NBd.5-ClCH32-OCF2CF21.3931 NBd.5-ClCH33-OCF2CF21.3932 NBd.5-ClCH34-OCF2CF21.3933 NBd.5-ClCH32-OC2F51.3934 NBd.5-ClCH33-OC2F51.3935 NBd.5-ClCH34-OC2F51.3936 NBd.5-ClCH32-OC6H51.3937 NBd.5-ClCH33-OC6H51.3938 NBd.5-ClCH34-OC6H51.3939 NBd.5-ClCH32-C(O)C6H51.3940 NBd.5-ClCH33-C(O)C6H51.3941 NBd.5-ClCH34-C(O)C6H51.3942 NBd.5-ClCF3H1.3943 NBd.5-ClCF32-Cl1.3944 NBd.5-ClCF33-Cl1.3945 NBd.5-ClCF34-Cl1.3946 NBd.5-ClCF32-F1.3947 NBd.5-ClCF33-F1.3948 NBd.5-ClCF34-F1.3949 NBd.5-ClCF32-CH31.3950 NBd.5-ClCF33-CH31.3951 NBd.5-ClCF34-CH31.3952 NBd.5-ClCF32-OCH31.3953 NBd.5-ClCF33-OCH31.3954 NBd.5-ClCF34-OCH31.3955 NBd.5-ClCF32-CF31.3956 NBd.5-ClCF33-CF31.3957 NBd.5-ClCF34-CF31.3958 NBd.5-ClCF32-OCF31.3959 NBd.5-ClCF33-OCF31.3960 NBd.5-ClCF34-OCF31.3961 NBd.5-ClCF32-OCF2CF21.3962 NBd.5-ClCF33-OCF2CF21.3963 NBd.5-ClCF34-OCF2CF21.3964 NBd.5-ClCF32-OC2F51.3965 NBd.5-ClCF33-OC2F51.3966 NBd.5-ClCF34-OC2F51.3967 NBd.5-ClCF32-OC6H5
1.3968 NBd.5-ClCF33-OC6H51.3969 NBd.5-ClCF34-OC6H51.3970 NBd.5-ClCF32-C(O)C6H51.3971 NBd.5-ClCF33-C(O)C6H51.3972 NBd.5-ClCF34-C(O)C6H51.3973 NBd.5-ClSCH3H1.3974 NBd.5-ClSCH32-Cl1.3975 NBd.5-ClSCH33-Cl1.3976 NBd.5-ClSCH34-Cl1.3977 NBd.5-ClSCH32-F1.3978 NBd.5-ClSCH33-F1.3979 NBd.5-ClSCH34-F1.3980 NBd.5-ClSCH32-CH31.3981 NBd.5-ClSCH33-CH31.3982 NBd.5-ClSCH34-CH31.3983 NBd.5-ClSCH32-OCH31.3984 NBd.5-ClSCH33-OCH31.3985 NBd.5-ClSCH34-OCH31.3986 NBd.5-ClSCH32-CF31.3987 NBd.5-ClSCH33-CF31.3988 NBd.5-ClSCH34-CF31.3989 NBd.5-ClSCH32-OCF31.3990 NBd.5-ClSCH33-OCF31.3991 NBd.5-ClSCH34-OCF31.3992 NBd.5-ClSCH32-OCF2CF21.3993 NBd.5-ClSCH33-OCF2CF21.3994 NBd.5-ClSCH34-OCF2CF21.3995 NBd.5-ClSCH32-OC2F51.3996 NBd.5-ClSCH33-OC2F51.3997 NBd.5-ClSCH34-OC2F51.3998 NBd.5-ClSCH32-OC6H51.3999 NBd.5-ClSCH33-OC6H51.4000 NBd.5-ClSCH34-OC6H51.4001 NBd.5-ClSCH32-C(O)C6H51.4002 NBd.5-ClSCH33-C(O)C6H51.4003 NBd.5-ClSCH34-C(O)C6H51.4004 NBd.5-Cl噻唑-4-基 H1.4005 NBd.5-Cl噻唑-4-基 2-Cl1.4006 NBd.5-Cl噻唑-4-基 3-Cl1.4007 NBd.5-Cl噻唑-4-基 4-Cl1.4008 NBd.5-Cl噻唑-4-基 2-F1.4009 NBd.5-Cl噻唑-4-基 3-F1.4010 NBd.5-Cl噻唑-4-基 4-F1.4011 NBd.5-Cl噻唑-4-基 2-CH31.4012 NBd.5-Cl噻唑-4-基 3-CH31.4013 NBd.5-Cl噻唑-4-基 4-CH31.4014 NBd.5-Cl噻唑-4-基 2-OCH31.4015 NBd.5-Cl噻唑-4-基 3-OCH31.4016 NBd.5-Cl噻唑-4-基 4-OCH31.4017 NBd.5-Cl噻唑-4-基 2-CF31.4018 NBd.5-Cl噻唑-4-基 3-CF31.4019 NBd.5-Cl噻唑-4-基 4-CF31.4020 NBd.5-Cl噻唑-4-基 2-OCF3
1.4021 NBd.5-Cl噻唑-4-基3-OCF31.4022 NBd.5-Cl噻唑-4-基4-OCF31.4023 NBd.5-Cl噻唑-4-基2-OCF2CF21.4024 NBd.5-Cl噻唑-4-基3-OCF2CF21.4025 NBd.5-Cl噻唑-4-基4-OCF2CF21.4026 NBd.5-Cl噻唑-4-基2-OC2F51.4027 NBd.5-Cl噻唑-4-基3-OC2F51.4028 NBd.5-Cl噻唑-4-基4-OC2F51.4029 NBd.5-Cl噻唑-4-基2-OC6H51.4030 NBd.5-Cl噻唑-4-基3-OC6H51.4031 NBd.5-Cl噻唑-4-基4-OC6H51.4032 NBd.5-Cl噻唑-4-基2-C(O)C6H51.4033 NBd.5-Cl噻唑-4-基3-C(O)C6H51.4034 NBd.5-Cl噻唑-4-基4-C(O)C6H51.4035 NBd.6-ClHH1.4036 NBd.6-ClH2-Cl1.4037 NBd.6-ClH3-Cl1.4038 NBd.6-ClH4-Cl1.4039 NBd.6-ClH2-F1.4040 NBd.6-ClH3-F1.4041 NBd.6-ClH4-F1.4042 NBd.6-ClH2-CH31.4043 NBd.6-ClH3-CH31.4044 NBd.6-ClH4-CH31.4045 NBd.6-ClH2-OCH31.4046 NBd.6-ClH3-OCH31.4047 NBd.6-ClH4-OCH31.4048 NBd.6-ClH2-CF31.4049 NBd.6-ClH3-CF31.4050 NBd.6-ClH4-CF31.4051 NBd.6-ClH2-OCF31.4052 NBd.6-ClH3-OCF31.4053 NBd.6-ClH4-OCF31.4054 NBd.6-ClH2-OCF2CF21.4055 NBd.6-ClH3-OCF2CF21.4056 NBd.6-ClH4-OCF2CF21.4057 NBd.6-ClH2-OC2F51.4058 NBd.6-ClH3-OC2F51.4059 NBd.6-ClH4-OC2F51.4060 NBd.6-ClH2-OC6H51.4061 NBd.6-ClH3-OC6H51.4062 NBd.6-ClH4-OC6H51.4063 NBd.6-ClH2-C(O)C6H51.4064 NBd.6-ClH3-C(O)C6H51.4065 NBd.6-ClH4-C(O)C6H51.4066 NBd.6-ClCH3H1.4067 NBd.6-ClCH32-Cl1.4068 NBd.6-ClCH33-Cl1.4069 NBd.6-ClCH34-Cl1.4070 NBd.6-ClCH32-F1.4071 NBd.6-ClCH33-F1.4072 NBd.6-ClCH34-F1.4073 NBd.6-ClCH32-CH3
1.4074 NBd.6-ClCH33-CH31.4075 NBd.6-ClCH34-CH31.4076 NBd.6-ClCH32-OCH31.4077 NBd.6-ClCH33-OCH31.4078 NBd.6-ClCH34-OCH31.4079 NBd.6-ClCH32-CF31.4080 NBd.6-ClCH33-CF31.4081 NBd.6-ClCH34-CF31.4082 NBd.6-ClCH32-OCF31.4083 NBd.6-ClCH33-OCF31.4084 NBd.6-ClCH34-OCF31.4085 NBd.6-ClCH32-OCF2CF21.4086 NBd.6-ClCH33-OCF2CF21.4087 NBd.6-ClCH34-OCF2CF21.4088 NBd.6-ClCH32-OC2F51.4089 NBd.6-ClCH33-OC2F51.4090 NBd.6-ClCH34-OC2F51.4091 NBd.6-ClCH32-OC6H51.4092 NBd.6-ClCH33-OC6H51.4093 NBd.6-ClCH34-OC6H51.4094 NBd.6-ClCH32-C(O)C6H51.4095 NBd.6-ClCH33-C(O)C6H51.4096 NBd.6-ClCH34-C(O)C6H51.4097 NBd.6-ClCF3H1.4098 NBd.6-ClCF32-Cl1.4099 NBd.6-ClCF33-Cl1.4100 NBd.6-ClCF34-Cl1.4101 NBd.6-ClCF32-F1.4102 NBd.6-ClCF33-F1.4103 NBd.6-ClCF34-F1.4104 NBd.6-ClCF32-CH31.4105 NBd.6-ClCF33-CH31.4106 NBd.6-ClCF34-CH31.4107 NBd.6-ClCF32-OCH31.4108 NBd.6-ClCF33-OCH31.4109 NBd.6-ClCF34-OCH31.4110 NBd.6-ClCF32-CF31.4111 NBd.6-ClCF33-CF31.4112 NBd.6-ClCF34-CF31.4113 NBd.6-ClCF32-OCF31.4114 NBd.6-ClCF33-OCF31.4115 NBd.6-ClCF34-OCF31.4116 NBd.6-ClCF32-OCF2CF21.4117 NBd.6-ClCF33-OCF2CF21.4118 NBd.6-ClCF34-OCF2CF21.4119 NBd.6-ClCF32-OC2F51.4120 NBd.6-ClCF33-OC2F51.4121 NBd.6-ClCF34-OC2F51.4122 NBd.6-ClCF32-OC6H51.4123 NBd.6-ClCF33-OC6H51.4124 NBd.6-ClCF34-OC6H51.4125 NBd.6-ClCF32-C(O)C6H51.4126 NBd.6-ClCF33-C(O)C6H51.4127 NBd.6-ClCF34-C(O)C6H51.4128 NBd.6-ClSCH3H
1.4129 NBd.6-Cl SCH32-Cl1.4130 NBd.6-Cl SCH33-Cl1.4131 NBd.6-Cl SCH34-Cl1.4132 NBd.6-Cl SCH32-F1.4133 NBd.6-Cl SCH33-F1.4134 NBd.6-Cl SCH34-F1.4135 NBd.6-Cl SCH32-CH31.4136 NBd.6-Cl SCH33-CH31.4137 NBd.6-Cl SCH34-CH31.4138 NBd.6-Cl SCH32-OCH31.4139 NBd.6-Cl SCH33-OCH31.4140 NBd.6-Cl SCH34-OCH31.4141 NBd.6-Cl SCH32-CF31.4142 NBd.6-Cl SCH33-CF31.4143 NBd.6-Cl SCH34-CF31.4144 NBd.6-Cl SCH32-OCF31.4145 NBd.6-Cl SCH33-OCF31.4146 NBd.6-Cl SCH34-OCF31.4147 NBd.6-Cl SCH32-OCF2CF21.4148 NBd.6-Cl SCH33-OCF2CF21.4149 NBd.6-Cl SCH34-OCF2CF21.4150 NBd.6-Cl SCH32-OC2F51.4151 NBd.6-Cl SCH33-OC2F51.4152 NBd.6-Cl SCH34-OC2F51.4153 NBd.6-Cl SCH32-OC6H51.4154 NBd.6-Cl SCH33-OC6H51.4155 NBd.6-Cl SCH34-OC6H51.4156 NBd.6-Cl SCH32-C(O)C6H51.4157 NBd.6-Cl SCH33-C(O)C6H51.4158 NBd.6-Cl SCH34-C(O)C6H51.4159 NBd.6-Cl 噻唑-4-基 H1.4160 NBd.6-Cl 噻唑-4-基 2-Cl1.4161 NBd.6-Cl 噻唑-4-基 3-Cl1.4162 NBd.6-Cl 噻唑-4-基 4-Cl1.4163 NBd.6-Cl 噻唑-4-基 2-F1.4164 NBd.6-Cl 噻唑-4-基 3-F1.4165 NBd.6-Cl 噻唑-4-基 4-F1.4166 NBd.6-Cl 噻唑-4-基 2-CH31.4167 NBd.6-Cl 噻唑-4-基 3-CH31.4168 NBd.6-Cl 噻唑-4-基 4-CH31.4169 NBd.6-Cl 噻唑-4-基 2-OCH31.4170 NBd.6-Cl 噻唑-4-基 3-OCH31.4171 NBd.6-Cl 噻唑-4-基 4-OCH31.4172 NBd.6-Cl 噻唑-4-基 2-CF31.4173 NBd.6-Cl 噻唑-4-基 3-CF31.4174 NBd.6-Cl 噻唑-4-基 4-CF31.4175 NBd.6-Cl 噻唑-4-基 2-OCF31.4176 NBd.6-Cl 噻唑-4-基 3-OCF31.4177 NBd.6-Cl 噻唑-4-基 4-OCF31.4178 NBd.6-Cl 噻唑-4-基 2-OCF2CF21.4179 NBd.6-Cl 噻唑-4-基 3-OCF2CF21.4180 NBd.6-Cl 噻唑-4-基 4-OCF2CF2
1.4181 NBd.6-Cl 噻唑-4-基2-OC2F51.4182 NBd.6-Cl 噻唑-4-基3-OC2F51.4183 NBd.6-Cl 噻唑-4-基4-OC2F51.4184 NBd.6-Cl 噻唑-4-基2-OC6H51.4185 NBd.6-Cl 噻唑-4-基3-OC6H51.4186 NBd.6-Cl 噻唑-4-基4-OC6H51.4187 NBd.6-Cl 噻唑-4-基2-C(O)C6H51.4188 NBd.6-Cl 噻唑-4-基3-C(O)C6H51.4189 NBd.6-Cl 噻唑-4-基4-C(O)C6H51.4190 NBd.5-F HH1.4191 NBd.5-F H2-Cl1.4192 NBd.5-F H3-Cl1.4193 NBd.5-F H4-Cl1.4194 NBd.5-F H2-F1.4195 NBd.5-F H3-F1.4196 NBd.5-F H4-F1.4197 NBd.5-F H2-CH31.4198 NBd.5-F H3-CH31.4199 NBd.5-F H4-CH31.4200 NBd.5-F H2-OCH31.4201 NBd.5-F H3-OCH31.4202 NBd.5-F H4-OCH31.4203 NBd.5-F H2-CF31.4204 NBd.5-F H3-CF31.4205 NBd.5-F H4-CF31.4206 NBd.5-F H2-OCF31.4207 NBd.5-F H3-OCF31.4208 NBd.5-F H4-OCF31.4209 NBd.5-F H2-OCF2CF21.4210 NBd.5-F H3-OCF2CF21.4211 NBd.5-F H4-OCF2CF21.4212 NBd.5-F H2-OC2F51.4213 NBd.5-F H3-OC2F51.4214 NBd.5-F H4-OC2F51.4215 NBd.5-F H2-OC6H51.4216 NBd.5-F H3-OC6H51.4217 NBd.5-F H4-OC6H51.4218 NBd.5-F H2-C(O)C6H51.4219 NBd.5-F H3-C(O)C6H51.4220 NBd.5-F H4-C(O)C6H51.4221 NBd.5-F CH3H1.4222 NBd.5-F CH32-Cl1.4223 NBd.5-F CH33-Cl1.4224 NBd.5-F CH34-Cl1.4225 NBd.5-F CH32-F1.4226 NBd.5-F CH33-F1.4227 NBd.5-F CH34-F1.4228 NBd.5-F CH32-CH31.4229 NBd.5-F CH33-CH31.4230 NBd.5-F CH34-CH31.4231 NBd.5-F CH32-OCH31.4232 NBd.5-F CH33-OCH31.4233 NBd.5-F CH34-OCH31.4234 NBd.5-F CH32-CF3
1.4235 NBd.5-F CH33-CF31.4236 NBd.5-F CH34-CF31.4237 NBd.5-F CH32-OCF31.4238 NBd.5-F CH33-OCF31.4239 NBd.5-F CH34-OCF31.4240 NBd.5-F CH32-OCF2CF21.4241 NBd.5-F CH33-OCF2CF21.4242 NBd.5-F CH34-OCF2CF21.4243 NBd.5-F CH32-OC2F51.4244 NBd.5-F CH33-OC2F51.4245 NBd.5-F CH34-OC2F51.4246 NBd.5-F CH32-OC6H51.4247 NBd.5-F CH33-OC6H51.4248 NBd.5-F CH34-OC6H51.4249 NBd.5-F CH32-C(O)C6H51.4250 NBd.5-F CH33-C(O)C6H51.4251 NBd.5-F CH34-C(O)C6H51.4252 NBd.5-F CF3H1.4253 NBd.5-F CF32-Cl1.4254 NBd.5-F CF33-Cl1.4255 NBd.5-F CF34-Cl1.4256 NBd.5-F CF32-F1.4257 NBd.5-F CF33-F1.4258 NBd.5-F CF34-F1.4259 NBd.5-F CF32-CH31.4260 NBd.5-F CF33-CH31.4261 NBd.5-F CF34-CH31.4262 NBd.5-F CF32-OCH31.4263 NBd.5-F CF33-OCH31.4264 NBd.5-F CF34-OCH31.4265 NBd.5-F CF32-CF31.4266 NBd.5-F CF33-CF31.4267 NBd.5-F CF34-CF31.4268 NBd.5-F CF32-OCF31.4269 NBd.5-F CF33-OCF31.4270 NBd.5-F CF34-OCF31.4271 NBd.5-F CF32-OCF2CF21.4272 NBd.5-F CF33-OCF2CF21.4273 NBd.5-F CF34-OCF2CF21.4274 NBd.5-F CF32-OC2F51.4275 NBd.5-F CF33-OC2F51.4276 NBd.5-F CF34-OC2F51.4277 NBd.5-F CF32-OC6H51.4278 NBd.5-F CF33-OC6H51.4279 NBd.5-F CF34-OC6H51.4280 NBd.5-F CF32-C(O)C6H51.4281 NBd.5-F CF33-C(O)C6H51.4282 NBd.5-F CF34-C(O)C6H51.4283 NBd.5-F SCH3H1.4284 NBd.5-F SCH32-Cl1.4285 NBd.5-F SCH33-Cl1.4286 NBd.5-F SCH34-Cl1.4287 NBd.5-F SCH32-F1.4288 NBd.5-F SCH33-F1.4289 NBd.5-F SCH34-F
1.4290 NBd.5-F SCH32-CH31.4291 NBd.5-F SCH33-CH31.4292 NBd.5-F SCH34-CH31.4293 NBd.5-F SCH32-OCH31.4294 NBd.5-F SCH33-OCH31.4295 NBd.5-F SCH34-OCH31.4296 NBd.5-F SCH32-CF31.4297 NBd.5-F SCH33-CF31.4298 NBd.5-F SCH34-CF31.4299 NBd.5-F SCH32-OCF31.4300 NBd.5-F SCH33-OCF31.4301 NBd.5-F SCH34-OCF31.4302 NBd.5-F SCH32-OCF2CF21.4303 NBd.5-F SCH33-OCF2CF21.4304 NBd.5-F SCH34-OCF2CF21.4305 NBd.5-F SCH32-OC2F51.4306 NBd.5-F SCH33-OC2F51.4307 NBd.5-F SCH34-OC2F51.4308 NBd.5-F SCH32-OC6H51.4309 NBd.5-F SCH33-OC6H51.4310 NBd.5-F SCH34-OC6H51.4311 NBd.5-F SCH32-C(O)C6H51.4312 NBd.5-F SCH33-C(O)C6H51.4313 NBd.5-F SCH34-C(O)C6H51.4314 NBd.5-F 噻唑-4-基H1.4315 NBd.5-F 噻唑-4-基2-Cl1.4316 NBd.5-F 噻唑-4-基3-Cl1.4317 NBd.5-F 噻唑-4-基4-Cl1.4318 NBd.5-F 噻唑-4-基2-F1.4319 NBd.5-F 噻唑-4-基3-F1.4320 NBd.5-F 噻唑-4-基4-F1.4321 NBd.5-F 噻唑-4-基2-CH31.4322 NBd.5-F 噻唑-4-基3-CH31.4323 NBd.5-F 噻唑-4-基4-CH31.4324 NBd.5-F 噻唑-4-基2-OCH31.4325 NBd.5-F 噻唑-4-基3-OCH31.4326 NBd.5-F 噻唑-4-基4-OCH31.4327 NBd.5-F 噻唑-4-基2-CF31.4328 NBd.5-F 噻唑-4-基3-CF31.4329 NBd.5-F 噻唑-4-基4-CF31.4330 NBd.5-F 噻唑-4-基2-OCF31.4331 NBd.5-F 噻唑-4-基3-OCF31.4332 NBd.5-F 噻唑-4-基4-OCF31.4333 NBd.5-F 噻唑-4-基2-OCF2CF21.4334 NBd.5-F 噻唑-4-基3-OCF2CF21.4335 NBd.5-F 噻唑-4-基4-OCF2CF21.4336 NBd.5-F 噻唑-4-基2-OC2F51.4337 NBd.5-F 噻唑-4-基3-OC2F51.4338 NBd.5-F 噻唑-4-基4-OC2F51.4339 NBd.5-F 噻唑-4-基2-OC6H51.4340 NBd.5-F 噻唑-4-基3-OC6H51.4341 NBd.5-F 噻唑-4-基4-OC6H5
1.4342 NBd.5-F 噻唑-4-基2-C(O)C6H51.4343 NBd.5-F 噻唑-4-基3-C(O)C6H51.4344 NBd.5-F 噻唑-4-基4-C(O)C6H51.4345 NBd.5-CN HH1.4346 NBd.5-CN H2-Cl1.4347 NBd.5-CN H3-Cl1.4348 NBd.5-CN H4-Cl1.4349 NBd.5-CN H2-F1.4350 NBd.5-CN H3-F1.4351 NBd.5-CN H4-F1.4352 NBd.5-CN H2-CH31.4353 NBd.5-CN H3-CH31.4354 NBd.5-CN H4-CH31.4355 NBd.5-CN H2-OCH31.4356 NBd.5-CN H3-OCH31.4357 NBd.5-CN H4-OCH31.4358 NBd.5-CN H2-CF31.4359 NBd.5-CN H3-CF31.4360 NBd.5-CN H4-CF31.4361 NBd.5-CN H2-OCF31.4362 NBd.5-CN H3-OCF31.4363 NBd.5-CN H4-OCF31.4364 NBd.5-CN H2-OCF2CF21.4365 NBd.5-CN H3-OCF2CF21.4366 NBd.5-CN H4-OCF2CF21.4367 NBd.5-CN H2-OC2F51.4368 NBd.5-CN H3-OC2F51.4369 NBd.5-CN H4-OC2F51.4370 NBd.5-CN H2-OC6H51.4371 NBd.5-CN H3-OC6H51.4372 NBd.5-CN H4-OC6H51.4373 NBd.5-CN H2-C(O)C6H51.4374 NBd.5-CN H3-C(O)C6H51.4375 NBd.5-CN H4-C(O)C6H51.4376 NBd.5-CN CH3H1.4377 NBd.5-CN CH32-Cl1.4378 NBd.5-CN CH33-Cl1.4379 NBd.5-CN CH34-Cl1.4380 NBd.5-CN CH32-F1.4381 NBd.5-CN CH33-F1.4382 NBd.5-CN CH34-F1.4383 NBd.5-CN CH32-CH31.4384 NBd.5-CN CH33-CH31.4385 NBd.5-CN CH34-CH31.4386 NBd.5-CN CH32-OCH31.4387 NBd.5-CN CH33-OCH31.4388 NBd.5-CN CH34-OCH31.4389 NBd.5-CN CH32-CF31.4390 NBd.5-CN CH33-CF31.4391 NBd.5-CN CH34-CF31.4392 NBd.5-CN CH32-OCF31.4393 NBd.5-CN CH33-OCF31.4394 NBd.5-CN CH34-OCF31.4395 NBd.5-CN CH32-OCF2CF21.4396 NBd.5-CN CH33-OCF2CF2
1.4397 N Bd.5-CN CH34-OCF2CF21.4398 N Bd.5-CN CH32-OC2F51.4399 N Bd.5-CN CH33-OC2F51.4400 N Bd.5-CN CH34-OC2F51.4401 N Bd.5-CN CH32-OC6H51.4402 N Bd.5-CN CH33-OC6H51.4403 N Bd.5-CN CH34-OC6H51.4404 N Bd.5-CN CH32-C(O)C6H51.4405 N Bd.5-CN CH33-C(O)C6H51.4406 N Bd.5-CN CH34-C(O)C6H51.4407 N Bd.5-CN CF3H1.4408 N Bd.5-CN CF32-Cl1.4409 N Bd.5-CN CF33-Cl1.4410 N Bd.5-CN CF34-Cl1.4411 N Bd.5-CN CF32-F1.4412 N Bd.5-CN CF33-F1.4413 N Bd.5-CN CF34-F1.4414 N Bd.5-CN CF32-CH31.4415 N Bd.5-CN CF33-CH31.4416 N Bd.5-CN CF34-CH31.4417 N Bd.5-CN CF32-OCH31.4418 N Bd.5-CN CF33-OCH31.4419 N Bd.5-CN CF34-OCH31.4420 N Bd.5-CN CF32-CF31.4421 N Bd.5-CN CF33-CF31.4422 N Bd.5-CN CF34-CF31.4423 N Bd.5-CN CF32-OCF31.4424 N Bd.5-CN CF33-OCF31.4425 N Bd.5-CN CF34-OCF31.4426 N Bd.5-CN CF32-OCF2CF21.4427 N Bd.5-CN CF33-OCF2CF21.4428 N Bd.5-CN CF34-OCF2CF21.4429 N Bd.5-CN CF32-OC2F51.4430 N Bd.5-CN CF33-OC2F51.4431 N Bd.5-CN CF34-OC2F51.4432 N Bd.5-CN CF32-OC6H51.4433 N Bd.5-CN CF33-OC6H51.4434 N Bd.5-CN CF34-OC6H51.4435 N Bd.5-CN CF32-C(O)C6H51.4436 N Bd.5-CN CF33-C(O)C6H51.4437 N Bd.5-CN CF34-C(O)C6H51.4438 N Bd.5-CN SCH3H1.4439 N Bd.5-CN SCH32-Cl1.4440 N Bd.5-CN SCH33-Cl1.4441 N Bd.5-CN SCH34-Cl1.4442 N Bd.5-CN SCH32-F1.4443 N Bd.5-CN SCH33-F1.4444 N Bd.5-CN SCH34-F1.4445 N Bd.5-CN SCH32-CH31.4446 N Bd.5-CN SCH33-CH31.4447 N Bd.5-CN SCH34-CH31.4448 N Bd.5-CN SCH32-OCH31.4449 N Bd.5-CN SCH33-OCH31.4450 N Bd.5-CN SCH34-OCH31.4451 N Bd.5-CN SCH32-CF3
1.4452 N Bd.5-CN SCH33-CF31.4453 N Bd.5-CN SCH34-CF31.4454 N Bd.5-CN SCH32-OCF31.4455 N Bd.5-CN SCH33-OCF31.4456 N Bd.5-CN SCH34-OCF31.4457 N Bd.5-CN SCH32-OCF2CF21.4458 N Bd.5-CN SCH33-OCF2CF21.4459 N Bd.5-CN SCH34-OCF2CF21.4460 N Bd.5-CN SCH32-OC2F51.4461 N Bd.5-CN SCH33-OC2F51.4462 N Bd.5-CN SCH34-OC2F51.4463 N Bd.5-CN SCH32-OC6H51.4464 N Bd.5-CN SCH33-OC6H51.4465 N Bd.5-CN SCH34-OC6H51.4466 N Bd.5-CN SCH32-C(O)C6H51.4467 N Bd.5-CN SCH33-C(O)C6H51.4468 N Bd.5-CN SCH34-C(O)C6H51.4469 N Bd.5-CN 噻唑-4-基H1.4470 N Bd.5-CN 噻唑-4-基2-Cl1.4471 N Bd.5-CN 噻唑-4-基3-Cl1.4472 N Bd.5-CN 噻唑-4-基4-Cl1.4473 N Bd.5-CN 噻唑-4-基2-F1.4474 N Bd.5-CN 噻唑-4-基3-F1.4475 N Bd.5-CN 噻唑-4-基4-F1.4476 N Bd.5-CN 噻唑-4-基2-CH31.4477 N Bd.5-CN 噻唑-4-基3-CH31.4478 N Bd.5-CN 噻唑-4-基4-CH31.4479 N Bd.5-CN 噻唑-4-基2-OCH31.4480 N Bd.5-CN 噻唑-4-基3-OCH31.4481 N Bd.5-CN 噻唑-4-基4-OCH31.4482 N Bd.5-CN 噻唑-4-基2-CF31.4483 N Bd.5-CN 噻唑-4-基3-CF31.4484 N Bd.5-CN 噻唑-4-基4-CF31.4485 N Bd.5-CN 噻唑-4-基2-OCF31.4486 N Bd.5-CN 噻唑-4-基3-OCF31.4487 N Bd.5-CN 噻唑-4-基4-OCF31.4488 N Bd.5-CN 噻唑-4-基2-OCF2CF21.4489 N Bd.5-CN 噻唑-4-基3-OCF2CF21.4490 N Bd.5-CN 噻唑-4-基4-OCF2CF21.4491 N Bd.5-CN 噻唑-4-基2-OC2F51.4492 N Bd.5-CN 噻唑-4-基3-OC2F51.4493 N Bd.5-CN 噻唑-4-基4-OC2F51.4494 N Bd.5-CN 噻唑-4-基2-OC6H51.4495 N Bd.5-CN 噻唑-4-基3-OC6H51.4496 N Bd.5-CN 噻唑-4-基4-OC6H51.4497 N Bd.5-CN 噻唑-4-基2-C(O)C6H51.4498 N Bd.5-CN 噻唑-4-基3-C(O)C6H51.4499 N Bd.5-CN 噻唑-4-基4-C(O)C6H51.4500 N Bd.5-OCH3HH1.4501 N Bd.5-OCH3H2-Cl1.4502 N Bd.5-OCH3H3-Cl
1.4503 N Bd.5-OCH3H 4-Cl1.4504 N Bd.5-OCH3H 2-F1.4505 N Bd.5-OCH3H 3-F1.4506 N Bd.5-OCH3H 4-F1.4507 N Bd.5-OCH3H 2-CH31.4508 N Bd.5-OCH3H 3-CH31.4509 N Bd.5-OCH3H 4-CH31.4510 N Bd.5-OCH3H 2-OCH31.4511 N Bd.5-OCH3H 3-OCH31.4512 N Bd.5-OCH3H 4-OCH31.4513 N Bd.5-OCH3H 2-CF31.4514 N Bd.5-OCH3H 3-CF31.4515 N Bd.5-OCH3H 4-CF31.4516 N Bd.5-OCH3H 2-OCF31.4517 N Bd.5-OCH3H 3-OCF31.4518 N Bd.5-OCH3H 4-OCF31.4519 N Bd.5-OCH3H 2-OCF2CF21.4520 N Bd.5-OCH3H 3-OCF2CF21.4521 N Bd.5-OCH3H 4-OCF2CF21.4522 N Bd.5-OCH3H 2-OC2F51.4523 N Bd.5-OCH3H 3-OC2F51.4524 N Bd.5-OCH3H 4-OC2F51.4525 N Bd.5-OCH3H 2-OC6H51.4526 N Bd.5-OCH3H 3-OC6H51.4527 N Bd.5-OCH3H 4-OC6H51.4528 N Bd.5-OCH3H 2-C(O)C6H51.4529 N Bd.5-OCH3H 3-C(O)C6H51.4530 N Bd.5-OCH3H 4-C(O)C6H51.4531 N Bd.5-OCH3CH3H1.4532 N Bd.5-OCH3CH32-Cl1.4533 N Bd.5-OCH3CH33-Cl1.4534 N Bd.5-OCH3CH34-Cl1.4535 N Bd.5-OCH3CH32-F1.4536 N Bd.5-OCH3CH33-F1.4537 N Bd.5-OCH3CH34-F1.4538 N Bd.5-OCH3CH32-CH31.4539 N Bd.5-OCH3CH33-CH31.4540 N Bd.5-OCH3CH34-CH31.4541 N Bd.5-OCH3CH32-OCH31.4542 N Bd.5-OCH3CH33-OCH31.4543 N Bd.5-OCH3CH34-OCH31.4544 N Bd.5-OCH3CH32-CF31.4545 N Bd.5-OCH3CH33-CF31.4546 N Bd.5-OCH3CH34-CF31.4547 N Bd.5-OCH3CH32-OCF31.4548 N Bd.5-OCH3CH33-OCF31.4549 N Bd.5-OCH3CH34-OCF31.4550 N Bd.5-OCH3CH32-OCF2CF21.4551 N Bd.5-OCH3CH33-OCF2CF21.4552 N Bd.5-OCH3CH34-OCF2CF21.4553 N Bd.5-OCH3CH32-OC2F51.4554 N Bd.5-OCH3CH33-OC2F51.4555 N Bd.5-OCH3CH34-OC2F51.4556 N Bd.5-OCH3CH32-OC6H51.4557 N Bd.5-OCH3CH33-OC6H5
1.4558 N Bd.5-OCH3CH34-OC6H51.4559 N Bd.5-OCH3CH32-C(O)C6H51.4560 N Bd.5-OCH3CH33-C(O)C6H51.4561 N Bd.5-OCH3CH34-C(O)C6H51.4562 N Bd.5-OCH3CF3H1.4563 N Bd.5-OCH3CF32-Cl1.4564 N Bd.5-OCH3CF33-Cl1.4565 N Bd.5-OCH3CF34-Cl1.4566 N Bd.5-OCH3CF32-F1.4567 N Bd.5-OCH3CF33-F1.4568 N Bd.5-OCH3CF34-F1.4569 N Bd.5-OCH3CF32-CH31.4570 N Bd.5-OCH3CF33-CH31.4571 N Bd.5-OCH3CF34-CH31.4572 N Bd.5-OCH3CF32-OCH31.4573 N Bd.5-OCH3CF33-OCH31.4574 N Bd.5-OCH3CF34-OCH31.4575 N Bd.5-OCH3CF32-CF31.4576 N Bd.5-OCH3CF33-CF31.4577 N Bd.5-OCH3CF34-CF31.4578 N Bd.5-OCH3CF32-OCF31.4579 N Bd.5-OCH3CF33-OCF31.4580 N Bd.5-OCH3CF34-OCF31.4581 N Bd.5-OCH3CF32-OCF2CF21.4582 N Bd.5-OCH3CF33-OCF2CF21.4583 N Bd.5-OCH3CF34-OCF2CF21.4584 N Bd.5-OCH3CF32-OC2F51.4585 N Bd.5-OCH3CF33-OC2F51.4586 N Bd.5-OCH3CF34-OC2F51.4587 N Bd.5-OCH3CF32-OC6H51.4588 N Bd.5-OCH3CF33-OC6H51.4589 N Bd.5-OCH3CF34-OC6H51.4590 N Bd.5-OCH3CF32-C(O)C6H51.4591 N Bd.5-OCH3CF33-C(O)C6H51.4592 N Bd.5-OCH3CF34-C(O)C6H51.4593 N Bd.5-OCH3SCH3H1.4594 N Bd.5-OCH3SCH32-Cl1.4595 N Bd.5-OCH3SCH33-Cl1.4596 N Bd.5-OCH3SCH34-Cl1.4597 N Bd.5-OCH3SCH32-F1.4598 N Bd.5-OCH3SCH33-F1.4599 N Bd.5-OCH3SCH34-F1.4600 N Bd.5-OCH3SCH32-CH31.4601 N Bd.5-OCH3SCH33-CH31.4602 N Bd.5-OCH3SCH34-CH31.4603 N Bd.5-OCH3SCH32-OCH31.4604 N Bd.5-OCH3SCH33-OCH31.4605 N Bd.5-OCH3SCH34-OCH31.4606 N Bd.5-OCH3SCH32-CF31.4607 N Bd.5-OCH3SCH33-CF31.4608 N Bd.5-OCH3SCH34-CF31.4609 N Bd.5-OCH3SCH32-OCF31.4610 N Bd.5-OCH3SCH33-OCF31.4611 N Bd.5-OCH3SCH34-OCF31.4612 N Bd.5-OCH3SCH32-OCF2CF2
1.4613 N Bd.5-OCH3SCH33-OCF2CF21.4614 N Bd.5-OCH3SCH34-OCF2CF21.4615 N Bd.5-OCH3SCH32-OC2F51.4616 N Bd.5-OCH3SCH33-OC2F51.4617 N Bd.5-OCH3SCH34-OC2F51.4618 N Bd.5-OCH3SCH32-OC6H51.4619 N Bd.5-OCH3SCH33-OC6H51.4620 N Bd.5-OCH3SCH34-OC6H51.4621 N Bd.5-OCH3SCH32-C(O)C6H51.4622 N Bd.5-OCH3SCH33-C(O)C6H51.4623 N Bd.5-OCH3SCH34-C(O)C6H51.4624 N Bd.5-OCH3噻唑-4-基H1.4625 N Bd.5-OCH3噻唑-4-基2-Cl1.4626 N Bd.5-OCH3噻唑-4-基3-Cl1.4627 N Bd.5-OCH3噻唑-4-基4-Cl1.4628 N Bd.5-OCH3噻唑-4-基2-F1.4629 N Bd.5-OCH3噻唑-4-基3-F1.4630 N Bd.5-OCH3噻唑-4-基4-F1.4631 N Bd.5-OCH3噻唑-4-基2-CH31.4632 N Bd.5-OCH3噻唑-4-基3-CH31.4633 N Bd.5-OCH3噻唑-4-基4-CH31.4634 N Bd.5-OCH3噻唑-4-基2-OCH31.4635 N Bd.5-OCH3噻唑-4-基3-OCH31.4636 N Bd.5-OCH3噻唑-4-基4-OCH31.4637 N Bd.5-OCH3噻唑-4-基2-CF31.4638 N Bd.5-OCH3噻唑-4-基3-CF31.4639 N Bd.5-OCH3噻唑-4-基4-CF31.4640 N Bd.5-OCH3噻唑-4-基2-OCF31.4641 N Bd.5-OCH3噻唑-4-基3-OCF31.4642 N Bd.5-OCH3噻唑-4-基4-OCF31.4643 N Bd.5-OCH3噻唑-4-基2-OCF2CF21.4644 N Bd.5-OCH3噻唑-4-基3-OCF2CF21.4645 N Bd.5-OCH3噻唑-4-基4-OCF2CF21.4646 N Bd.5-OCH3噻唑-4-基2-OC2F51.4647 N Bd.5-OCH3噻唑-4-基3-OC2F51.4648 N Bd.5-OCH3噻唑-4-基4-OC2F51.4649 N Bd.5-OCH3噻唑-4-基2-OC6H51.4650 N Bd.5-OCH3噻唑-4-基3-OC6H51.4651 N Bd.5-OCH3噻唑-4-基4-OC6H51.4652 N Bd.5-OCH3噻唑-4-基2-C(O)C6H51.4653 N Bd.5-OCH3噻唑-4-基3-C(O)C6H51.4654 N Bd.5-OCH3噻唑-4-基4-C(O)C6H51.4655 N CH2H HH1.4656 N CH2H H2-Cl1.4657 N CH2H H3-Cl1.4658 N CH2H H4-Cl1.4659 N CH2H H2-F1.4660 N CH2H H3-F1.4661 N CH2H H4-F1.4662 N CH2H H2-CH31.4663 N CH2H H3-CH3
1.4664 NCH2H H 4-CH31.4665 NCH2H H 2-OCH31.4666 NCH2H H 3-OCH31.4667 NCH2H H 4-OCH31.4668 NCH2H H 2-CF31.4669 NCH2H H 3-CF31.4670 NCH2H H 4-CF31.4671 NCH2H H 2-OCF31.4672 NCH2H H 3-OCF31.4673 NCH2H H 4-OCF31.4674 NCH2H H 2-OCF2CF21.4675 NCH2H H 3-OCF2CF21.4676 NCH2H H 4-OCF2CF21.4677 NCH2H H 2-OC2F51.4678 NCH2H H 3-OC2F51.4679 NCH2H H 4-OC2F51.4680 NCH2H H 2-OC6H51.4681 NCH2H H 3-OC6H51.4682 NCH2H H 4-OC6H51.4683 NCH2H H 2-C(O)C6H51.4684 NCH2H H 3-C(O)C6H51.4685 NCH2H H 4-C(O)C6H51.4686 NCH2H CH3H1.4687 NCH2H CH32-Cl1.4688 NCH2H CH33-Cl1.4689 NCH2H CH34-Cl1.4690 NCH2H CH32-F1.4691 NCH2H CH33-F1.4692 NCH2H CH34-F1.4693 NCH2H CH32-CH31.4694 NCH2H CH33-CH31.4695 NCH2H CH34-CH31.4696 NCH2H CH32-OCH31.4697 NCH2H CH33-OCH31.4698 NCH2H CH34-OCH31.4699 NCH2H CH32-CF31.4700 NCH2H CH33-CF31.4701 NCH2H CH34-CF31.4702 NCH2H CH32-OCF31.4703 NCH2H CH33-OCF31.4704 NCH2H CH34-OCF31.4705 NCH2H CH32-OCF2CF21.4706 NCH2H CH33-OCF2CF21.4707 NCH2H CH34-OCF2CF21.4708 NCH2H CH32-OC2F51.4709 NCH2H CH33-OC2F51.4710 NCH2H CH34-OC2F51.4711 NCH2H CH32-OC6H51.4712 NCH2H CH33-OC6H51.4713 NCH2H CH34-OC6H51.4714 NCH2H CH32-C(O)C6H51.4715 NCH2H CH33-C(O)C6H51.4716 NCH2H CH34-C(O)C6H51.4717 NCH2H CF3H1.4718 NCH2H CF32-Cl
1.4719 NCH2H CF33-Cl1.4720 NCH2H CF34-Cl1.4721 NCH2H CF32-F1.4722 NCH2H CF33-F1.4723 NCH2H CF34-F1.4724 NCH2H CF32-CH31.4725 NCH2H CF33-CH31.4726 NCH2H CF34-CH31.4727 NCH2H CF32-OCH31.4728 NCH2H CF33-OCH31.4729 NCH2H CF34-OCH31.4730 NCH2H CF32-CF31.4731 NCH2H CF33-CF31.4732 NCH2H CF34-CF31.4733 NCH2H CF32-OCF31.4734 NCH2H CF33-OCF31.4735 NCH2H CF34-OCF31.4736 NCH2H CF32-OCF2CF21.4737 NCH2H CF33-OCF2CF21.4738 NCH2H CF34-OCF2CF21.4739 NCH2H CF32-OC2F51.4740 NCH2H CF33-OC2F51.4741 NCH2H CF34-OC2F51.4742 NCH2H CF32-OC6H51.4743 NCH2H CF33-OC6H51.4744 NCH2H CF34-OC6H51.4745 NCH2H CF32-C(O)C6H51.4746 NCH2H CF33-C(O)C6H51.4747 NCH2H CF34-C(O)C6H51.4748 NCH2H SCH3H1.4749 NCH2H SCH32-Cl1.4750 NCH2H SCH33-Cl1.4751 NCH2H SCH34-Cl1.4752 NCH2H SCH32-F1.4753 NCH2H SCH33-F1.4754 NCH2H SCH34-F1.4755 NCH2H SCH32-CH31.4756 NCH2H SCH33-CH31.4757 NCH2H SCH34-CH31.4758 NCH2H SCH32-OCH31.4759 NCH2H SCH33-OCH31.4760 NCH2H SCH34-OCH31.4761 NCH2H SCH32-CF31.4762 NCH2H SCH33-CF31.4763 NCH2H SCH34-CF31.4764 NCH2H SCH32-OCF31.4765 NCH2H SCH33-OCF31.4766 NCH2H SCH34-OCF31.4767 NCH2H SCH32-OCF2CF21.4768 NCH2H SCH33-OCF2CF21.4769 NCH2H SCH34-OCF2CF21.4770 NCH2H SCH32-OC2F51.4771 NCH2H SCH33-OC2F51.4772 NCH2H SCH34-OC2F51.4773 NCH2H SCH32-OC6H5
1.4774 NCH2H SCH33-OC6H51.4775 NCH2H SCH34-OC6H51.4776 NCH2H SCH32-C(O)C6H51.4777 NCH2H SCH33-C(O)C6H51.4778 NCH2H SCH34-C(O)C6H51.4779 NCH2H 噻唑-4-基H1.4780 NCH2H 噻唑-4-基2-Cl1.4781 NCH2H 噻唑-4-基3-Cl1.4782 NCH2H 噻唑-4-基4-Cl1.4783 NCH2H 噻唑-4-基2-F1.4784 NCH2H 噻唑-4-基3-F1.4785 NCH2H 噻唑-4-基4-F1.4786 NCH2H 噻唑-4-基2-CH31.4787 NCH2H 噻唑-4-基3-CH31.4788 NCH2H 噻唑-4-基4-CH31.4789 NCH2H 噻唑-4-基2-OCH31.4790 NCH2H 噻唑-4-基3-OCH31.4791 NCH2H 噻唑-4-基4-OCH31.4792 NCH2H 噻唑-4-基2-CF31.4793 NCH2H 噻唑-4-基3-CF31.4794 NCH2H 噻唑-4-基4-CF31.4795 NCH2H 噻唑-4-基2-OCF31.4796 NCH2H 噻唑-4-基3-OCF31.4797 NCH2H 噻唑-4-基4-OCF31.4798 NCH2H 噻唑-4-基2-OCF2CF21.4799 NCH2H 噻唑-4-基3-OCF2CF21.4800 NCH2H 噻唑-4-基4-OCF2CF21.4801 NCH2H 噻唑-4-基2-OC2F51.4802 NCH2H 噻唑-4-基3-OC2F51.4803 NCH2H 噻唑-4-基4-OC2F51.4804 NCH2H 噻唑-4-基2-OC6H51.4805 NCH2H 噻唑-4-基3-OC6H51.4806 NCH2H 噻唑-4-基4-OC6H51.4807 NCH2H 噻唑-4-基2-C(O)C6H51.4808 NCH2H 噻唑-4-基3-C(O)C6H51.4809 NCH2H 噻唑-4-基4-C(O)C6H51.4810 NCH25-Cl HH1.4811 NCH25-Cl H2-Cl1.4812 NCH25-Cl H3-Cl1.4813 NCH25-Cl H4-Cl1.4814 NCH25-Cl H2-F1.4815 NCH25-Cl H3-F1.4816 NCH25-Cl H4-F1.4817 NCH25-Cl H2-CH31.4818 NCH25-Cl H3-CH31.4819 NCH25-Cl H4-CH31.4820 NCH25-Cl H2-OCH31.4821 NCH25-Cl H3-OCH31.4822 NCH25-Cl H4-OCH31.4823 NCH25-Cl H2-CF31.4824 NCH25-Cl H3-CF3
1.4825 NCH25-ClH 4-CF31.4826 NCH25-ClH 2-OCF31.4827 NCH25-ClH 3-OCF31.4828 NCH25-ClH 4-OCF31.4829 NCH25-ClH 2-OCF2CF21.4830 NCH25-ClH 3-OCF2CF21.4831 NCH25-ClH 4-OCF2CF21.4832 NCH25-ClH 2-OC2F51.4833 NCH25-ClH 3-OC2F51.4834 NCH25-ClH 4-OC2F51.4835 NCH25-ClH 2-OC6H51.4836 NCH25-ClH 3-OC6H51.4837 NCH25-ClH 4-OC6H51.4838 NCH25-ClH 2-C(O)C6H51.4839 NCH25-ClH 3-C(O)C6H51.4840 NCH25-ClH 4-C(O)C6H51.4841 NCH25-ClCH3H1.4842 NCH25-ClCH32-Cl1.4843 NCH25-ClCH33-Cl1.4844 NCH25-ClCH34-Cl1.4845 NCH25-ClCH32-F1.4846 NCH25-ClCH33-F1.4847 NCH25-ClCH34-F1.4848 NCH25-ClCH32-CH31.4849 NCH25-ClCH33-CH31.4850 NCH25-ClCH34-CH31.4851 NCH25-ClCH32-OCH31.4852 NCH25-ClCH33-OCH31.4853 NCH25-ClCH34-OCH31.4854 NCH25-ClCH32-CF31.4855 NCH25-ClCH33-CF31.4856 NCH25-ClCH34-CF31.4857 NCH25-ClCH32-OCF31.4858 NCH25-ClCH33-OCF31.4859 NCH25-ClCH34-OCF31.4860 NCH25-ClCH32-OCF2CF21.4861 NCH25-ClCH33-OCF2CF21.4862 NCH25-ClCH34-OCF2CF21.4863 NCH25-ClCH32-OC2F51.4864 NCH25-ClCH33-OC2F51.4865 NCH25-ClCH34-OC2F51.4866 NCH25-ClCH32-OC6H51.4867 NCH25-ClCH33-OC6H51.4868 NCH25-ClCH34-OC6H51.4869 NCH25-ClCH32-C(O)C6H51.4870 NCH25-ClCH33-C(O)C6H51.4871 NCH25-ClCH34-C(O)C6H51.4872 NCH25-ClCF3H1.4873 NCH25-ClCF32-Cl1.4874 NCH25-ClCF33-Cl1.4875 NCH25-ClCF34-Cl1.4876 NCH25-ClCF32-F1.4877 NCH25-ClCF33-F1.4878 NCH25-ClCF34-F1.4879 NCH25-ClCF32-CH3
1.4880 NCH25-ClCF33-CH31.4881 NCH25-ClCF34-CH31.4882 NCH25-ClCF32-OCH31.4883 NCH25-ClCF33-OCH31.4884 NCH25-ClCF34-OCH31.4885 NCH25-ClCF32-CF31.4886 NCH25-ClCF33-CF31.4887 NCH25-ClCF34-CF31.4888 NCH25-ClCF32-OCF31.4889 NCH25-ClCF33-OCF31.4890 NCH25-ClCF34-OCF31.4891 NCH25-ClCF32-OCF2CF21.4892 NCH25-ClCF33-OCF2CF21.4893 NCH25-ClCF34-OCF2CF21.4894 NCH25-ClCF32-OC2F51.4895 NCH25-ClCF33-OC2F51.4896 NCH25-ClCF34-OC2F51.4897 NCH25-ClCF32-OC6H51.4898 NCH25-ClCF33-OC6H51.4899 NCH25-ClCF34-OC6H51.4900 NCH25-ClCF32-C(O)C6H51.4901 NCH25-ClCF33-C(O)C6H51.4902 NCH25-ClCF34-C(O)C6H51.4903 NCH25-ClSCH3H1.4904 NCH25-ClSCH32-Cl1.4905 NCH25-ClSCH33-Cl1.4906 NCH25-ClSCH34-Cl1.4907 NCH25-ClSCH32-F1.4908 NCH25-ClSCH33-F1.4909 NCH25-ClSCH34-F1.4910 NCH25-ClSCH32-CH31.4911 NCH25-ClSCH33-CH31.4912 NCH25-ClSCH34-CH31.4913 NCH25-ClSCH32-OCH31.4914 NCH25-ClSCH33-OCH31.4915 NCH25-ClSCH34-OCH31.4916 NCH25-ClSCH32-CF31.4917 NCH25-ClSCH33-CF31.4918 NCH25-ClSCH34-CF31.4919 NCH25-ClSCH32-OCF31.4920 NCH25-ClSCH33-OCF31.4921 NCH25-ClSCH34-OCF31.4922 NCH25-ClSCH32-OCF2CF21.4923 NCH25-ClSCH33-OCF2CF21.4924 NCH25-ClSCH34-OCF2CF21.4925 NCH25-ClSCH32-OC2F51.4926 NCH25-ClSCH33-OC2F51.4927 NCH25-ClSCH34-OC2F51.4928 NCH25-ClSCH32-OC6H51.4929 NCH25-ClSCH33-OC6H51.4930 NCH25-ClSCH34-OC6H51.4931 NCH25-ClSCH32-C(O)C6H51.4932 NCH25-ClSCH33-C(O)C6H51.4933 NCH25-ClSCH34-C(O)C6H51.4934 NCH25-Cl噻唑-4-基 H
1.4935 NCH25-Cl噻唑-4-基2-Cl1.4936 NCH25-Cl噻唑-4-基3-Cl1.4937 NCH25-Cl噻唑-4-基4-Cl1.4938 NCH25-Cl噻唑-4-基2-F1.4939 NCH25-Cl噻唑-4-基3-F1.4940 NCH25-Cl噻唑-4-基4-F1.4941 NCH25-Cl噻唑-4-基2-CH31.4942 NCH25-Cl噻唑-4-基3-CH31.4943 NCH25-Cl噻唑-4-基4-CH31.4944 NCH25-Cl噻唑-4-基2-OCH31.4945 NCH25-Cl噻唑-4-基3-OCH31.4946 NCH25-Cl噻唑-4-基4-OCH31.4947 NCH25-Cl噻唑-4-基2-CF31.4948 NCH25-Cl噻唑-4-基3-CF31.4949 NCH25-Cl噻唑-4-基4-CF31.4950 NCH25-Cl噻唑-4-基2-OCF31.4951 NCH25-Cl噻唑-4-基3-OCF31.4952 NCH25-Cl噻唑-4-基4-OCF31.4953 NCH25-Cl噻唑-4-基2-OCF2CF21.4954 NCH25-Cl噻唑-4-基3-OCF2CF21.4955 NCH25-Cl噻唑-4-基4-OCF2CF21.4956 NCH25-Cl噻唑-4-基2-OC2F51.4957 NCH25-Cl噻唑-4-基3-OC2F51.4958 NCH25-Cl噻唑-4-基4-OC2F51.4959 NCH25-Cl噻唑-4-基2-OC6H51.4960 NCH25-Cl噻唑-4-基3-OC6H51.4961 NCH25-Cl噻唑-4-基4-OC6H51.4962 NCH25-Cl噻唑-4-基2-C(O)C6H51.4963 NCH25-Cl噻唑-4-基3-C(O)C6H51.4964 NCH25-Cl噻唑-4-基4-C(O)C6H51.4965 NCH26-ClHH1.4966 NCH26-ClH2-Cl1.4967 NCH26-ClH3-Cl1.4968 NCH26-ClH4-Cl1.4969 NCH26-ClH2-F1.4970 NCH26-ClH3-F1.4971 NCH26-ClH4-F1.4972 NCH26-ClH2-CH31.4973 NCH26-ClH3-CH31.4974 NCH26-ClH4-CH31.4975 NCH26-ClH2-OCH31.4976 NCH26-ClH3-OCH31.4977 NCH26-ClH4-OCH31.4978 NCH26-ClH2-CF31.4979 NCH26-ClH3-CF31.4980 NCH26-ClH4-CF31.4981 NCH26-ClH2-OCF31.4982 NCH26-ClH3-OCF31.4983 NCH26-ClH4-OCF31.4984 NCH26-ClH2-OCF2CF21.4985 NCH26-ClH3-OCF2CF2
1.4986 NCH26-ClH 4-OCF2CF21.4987 NCH26-ClH 2-OC2F51.4988 NCH26-ClH 3-OC2F51.4989 NCH26-ClH 4-OC2F51.4990 NCH26-ClH 2-OC6H51.4991 NCH26-ClH 3-OC6H51.4992 NCH26-ClH 4-OC6H51.4993 NCH26-ClH 2-C(O)C6H51.4994 NCH26-ClH 3-C(O)C6H51.4995 NCH26-ClH 4-C(O)C6H51.4996 NCH26-ClCH3H1.4997 NCH26-ClCH32-Cl1.4998 NCH26-ClCH33-Cl1.4999 NCH26-ClCH34-Cl1.5000 NCH26-ClCH32-F1.5001 NCH26-ClCH33-F1.5002 NCH26-ClCH34-F1.5003 NCH26-ClCH32-CH31.5004 NCH26-ClCH33-CH31.5005 NCH26-ClCH34-CH31.5006 NCH26-ClCH32-OCH31.5007 NCH26-ClCH33-OCH31.5008 NCH26-ClCH34-OCH31.5009 NCH26-ClCH32-CF31.5010 NCH26-ClCH33-CF31.5011 NCH26-ClCH34-CF31.5012 NCH26-ClCH32-OCF31.5013 NCH26-ClCH33-OCF31.5014 NCH26-ClCH34-OCF31.5015 NCH26-ClCH32-OCF2CF21.5016 NCH26-ClCH33-OCF2CF21.5017 NCH26-ClCH34-OCF2CF21.5018 NCH26-ClCH32-OC2F51.5019 NCH26-ClCH33-OC2F51.5020 NCH26-ClCH34-OC2F51.5021 NCH26-ClCH32-OC6H51.5022 NCH26-ClCH33-OC6H51.5023 NCH26-ClCH34-OC6H51.5024 NCH26-ClCH32-C(O)C6H51.5025 NCH26-ClCH33-C(O)C6H51.5026 NCH26-ClCH34-C(O)C6H51.5027 NCH26-ClCF3H1.5028 NCH26-ClCF32-Cl1.5029 NCH26-ClCF33-Cl1.5030 NCH26-ClCF34-Cl1.5031 NCH26-ClCF32-F1.5032 NCH26-ClCF33-F1.5033 NCH26-ClCF34-F1.5034 NCH26-ClCF32-CH31.5035 NCH26-ClCF33-CH31.5036 NCH26-ClCF34-CH31.5037 NCH26-ClCF32-OCH31.5038 NCH26-ClCF33-OCH31.5039 NCH26-ClCF34-OCH31.5040 NCH26-ClCF32-CF3
1.5041 NCH26-ClCF33-CF31.5042 NCH26-ClCF34-CF31.5043 NCH26-ClCF32-OCF31.5044 NCH26-ClCF33-OCF31.5045 NCH26-ClCF34-OCF31.5046 NCH26-ClCF32-OCF2CF21.5047 NCH26-ClCF33-OCF2CF21.5048 NCH26-ClCF34-OCF2CF21.5049 NCH26-ClCF32-OC2F51.5050 NCH26-ClCF33-OC2F51.5051 NCH26-ClCF34-OC2F51.5052 NCH26-ClCF32-OC6H51.5053 NCH26-ClCF33-OC6H51.5054 NCH26-ClCF34-OC6H51.5055 NCH26-ClCF32-C(O)C6H51.5056 NCH26-ClCF33-C(O)C6H51.5057 NCH26-ClCF34-C(O)C6H51.5058 NCH26-ClSCH3H1.5059 NCH26-ClSCH32-Cl1.5060 NCH26-ClSCH33-Cl1.5061 NCH26-ClSCH34-Cl1.5062 NCH26-ClSCH32-F1.5063 NCH26-ClSCH33-F1.5064 NCH26-ClSCH34-F1.5065 NCH26-ClSCH32-CH31.5066 NCH26-ClSCH33-CH31.5067 NCH26-ClSCH34-CH31.5068 NCH26-ClSCH32-OCH31.5069 NCH26-ClSCH33-OCH31.5070 NCH26-ClSCH34-OCH31.5071 NCH26-ClSCH32-CF31.5072 NCH26-ClSCH33-CF31.5073 NCH26-ClSCH34-CF31.5074 NCH26-ClSCH32-OCF31.5075 NCH26-ClSCH33-OCF31.5076 NCH26-ClSCH34-OCF31.5077 NCH26-ClSCH32-OCF2CF21.5078 NCH26-ClSCH33-OCF2CF21.5079 NCH26-ClSCH34-OCF2CF21.5080 NCH26-ClSCH32-OC2F51.5081 NCH26-ClSCH33-OC2F51.5082 NCH26-ClSCH34-OC2F51.5083 NCH26-ClSCH32-OC6H51.5084 NCH26-ClSCH33-OC6H51.5085 NCH26-ClSCH34-OC6H51.5086 NCH26-ClSCH32-C(O)C6H51.5087 NCH26-ClSCH33-C(O)C6H51.5088 NCH26-ClSCH34-C(O)C6H51.5089 NCH26-Cl噻唑-4-基 H1.5090 NCH26-Cl噻唑-4-基 2-Cl1.5091 NCH26-Cl噻唑-4-基 3-Cl1.5092 NCH26-Cl噻唑-4-基 4-Cl1.5093 NCH26-Cl噻唑-4-基 2-F1.5094 NCH26-Cl噻唑-4-基 3-F
1.5095 NCH26-Cl噻唑-4-基4-F1.5096 NCH26-Cl噻唑-4-基2-CH31.5097 NCH26-Cl噻唑-4-基3-CH31.5098 NCH26-Cl噻唑-4-基4-CH31.5099 NCH26-Cl噻唑-4-基2-OCH31.5100 NCH26-Cl噻唑-4-基3-OCH31.5101 NCH26-Cl噻唑-4-基4-OCH31.5102 NCH26-Cl噻唑-4-基2-CF31.5103 NCH26-Cl噻唑-4-基3-CF31.5104 NCH26-Cl噻唑-4-基4-CF31.5105 NCH26-Cl噻唑-4-基2-OCF31.5106 NCH26-Cl噻唑-4-基3-OCF31.5107 NCH26-Cl噻唑-4-基4-OCF31.5108 NCH26-Cl噻唑-4-基2-OCF2CF21.5109 NCH26-Cl噻唑-4-基3-OCF2CF21.5110 NCH26-Cl噻唑-4-基4-OCF2CF21.5111 NCH26-Cl噻唑-4-基2-OC2F51.5112 NCH26-Cl噻唑-4-基3-OC2F51.5113 NCH26-Cl噻唑-4-基4-OC2F51.5114 NCH26-Cl噻唑-4-基2-OC6H51.5115 NCH26-Cl噻唑-4-基3-OC6H51.5116 NCH26-Cl噻唑-4-基4-OC6H51.5117 NCH26-Cl噻唑-4-基2-C(O)C6H51.5118 NCH26-Cl噻唑-4-基3-C(O)C6H51.5119 NCH26-Cl噻唑-4-基4-C(O)C6H51.5120 NCH25-F HH1.5121 NCH25-F H2-Cl1.5122 NCH25-F H3-Cl1.5123 NCH25-F H4-Cl1.5124 NCH25-F H2-F1.5125 NCH25-F H3-F1.5126 NCH25-F H4-F1.5127 NCH25-F H2-CH31.5128 NCH25-F H3-CH31.5129 NCH25-F H4-CH31.5130 NCH25-F H2-OCH31.5131 NCH25-F H3-OCH31.5132 NCH25-F H4-OCH31.5133 NCH25-F H2-CF31.5134 NCH25-F H3-CF31.5135 NCH25-F H4-CF31.5136 NCH25-F H2-OCF31.5137 NCH25-F H3-OCF31.5138 NCH25-F H4-OCF31.5139 NCH25-F H2-OCF2CF21.5140 NCH25-F H3-OCF2CF21.5141 NCH25-F H4-OCF2CF21.5142 NCH25-F H2-OC2F51.5143 NCH25-F H3-OC2F51.5144 NCH25-F H4-OC2F51.5145 NCH25-F H2-OC6H51.5146 NCH25-F H3-OC6H5
1.5147 NCH25-FH 4-OC6H51.5148 NCH25-FH 2-C(O)C6H51.5149 NCH25-FH 3-C(O)C6H51.5150 NCH25-FH 4-C(O)C6H51.5151 NCH25-FCH3H1.5152 NCH25-FCH32-Cl1.5153 NCH25-FCH33-Cl1.5154 NCH25-FCH34-Cl1.5155 NCH25-FCH32-F1.5156 NCH25-FCH33-F1.5157 NCH25-FCH34-F1.5158 NCH25-FCH32-CH31.5159 NCH25-FCH33-CH31.5160 NCH25-FCH34-CH31.5161 NCH25-FCH32-OCH31.5162 NCH25-FCH33-OCH31.5163 NCH25-FCH34-OCH31.5164 NCH25-FCH32-CF31.5165 NCH25-FCH33-CF31.5166 NCH25-FCH34-CF31.5167 NCH25-FCH32-OCF31.5168 NCH25-FCH33-OCF31.5169 NCH25-FCH34-OCF31.5170 NCH25-FCH32-OCF2CF21.5171 NCH25-FCH33-OCF2CF21.5172 NCH25-FCH34-OCF2CF21.5173 NCH25-FCH32-OC2F51.5174 NCH25-FCH33-OC2F51.5175 NCH25-FCH34-OC2F51.5176 NCH25-FCH32-OC6H51.5177 NCH25-FCH33-OC6H51.5178 NCH25-FCH34-OC6H51.5179 NCH25-FCH32-C(O)C6H51.5180 NCH25-FCH33-C(O)C6H51.5181 NCH25-FCH34-C(O)C6H51.5182 NCH25-FCF3H1.5183 NCH25-FCF32-Cl1.5184 NCH25-FCF33-Cl1.5185 NCH25-FCF34-Cl1.5186 NCH25-FCF32-F1.5187 NCH25-FCF33-F1.5188 NCH25-FCF34-F1.5189 NCH25-FCF32-CH31.5190 NCH25-FCF33-CH31.5191 NCH25-FCF34-CH31.5192 NCH25-FCF32-OCH31.5193 NCH25-FCF33-OCH31.5194 NCH25-FCF34-OCH31.5195 NCH25-FCF32-CF31.5196 NCH25-FCF33-CF31.5197 NCH25-FCF34-CF31.5198 NCH25-FCF32-OCF31.5199 NCH25-FCF33-OCF31.5200 NCH25-FCF34-OCF31.5201 NCH25-FCF32-OCF2CF2
1.5202 NCH25-FCF33-OCF2CF21.5203 NCH25-FCF34-OCF2CF21.5204 NCH25-FCF32-OC2F51.5205 NCH25-FCF33-OC2F51.5206 NCH25-FCF34-OC2F51.5207 NCH25-FCF32-OC6H51.5208 NCH25-FCF33-OC6H51.5209 NCH25-FCF34-OC6H51.5210 NCH25-FCF32-C(O)C6H51.5211 NCH25-FCF33-C(O)C6H51.5212 NCH25-FCF34-C(O)C6H51.5213 NCH25-FSCH3H1.5214 NCH25-FSCH32-Cl1.5215 NCH25-FSCH33-Cl1.5216 NCH25-FSCH34-Cl1.5217 NCH25-FSCH32-F1.5218 NCH25-FSCH33-F1.5219 NCH25-FSCH34-F1.5220 NCH25-FSCH32-CH31.5221 NCH25-FSCH33-CH31.5222 NCH25-FSCH34-CH31.5223 NCH25-FSCH32-OCH31.5224 NCH25-FSCH33-OCH31.5225 NCH25-FSCH34-OCH31.5226 NCH25-FSCH32-CF31.5227 NCH25-FSCH33-CF31.5228 NCH25-FSCH34-CF31.5229 NCH25-FSCH32-OCF31.5230 NCH25-FSCH33-OCF31.5231 NCH25-FSCH34-OCF31.5232 NCH25-FSCH32-OCF2CF21.5233 NCH25-FSCH33-OCF2CF21.5234 NCH25-FSCH34-OCF2CF21.5235 NCH25-FSCH32-OC2F51.5236 NCH25-FSCH33-OC2F51.5237 NCH25-FSCH34-OC2F51.5238 NCH25-FSCH32-OC6H51.5239 NCH25-FSCH33-OC6H51.5240 NCH25-FSCH34-OC6H51.5241 NCH25-FSCH32-C(O)C6H51.5242 NCH25-FSCH33-C(O)C6H51.5243 NCH25-FSCH34-C(O)C6H51.5244 NCH25-F噻唑-4-基 H1.5245 NCH25-F噻唑-4-基 2-Cl1.5246 NCH25-F噻唑-4-基 3-Cl1.5247 NCH25-F噻唑-4-基 4-Cl1.5248 NCH25-F噻唑-4-基 2-F1.5249 NCH25-F噻唑-4-基 3-F1.5250 NCH25-F噻唑-4-基 4-F1.5251 NCH25-F噻唑-4-基 2-CH31.5252 NCH25-F噻唑-4-基 3-CH31.5253 NCH25-F噻唑-4-基 4-CH31.5254 NCH25-F噻唑-4-基 2-OCH31.5255 NCH25-F噻唑-4-基 3-OCH3
1.5256 NCH25-F 噻唑-4-基4-OCH31.5257 NCH25-F 噻唑-4-基2-CF31.5258 NCH25-F 噻唑-4-基3-CF31.5259 NCH25-F 噻唑-4-基4-CF31.5260 NCH25-F 噻唑-4-基2-OCF31.5261 NCH25-F 噻唑-4-基3-OCF31.5262 NCH25-F 噻唑-4-基4-OCF31.5263 NCH25-F 噻唑-4-基2-OCF2CF21.5264 NCH25-F 噻唑-4-基3-OCF2CF21.5265 NCH25-F 噻唑-4-基4-OCF2CF21.5266 NCH25-F 噻唑-4-基2-OC2F51.5267 NCH25-F 噻唑-4-基3-OC2F51.5268 NCH25-F 噻唑-4-基4-OC2F51.5269 NCH25-F 噻唑-4-基2-OC6H51.5270 NCH25-F 噻唑-4-基3-OC6H51.5271 NCH25-F 噻唑-4-基4-OC6H51.5272 NCH25-F 噻唑-4-基2-C(O)C6H51.5273 NCH25-F 噻唑-4-基3-C(O)C6H51.5274 NCH25-F 噻唑-4-基4-C(O)C6H51.5275 NCH25-CN HH1.5276 NCH25-CN H2-Cl1.5277 NCH25-CN H3-Cl1.5278 NCH25-CN H4-Cl1.5279 NCH25-CN H2-F1.5280 NCH25-CN H3-F1.5281 NCH25-CN H4-F1.5282 NCH25-CN H2-CH31.5283 NCH25-CN H3-CH31.5284 NCH25-CN H4-CH31.5285 NCH25-CN H2-OCH31.5286 NCH25-CN H3-OCH31.5287 NCH25-CN H4-OCH31.5288 NCH25-CN H2-CF31.5289 NCH25-CN H3-CF31.5290 NCH25-CN H4-CF31.5291 NCH25-CN H2-OCF31.5292 NCH25-CN H3-OCF31.5293 NCH25-CN H4-OCF31.5294 NCH25-CN H2-OCF2CF21.5295 NCH25-CN H3-OCF2CF21.5296 NCH25-CN H4-OCF2CF21.5297 NCH25-CN H2-OC2F51.5298 NCH25-CN H3-OC2F51.5299 NCH25-CN H4-OC2F51.5300 NCH25-CN H2-OC6H51.5301 NCH25-CN H3-OC6H51.5302 NCH25-CN H4-OC6H51.5303 NCH25-CN H2-C(O)C6H51.5304 NCH25-CN H3-C(O)C6H51.5305 NCH25-CN H4-C(O)C6H51.5306 NCH25-CN CH3H1.5307 NCH25-CN CH32-Cl1.5308 NCH25-CN CH33-Cl
1.5309 NCH25-CN CH34-Cl1.5310 NCH25-CN CH32-F1.5311 NCH25-CN CH33-F1.5312 NCH25-CN CH34-F1.5313 NCH25-CN CH32-CH31.5314 NCH25-CN CH33-CH31.5315 NCH25-CN CH34-CH31.5316 NCH25-CN CH32-OCH31.5317 NCH25-CN CH33-OCH31.5318 NCH25-CN CH34-OCH31.5319 NCH25-CN CH32-CF31.5320 NCH25-CN CH33-CF31.5321 NCH25-CN CH34-CF31.5322 NCH25-CN CH32-OCF31.5323 NCH25-CN CH33-OCF31.5324 NCH25-CN CH34-OCF31.5325 NCH25-CN CH32-OCF2CF21.5326 NCH25-CN CH33-OCF2CF21.5327 NCH25-CN CH34-OCF2CF21.5328 NCH25-CN CH32-OC2F51.5329 NCH25-CN CH33-OC2F51.5330 NCH25-CN CH34-OC2F51.5331 NCH25-CN CH32-OC6H51.5332 NCH25-CN CH33-OC6H51.5333 NCH25-CN CH34-OC6H51.5334 NCH25-CN CH32-C(O)C6H51.5335 NCH25-CN CH33-C(O)C6H51.5336 NCH25-CN CH34-C(O)C6H51.5337 NCH25-CN CF3H1.5338 NCH25-CN CF32-Cl1.5339 NCH25-CN CF33-Cl1.5340 NCH25-CN CF34-Cl1.5341 NCH25-CN CF32-F1.5342 NCH25-CN CF33-F1.5343 NCH25-CN CF34-F1.5344 NCH25-CN CF32-CH31.5345 NCH25-CN CF33-CH31.5346 NCH25-CN CF34-CH31.5347 NCH25-CN CF32-OCH31.5348 NCH25-CN CF33-OCH31.5349 NCH25-CN CF34-OCH31.5350 NCH25-CN CF32-CF31.5351 NCH25-CN CF33-CF31.5352 NCH25-CN CF34-CF31.5353 NCH25-CN CF32-OCF31.5354 NCH25-CN CF33-OCF31.5355 NCH25-CN CF34-OCF31.5356 NCH25-CN CF32-OCF2CF21.5357 NCH25-CN CF33-OCF2CF21.5358 NCH25-CN CF34-OCF2CF21.5359 NCH25-CN CF32-OC2F51.5360 NCH25-CN CF33-OC2F51.5361 NCH25-CN CF34-OC2F51.5362 NCH25-CN CF32-OC6H51.5363 NCH25-CN CF33-OC6H5
1.5364 NCH25-CNCF34-OC6H51.5365 NCH25-CNCF32-C(O)C6H51.5366 NCH25-CNCF33-C(O)C6H51.5367 NCH25-CNCF34-C(O)C6H51.5368 NCH25-CNSCH3H1.5369 NCH25-CNSCH32-Cl1.5370 NCH25-CNSCH33-Cl1.5371 NCH25-CNSCH34-Cl1.5372 NCH25-CNSCH32-F1.5373 NCH25-CNSCH33-F1.5374 NCH25-CNSCH34-F1.5375 NCH25-CNSCH32-CH31.5376 NCH25-CNSCH33-CH31.5377 NCH25-CNSCH34-CH31.5378 NCH25-CNSCH32-OCH31.5379 NCH25-CNSCH33-OCH31.5380 NCH25-CNSCH34-OCH31.5381 NCH25-CNSCH32-CF31.5382 NCH25-CNSCH33-CF31.5383 NCH25-CNSCH34-CF31.5384 NCH25-CNSCH32-OCF31.5385 NCH25-CNSCH33-OCF31.5386 NCH25-CNSCH34-OCF31.5387 NCH25-CNSCH32-OCF2CF21.5388 NCH25-CNSCH33-OCF2CF21.5389 NCH25-CNSCH34-OCF2CF21.5390 NCH25-CNSCH32-OC2F51.5391 NCH25-CNSCH33-OC2F51.5392 NCH25-CNSCH34-OC2F51.5393 NCH25-CNSCH32-OC6H51.5394 NCH25-CNSCH33-OC6H51.5395 NCH25-CNSCH34-OC6H51.5396 NCH25-CNSCH32-C(O)C6H51.5397 NCH25-CNSCH33-C(O)C6H51.5398 NCH25-CNSCH34-C(O)C6H51.5399 NCH25-CN噻唑-4-基 H1.5400 NCH25-CN噻唑-4-基 2-Cl1.5401 NCH25-CN噻唑-4-基 3-Cl1.5402 NCH25-CN噻唑-4-基 4-Cl1.5403 NCH25-CN噻唑-4-基 2-F1.5404 NCH25-CN噻唑-4-基 3-F1.5405 NCH25-CN噻唑-4-基 4-F1.5406 NCH25-CN噻唑-4-基 2-CH31.5407 NCH25-CN噻唑-4-基 3-CH31.5408 NCH25-CN噻唑-4-基 4-CH31.5409 NCH25-CN噻唑-4-基 2-OCH31.5410 NCH25-CN噻唑-4-基 3-OCH31.5411 NCH25-CN噻唑-4-基 4-OCH31.5412 NCH25-CN噻唑-4-基 2-CF31.5413 NCH25-CN噻唑-4-基 3-CF31.5414 NCH25-CN噻唑-4-基 4-CF31.5415 NCH25-CN噻唑-4-基 2-OCF31.5416 NCH25-CN噻唑-4-基 3-OCF3
1.5417 NCH25-CN 噻唑-4-基4-OCF31.5418 NCH25-CN 噻唑-4-基2-OCF2CF21.5419 NCH25-CN 噻唑-4-基3-OCF2CF21.5420 NCH25-CN 噻唑-4-基4-OCF2CF21.5421 NCH25-CN 噻唑-4-基2-OC2F51.5422 NCH25-CN 噻唑-4-基3-OC2F51.5423 NCH25-CN 噻唑-4-基4-OC2F51.5424 NCH25-CN 噻唑-4-基2-OC6H51.5425 NCH25-CN 噻唑-4-基3-OC6H51.5426 NCH25-CN 噻唑-4-基4-OC6H51.5427 NCH25-CN 噻唑-4-基2-C(O)C6H51.5428 NCH25-CN 噻唑-4-基3-C(O)C6H51.5429 NCH25-CN 噻唑-4-基4-C(O)C6H51.5430 NCH25-OCH3HH1.5431 NCH25-OCH3H2-Cl1.5432 NCH25-OCH3H3-Cl1.5433 NCH25-OCH3H4-Cl1.5434 NCH25-OCH3H2-F1.5435 NCH25-OCH3H3-F1.5436 NCH25-OCH3H4-F1.5437 NCH25-OCH3H2-CH31.5438 NCH25-OCH3H3-CH31.5439 NCH25-OCH3H4-CH31.5440 NCH25-OCH3H2-OCH31.5441 NCH25-OCH3H3-OCH31.5442 NCH25-OCH3H4-OCH31.5443 NCH25-OCH3H2-CF31.5444 NCH25-OCH3H3-CF31.5445 NCH25-OCH3H4-CF31.5446 NCH25-OCH3H2-OCF31.5447 NCH25-OCH3H3-OCF31.5448 NCH25-OCH3H4-OCF31.5449 NCH25-OCH3H2-OCF2CF21.5450 NCH25-OCH3H3-OCF2CF21.5451 NCH25-OCH3H4-OCF2CF21.5452 NCH25-OCH3H2-OC2F51.5453 NCH25-OCH3H3-OC2F51.5454 NCH25-OCH3H4-OC2F51.5455 NCH25-OCH3H2-OC6H51.5456 NCH25-OCH3H3-OC6H51.5457 NCH25-OCH3H4-OC6H51.5458 NCH25-OCH3H2-C(O)C6H51.5459 NCH25-OCH3H3-C(O)C6H51.5460 NCH25-OCH3H4-C(O)C6H51.5461 NCH25-OCH3CH3H1.5462 NCH25-OCH3CH32-Cl1.5463 NCH25-OCH3CH33-Cl1.5464 NCH25-OCH3CH34-Cl1.5465 NCH25-OCH3CH32-F1.5466 NCH25-OCH3CH33-F1.5467 NCH25-OCH3CH34-F1.5468 NCH25-OCH3CH32-CH31.5469 NCH25-OCH3CH33-CH31.5470 NCH25-OCH3CH34-CH3
1.5471 NCH25-OCH3CH32-OCH31.5472 NCH25-OCH3CH33-OCH31.5473 NCH25-OCH3CH34-OCH31.5474 NCH25-OCH3CH32-CF31.5475 NCH25-OCH3CH33-CF31.5476 NCH25-OCH3CH34-CF31.5477 NCH25-OCH3CH32-OCF31.5478 NCH25-OCH3CH33-OCF31.5479 NCH25-OCH3CH34-OCF31.5480 NCH25-OCH3CH32-OCF2CF21.5481 NCH25-OCH3CH33-OCF2CF21.5482 NCH25-OCH3CH34-OCF2CF21.5483 NCH25-OCH3CH32-OC2F51.5484 NCH25-OCH3CH33-OC2F51.5485 NCH25-OCH3CH34-OC2F51.5486 NCH25-OCH3CH32-OC6H51.5487 NCH25-OCH3CH33-OC6H51.5488 NCH25-OCH3CH34-OC6H51.5489 NCH25-OCH3CH32-C(O)C6H51.5490 NCH25-OCH3CH33-C(O)C6H51.5491 NCH25-OCH3CH34-C(O)C6H51.5492 NCH25-OCH3CF3H1.5493 NCH25-OCH3CF32-Cl1.5494 NCH25-OCH3CF33-Cl1.5495 NCH25-OCH3CF34-Cl1.5496 NCH25-OCH3CF32-F1.5497 NCH25-OCH3CF33-F1.5498 NCH25-OCH3CF34-F1.5499 NCH25-OCH3CF32-CH31.5500 NCH25-OCH3CF33-CH31.5501 NCH25-OCH3CF34-CH31.5502 NCH25-OCH3CF32-OCH31.5503 NCH25-OCH3CF33-OCH31.5504 NCH25-OCH3CF34-OCH31.5505 NCH25-OCH3CF32-CF31.5506 NCH25-OCH3CF33-CF31.5507 NCH25-OCH3CF34-CF31.5508 NCH25-OCH3CF32-OCF31.5509 NCH25-OCH3CF33-OCF31.5510 NCH25-OCH3CF34-OCF31.5511 NCH25-OCH3CF32-OCF2CF21.5512 NCH25-OCH3CF33-OCF2CF21.5513 NCH25-OCH3CF34-OCF2CF21.5514 NCH25-OCH3CF32-OC2F51.5515 NCH25-OCH3CF33-OC2F51.5516 NCH25-OCH3CF34-OC2F51.5517 NCH25-OCH3CF32-OC6H51.5518 NCH25-OCH3CF33-OC6H51.5519 NCH25-OCH3CF34-OC6H51.5520 NCH25-OCH3CF32-C(O)C6H51.5521 NCH25-OCH3CF33-C(O)C6H51.5522 NCH25-OCH3CF34-C(O)C6H51.5523 NCH25-OCH3SCH3H1.5524 NCH25-OCH3SCH32-Cl1.5525 NCH25-OCH3SCH33-Cl
1.5526 NCH25-OCH3SCH34-Cl1.5527 NCH25-OCH3SCH32-F1.5528 NCH25-OCH3SCH33-F1.5529 NCH25-OCH3SCH34-F1.5530 NCH25-OCH3SCH32-CH31.5531 NCH25-OCH3SCH33-CH31.5532 NCH25-OCH3SCH34-CH31.5533 NCH25-OCH3SCH32-OCH31.5534 NCH25-OCH3SCH33-OCH31.5535 NCH25-OCH3SCH34-OCH31.5536 NCH25-OCH3SCH32-CF31.5537 NCH25-OCH3SCH33-CF31.5538 NCH25-OCH3SCH34-CF31.5539 NCH25-OCH3SCH32-OCF31.5540 NCH25-OCH3SCH33-OCF31.5541 NCH25-OCH3SCH34-OCF31.5542 NCH25-OCH3SCH32-OCF2CF21.5543 NCH25-OCH3SCH33-OCF2CF21.5544 NCH25-OCH3SCH34-OCF2CF21.5545 NCH25-OCH3SCH32-OC2F51.5546 NCH25-OCH3SCH33-OC2F51.5547 NCH25-OCH3SCH34-OC2F51.5548 NCH25-OCH3SCH32-OC6H51.5549 NCH25-OCH3SCH33-OC6H51.5550 NCH25-OCH3SCH34-OC6H51.5551 NCH25-OCH3SCH32-C(O)C6H51.5552 NCH25-OCH3SCH33-C(O)C6H51.5553 NCH25-OCH3SCH34-C(O)C6H51.5554 NCH25-OCH3噻唑-4-基H1.5555 NCH25-OCH3噻唑-4-基2-Cl1.5556 NCH25-OCH3噻唑-4-基3-Cl1.5557 NCH25-OCH3噻唑-4-基4-Cl1.5558 NCH25-OCH3噻唑-4-基2-F1.5559 NCH25-OCH3噻唑-4-基3-F1.5560 NCH25-OCH3噻唑-4-基4-F1.5561 NCH25-OCH3噻唑-4-基2-CH31.5562 NCH25-OCH3噻唑-4-基3-CH31.5563 NCH25-OCH3噻唑-4-基4-CH31.5564 NCH25-OCH3噻唑-4-基2-OCH31.5565 NCH25-OCH3噻唑-4-基3-OCH31.5566 NCH25-OCH3噻唑-4-基4-OCH31.5567 NCH25-OCH3噻唑-4-基2-CF31.5568 NCH25-OCH3噻唑-4-基3-CF31.5569 NCH25-OCH3噻唑-4-基4-CF31.5570 NCH25-OCH3噻唑-4-基2-OCF31.5571 NCH25-OCH3噻唑-4-基3-OCF31.5572 NCH25-OCH3噻唑-4-基4-OCF31.5573 NCH25-OCH3噻唑-4-基2-OCF2CF21.5574 NCH25-OCH3噻唑-4-基3-OCF2CF21.5575 NCH25-OCH3噻唑-4-基4-OCF2CF21.5576 NCH25-OCH3噻唑-4-基2-OC2F51.5577 NCH25-OCH3噻唑-4-基3-OC2F5
1.5578 NCH25-OCH3噻唑-4-基4-OC2F51.5579 NCH25-OCH3噻唑-4-基2-OC6H51.5580 NCH25-OCH3噻唑-4-基3-OC6H51.5581 NCH25-OCH3噻唑-4-基4-OC6H51.5582 NCH25-OCH3噻唑-4-基2-C(O)C6H51.5583 NCH25-OCH3噻唑-4-基3-C(O)C6H51.5584 NCH25-OCH3噻唑-4-基4-C(O)C6H5
生物學(xué)實(shí)施例1.經(jīng)口給藥治療蒙古種沙鼠(長爪沙鼠)的毛圓線蟲和捻轉(zhuǎn)血矛線蟲的體內(nèi)測定通過人工喂養(yǎng)采用約2000個第三期的幼蟲蛇形毛圓線蟲和捻轉(zhuǎn)血矛線蟲使6-8周大的蒙古種沙鼠感染。感染6天后，將該沙鼠用N2O輕微麻醉，并經(jīng)口給予所試化合物，所述化合物溶于2份的DMSO和1份的聚乙二醇(PEG 300)混合物中，給藥量分別為100、32和10-0.1mg/kg。于第9天(治療3天后)，當(dāng)仍存在的大部分捻轉(zhuǎn)血矛線蟲為第四期的幼蟲以及大部分毛圓線蟲為不成熟的成蟲時(shí)，殺死沙鼠以計(jì)數(shù)寄生蟲的數(shù)量。其治療效果以每一沙鼠中的寄生蟲與8個感染寄生蟲但未治療的沙鼠中寄生蟲的幾何平均數(shù)相比的減少數(shù)量的％表示。
在該測試中，采用式I合物(特別如表1所示的化合物)治療沙鼠的線蟲感染有大量減少。
為測定式I化合物在動物和植物體內(nèi)的殺蟲和/或殺螨活性，可以采用下述試驗(yàn)方法。
2.絲光綠蠅L1幼蟲活性于約50℃，將1ml所試活性物質(zhì)的水懸浮液與3ml特別的幼蟲生長培養(yǎng)液混合，從而得到含有250或125ppm活性成分的均勻混合物。在每一測試試管樣本中，均使用約30綠蠅幼蟲(L1)。4天后，測定死亡率。
3.對微小牛蜱(Biarra strain)的殺螨活性將一片粘性膠帶水平地連接至PVC片，以便使10個飽食的雌性微小牛蜱(Biarra strain)的背部粘附在上面，并排成一列。采用注射針，將1μl液體注射入每一蜱中。該液體為1∶1的聚乙二醇和丙酮混合物，并且包含溶于其中的一定量的選自1、0.1或0.01μg每蜱的活性成分。給予對照組動物注射不含活性成分的液體。治療后，將該動物在通常條件下喂養(yǎng)(如在昆蟲館，于約28℃和80％的相對濕度下)至產(chǎn)卵，并且自對照組動物卵中產(chǎn)出幼蟲為止。所試物質(zhì)的活性以IR90確定，即以30天后，9/10的雌性蜱(＝90％)產(chǎn)的卵仍是不育的活性成分的量評價(jià)。
4.對飽食的雌性微小牛蜱(BIARRA)的體外效果將OP抗性的BIARRA strain的4×10只飽食的雌性蜱粘附于粘性帶上并用吸滿所試化合物的乳液或懸浮液(濃度分別為500、125、31和8ppm的藥棉球覆蓋1小時(shí))。于28天后，以死亡率、產(chǎn)卵和孵化幼蟲來評價(jià)所試化合物的效果。
所試化合物的活性以具有下列行為的雌性蜱的數(shù)量表示-產(chǎn)卵前迅速死亡，-存活一段時(shí)間，未產(chǎn)卵，-產(chǎn)卵，但未形成胚胎，-產(chǎn)卵且形成胚胎，但無幼蟲孵化，以及-產(chǎn)卵且形成胚胎，通常于26-27天孵化幼蟲。
5.對花蜱屬(Amblyomma)hebraeum若蟲的體外效果將約5個禁食的若蟲置于含有2ml的所試化合物的溶液、懸浮液或乳液的聚苯乙烯試管中。
浸泡10分鐘后，在旋轉(zhuǎn)混合器上搖晃2×10秒，將一緊密的藥棉球塞入試管并旋轉(zhuǎn)。當(dāng)所有的液體被藥棉球吸收后，將藥棉球推至仍舊旋轉(zhuǎn)的試管中間，以使大部分液體壓出藥棉球并流入下面的皮氏培養(yǎng)皿中。
隨后于室溫下，將該試管置于光照的室內(nèi)待測。14天后，將試管浸入裝有沸水的燒杯中。如果蜱對溫度有反應(yīng)且開始移動，則所試物質(zhì)在測試的濃度下無活性，否則認(rèn)為蜱已經(jīng)死亡，即認(rèn)為所試物質(zhì)在測試的濃度下有活性。所有測試物質(zhì)的濃度范圍為0.1至100ppm。
6.抗雞皮刺螨活性將2至3ml含有10ppm活性成分的溶液和約200個在不同發(fā)育時(shí)期的螨(雞皮刺螨)加至于頂部開口的玻璃容器中。隨后用一塊藥棉密封該容器，搖晃10分鐘至螨完全濕透，然后快速倒置以使剩余的測試溶液被藥棉吸收。3天后，通過計(jì)數(shù)死亡個體以確定螨的死亡率，并以百分比表示。
7.抗家蠅活性用試驗(yàn)物質(zhì)的溶液處理方糖以使所試驗(yàn)物質(zhì)在糖中的濃度(干燥過夜后)為250ppm。將以此方法處理后的方糖置于放有濕潤的藥棉和10個OP抗性株的成熟家蠅的鋁碟中，用燒杯覆蓋并于25℃培養(yǎng)。24小時(shí)后測定死亡率。
權(quán)利要求
1.式I化合物 其中R1表示氫、鹵素、氰基、硝基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷硫基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷基羰基、鹵代-C1-C6-烷基羰基、C1-C6-烷基亞硫酰基、C1-C6-烷基磺?；1-C6-烷基氨基、二(C1-C6-烷基)氨基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫酰基、鹵代-C1-C6-烷基亞硫酰基、C1-C6-烷基磺?；望u代-C1-C6-烷基磺酰基；R2表示氫、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷硫基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷基亞硫?；1-C6-烷基磺?；R8R9、未取代或被一次或多次取代的雜芳基、未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基和鹵代-C1-C6-烷氧基；R3、R4和R5也互相獨(dú)立，表示氫、鹵素、C1-C6-烷基、鹵代-C1-C6-烷基、未取代或被一次或多次取代的C3-C6-環(huán)烷基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素和C1-C6-烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；?、鹵代-C1-C6-烷基亞硫?；1-C6-烷基磺?；?、鹵代-C1-C6-烷基磺?；1-C6-烷基氨基或二-(C1-C6-烷基)氨基；或R4和R5一起表示C2-C6-亞烷基；R6表示氫、C1-C6-烷基、C1-C6-烷基羰基、C1-C6-烷氧基-C1-C6-烷基、氨基羰基、C1-C6-烷氧基羰基、鹵代-C1-C6-烷基羰基、硫代-C1-C6-烷基羰基或芐基；R7表示氫、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基、二(C1-C6-烷基)氨基、未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基、鹵代-C2-C6-鏈烯基、C2-C6-炔基、C3-C6-環(huán)烷基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基磺酰基氧基、鹵代-C1-C6-烷基磺酰基氧基、C1-C6-烷基亞硫酰基、鹵代-C1-C6-烷基亞硫酰基、C1-C6-烷基磺?；?、鹵代-C1-C6-烷基磺?；2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫?；Ⅺu代-C2-C6-鏈烯基亞硫?；2-C6-鏈烯基磺?；?、鹵代-C2-C6-鏈烯基磺酰基、C1-C6-烷基氨基、二(C1-C6-烷基)氨基、C1-C6-烷基磺酰基氨基、鹵代-C1-C6-烷基磺?；被?、C1-C6-烷基羰基、鹵代-C1-C6-烷基羰基、C1-C6-烷氧基羰基、C1-C6-烷基氨基羰基、二(C1-C6-烷基)氨基羰基；未取代或被一次或多次取代的芳基-C1-C6-烷基、未取代或被一次或多次取代的芳基氨基、未取代或被一次或多次取代的芳基羰基、未取代或被一次或多次取代的芳基羰基氧基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C6-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C6-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺酰基、未取代或被一次或多次取代的芳基磺?；被?、未取代或被一次或多次取代的吡啶基氧基和未取代或被一次或多次取代的苯基乙炔基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；Ⅺu代-C1-C6-烷基亞硫?；?、C1-C6-烷基磺?；望u代-C1-C6-烷基磺?；?；未取代或被一次或多次取代的雜芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；?、鹵代-C1-C6-烷基亞硫?；2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫酰基、鹵代-C2-C6-鏈烯基亞硫?；1-C6-烷基磺?；望u代-C1-C6-烷基磺酰基、C2-C6-鏈烯基磺?；?、鹵代-C2-C6-鏈烯基磺?；1-C6-烷基氨基和二-(C1-C6-烷基)氨基；未取代或被一次或多次取代的萘基或喹啉基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C6-烷基、鹵代-C1-C6-烷基、C1-C6-烷氧基、鹵代-C1-C6-烷氧基、C2-C6-鏈烯基氧基、鹵代-C2-C6-鏈烯基氧基、C1-C6-烷硫基、鹵代-C1-C6-烷硫基、C1-C6-烷基亞硫?；Ⅺu代-C1-C6-烷基亞硫?；?、C2-C6-鏈烯硫基、鹵代-C2-C6-鏈烯硫基、C2-C6-鏈烯基亞硫酰基、鹵代-C2-C6-鏈烯基亞硫酰基、C1-C6-烷基磺?；望u代-C1-C6-烷基磺酰基、C2-C6-鏈烯基磺?；?、鹵代-C2-C6-鏈烯基磺?；?、C1-C6-烷基氨基和二-(C1-C6-烷基)氨基；R8和R9互相獨(dú)立，表示氫、C1-C6-烷基、C1-C6-烷氧基羰基、C1-C6-烷基羰基、C1-C6-烷硫基羰基、硫代-C1-C6-烷基羰基、芳基或雜芳基；X表示C(R10)或N；R10表示氫、氰基、硝基、C1-C6-烷基、鹵代-C1-C6-烷基或C1-C6-烷氧基；Y表示鍵、C(O)、C(S)或S(O)n；a表示1、2或3；且n為0、1或2。
2.權(quán)利要求1的化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C4-烷基磺?；蛭慈〈蛉〈谋窖趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基。
3.權(quán)利要求1的式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基。
4.權(quán)利要求1的式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基。
5.權(quán)利要求1的式I化合物，其中R2表示氫、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷硫基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基或C1-C4-烷基磺?；?br> 6.權(quán)利要求1的式I化合物，其中R2表示氫、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷硫基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基。
7.權(quán)利要求1的式I化合物，其中R2表示氫、甲基、鹵代甲基、甲硫基、甲氧基或鹵代甲氧基。
8.權(quán)利要求1的式I化合物，其中R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C3-C6-環(huán)烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基；C1-C4-烷硫基和鹵代-C1-C4-烷硫基；或R4和R5一起為C2-C6-亞烷基。
9.權(quán)利要求1的式I化合物，其中R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C2-烷基、鹵代-C1-C2-烷基或C3-C6-環(huán)烷基。
10.權(quán)利要求1的式I化合物，其中R3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C2-烷基、鹵代-C1-C2-烷基或C3-C6-環(huán)烷基。
11.權(quán)利要求1的式I化合物，其中R3、R4和R5互相獨(dú)立，為氫、甲基或鹵代甲基。
12.權(quán)利要求1的式I化合物，其中R6為氫、C1-C4-烷基、C1-C4-烷基羰基、C1-C6-烷氧基-C1-C6-烷基或芐基。
13.權(quán)利要求1的式I化合物，其中R6為氫、C1-C2-烷基、C1-C2-烷基羰基或芐基。
14.權(quán)利要求1的式I化合物，其中R6為氫或C1-C2-烷基。
15.權(quán)利要求1的式I化合物，其中R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基、鹵代-C2-C4-鏈烯基、C2-C4-炔基、C3-C6-環(huán)烷基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；趸Ⅺu代-C1-C4-烷基磺?；趸1-C4-烷基磺?；Ⅺu代-C1-C4-烷基磺?；?、C2-C4-鏈烯基磺?；?、鹵代-C2-C4-鏈烯基磺?；?、C1-C4-烷基氨基、二(C1-C4-烷基)氨基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C6-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺?；臀慈〈虮灰淮位蚨啻稳〈倪拎せ趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺酰基；未取代或被一次或多次取代的雜芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；未取代或被一次或多次取代的萘基或喹啉基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C2-C4-鏈烯硫基、鹵代-C2-C4-鏈烯硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺酰基。
16.權(quán)利要求1的式I化合物，其中R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；Ⅺu代-C1-C2-烷基磺?；?、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C2-烷基和未取代或被一次或多次取代的吡啶基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺酰基和鹵代-C1-C2-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈碾s芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；望u代-C1-C2-烷基磺酰基。
17.權(quán)利要求1的式I化合物，其中R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基和未取代或被一次或多次取代的芳基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基和鹵代-C1-C2-烷氧基。
18.權(quán)利要求1的式I化合物，其中R10表示氫、氰基、硝基或C1-C4-烷基。
19.權(quán)利要求1的式I化合物，其中R10表示氫或氰基。
20.權(quán)利要求1的式I化合物，其中R10表示氫。
21.權(quán)利要求1的式I化合物，其中Y為C(O)或S(O)n。
22.權(quán)利要求1的式I化合物，其中Y為C(O)。
23.權(quán)利要求1的式I化合物，其中a為1或2。
24.權(quán)利要求1的式I化合物，其中a為1。
25.權(quán)利要求1的式I化合物，其中n為2。
26.權(quán)利要求1的式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C4-烷基磺?；蛭慈〈蛉〈谋窖趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；R2為氫、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷硫基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基或C1-C4-烷基磺?；籖3、R4和R5互相獨(dú)立，為氫、鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C3-C6-環(huán)烷基；未取代或被一次或多次取代的苯基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基；C1-C4-烷硫基和鹵代-C1-C4-烷硫基；或R4和R5一起為C2-C6-亞烷基；R6為氫、C1-C4-烷基、C1-C4-烷基羰基、C1-C6-烷氧基-C1-C6-烷基或芐基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基、鹵代-C2-C4-鏈烯基、C2-C4-炔基、C3-C6-環(huán)烷基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺?；趸?、鹵代-C1-C4-烷基磺?；趸?、C1-C4-烷基磺?；?、鹵代-C1-C4-烷基磺?；2-C4-鏈烯基磺?；Ⅺu代-C2-C4-鏈烯基磺?；?、C1-C4-烷基氨基、二(C1-C4-烷基)氨基、C1-C4-烷基羰基、鹵代-C1-C4-烷基羰基、C1-C6-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的雜芳基氧基-C1-C4-烷基、未取代或被一次或多次取代的芳基氧基羰基、未取代或被一次或多次取代的芳基磺?；臀慈〈虮灰淮位蚨啻稳〈倪拎せ趸?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺酰基和鹵代-C1-C4-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈碾s芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C1-C4-烷基磺酰基和鹵代-C1-C4-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈妮粱蜞?，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基、鹵代-C1-C4-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C4-烷硫基、鹵代-C1-C4-烷硫基、C2-C4-鏈烯硫基、鹵代-C2-C4-鏈烯硫基、C1-C4-烷基磺?；望u代-C1-C4-烷基磺?；?；Y為C(O)或S(O)n；a表示1或2；且n表示2。
27.權(quán)利要求1的式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基或未取代或取代的苯氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、C1-C4-烷基、鹵代-C1-C4-烷基、C1-C4-烷氧基和鹵代-C1-C4-烷氧基；R2表示氫、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷硫基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；R3、R4和R5互相獨(dú)立，表示氫、鹵素、C1-C2-烷基、鹵代-C1-C2-烷基或C3-C6-環(huán)烷基；R6表示氫、C1-C2-烷基、C1-C2-烷基羰基或芐基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺酰基、鹵代-C1-C2-烷基磺酰基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基、未取代或被一次或多次取代的芳基氧基、未取代或被一次或多次取代的芳基氧基-C1-C2-烷基和未取代或被一次或多次取代的吡啶基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；望u代-C1-C2-烷基磺?；晃慈〈虮灰淮位蚨啻稳〈碾s芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、硝基、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C2-C4-鏈烯基氧基、鹵代-C2-C4-鏈烯基氧基、C1-C2-烷硫基、鹵代-C1-C2-烷硫基、C1-C2-烷基磺?；望u代-C1-C2-烷基磺酰基；R10表示氫或氰基；Y表示C(O)；且a表示1。
28.權(quán)利要求1的式I化合物，其中R1表示氫、鹵素、氰基、硝基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基或鹵代-C1-C2-烷氧基；R2表示氫、甲基、鹵代甲基、甲硫基、甲氧基或鹵代甲氧基；R3、R4和R5互相獨(dú)立，表示氫、甲基或鹵代甲基；R6表示氫或C1-C2-烷基；R7表示未取代或被一次或多次取代的芳基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基、鹵代-C1-C2-烷氧基、C3-C5-環(huán)烷基、C1-C2-烷基羰基、鹵代-C1-C2-烷基羰基、C1-C2-烷氧基羰基；未取代或被一次或多次取代的芳基-C1-C2-烷基和未取代或被一次或多次取代的芳基氧基，所述取代基互相獨(dú)立并選自下列基團(tuán)鹵素、氰基、C1-C2-烷基、鹵代-C1-C2-烷基、C1-C2-烷氧基和鹵代-C1-C2-烷氧基；R10表示氫；Y表示C(O)；且a為1。
29.制備分別為游離形式或鹽形式的權(quán)利要求1的式I化合物的方法，該方法包括使式II化合物 該化合物已知或采用類似于相應(yīng)的已知化合物的制備方法生產(chǎn)，且其中R1、R2、R3、R4、R5、R6、X和a與式I所給定義相同，與式III化合物反應(yīng)Q-Y-R7III，該化合物已知或采用類似于相應(yīng)的已知化合物的制備方法制備，且其中Y和R7與式I所給定義相同且Q為離去基團(tuán)，任選在堿催化劑存在下反應(yīng)，并且如果需要，將根據(jù)該方法或其他方法得到的游離形式或鹽形式的式I化合物轉(zhuǎn)化為另一式I化合物，將根據(jù)該方法得到的異構(gòu)體的混合物分離并將根據(jù)該方法分離的所需的異構(gòu)體和/或得到的游離的式I化合物轉(zhuǎn)化為鹽，或?qū)⒏鶕?jù)該方法得到的式I化合物的鹽轉(zhuǎn)化為游離的式I化合物或另一種鹽。
30.控制寄生蟲的組合物，該組合物包含作為活性成分的至少一種權(quán)利要求1的式I化合物，以及載體和/或分散劑。
31.權(quán)利要求1的式I化合物在用于控制寄生蟲中的用途。
32.控制寄生蟲的方法，該方法包括將有效量的至少一種權(quán)利要求1的式I化合物用于寄生蟲上。
33.權(quán)利要求1的式I化合物在控制溫血動物寄生蟲的方法中的用途。
34.權(quán)利要求1的式I化合物在制備用于抗溫血動物寄生蟲的藥用組合物中的用途。
全文摘要
本發(fā)明涉及通式I化合物和任選的它們的對映體，在式I中，R
文檔編號C07D235/10GK1599725SQ02824105
公開日2005年3月23日 申請日期2002年11月13日 優(yōu)先權(quán)日2001年11月14日
發(fā)明者P·迪克雷, T·格貝爾 申請人:諾瓦提斯公司